Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 3899967 | Current trends in the research on antiinflammatory agents. | 1985 | Current trends of pharmacological research on inflammation are outlined, with particular reference to some agents differing from the aspirin-like and the corticosteroids in their mode and mechanism of action. As an example, animal models used for the study of benzydamine, and its predominant features, are illustrated. A discussion is also made on the role of protein denaturation in inflammatory conditions where cell degeneration prevails over the active response, and the rationale used for developing bendazac is presented. | |
| 6602884 | The incidence of anti-RANA in Mexican Mestizo populations with rheumatoid arthritis or oth | 1983 Apr | The anti-RANA antibody was first described as a serologic characteristic of Caucasian patients with seropositive rheumatoid arthritis (RA). To determine whether there is uniformity among diverse racial groups in the finding of elevated titers of anti-RANA in RA, we studied a Mexican Mestizo population. We found that this population also has a high frequency of anti-RANA and indicates that high frequencies of anti-RANA in RA will probably be true for all populations. A previously unrecognized association between extraarticular manifestations and positive anti-RANA was suggested among RA patients. The possible significance of elevated anti-RANA titers in RA is discussed. | |
| 3978367 | Effects of joint lavage on knee synovitis in rheumatoid arthritis. | 1985 Feb | Ten patients with rheumatoid arthritis and persistent knee synovitis had synovial fluid aspirated through a 14 gauge wide-bore needle followed by joint lavage and intra-articular triamcinolone. This resulted in the removal of variable quantities of intra-articular debris including rice bodies. When compared to a control group of patients, the addition of joint lavage to the standard procedure of aspiration and injection of corticosteroid resulted in more sustained resolution of synovitis after 12 weeks as judged by knee tenderness and circumference, recurrence of effusion, and synovial fluid leucocyte count. This study suggests that knee joint lavage may be a useful adjunct to therapy in rheumatoid arthritis patients having persistent knee synovitis. | |
| 636668 | The relationship between polymorphonuclear granulocytes and cartilage destruction in rheum | 1978 Mar | The pannus-cartilage junction was investigated in cases of rheumatoid joint destruction. By a histochemical method for demonstrating the presence of neutrophil granulocytes, it became obvious that these cells in some cases were found in high numbers in the immediate vicinity of the cartilage in the process of being destroyed. It is concluded that these blood-carried cells may also participate in cartilage destruction in acute phases of chronic rheumatoid disease. | |
| 4081576 | [Rheumatoid polyarthritis and life events]. | 1985 Oct | By applying the systematic and quantitative method of life events to 56 patients with rheumatoid arthritis, the activity of which was assessed both clinically and by means of laboratory tests, the authors demonstrated a significantly higher value for the cumulative life event score over the three years prior to the examination (with or without weighting) in patients in an active phase of the disease compared with patients in remission. These results seem to support the concept that the accumulation of life events may increase the incidence of subsequent episodes of the disease and conversely. The non specific nature of the phenomenon seems to be demonstrated by the study of a control group of subjects hospitalised for disease other than rheumatoid arthritis. | |
| 6261219 | [Destruction and inflammation of the joints in rheumatoid arthritis: a pathogenic hypothes | 1981 Mar 21 | On the basis of recent in vitro studies, the authors hypothetize on the mechanism of joint destruction in rheumatoid arthritis. They suggest that the leading part is played by the cells of the synovial membrane, which have been found in cultures to secrete biochemical substances, such as collagenase or PGE2, involved in the destruction of articular surfaces. The secretion of these substances is considerably increased by soluble factors produced by monocytes under the influence of lymphocytes, and lymphocytes are known to participate in the chronic inflammatory reaction characteristic of the disease. Such a pathogenic sequence might lead to new therapeutic approaches. | |
| 887387 | [Treatment of rheumatoid arthritis with levamisole. Preliminary study of clinical and immu | 1977 May 28 | From September 1975 to September 1976, eleven patients suffering from rheumatoid arthritis in whom gold salts were either inactive or contraindicated were treated with levamisole. Treatment was interrupted in one case because of an allergic rash and in one as a precaution. There was an improvement in six, taking the form of a decrease in clinical symptoms and signs and a slowing of sedimentation rate. Certain immunitary changes were seen, in the sense of a reinforcement of humoural and cellular immunity. Fear of sudden agranulocytosis should lead to caution in further clinical trials. | |
| 6587517 | [Cross reactions of HLA A and B antigens in 63 patients with rheumatoid arthritis]. | 1984 Apr | Cross reactions are very frequently observed when HLA A and B antigens are determined by a routine lymphocytotoxicity method. Such cross reactions are probably due to biochemical structural similarities shared by several HLA antigens. In this work, we studied the cross reactions which occurred during HLA A and B typing of 63 patients with classical or definite rheumatoid arthritis (RA) according to the ARA criteria. No association was found between RA and any single HLA A or B antigen. In contrast, when cross reactions were taken into account, the B8 B14 cross reactant group frequency was increased in RA patients (34,9 p. cent) as compared to controls (20 p. cent, p less than 0,004) and was even more clearly elevated in the 42 seropositive RA patients (40,5 p. cent, p less than 0,002). No relation was found between HLA phenotype and Sjögren's syndrome even when cross reactions were considered. The B8 DR3 haplotype has been shown to be associated with drug intolerance . The B8 B14 cross reactant group was present in 22 out of our 63 RA patients, 16 of whom were B8+. Among the latter, 6 patients exhibited poor tolerance to gold salts and 6 other patients did not respond to gold therapy, suggesting that the B8 antigen could predict not only a poor tolerance but also a poor response to disease modifying drugs. | |
| 7081780 | Studies of phagocytic cell function in rheumatoid arthritis. I. Phagocytic and metabolic a | 1982 May | The polymorphonuclear cells (PMN's) of 20 patients with rheumatoid arthritis (RA) were analyzed for endocytic ability and metabolic capacity and were compared to those from a healthy control group over short intervals. The results of these studies indicate that the phagocytic activity (PA) and the nitroblue tetrazolium (NBT) dye reduction were significantly decreased in RA patients after 30 minutes of incubation. The rheumatoid patients showed a higher percentage of band cells and hypersegmented nuclei of their peripheral blood PMN's (PB-PMN's). No correlation was found between neutrophil functions and other parameters of the rheumatoid disease activity. | |
| 504947 | [The patella and the femoro-patellar joint during rheumatoid polyarthritis]. | 1979 Jul | The authors report 2 series of cases of rheumatoid arthritis, one prospective of 115 cases, the other retrospective of 72 cases, and note the frequency of clinical and radiological patellar and femoro-patellar involvement during this disease. Signs of active rheumatoid disease in the patella were present in 31 cases. The most common lesions of the femoro-patellar joint space are narrowing and lateral dislocation of the patella. The femoro-patellar lesions evolve in parallel to the femoro-tibial lesions, but dissociation is possible. The early detection of a femoro-patellar syndrome permits effective treatment by isometric rehabilitation of the quadriceps. On the most advanced lesions, and when pain is limited to the femur and patella, an operation of reaxation of the patella may provide remarkable functional improvement. | |
| 6467849 | Lymphapheresis as compared with rest period in treatment of severe rheumatoid arthritis. | 1984 Mar | In this study lymphapheresis over a 5-week period was compared with a period of rest in 8 patients with active severe rheumatoid arthritis. These patients failed to respond to gold or/and to D-penicillamine. All the patients treated by lymphapheresis improved in the first 2 or 3 weeks and one patient in the control group improved in 3 weeks. The laboratory findings and the 99mTc-pertechnetate uptake index of the joints were inconsistent. In this study lymphapheresis had a clinically modest beneficial effect which in 3 of 4 patients persisted even after 18 weeks. | |
| 6711283 | Seventy-four Attenborough knee replacements for rheumatoid arthritis. A clinical and radio | 1984 Apr | Seventy-four Attenborough total knee replacements in patients with severe classical rheumatoid arthritis were followed for 2-5 years. The preoperative radiograms were evaluated according to two different scoring systems. At follow-up, radiographic whole leg examinations were performed. Mean malalignment was 7 degrees. The overall results were not encouraging with definite failure in eight knees and probable failure in another 21 knees. Failure was significantly correlated with postoperative malalignment. | |
| 6157259 | [Changes in the immunological components of the blood during balneotherapy in patients wit | 1980 Apr 1 | The changes of the immunoglobulin G, the C-reactive protein and the acid alpha 1-glycoprotein which were observed under spa therapy in patients with rheumatoid arthritis. In these cases was shown that these parameters undergo regulative influences which in typical relationship to the initial tissue lead to a cross-over-phenomenon with demarcation of a regulatory zero- (or normal) region. Here patients with rheumatoid arthritis show the tendency to maintain a slightly increased defensive condition under the cure. On the basis of a narrowing of the dispersion of the immune components to the end of the cure compared with the beginning of the cure is concluded that the changes of defensive components to the blood which are to be observed in different initial values are not only based on the endogenic rhythmicity but partly also on the effects of the spa therapy. | |
| 6614848 | The surgical treatment of the rheumatoid shoulder. | 1983 Apr | Rheumatoid disease of the shoulder may affect not only the gleno-humeral joint but also the other joints of the shoulder girdle complex. Excision arthroplasty of the acromioclavicular and much less commonly of the sternoclavicular joints may be necessary to relieve persistent symptoms. Bursectomyin conjunction with anterior acromioplasty should provide a definitive solution to rheumatoid involvement of the subacromial bursa when this fails to respond to simple aspiration and hydrocortisone injection. Synovectomy has been little employed and perhaps deserves re-appraisal with regard to its role in the management of early cases of glenohumeral disease. Where pain is the predominant presenting symptom and until such time as joint replacement becomes more fully established and reliable double osteotomy may be worth considering as a very simple and in no way irrevocable surgical procedure. Glenoidectomy on the other hand should probably be regarded as obsolete except in cases where total joint replacement will be permanently contra-indicated. Even then arthrodesis may provide a stronger more stable and lasting solution, but before this operation is exhibited, pre-operative investigation must establish that the patient will be able post-operatively to remain independent with regard to routine activities of daily living and in particular perineal toilet. Arthroplasty of the shoulder must still be regarded as being in the developmental if not frankly experimental stage. The results from several sizeable series however are now beginning to show promising results. Moreover the pendulum is tending to swing towards the concept of a minimally constrained joint such as the Neer prosthesis which will mimic anatomical function and minimise the risks of scapular loosening. Careful attention to the soft tissues and very intensive and prolonged post-operative physio-therapy are vital to a successful outcome. It remains to be seen however whether more constrained joints would provide better functional results in the rheumatoid patient with severe bone erosion and rotator cuff destruction. In spite of the problems still to be solved, the author would regard total joint replacement as being the treatment of choice in the markedly eroded gleno-humeral joint presenting with severe pain and limitation of function. Moreover in the event of mechanical failure or infection, it would still seem to be possible to salvage adequate painfree function either by removal of the prosthesis and the creation of a pseudarthrosis or by arthrodesis. | |
| 622837 | [Regeneration of synovial tissue in rheumatoid arthritis following synovectomy (author's t | 1978 Feb 3 | A study was carried out on 83 knee joints which had been subjected to synovectomy for rheumatoid arthritis. The morphological changes in the synovial tissue were divided into two types, Type I or hypertrophic and Type II or hypotrophic. Type I (hypertrophic) exhibited oedema, hypervascularization, fibrinous layers, large amounts of villi and granulationlike tissue, lymphocytes and plasma cells. Type II (hypotrophic) contained all the above elements, but to a much lesser degree, and fibrosis was the dominant feature. Regenerated synovial tissue was removed one to three years after the original synovectomy by arthrotomy or biopsy in 26 patients who were symptom-free. The tissue was thinner and hardly any villi were seen. The typical inflammatory elements were seen, but were not as pronounced as in the original tissue, irrespective of type. A heavy fibrosis was most frequently seen, but apart from this the regenerated tissue greatly resembled the original. | |
| 6421253 | Does second-line therapy affect the radiological progression of rheumatoid arthritis? | 1984 Feb | The effect of 'second-line' drugs on radiological progression in rheumatoid arthritis is not clear, and previous studies have yielded contradictory results. Sixty-seven patients with rheumatoid arthritis have been followed up clinically and radiologically for approximately 2 years (26 patients were receiving intramuscular gold, 21 penicillamine, 10 levamisole, and there were 10 controls who had consistently refused second-line therapy). Patients on gold and penicillamine showed improvement in erythrocyte sedimentation rate and haemoglobin over 2 years which was not seen in levamisole and control patients, but hand radiograph scores in all 4 groups showed statistically significant deterioration. There was a trend towards slowing of the rate of erosion in the gold and penicillamine groups in comparison with controls, but healing of erosions was extremely unusual. | |
| 7044386 | Clinical responses during gold therapy for rheumatoid arthritis. Changes in synovitis, rad | 1982 May | Gold therapy given to 73 patients with rheumatoid arthritis was associated with remission of synovitis for 3 months or longer in 27 patients and 50% or greater improvement in 20 patients. New joint deformities did not develop in patients who experienced remission, and progression of radiologically detectable erosive changes was prevented. Serum protein and serologic abnormalities were improved in all groups, but patients who had a good response experienced the greatest improvement. No single clinical or laboratory feature in the pretreatment assessment predicted response, but, as a group, the patients with the best response also ranked best for most prognostic indicators. | |
| 7065741 | The incidence of malignant disease in patients receiving cytotoxic therapy for rheumatoid | 1982 | One hundred and twenty-six patients with definite or classical rheumatoid arthritis admitted to hospital between 1965 and 1974 for cytotoxic therapy were studied for the presence and type of malignant disease. Each of the cytotoxic treated patients was age and sex matched to a rheumatoid arthritis patient admitted to hospital during the same years but who did not receive cytotoxic therapy. There was no increase in malignancy in the cytotoxic treated group over the control group. | |
| 814410 | [Is the activity of rheumatoid arthritis affected by repeated surgical operations?(author' | 1975 Nov 7 | 37 R.A. patients who had been operated on several times (synovectomy and reconstructive surgery) were re-examined within 1 to 6 years after operation. Pain and function were improved in 2/3 of the patients, morning stiffness, ESR, and medicine consumption decreased in 2/3. The lower cortisone requirement in 28 patients (75%) was particularly impressive. 25 patients (67%) became cortisone-free. The joint index was reduced in 30 patients (81%). The impression exists that the rheumatic process can be influenced surgically for a long time. | |
| 1101571 | [Do the severity and duration of rheumatoid arthritis influence pulmonary ventilation?]. | 1975 Jul | Pulmonary ventilation was studied in 100 patients with rheumatoid arthritis of an outpatient clinic, using whole-body plethysmography, spirography, and pneumometry. The patients with more or less severe joint involvement, as well as the patients with shorter or longer duration of their disease, did not show any significant difference in their dynamic and static pulmonary fuction. Patients with serious joint destructions showed a bronchial obstruction in 29%. 36 patients who were treated with thioglucose gold had a significantly better expiration capacity. A causal connection with the underlying disease is discussed. Further examinations should take therapeutic procedures and longitudinal studies into consideration. It is doubtful that significant restriction of ventilation is present in rheumatoid-arthritis. Methodically there was a good argreement between whole body plethysmography and pneumometry. |