Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 7291958 | Varying distribution of acetylation phenotypes in RA patients with and without Sjögren's | 1981 | The acetylator phenotype status was studied in 61 patients with rheumatoid arthritis (RA), of whom 27 had associated Sjögren's syndrome (SS). The acetylation tests were carried out by means of isoniazid and in 24 patients also with the use of dapsone; there was complete agreement between the outcome of the two tests. The results showed that the frequency of slow acetylators in the whole material was 59%. In RA patients with SS, however, the frequency of slow acetylators was as great as 78%, while it was only 44% among patients without SS (p less than 0.02). Thus, there appears to exist a (pharmaco) genetic difference between RA patients with and without SS. In addition, toxicodermias were found to be more frequent in RA patients with than without SS (P less than 0.01). However, this could not be systematically correlated to slow acetylation. | |
| 727633 | Fundus lesions in rheumatoid arthritis. | 1978 Nov | Cotton wool exudates were found in a patient during a flare-up of seropositive rheumatoid disease with polyarthritis and pericarditis. After therapy with cortisone a concomitant improvement of the cardiac arthritic and fundal lesions was observed. It is suggested that the fundal lesions in this patient were due to the rheumatoid disease. | |
| 6569527 | The medical, personal, and social costs of rheumatoid arthritis. | 1984 Dec | Not all arthritics are affected by the same outcomes nor are they affected to the same degree. For some, disability, either physical or psychological, is the most troublesome. For others, their inability to lead a more active life is the main concern. The nurse caring for the arthritic patient can play an important role in diminishing the potential negative impact of these disease consequences. With education and counseling, she can provide the patient with an intelligent understanding of the disease. Anxiety can be reduced if the patient is aware of disease characteristics and possible outcomes. Disability and pain can be minimized, personal and social adjustments can be made in a supportive environment, and realistic expectations can lead to an increased quality of life. | |
| 1086655 | Effect of penicillamine therapy on circulating immune complexes in rheumatoid arthritis. | 1975 Oct | The sera of 40 patients with severe progressive rheumatoid arthritis were examined for the presence of soluble immune complexes before penicillamine therapy was started, and again after treatment for a mean period of 14-4 months. The methods used were radiobioassay (macrophage uptake), C1q-binding capacity, and precipitation by 4% polyethylene glycol. Before treatment the sera of 37 patients showed significantly enhanced uptake of 125I-labelled aggregated human IgG by guinea pig macrophages. Treatment produced significant falls in mean erythrocyte sedimentation rate, differential agglutination titre, and serum IgG and IgM levels, and enhancing complexes (EC) decreased or disappeared in 20 patients. In 9 patients EC changed to inhibiting complexes, and in 8 EC levels were unchanged. In 6 of 8 patients with cutaneous vasculitis initially, both lesions and EC disappeared. The total protein and the IgG and IgM precipitated from patients' sera by 4% polyethylene glycol fell significantly on treatment. Antinuclear antibody titres were unchanged by penicillamine, and 3 patients acquired these antibodies during treatment. These findings suggest that penicillamine treatment in rheumatoid arthritis reduces the level of circulating soluble immune complexes in which IgM rheumatoid factor is a component. | |
| 6306757 | [Rheumatoid polyarthritis of adults in tropical Africa. Apropos of 50 cases in the Ivory C | 1983 Mar | The joint manifestations of rheumatoid arthritis in tropical Africa are characterized by the discreteness of the involvement of the hips and perhaps of the cervical spine. The extra-articular manifestations are rare and principally of the pulmonary fibrosis type. It is difficult to conclude on the more frequent sero-negativity of the disease, as the studies are incomplete. The overall tolerance of the disease appears to be good despite the limited treatment available. | |
| 7416818 | Excision of the ulnar head in patients with rheumatoid arthritis. | 1980 Jun | In 40 patients with rheumatoid arthritis 43 operations for excision of the ulnar head were performed. A follow-up study was performed after 35 months. In 38 patients wrist pain had disappeared completely or almost completely. The function in use, supination and pronation of the wrists, and wrist strength had all much improved. The stability of the radiocarpal joint was good after operation. Only minor complications were seen. | |
| 6677952 | [The hand in psoriatic arthropathy. Radiographic and xeroradiographic comparison]. | 1983 Nov | The hands of 45 cases of psoriasis with arthritis and of 100 cases of rheumatoid arthritis without psoriasis were studied by radiographic and xerographic techniques. The characteristic findings of both methods were recorded separately and compared later. In 44% of cases of psoriatic arthritis, radiographic and xerographic changes are indistinguishable from typical rheumatoid arthritis, but with predominant involvement of distal interphalangeal joints, often bilaterally asymmetric. On the contrary, in 31% of cases, erosive polyarthritis associated with proliferation of subperiosteal new bone (enthesopathy) is present, also with characteristic feature of arthritis mutilans. In 25% of cases, psoriasis of the skin and/or nails is associated with clinical manifestations of rheumatoid arthritis, without roentgenographic findings of arthropathy. The xerographs and radiographs of each patient were compared, assessing the degree of subperiosteal erosion, soft tissue swelling, acro-osteolysis, distruction of small joints and osteolysis of the phalanges, bony ankylosis. The soft tissue swelling ("sausage" finger) was more easily demonstrated by xeroradiography than by conventional radiography, because of its wide recording latitude. However, radiograph remains the technique of choice in the assessment of bone changes of the hand, especially at the first stage of arthritides. | |
| 2863375 | Sulfasalazine in severe rheumatoid arthritis: a study to assess potential correlates of ef | 1985 Apr | Thirty-one patients with chronic active rheumatoid arthritis (RA) resistant to gold and/or penicillamine therapy, were treated with sulfasalazine, 2-3 g daily, in a 12-week open study. Nineteen patients completed the study, and of these, 13 showed clinical improvement. Twelve patients were withdrawn from the study because of nausea (8), mouth ulcers (1), disease flare (1) and noncompliance (2). There was no significant difference in serum sulfasalazine concentrations among responders, nonresponders and patients who were withdrawn. Our data suggest that sulfasalazine may be of benefit in the treatment of RA. Further studies are necessary to determine if toxicity and/or efficacy might be related to serum concentrations of sulfasalazine metabolites. | |
| 684505 | Total hip replacement in patients with rheumatoid arthritis. | 1978 Sep | In this prospective study, 50 patients with a confirmed diagnosis of rheumatoid arthritis had total hip replacement. Preoperatively and at regular intervals postoperatively, all patients had evaluation of pain, ambulation, and range of motion according to the scale of d'Aubigne and Postel. Follow-up ranged from three to seven years, with the average being longer than four years. All patients demonstrated significant improvement in these parameters. Specific problems of the rheumatoid patient are discussed in detail. | |
| 7097680 | Circulating activated lymphocytes in rheumatoid arthritis: a marker of synovial inflammati | 1982 Mar | Peripheral blood lymphocytes have been studied in rheumatoid arthritis using a Ficoll density gradient in which activated cells separate as low density lymphocytes (LDL). Increased numbers of LDL are found in rheumatoid patients with active synovitis but not in those with active extraarticular disease such as vasculitis in the absence of active synovitis. The association of activated cells with synovitis is confirmed by serial studies during cyclophosphamide therapy in which LDL correlate with a computerized thermographic index of joint inflammation. The separate immunological markers of vasculitis and synovitis, and the possible role of LDL in the pathogenesis of the latter, are discussed. | |
| 857803 | Multicenter evaluation of synovectomy in the treatment of rheumatoid arthritis. Report of | 1977 Apr | A controlled multicenter evaluation of synovectomy in the treatment of rheumatoid arthritis followed 59 patients for 3 years. Finger joints and knees were studied. After 1 year synovectomized joints were better than controls in several features. After 3 years these differences had disappeared in the fingers, but swelling remained less in synovectomized knees. Recurrences were as frequent in synovectomized as in control finger joints, but were slightly less frequent in synovectomized than in control knees. Radiologic bony erosions in fingers and knees of both groups progressed equally during the 3 years. | |
| 6814682 | Alternative medicine: cost and subjective benefit in rheumatoid arthritis. | 1982 Dec 4 | Seventy-eight patients with seropositive rheumatoid arthritis were asked about money spent in an attempt to help their arthritis. This included expenditure on alternative medicine, aids for the home, and conventional medicine. Most money was spent on, and most benefit was derived from, aids for the home. Sixty per cent of the patients had tried alternative medicine, but expenditure on this was relatively low and only a small proportion found it helpful. | |
| 646604 | Hand function after metacarpophalangeal joint replacement in rheumatoid arthritis. | 1978 Apr | Hand function, determined by a standardized test, was compared before and after total metacarpophalangeal joint replacement with the Swanson Silastic rubber metacarpophalangeal prosthesis in patients with destructive rheumatoid arthritis. Two groups of rheumatoid patients were tested. Group 1 consisted of 10 patients who were examined 3 to 4 months after surgery. Group 2 included 11 patients who were evaluated 6 to 12 months postoperatively. Each group represented 43 prosthetic replacement procedures performed on 12 hands. Results indicate substantial postoperative improvement in tip prehension and grasp, while performance remained essentially unchanged for lateral prehension, pinch force, and power grip. A postoperative program of therapeutic exercises, functional hand activities and splinting is discussed. | |
| 7015239 | [Plasmatic and urinary zinc in rheumatoid arthritis (author's transl)]. | 1981 Feb | The analysis of the plasmatic and urinary levels of zinc in 50 patients presenting a non inflammatory disease and in 50 rheumatoid arthritis, points out to an high significative difference between plasmatic data (13,37 +/- 2,72 mumol/l and 11,32 +/- 2,22 mumol/l respectively ; p less than 0,001). No difference was found in urinary levels and neither age, nor sex, duration of the disease, most biologic parameters, nor long term medications can explain the difference which seems related to the inflammatory tissue process. | |
| 1273552 | Do you die from rheumatism? The five-year mortality in a middle-aged population sample wit | 1976 | With special reference to reported joint symptoms, the five-year mortality was studied of a population sample of 3394 persons, 56-60 years old in 1965. An age- and sex-matched comparison was made between the mortality of the total population of the same age-group, and the sample investigated. A significant excess mortality was found for males reporting previous hospital admission for "rheumatoid arthritis". In this group, however, only 28% really had rheumatoid arthritis according to generally used criteria. The other diseases were mainly previous rheumatic fever and degenerative joint disease. It is concluded that males are harder hit by degenerative joint disease than females. The sample investigated had a lower mortality than the population from which it was sampled. The comparability of a fixed sample and a mean population found in official statistics is discussed. The non-response group was estimated to have a considerable excess mortality. | |
| 441638 | Management of the rheumatoid hand. | 1979 | The hand is often forgotten in the management of rheumatoid arthritis. Rheumatoid disease in the hand, as elsewhere, can be divided into three phases: the early proliferative stage, the period of synovial regression and the stage of fixed deformity. Our studies suggest that the eventual pattern of hand deformity is related to the site, severity and sequence of synovial involvement. It is, therefore, likely that the results of early medical and surgical treatment of the rheumatoid hand will be more rewarding than those of late reconstructive procedures. | |
| 6501371 | Surface replacement of the elbow in rheumatoid arthritis. Early results with the Wadsworth | 1984 Nov | Fifteen patients with rheumatoid arthritis had 19 elbow arthroplasties with the Wadsworth type of surface replacement prosthesis. After a follow-up period averaging 30 months, 11 patients with 15 elbow arthroplasties were entirely satisfied with their freedom from pain and range of movement. Radiologically, however, the humeral component was loose in 10 of the 19 elbows and the ulnar component in 5. Two patients had reoperation, one to remove a prosthesis for early deep infection and one to exchange a humeral component which was loose. The risk of mechanical loosening is reduced by accurate positioning of the humeral component, but there is a high potential for failure. Changes in the design of the prosthesis and better instrumentation for alignment of the components are desirable. Prosthetic replacement of the elbow should still be regarded as experimental. | |
| 1198013 | The use of beta-N-acetylglucosaminidase excretion to investigate renal disease in rheumato | 1975 Nov | Urine levels of the lysosomal enzyme beta-N-acetylglucosaminidase have been measured in patients with arthritic disorders; significantly higher levels were found in patients with rheumatoid arthritis (mean: 332.9 nmol/h/mg creat.) than in those with degenerative joint disease (mean: 86.31 nmol/h/mg creat.; P less than 0.001). Analysis of the results shows that salicylates were responsible for some of this difference, but suggests that rheumatoid disease itself may cause renal damage. | |
| 6669871 | A synovectomy trial and the history of early knee synovitis in rheumatoid arthritis. A mul | 1983 | The results of a randomized synovectomy trial are reported and the history of early knee synovitis in 121 patients with rheumatoid arthritis is described. Conservative treatment (rest in splints, non-steroidal anti-inflammatory drugs and gold or an anti-malaria agent) for 4-5 months led to improvement in 81 of the 121 patients with early knee synovitis. In one-third of these 81 patients, the improvement continued, according to their own and the doctor's opinion, during 5 years of follow-up. Ten of the 22 patients who fulfilled the criteria for the synovectomy trial were operated upon. They showed improvement for 4 years. Over the 5-year period, two-thirds of the group were constantly seropositive or seronegative and in the other third the serology varied, but such that at each assessment 50% of the group were seropositive. Radiologically, all of the patients showed deterioration. The surgical group deteriorated more slowly for the first 2-3 years, but then showed the same pattern as the other groups. The disappearance of the clinical features of synovitis does not mean that radiological deterioration has ceased. | |
| 174201 | [Destructive lesions of the middle and lower part of the cervical spine during rheumatoid | 1975 Apr 8 | Lesions of the middle and lower part of the cervical spine during rheumatoid arthritis are less frequent than those of the cervico-occipital joint. They concern the discs on the one hand, the posterior inter-apophyseal joints, on the other hand. The authors report a case of rheumatic spondylodiscitis of C5-C6 with dislocation, complicated by quadriplegia, and review other published cases of rheumatoid lesions of the middle and lower cervical spine with neurological complications. The mechanisms of these lesions and their complications are then discussed. |