Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 827018 | Cost-benefit analysis of synovectomy of the knee. | 1976 | The subject of this study was the cost-benefit ratio of synovectomy of the knee. Synovectomy of the knee is the most common operation at the Rheumatism Foundation Hospital, Heinola. In 1973 it accounted for 8.8% of all orthopedic operations performed. The survey material comprises 225 synovectomies of the knee performed on 208 patients. The age and sex distribution of the patients has been obtained from the material for 1973. The second series consists of 181 patients who underwent synovectomy of the knee during the period 1960-65 and who were re-examined in 1970-75. From the said material, data have been obtained on the postoperative professional working activity of patients and on the number of other hospital treatments given to these patients. These coefficients have been transferred to relate to the year 1973. Of those patients who underwent an operation in 1973, 70.9% were women and 29.1% were men. Their average age at the time of operation was 41 years. Their working age was 24 years on average. The operation and related total patient treatment inclusive of other orthopedic operations constitute a vital measure of the preservation of the patient's working ability. Cost-benefit analysis was the research method employed. The year 1973 was chosen as the period for investigagion. Costs due to synovectomy of the knee amounted in 1973 to about 1.6 million marks. Total costs averaged 7000 marks per operation. The greatest potential benefits accruing from synovectomies of the knee prove to be multiple as compared with with costs. Reckoned according to different rates of interest (6% and 9%) maximum benefits are about 8.2-9.8 million marks. As compared with costs, benefits are approx. 5.2-6.2 times as great. Maximum net benefits per one operation are about 43770 marks. Operations can be regarded as economically justifiable even in those cases where it is possible to preserve working ability for a period of 10 years for 10% of the patients. Furthermore, the effect of non-quantified benefits should also be considered. | |
| 6344195 | IgG rheumatoid factor-secreting lymphocytes in rheumatoid arthritis: evaluation of a haemo | 1983 May | A haemolytic plaque-forming cell (PFC) assay detecting human B lymphocytes secreting IgG rheumatoid factor (RF) was established using sheep erythrocytes (SRBC) sensitized with rabbit IgG, developing rabbit anti-human IgG, and complement. IgG-RF PFC were only demonstrated with IgG-depleted guinea-pig serum as the source of complement. Cells spontaneously secreting IgG-RF were found among synovial fluid mononuclear cells (mean, 134/10(6)) and synovial tissue mononuclear cells (mean, 1775/10(6)) from patients with rheumatoid arthritis, whereas few were recorded among blood lymphocytes (mean, 3/10(6)). The experiments revealed that the RF-IgG PFC were protein-synthesizing B lymphocytes. The antibody specificity of the secreted IgF-RF was verified by the inhibitory effect of exogenous human and rabbit IgG on PFC formation. | |
| 114642 | Action of gold salts on the inflammatory response and inflammatory cell function. | 1979 | Information relating to the effect and mechanism of action of gold salts on acute and chronic inflammatory processes has been reviewed. Gold salts are effective in suppressing various aspects of the acute inflammatory process although large gaps exist in the knowledge of the mechanisms involved. Available evidence indicates that gold salts affect many biochemical pathways and that interaction with enzymes plays a major role in their pharmacology. Because they are more difficult to investigate, the action of gold salts on various important aspects of chronic inflammation have not yet received much attention. | |
| 944042 | A pathogenetic model for erosive synovitis: lessons from animal arthritides. | 1976 Mar | Adjuvant arthritis, streptococcal cell wall-induced arthritis, and Erysipelothrix insidiosa arthritis are laboratory models of relapsing, erosive synovitis. A review of the experimental literature suggests that their pathogenesis is similar. The persistence in macrophages in the pannus of nonbiodegradable microbial cell wall components containing the peptidoglycan moeity is the central event. Based on this experimental literature, a model for the pathogenesis of these arthritides is developed. This model is testable and relevant to erosive synovitis in man. | |
| 4549570 | Immunological detection of nucleic acids and antibodies to nucleic acids and nuclear antig | 1974 May | A counterimmunoelectrophoresis (CIEP) technique has been developed for the rapid, simple, specific detection of nucleic acids as antigens, or for the detection of precipitating antibodies to nucleic acids or nuclear antigens. The majority of precipitins could be detected within 1 hr. As little as 0·0015 μg of antigen per ml (e.g. poly A: poly U) could be detected. Specificity of rabbit antisera to nucleic acids was demonstrated by selective reactions using a panel of polynucleotides. 1091 patient sera were examined for precipitins to DNA, single-stranded DNA, nucleoprotein and calf thymus nucleoprotein. Precipitins to DNA were found in 42% of systemic lupus erythematosus sera, 9% of rheumatoid arthritis sera and 4% of juvenile rheumatoid arthritis sera. Results with the CIEP method showed equal sensitivity as results obtained by complement fixation or binding assays, but were more sensitive than double diffusion in agar (Ouchterlony). | |
| 3874658 | [Cytotoxic antibodies to thymocyte antigens in rheumatism and other diseases]. | 1985 Jun | Cytotoxic antibodies reacting with mouse and human thymocytes were detected in rheumatic patients' sera. The level of cytotoxic antibodies was considerably higher in active than in inactive process. A correlation was found between the antibody level and the clinical course of rheumatic fever. The cytotoxic index was the highest in sera of patients with acute rheumatic fever. Thymocytotoxic antibodies were also found in other autoimmune diseases. In sera of normal individuals, antibodies to thymocytes were revealed rarely and in small quantities. A possible role of thymocytotoxic antibodies as a cause of deficit of T suppressors in autoimmune diseases is discussed. | |
| 7056595 | Effects of levamisole and D-penicillamine on contact sensitivity to oxazolone in rats. | 1982 | Levamisole, but not D-penicillamine, inhibited the oxazolone delayed hypersensitivity in rats. It was more effective when given locally to the ear (the tissue being challenged with oxazolone) or when injected intraperitoneally 24 h previously. Rats bred for resistance to the dextran anaphylactoid reaction exhibit contact sensitivity to oxazolone even better than rats which respond to clinical dextran. | |
| 1159573 | Bone growth kinetics IV: a preliminary investigation on a biorhythm in human osteogenesis. | 1975 May | Multiple doses of oxytetracycline were administered at regular but different intervals to groups of patients undergoin orthopaedic surgery. It was found that doses of the drug were incorporated at bone growth sites most frequently if the intervals between those doses were 3 or 6 days. This suggests a biorhythm in human bone growth with a periodicity of 3 days: this biorhythm may be altered by hormones or drugs. | |
| 6798978 | Serum IgG and IgM rheumatoid factors by solid phase radioimmunoassay. A comparison between | 1981 Dec | In this report, solid phase radioimmunoassays that specifically measure IgG rheumatoid factor (RF) and IgM RF in absolute concentrations are described. Polyclonal RF preparations were utilized as standards, and as little as 40 ng/ml of IgG RF and I ng/ml of IgM RF were detected. The IgG RF concentration of 26 seropositive rheumatoid sera was 439 +/ 755 micrograms/ml (mean +/- 1 SD), a level 107 times that of normal controls (P less than 0.001). In contrast, levels for 49 children with juvenile rheumatoid arthritis (JRA) were 6.1 +/- 3.7 micrograms/ml for those with a polyarticular onset (JRA-Po), and 27.3 +/- 113 micrograms/ml for the pauciarticular group (JRA-Pa), and 12.6 +/- 20.7 micrograms/ml for the group with a systemic onset (JRA-S). None of these values differed significantly from the value of 6.0 +/- 3.9 micrograms/ml measured in a juvenile control group. The IgM RF level in adult rheumatoid arthritis (RA) of 175 +/- 221 micrograms/ml was also significantly elevated compared to controls (P less than 0.001). In JRA, however, mean levels of 1.4 +/- 2.0 micrograms/ml (JRA-Po), 2.8 +/- 8.3 micrograms/ml (JRA-Pa), and 1.1 +/- 0.7 micrograms /ml (JRA-S) were not elevated significantly above the value of 1.2 +/-1.2 micrograms/ml measured in the juvenile control group. Hidden IgM RF was not found in 9 JRA sera tested. These marked differences in RF levels provide another indication that adult RA and JRA are distinct diseases. | |
| 1005658 | Penicillamine nephropathy in rheumatoid arthritis. A clinical, pathological and immunologi | 1976 Oct | Fourteen patients who developed persistent proteinuria while on penicillamine for rheumatoid arthritis, were collected over a period of one year. Eleven patients had a frank nephrotic syndrome and three had a lesser degree of proteinuria but no oedema. The patients had received penicillamine (mean daily dose 1015 mg) for less than one year (mean 7-5 months) when the nephropathy was detected. Clinical investigations have been correlated with renal biopsy material. Light microscopy detected no abnormalities except for minimal hypercellularity in a few patients. In markde contrast, the electron-microscope revealed numerous electron-dense deposits (EED's) in the outer layer of the basement membrane. Immunofluorescence showed the presence of IgG and complement in the basement membrane, the intensity of which correlated with the number of EED's. The pathological picture was essentially the same in those patients with the nephrotic syndrome and those with proteinuria. In this series, we found no evidence that penicillamine induced renal damage by any other mechanism except immune complex deposition. Serological tests revealed little evidence for complement activation or consumption and platelet aggregation was the only positive direct test for circulating immune complexes. Renal biopsies were performed at differing intervals after the cessation of penicillamine therapy, which allowed assessment of the natural history of the pathological lesion and revealed a striking persistence of EDD's in some patients. Two patients showed an almost identical picture initially and at re-biopsy one year later. Persistent proteinuria was also a feature of the group as a whole. The pathological picture has similarities with that of idiopathic membranous glomerulopathy. This study suggests that the use of penicillamine in rheumatoid arthritis may induce persistent renal damage. | |
| 1224927 | [Side effects of gold therapy]. | 1975 | 461 courses of chrysotherapy, mechanisms of action, effects, side effects and treatment of the latter are reported. With regard to changes of skin and mucous membranes, of peripheral blood count, urine, and liver enzymes the necessity of periodic controls is stressed. Before gold injection uncommon sensations as e.g. itching or "metallic taste" should be ruled out. | |
| 52135 | Temporomandibular degenerative joint disease. Part II. Diagnostic procedure and comprehens | 1975 Sep | The diagnostic procedure is given in the detail necessary to arrive at an accurate diagnosis of temporomandibular degenerative joint disease (TDJD). The differentiating clinical findings of degenerative joint disease (DJD) and rheumatoid arthritis of the temporomandibular joint (TMJ) are described. Principles and modalities of comprehensive management of TDJD are presented in the manner and sequence needed to allow practical clinical application. Methods of treatment are applied to the management of patients with acute and chronic TDJD. The surgical procedure for TDJD, intracapsular high condylectomy with a preauricular incision, is described in the detail required for individual application. Case reports are presented to illustrate the comprehensive management of TDJD. | |
| 1086507 | Prolonged treatment with tolfenamic acid in inflammatory rheumatic diseases. | 1976 | The aim of this study was in the first place to elucidate the tolerance of rheumatic patients to prolonged treatment with tolfenamic acid. 91 patients took part in the trial, most of them suffering from rheumatoid arthritis. The daily dose of tolfenamic acid was 600 mg and the trial lasted 6 months. The side-effects were usually slight: diarrhea occurred in 8, other gastrointestinal disturbances in 11, dysuria in 8 and other side-effects in 3 cases. Six patients broke off their treatment because of side-effects ascribed to tolfenamic acid. However, laboratory tests failed to show any significant changes caused by this drug. One case of reversible thrombopenia was seen in a patient who had also received gold treatment. On the whole, the clinical effect was found to be good, and tolfenamic acid appeared to be well suited for long-term symptomatic treatment of rheumatics. | |
| 7160109 | Studies of circulating immune complexes in ankylosing spondylitis. | 1982 | Circulating immune complexes (CIC) were sought, by a fluorescent antibody immunophagocytosis (FIP) assay, in the sera of 30 patients with ankylosing spondylitis (AS), 62 with rheumatoid arthritis (RA), 27 with systemic lupus erythematosus (SLE) and 67 normal controls. Component analysis of CIC revealed significant elevations of total immunoglobulin (TIg), IgM and C3 for all patient study groups. In contrast to RA and SLE, CIC in AS sera contained significantly increased IgA and decreased IgG components. Categorization of AS patients as Grade I (mild disease) or Grade II (moderate/advanced disease) revealed no significant differences between the 2 groups in mean serum levels, component composition or prevalence of CIC. These results confirm the occurrence of CIC in AS but do not clarify the pathogenetic influence, if any, of CIC in this disease. | |
| 1126116 | Pharmacokinetic studies of tolmetin in man. | 1975 May | The pharmacokinetics of the new anti-inflammatory agent tolmetin have been studied after its oral administration to normal subjects and to patients with rheumatoid arthritis. Plasma concentration-time data were fitted to a one-compartment open model. Following single oral doses, no basic differences in rates of drug absorption and elimination were found between normal subjects and arthritic patients. For the 12 subjects studied, the overall mean elimination rate constant was 0.839 hr-1, corresponding to a plasma half-life of 0.83 hr. The drug was rapidly absorbed and had a mean apparent volume of distribution of 0.098 l/kg. Plasma levels and pharmacokinetic parameters of tolmetin in arthritic patients after multiple dosing were smaller to those after a single dose. | |
| 6526999 | Frequency of occurrence of antibodies to tissues in the sera of various groups of populati | 1984 | A new method of detecting antibodies to tissues (ATA) in the sera of humans has been developed. The method is based on special treatment of human erythrocytes of the first group (rhesus-negative) with glutaric aldehyde rendering them capable of reacting with antibodies to tissues. Positive reaction is recorded in the form of haemagglutination. The reaction is easy to perform and open to mass examination of sera of children and adult population. The incidence of antibodies to tissues in the sera of sick and healthy children and adults was investigated. A total of 723 sera including 160 sera obtained from sick adults, 255 from healthy adults, 110 from sick children and 198 from healthy children were examined in the haemagglutination reaction using a microtechnique. It has been established that no antibodies to tissues were present in the sera of most healthy subjects (79.2%), children or adults. In 19.4% ATA were detected in titres 1:2-1:4, while an increased level (ATA titres 1:8 and higher) was found in only 1.4% of the sera. The subjects whose sera contained ATA predominated in the group of sick adults and children. In 52.9% of cases, ATA titres were 1:2-1:4. In 30.8% they were higher (1:8 and higher). The method can be recommended for mass examinations with the purpose of evaluating the immune state of the population. | |
| 539844 | A comparative radiological study of the pubic symphysis in rheumatic disorders. | 1979 Dec | Radiological abnormalities are often seen at the pubic symphysis in rheumatic disorders. In a radiological study of 120 patients with rheumatic diseases osteitis pubis with erosive and sclerotic changes was a feature of ankylosing spondylitis. Irregularity and subluxation were not related to osteitis pubis or diagnostic group but were common in females and had a possible association with previous pregnancy. | |
| 3932651 | An analysis of worldwide safety experience with auranofin. | 1985 Aug | A total of 3,475 patients with rheumatoid arthritis have received auranofin (AF) during clinical trials in 27 countries. Over a 4-year period, treatment with AF was relatively well tolerated. Most reactions were mild, easily managed and occurred during the first few months of treatment. Gastrointestinal side effects were the most common problems reported with AF followed by mucocutaneous reactions. Less frequently observed were conjunctivitis, proteinuria and, rarely, thrombocytopenia. The percentage of patients withdrawn for adverse effects per patient-year was less with AF when compared to injectable gold (14 vs 40%). These results confirm previous reports of AF safety and improved tolerance versus parenteral gold. | |
| 6391932 | A double-blind, comparative study of diflunisal and naproxen in the treatment of rheumatoi | 1983 | A randomized, double-blind trial was carried out in 47 hospital out-patients, with classical rheumatoid arthritis, to compare the efficacy and tolerance of diflunisal with that of naproxen. After an initial one week washout period the patients received diflunisal 1000 mg daily or naproxen 750 mg daily using a double placebo, crossover method. Each drug was administered for a three week period separated by a one week between treatment washout. With both drugs there was an improvement in objective and subjective assessments of response indicating that they each had an effective anti-inflammatory action. Diflunisal produced a significantly greater improvement in evening pain (p = 0.03), morning stiffness (p = 0.01) and the average total grip strength (p = 0.05). Nearly 60% of patients preferred diflunisal to naproxen but this was not of statistical significance. Frequency and severity of side-effects were similar. The similarity of diflunisal to aspirin in urate lowering is commented upon. | |
| 775803 | [Kinetoplast of the flagellate crithidia luciliae: a suitable substrate for the detection | 1975 Dec 26 | Sera from 29 patients with systemic lupus erythematosus (SLE), 60 cases of rheumatoid arthritis, 34 of myasthenia gravis (MG), 10 of scleroderma and 20 control sera were investigated for the occurrence of antibodies to native, double-stranded (ds) deoxyribonucleic acid (DNA). An immunofluorescence procedure recently elaborated by Aarden and coworkers, which utilizes the kinetoplast of the hemoflagellate Crithidia luciliae as substrate, was employed. In this kinetoplast, native, ds-DNA is concentrated as a single large network. Antibodies reacting with kinetoplasts were restricted to the SLE group, with the exception of one MG serum which also exhibited a distinct kinetoplast fluorescence. The antibody activity of the SLE sera could be completely inhibited by small amounts of DNA and abolished by deoxyribonuclease treatment of the substrate. These findings underline the specificity of the test system for anti-ds-DNA antibodies and the high disease-specificity of these antibodies for SLE. With respect to its ease and speed of performance this highly reliable and specific flagellate test surpasses other known tests for the detection of anti-ds-DNA antibodies. |