Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 3933886 | Total lymphoid irradiation as an immunosuppressive agent for transplantation and the treat | 1985 Mar | Total lymphoid irradiation (TLI) is a powerful immunosuppressive agent. This immunosuppression has the potential for clinical application in certain selected situations. In this review, the immunological changes produced by TLI and its potential applications in organ transplantation and the treatment of certain 'autoimmune' diseases are discussed. | |
| 7012915 | [Reticulum cell sarcoma (large cell or histiocytic lymphoma) of the lung as a rare cause o | 1981 Mar | A rare case of pulmonary cavitation due to a histiocytic lymphoma, as the primary manifestation of the disease, is presented. A brief discussion of the pathological and radiological features follows. The differential diagnosis, therapy, and prognosis are mentioned. | |
| 6814807 | Visualisation of the intralaryngeal joints: a low voltage radiological study. | 1982 Nov | Low-voltage radiography of the neck was adjusted for visualisation of the crico-arytenoid joints. Sixty-four patients (48 males, 16 females) with laryngeal tumours were examined. The degree of ossification in the laryngeal cartilage around the crico-arytenoid joints was different in the males and the females. All males had ossification in the plate of the cricoid, and 94% in the arytenoids. The articular facets on the cricoid were visible in 94%, and on the arytenoid in 85%. All females had ossification in the arytenoids, and 94% in the plate of the cricoid. The articular facets on the arytenoids were visible in all females, and on the cricoid in 88%. One or both articular facets in the crico-arytenoid joints were visible in all patients, making the method useful in detecting erosive arthritis in the joints. | |
| 7248189 | The platelet count and mean platelet volume. | 1981 May | The Coulter Model S-Plus Counter provides a measure of the platelet count and the mean platelet volume (MPV). An analysis of 5000 unselected blood specimens showed an inverse relationship between the number of circulating platelets and their MPV. In nearly 95% of normal adults the platelet count varied from 150 to 450 X 10(9)/l and the MPV from 7.0 to 10.5 fl. Thrombocytosis was found in iron deficiency anaemia, after trauma and acute blood loss and in rhematoid arthritis. Although there is a normal platelet distribution in pregnancy, patients with pre-eclampsia and uncomplicated hypertension in late pregnancy tended to have lower platelet counts and larger platelets than controls. A variable platelet pattern was found in infection, renal failure and treated malignant disease. | |
| 4586742 | The response of synovial fluid lymphocytes to T and B stimulants in vitro. | 1973 Nov | Synovial fluid lymphocytes from patients with rheumatoid arthritis were effectively stimulated by B cell mitogens, such as pokeweed mitogen (PWM) and lipopolysaccharides (LPS), but their response to T cell mitogen, phytohaemagglutinin (PHA), was poor and no stimulation was observed in the presence of specific antigens, purified protein derivative (PPD) or Veillonella alcalescens sonicate. | |
| 2992958 | Inhibition, by lanthanides, of neutral proteinases secreted by human, rheumatoid synovium. | 1985 Aug 15 | Fragments of human, rheumatoid synovium were maintained on organ culture for three days under serum-less conditions. Their conditioned media contained collagenolytic, gelatinolytic and caseinolytic activities, which were susceptible to inhibition by lanthanide ions. Of the four lanthanides tested, Sm3+ proved the best inhibitor of gelatinase and caseinase, while La3+ inhibited collagenase the most strongly. Inhibition of collagenase by La3+ was uncompetitive. A direct binding assay confirmed the greater association between collagen fibrils and collagenase in the presence of La3+. Ca2+ was not required for binding of the uninhibited enzyme to collagen, but acted to stabilize collagenase against thermoinactivation. | |
| 1107489 | Arthritis in myasthenia gravis. | 1975 Nov | Seven patients with myasthenia gravis developed clinical signs of arthropathy. In two patients, the symptoms were due to a deforming rheumatoid arthritis and the myasthenic symptoms appeared as a transitory phase during the course of the disease. Muscle antibodies of IgG class were demonstrated with sera from both patients. Autoreactivity between muscle antibodies and rheumatoid factor was detected in one patient. Both patients died from sudden cardiac failure. Necropsy was performed in one and revealed a spotty myocardial necrosis. One patient had juvenile rheumatoid arthritis. Two patients had mild articular symptoms with indices of multivisceral disease and serological findings indicating a systemic lupus erythematous. One patient had classical ankylosing spondylitis, and one, unspecified arthropathy. | |
| 4049543 | Three kinds of foamy cells in the spleen: comparative histochemical and ultrastructural st | 1985 | By light and electron microscopy, we observed foamy cells in the spleens from a patient with hemolytic anemia due to red cell adenosine deaminase (ADA) overproduction, a patient with rheumatoid arthritis (RA) treated with gold, and patients with idiopathic thrombocytopenic purpura (ITP). The foamy cells associated with red cell ADA overproduction were essentially similar to Gaucher-like cells described in patients with thalassemia, and it was suggested that the accelerated destruction of red cells was one of the factors responsible for the development of foamy cells. Foamy cells in ITP and RA were closely associated with an increased destruction of platelets in the spleen. Morphologic transitions between phagocytosed platelets and myelin-like materials were traced in these disorders. In RA, however, foamy cells were heterogeneous from an ultrastructural standpoint, with different cytoplasmic inclusions. In addition to myelin-like materials, dense bodies, vacuoles with flocculent materials, and gold were noted in most of foamy cells. As gold compounds are known to inhibit lysosomal enzymes, we surmise that an acquired disturbance in lysosomal digestion is partially responsible for the accumulation of intermediate metabolites. In the pathogenesis of foamy cells associated with blood cell dyscrasia, the accelerated destruction of blood cells and/or acquired disorders in catabolic pathways within the macrophages are suggested to be the underlying mechanism of an intralysosomal accumulation of incompletely degraded cellular debris. | |
| 409414 | Postinjection nonvasomotor reactions during chrysotherapy. Constitutional and rheumatic sy | 1977 Jul | During gold sodium thiomalate (GST) therapy, 15% of 100 unselected patients described recurring postinjection reactions (PIRs), consisting of transient stiffness, arthralgias, myalgias, and constitutional symptoms. Six patients with more severe reactions requested discontinuation of chrysotherapy and for these, gold thioglucose (GTG) substitution abolished or amelioriated the reactions. The major significance of the PIR is that it may be a frequent cause of unwarranted premature abandonment of chrysotherapy. | |
| 3924468 | Gold: hepatotoxic and cholestatic reactions. | 1985 Jun | Gold hepatotoxicity is an uncommon but significant clinical problem. Hepatitis was first manifested one day to four weeks after the last dose of gold at a cumulative range of 35 to 2900 mg. An interesting dichotomy was noted between cholestatic and hepatotoxic reactions. Hepatotoxic reactions were associated with other clinical signs of hypersensitivity, thus facilitating differential diagnosis from viral hepatitis. Sudden clinical improvement in a patient receiving gold should stimulate evaluation for a hepatotoxic reaction. | |
| 305233 | Rheumatic disorders in primary biliary cirrhosis. | 1978 Feb | Eighty-three patients with primary biliary cirrhosis were investigated to determine the prevalence of rheumatic disorders. 14 had scleroderma, which tended to be mild but in several patients produced severe systemic manifestations. The CRST syndrome (calcinosis, Raynaud's phenomenon, sclerodactyly, telangiectasia) was only identified twice. There was an increased incidence of HLA A1+B8 in those patients with scleroderma. As well as those with scleroderma, 4 patients had a destructive arthropathy resembling avascular necrosis. 4 patients had an inflammatory arthritis, without specific features, but the frequency was no greater than might be expected in the general population. | |
| 6310723 | Immunocytological studies of Epstein-Barr viral antigen and antibody in rheumatoid synovia | 1983 | Evidence for intra-articular immunity to Epstein-Barr virus (EBV) was sought in synovial fluids (SF) and SF phagocytes derived from patients with and without rheumatoid arthritis (RA). Antibody titres to EBV were not significantly different in SF of 32 RA and 25 non-RA patients. Whereas the majority of RA patients (69%) showed Ig-containing complexes (IC) in SF phagocytes, fluorescent antibody staining of these by anti-EBV serum was negative except with 6 RA patients. Extended analysis of the SF phagocytes of the latter, however, showed no EBV specificity in their IC, suggesting that these represented non-specific "pseudo-IC'. These studies do not support a role for EBV-containing IC in the propagation of rheumatoid synovitis and demonstrate that not all immunofluorescent inclusions in RA phagocytes (ragocytes) represent immune complexes. | |
| 1096903 | [Clinical results of a multicentral double-blind examination of naproxen compared to indom | 1975 Feb | In a multicenter double-blind cross-over trial the therapeutic effect and the tolerance of d-2-(6'-methoxy-2'-naphthyl)-propionic acid (naproxen) and indometacin were compared including 46 patients with rheumatoid arthritis, 35 patients with ankylosing spondylitis and 19 patients with osteoarthrosis. Duration of treatment with both drugs was two to four weeks each. The daily dose of naproxen was 750 mg, that of indometacin l50 mg. In rheumatoid arthritis the combined clinical effect of indometacin was stronger than that of naproxen while both drugs had the same clinical effectiveness in ankylosing spondylitis and osteoarthrosis. When differentiating the total clinical effect as to indices of pain, inflammation and function, indometacin was shown to be superior in all three diseases with regard to pain index. On the other hand, naproxen showed a better effect in ankylosing spondylitis and osteoarthrosis than indometacin as to inflammation, and as to function in osteoarthrosis. | |
| 6264765 | Lymphocyte-macrophage-fibroblast co-operation in the inflammatory degradation of cartilage | 1980 | In tissue culture models of cartilage and connective tissue degradation, rabbit macrophages and fibroblasts are both independently capable to degrade cartilage proteoglycan due to the secretion of a metal-dependent neutral proteinase. However, only the fibroblasts significantly degrade the collagen due to a sufficient production of collagenase. Macrophages produce factor(s) that stimulate the secretion of collagenase and the degradation of collagen by fibroblasts. Soluble products released by stimulated lymphocytes increase that production and also markedly enhance the secretion of proteoglycan-degrading proteinase and of collagenase by the macrophages. These data support the view that macrophages and fibroblasts are among the main effector cells of cartilage degradation in rheumatoid arthritis and that they are regulated in this function by secretory products of nearby lymphocytes. | |
| 341285 | Ferastral in the treatment of patients with inflammatory anaemia. | 1977 | An investigation has been performed with a new parenteral iron preparation, iron-poly-(sorbitol-gluconic acid) complex (Ferastral) in the treatment with iron deficiency anaemia associated with inflammatory diseases, mainly rheumatoid arthritis. Fifteen moderately anaemic patients entered into the trial. These patients constituted a special group in whom the MCHCs were subnormal. Observations were made concerning the occurrence of side-effects. Particular attention was paid to those-side-effects which are known to be associated with the use of parenteral iron preparations in the treatment of rheumatoid subjects. Ferastral was administered by intramuscular by intramuscular injection. The single doses given on any one occasion varied from a minimum of 100 mg to a maximum of 500 mg, divided into two separate injections. The results of therapy, measured at eight weeks, showed significant increases in haemoglobin concentrations. Increases in erythrocyte count, MCHC and serum-iron concentration were also found. There were no signs of acute toxic effects with Ferastral and in no patient was there exacerbation of arthritis as has been previously reported with iron-dextran. | |
| 1190852 | Cardiac valvular disease in chronic inflammatory disorders of connective tissue. Factors i | 1975 Aug | Three cases of cardiac valvular disease complicating chronic inflammatory disorders of connective tissue are described. Each underwent surgical valve replacement. The outcome in the first case, a patient with aortitis complicating Reiter's syndrome and in good health otherwise, has been excellent. The other two patients, one with rheumatoid arthritis and vasculitis, the other with systemic lupus erythematosus and nephritis, died after operation as the result of their systemic disease. The importance of systemic features in assessing this type of patient is emphasized. | |
| 4084329 | Seronegative polyarthritis in giant cell arteritis. | 1985 Dec | Nineteen of 520 patients with biopsy-proven giant cell arteritis were found to have persistent seronegative, symmetric polyarthritis with a mean joint count of 20 (swollen plus tender). In 9 patients in the onset of polyarthritis occurred prior to the diagnosis of giant cell arteritis, 3 had simultaneous onset, and 7 developed polyarthritis within 3 years after the onset of giant cell arteritis. Ten of the 19 patients demonstrated radiographic features of joint space narrowing and/or erosions. In 1 patient in a synovial biopsy was performed, revealing marked multinucleated giant cell infiltration. A persistent seronegative polyarthritis, although uncommon in giant cell arteritis, may be its presenting symptom. Other symptoms of giant cell arteritis should be sought in patients who exhibit this feature, especially in those whose arthritis begins at age 50 or older. | |
| 6971489 | Monocyte cytotoxicity in connective tissue diseases. Correlation with disease groups. | 1981 | The proportion of antibody-dependent cytotoxic plaque-forming cells (PFC) with monocyte characteristics was estimated in peripheral blood mononuclear leukocyte suspensions from 40 patients with rheumatoid arthritis (RA), (29 seropositive and 11 seronegative), 7 with ankylosing spondylitis (AS), 14 with juvenile rheumatoid arthritis (JRA) and 7 with systemic lupus erythematosus (SLE). In RA and also in AS patients, higher mean proportions of PFC were found when compared with those of normal adult blood donors. Seropositive RA patients had a significantly higher proportion of PFC than seronegative RA patients. SLE patients showed values equal to those of the controls. Patients with JRA had a lower percentage of these cells than age-matched healthy children. | |
| 1084010 | [Pigmented villonodular synovitits of the hip: ultrastructure and aspects on scanning elec | 1976 May | The authors studied one case of pigmented, villonodular synovitis (PVNS) of the hip by means of optical microscopy and by transmission and scanning electron microscopy. Scanning electron microscopy showed that the surface of the PVNS is completely different from that of rheumatic synovitis, in particular that of rheumatoid synovitis. The composition and the cellular morphology of the outer layer of the PVNS appear, however, to be similar to those of normal synovial membrane of arthrosic synovial membrane. Clumps of red corpuscles, enclosed in a fibrin network, were visible on the surface of the PVNS in a way that the authors has never seen previously in the 19 other human synovial membranes, normal and pathological, they had studied in this way. The totality of the microscopic findings confirms the importance of the role played by the intra-articular and intra-synovial haemorrhages, and by the macrophage reactions that follow, in the development of the lesions that characterize PVNS. | |
| 61922 | Relations between fibrinogen degradation products and heparinocytes. | 1976 | In the emergency reaction there is a short-time increase of the values of basophilic leukocytes in connection with normal values of fibrinogen degradation products (FDP). After diminuation of basophils FDP are to be detected. In the chronical ill and under different hormonal contraceptives these two processes are overlapped disturbing a unique negative or positive correlation of heparinocytes and FDP. Concerning the situation under standardized conditions or in single cases worthful conclusions are possible about compensation or decompensation of a latent disseminated intravascular coagulation. |