Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 6968876 | [Changes of serum alpha 2-ceruloplasmin in patients with rheumatoid arthritis]. | 1980 Sep 26 | Significant changes of alpha 2-ceruloplasmin serum concentration and decreased number of T-lymphocites have been found only in 15 R F positive out of 25 patients with definite R.A. Possible correlation between these findings in discussed. | |
| 6435402 | Clinical and histological evaluation of synovial needle-biopsies in rheumatoid arthritis. | 1984 | The histological pattern of synovial needle-biopsies of 50 patients suffering from classical or definitive rheumatoid arthritis has been compared with the clinical activity of the disease. Each histological change was evaluated in terms of its value in characterizing local clinical activity. It was shown that most changes of the synovial ground tissue are in a positive correlation with local clinical activity. Among the vascular changes of the synovial membrane, oedema of vascular walls, exudation of fresh fibrin, leukocyte infiltration and thickening of vascular walls were in negative correlation, while chronic fibrin, lymphocytic or plasma cell infiltration and hyalinosis were in positive correlation with local clinical activity. | |
| 486218 | Lymphocyte depletion by continuous flow cell centrifugation in rheumatoid arthritis: clini | 1979 Oct | Four patients with active, severe rheumatoid arthritis were subjected to the removal of circulating lymphocytes (lymphapheresis) for a 6-week period by use of a continuous flow cell centrifuge. Repetitive venous access was gained through forearm arteriovenous fistulae. In all patients the Ritchie-Camp articular index declined rapidly in the first week and more slowly therafter for a total mean drop of 61% below the initial value. The index continued to decline after lymphapheresis but exacerbation of disease activity developed at an average of 19 weeks. No significant untoward effects of the procedure were observed; occasional transfusions were required to compensate for the small, unavoidable erythrocyte loss. | |
| 7209294 | Rheumatoid lung disease. (A clinical, physiological and histological study in 33 patients) | 1980 Oct | Clinical, physiological and histological investigations on lung involvement are reported in 33 rheumatoid patients. The clinico-pathological patterns of rheumatoid lung disease observed in 19/27 non-smoking female patients were characterized radiologically by diffuse interstitial opacities, functionally by V/Q inequality and microscopically by peribronchiolar and/or alveolar fibrosis. Emphasis is placed on the ventilation/perfusion relationship as well as histopathological studies for a more accurate diagnosis of lung disease in RA. Patients with pulmonary nodules and pleural opacities were also observed. A possible immunological aetiology is suggested on the basis of the simultaneous finding of IgG, complement and fibrinogen in the pulmonary tissue. | |
| 7299767 | Peripheral hyperostosis in rheumatoid arthritis in the absence of axial involvement. | 1981 Jul | When diffuse idiopathic skeletal hyperostosis (DISH), or Forestier's disease, coexists with rheumatoid arthritis (RA), the radiographic features of RA are characteristically altered and may be diagnostically misleading. Altered findings include the absence of osteoporosis, bony proliferation around erosions, osteophytosis and ankylosis. Previously reported cases of coexistent RA-DISH have all exhibited characteristic spinal hyperostosis. Two cases are discussed which demonstrate that the distinctive peripheral radiographic findings of RA-DISH may occur in the absence of vertebral involvement. | |
| 6251664 | [The use of 99mTc-pyrophosphate indices in the quantitative evaluation of rheumatoid arthr | 1980 May | The authors have presented their own method of defining "joint to bone" and "joint to joint" radioactivity indicators with the application of 99mTc-pyrophosphate. Investigations of the degree of 99mTc-pyrophosphate accumulation in the 4 chosen points have shown that the lowest coefficient of changeability points out at half of crus length. The authors have employed radioactivity measurement of this place as a constant reference point while defining all the indicators "joint to bone". On the basis of the investigations carried out in 45 patients with varied degrees of rheumatoid arthritis activity and in the control group of twenty individuals it was established that the applied method makes possible the quantitative evaluation of rheumatoid arthritis activity in a simple way and in a short time. | |
| 6880408 | [Effects of therapy, serology, stage and activity of rheumatoid arthritis on lymphocyte st | 1983 May | We utilized a new, whole blood method to study the stimulation of lymphocytes by phytohemagglutinin in patients with rheumatoid arthritis and healthy volunteers. We observed that lymphocytes of patients with rheumatoid arthritis were significantly less stimulated by phytohemagglutinin than lymphocytes of controls (p less than 0.05). The underlying T-cell defect appeared to be present at all stages and activity levels of disease, and in both seropositive and seronegative patients. | |
| 912975 | Loosening associated with G.S.B. hinge total elbow replacement in patients with rheumatoid | 1977 | Total elbow replacement utilizing the G.S.B. hinge prosthesis will improve function in patients with ankylosed or painful, unstable elbows in the early postoperative period. However, painful loosening has been the primary long-term problem and has led to the abandonment of this concept even for salvage of the destroyed rheumatoid elbow joint. | |
| 6532646 | The PIP joint. | 1984 Dec | The anatomy of the PIP joint has been reviewed, regarding it as a functional complex including extensor and flexor mechanisms, rather than as a simple hinge joint. The importance of stability and mobility has been stressed. The pathological changes affecting this joint, resulting from primary joint disease, primary extensor tendon disease and primary flexor tendon disease have been described. The management of the resulting deformities has been discussed under the headings of general management, splintage, steroid injection, and surgery, including synovectomy, restoration of flexion, restoration of extension, arthroplasty and arthrodesis. | |
| 3936932 | Esophago-bronchial fistula in a patient with rheumatoid arthritis. | 1985 Oct | A 58-year-old woman with active rheumatoid arthritis developed an esophago-bronchial fistula in close temporal proximity to the eruption of subcutaneous nodules and a worsening of her joint symptoms. Possible mechanisms to explain the fistula formation are discussed. | |
| 458790 | Manubrio-sternal joint subluxation in rheumatoid arthritis. | 1979 Mar | A patient is described in whom subluxation and erosions were present in the manubrio-sternal joint. The literature relating to the manubrio-sternal joint in rheumatoid arthritis is reviewed. | |
| 7299769 | Superior margin rib defects in rheumatoid arthritis. | 1981 Jul | Twenty patients with severe rheumatoid arthritis and 96 controls were examined for prevalence and type of superior margin rib defects. In both groups a high prevalence of minor degrees of defects were found (40% and 38.5%). Solely in the rheumatoid group, additional erosive-appearing rib defects were found in 3 of the 20 patients. Radionucleotide scanning of these 3 patients did not show increased activity over the involved rib areas. In the rheumatoid group, the presence of severe shoulder disease correlated with the occurrence of rib defect (both types). We suggest that rib defects, particularly the erosive type, are related to scapulothoracic joint disease. | |
| 7178861 | Coexistence of rheumatoid arthritis and systemic sclerosis in four patients. | 1982 | The classic skin and internal organ system manifestations of systemic sclerosis developed in 4 individuals, each with an erosive, destructive chronic polyarthritis characteristic of rheumatoid arthritis. All had serum rheumatoid factors, anti-nuclear antibodies, hypergammaglobulinemia and circulating immune complexes. Each of the 4 has been resistant to treatment. The features of these patients, together with an analysis of this unusual coexistence of two connective tissue disorders, are presented. | |
| 6546119 | Early management of the rheumatoid joint. | 1984 | The success of early management of the inflamed synovial joint in rheumatoid arthritis depends on a team effort. The patient, rheumatologist, orthopaedist, social worker, and physical therapist must communicate with each other and understand the objectives of any treatment program. Present medical therapy is encouraging, but there is still a place for early surgical management. Synovectomy has a definite role, and with careful patient selection using appropriate criteria, satisfactory long-term results may be expected. Future treatment plans will no doubt use medical synovectomy to a greater extent and employ new isotopes, for example, 165Dy. Also, better objective techniques of identifying appropriate candidates with adequate articular cartilage remaining must be developed. No matter which path therapeutic modalities follow, it is necessary to continue developing objective criteria of assessing the long-term results of treatment so that standard methods of reporting follow-up can be used to make appropriate comparisons. | |
| 198974 | The biology of the rheumatoid synovial cell. | 1977 Sep | Over the past 15 years, many of the elaborate research techniques of cell biology and biochemistry have been applied toward discovering the cause of rheumatoid arthritis. Consequently, it is valuable to review the morphological, physiological and biochemical alterations that have been observed in rheumatoid synovial cells. All of the changes observed suggest that a viral agent may form the basis for these alterations. However, studies to date have failed to isolate or identify the putative causative virus and the search continues. | |
| 7103303 | [Treatment of severe or vasculitis associated forms of rheumatoid arthritis by plasma exch | 1982 | Five patients with typical seropositive rheumatoid arthritis were treated by plasma exchange. All patients had severe affections resistant to conventional treatment, while in four cases the disease involved extra-articular localizations: rheumatoid nodules (3 cases), polyneuritis (1 case), skin necrosis (1 case). Each patient received between 5 and 10 plasma exchanges over a period of 3 to 4 weeks. No major complications were observed. Immediate results were very good in all cases, as shown by absence of clinical expression of the arthritis, marked regression in extra-articular symptoms, and reduction in erythrocyte sedimentation rate without parallel alterations in rheumatoid factor levels. Improvement lasted for only a few weeks in 3 patients, in one case preceded by an acutely painful episode. In the remaining 2 cases, with associated vasculitis, improvement has been sustained for a period that now exceeds one year. Results are compared with those reported in the published literature, and the mode of action and indications for plasma exchange in rheumatoid arthritis discussed. | |
| 4067369 | [Clinical studies and postoperative results of 51 nonambulatory rheumatoid patients with t | 1985 Jul | Between October 1971 and June 1984, total joint replacement was performed on 51 nonambulatory patients with rheumatoid arthritis (RA). These nonambulatory patients showed high RA activity, and many presented with extra-articular symptoms with reference to the heart, lung, etc. During follow-up, 13 patients died of diseases unrelated to the operation, and the whereabouts of other 3 patients were unknown. Thus, the total joint replacement was evaluated in the remaining 35 patients. The walking ability was improved in 27 patients. However, the hoped-for results were not attained in relation to various aspects of the activities of daily life. Complications developed in 6 joints of 6 patients. The factors responsible for poor results were loss of motivation, muscle weakness, reduced function of the upper extremities, osteoporosis, cervical spinal cord injury, etc. From these results, it is emphasized that properly-timed surgery at the right level can prevent RA patient from becoming nonambulatory. | |
| 6285227 | Vasculitic neuropathy in rheumatoid disease and Sjögren syndrome. | 1982 Aug | Two patients with rheumatoid arthritis and one with Sjögren syndrome had a severe sensorimotor neuropathy preceding or up to 5 years after the onset of the disease. Electrophysiologic and sural nerve biopsy studies revealed an axonal neuropathy. Myelinated fibers were affected to a greater extent than unmyelinated axons. Peripheral nerve damage was related to occlusion of the vasa nervorum, since vasculitic involvement of epineurial vessels was observed in all patients. Despite the severity of the neuropathy, it may recover, because, compared with axons, Schwann cells are perhaps less vulnerable to ischemia. | |
| 7270332 | Cell-cell interactions in the rheumatoid joint. | 1980 Dec | Although rheumatoid synovium has been extensively studied in organ culture, particularly with respect to the synthesis of prostaglandins and proteinases, the behaviour of normal human synovium in culture has been much less well characterized. In this study, cultures of fragments of normal synovial tissue produced significantly less prostaglandin E (PGE) than cultures of rheumatoid synovium. The difference, however, did not persist when synovial cells obtained by enzymatic dispersion of normal and rheumatoid tissue were compared in monolayer culture. Production of PGE could be reactivated in both normal and rheumatoid synovial cells by products of mononuclear blood cells and also by factors in culture medium obtained after incubation of fragments of either normal or rheumatoid synovial tissue. These products of mononuclear cells and of synovial tissue also stimulated the production of PGE by human articular chondrocytes in monolayer culture. If these types of cellular interactions observed in vitro also occur in the arthritic joint as a result of the failure of normal control mechanisms, they could play a part in the irreversible destruction of joint structures. | |
| 7069140 | Ankle synovectomy: an approach to the rheumatoid ankle. | 1982 Spring | Rheumatoid synovitis or pannus formation is chiefly responsible for pain, joint destruction, and eventual erosion in patients afflicted with rheumatoid arthritis. Synovectomy is a nondestructive means of arresting this inflammatory process in the rheumatoid ankle. The technique of ankle synovectomy is described. |