Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 992713 | Lymphocyte nucleolar activation as a marker of autoimmune disorders. II. Observations in p | 1976 Nov | An increased number of lymphocytes with active nucleoli was found in the peripheral blood of most patients suffering from connective tissue diseases associated with autoimmunity. | |
| 2938244 | Multiparameter analysis of human lymphocyte subpopulations using flow cytometry. | 1985 | This review has emphasized several recent advances in our understanding of human lymphocyte biology made possible by mAbs that recognize specific functional subpopulations of lymphocytes, coupled with multiparameter flow-cytometric analysis. In the last 3 years, both the T4+ and T8+ subsets of T cells have been further divided according to function and appearance of specific cell surface antigens. In addition, subpopulations of NK cells with different maturation states and B cells with distinct functional abilities have been discovered. Multiparameter flow-cytometric analysis of lymphocyte subpopulations can provide clues to the pathogenetic mechanisms of immune disorders, as has been demonstrated in AIDS patients and children with JRA. The use of multiparameter flow-cytometric analysis to study human immune responses in vitro has enabled a clearer understanding of the complex lymphoid interactions and, as we believe, may play an important role in the analysis of immune-associated disease processes. | |
| 4075886 | [Experiences with the RM isoelastic hip endoprosthesis]. | 1985 Nov | Since June 1979 we implant the RM isoelastic total hip endoprosthesis in younger patients (average age 53 years). Up to now 391 endoprostheses have been implanted. A follow-up examination of 60 operated hips in 55 patients 3 and 4 years after the implantation of the endoprosthesis was possible. In 46 hips there was no pain at all, in 12 hips a light or medium pain and in 2 hips a severe pain. 35 hips showed a range of motion of more than 90 degrees and between 30 degrees and 90 degrees. All patients were able to walk, 37 patients more than 1 hour. The patients declared the results of the operation in 50 hips to be very good or good, in 4 hips to be fair and in 6 hips to be poor. 5 times a potential loosening of the stem could be found. | |
| 7016933 | Penicillamine-associated pemphigus: is it really pemphigus? | 1981 May | Penicillamine-associated bullous eruptions share with spontaneously occurring pemphigus intraepidermal acantholysis, epidermal intercellular deposition of immunoglobulin, and circulating serum antibody against the intercellular regions of the epidermis. We report the case of a penicillamine-associated bullous eruption in which there were some of the histologic features of pemphigus, but none of the immunofluorescent features. Instead, the immunofluorescent findings of bullous pemphigoid were demonstrated. Review of the literature reveals that clinical and histologic features of penicillamine-associated bullous eruptions differ in important respects from those of spontaneously occurring pemphigus. Our report adds immunologic data to evidence that the penicillamine-associated bullous eruptions may not be the same disease as spontaneously occurring pemphigus. | |
| 6161179 | Isolation of DNA from DNA/anti-DNA antibody immune complexes in systemic lupus erythematos | 1981 Feb | A low molecular weight DNA fragment was isolated from DNA/anti-DNA antibody immune complexes found in patients with active systemic lupus erythematosus (SLE). Total sera were treated with 40% saturated ammonium sulfate to isolate gamma-globulin fraction and phenolized to partition proteins and nucleic acids. After being treated with RNAase, the sample was labeled at the 5' end with 32P-phosphate and electrophoresed in an 8% polyacrylamide gel, which was dried and autoradiographed. The sample that migrated at positions of molecular weight between 20,000 and 28,000 was susceptible to DNAase I but resistant to S1-nuclease. The data suggest that the immune complexes of SLE patients contain double-stranded DNA with 30 to 40 base pairs. | |
| 790550 | Ketoprofen -- a new anti-rheumatic agent. | 1976 | Ketoprofen (100 mg/day) and indomethacin (100 mg/day) were compared in a double-blind cross-over trial of four weeks duration in 46 patients with rheumatoid arthritis. The drugs were equally effective in all parameters measured, apart from the paracetamol (rescue drug) tablet count which favoured indomethacin. In a similarly designed study the same dosages of the two drugs were compared in 44 patients with osteoarthrosis of the hip. No significant differences occured between the two groups. A further double-blind cross-over study of 4 weeks duration compared 200 mg ketoprofen/day and 300 mg phenylbutazone/day in 47 patients with osteoarthrosis of the hip. No significant differences occured between the two drugs. In all three studies, side-effects with ketoprofen were infrequent and mild. Biological monitoring throughout revealed no abnormality. These studies have shown ketoprofen to be an effective anti-inflammatory for the treatment of rheumatoid arthritis and osteoarthrosis of the hip with an efficacy comparable to those of indomethacin and phenylbutazone. | |
| 6693477 | The long-term results of Stanmore total knee replacements. | 1984 Jan | One hundred and three sequential Stanmore knee replacements were reviewed retrospectively on two occasions with a maximal follow-up period of nine years three months. This knee prosthesis, which is hinged, was successful in alleviating pain, stabilising an unstable knee and modestly increasing the arc of flexion. Walking capacity was increased and flexion contractures were reduced. There were seven cases of infection and four of fracture around the prosthesis. All these proved difficult to treat and two knees with both fracture and infection needed amputation. Eight knees were revised for aseptic loosening and a further 14 were found to have radiological signs of loosening. The results have been analysed by the methods advocated by Tew and Waugh and give a cumulative success rate of 80 per cent at seven years, provided success is judged solely by whether the prosthesis is still in situ. The role of the Stanmore knee as a primary arthroplasty is discussed. | |
| 6613199 | [Bone marrow capacity and reaction]. | 1983 Jun 1 | The formation of the blood cells leads via proliferation, differentiation and maturation processes, in which cases the bone marrow capacity expresses the functional capacity of this comprehensive system of cell renovation. Nowadays clues to the quantitative behaviour of proliferation of the various compartments (stem cell compartment, indicator cell compartment and morphologically characterizable cell compartment) are already existing also for man, in which cases various proliferation-kinetic tests give adequate informations. Via a quantitative determination of the granulocytes of the bone marrow an estimation of the postmitotic bone marrow storage of the granulocytopoiesis is at present possible. The responsiveness of the neutrophil granulocytes after stimulation (glucocorticoids, endotoxin) may be used in the clinic as bone marrow functional test with restricted statement. The diagnostic possibilities of the agar-colony-technique for the judgment of the bone marrow capacity are represented on the basis of an instance. | |
| 168824 | Partial deficiency of hepatic glucose-6-phosphatase in an adult patient. | 1975 Aug | Patients with hepatic glucose-6-phosphatase deficiency usually have a striking clinical syndrome during childhood and are readily diagnosed by the pediatrician. An adult patient had childhood manifestations of glucose-6-phosphatase deficiency that were mild and unrecognized; symptoms of tophaceous gout, urate nephropathy and characteristic blood chemical studies suggested the diagnosis at age 39. Subsequent epinephrine and galactose tolerance tests were characteristic of hepatic glucose-6-phosphatase deficiency and direct assay of hepatic glucose-6-phosphatase confirmed a partial deficiency of the enzyme. The case emphasized that patients with this deficiency may escape diagnosis during childhood and that internists should consider the diagnosis in adolescents or young adults with acute gouty arthritis or tophaceous gout. | |
| 7428411 | Naproxen suppositories in combination with oral naproxen, indomethacin and ibuprofen in th | 1980 | A single-blind, crossover trial was carried out in 30 rheumatoid arthritis patients to compare the effectiveness and tolerance of 250 mg naproxen, 400 mg ibuprofen and 25 mg indomethacin twice daily in patients treated concurrently with a night-time 500 mg naproxen suppository. Each day-time drug was given for 3 weeks. Naproxen suppositories were used for the whole 9 weeks of the study. No difference between the combination treatments was seen in pain and morning stiffness, while articular index and P.I.P. joint size tended to improve most during the naproxen tablet and suppository phase. Patients' and physician's preferences were both significantly in favour of the naproxen tablet and suppository phase. Side-effects were similar during all treatment phases, except for vertigo which occurred during the indomethacin capsule and naproxen suppository phase. Combinations of two non-steroidal, anti-inflammatory drugs have been shown to be effective and well tolerated but to have no advantage over treatment with only one drug. Naproxen suppositories have been shown to be well tolerated over a 9-week period. | |
| 407457 | [Programmed diagnosis of rheumatic diseases in general practice (author's transl)]. | 1977 Jun 3 | In the large number of rheumatic diseases and their often very different types - typical symptomatology is seldom complete - a reliable classification of a particular form of disease is often not easy. The "programmed diagnosis" presented here should be a signpost from the clinical picture, by way of the provisional diagnosis and the necessary diagnostic measures, to the final diagnosis. | |
| 881147 | [HL-A B 27 a criterion for Reiter's syndrome]. | 1977 Jun 16 | The prevalence of 23 HLA antigens were examined in 21 patients with a typical Reiter's disease, 21 patients with incomplete Reiter's syndrome as well as 16 patients with non-gonococcal urethritis. HLA-B 27 antigen was found in 85,7% of patients with typical Reiter's disease as compared to 7,4% of 413 healthy controls. HLA-B 27 was also detectable in 57,1% of patients with clinical suspicion of Reiter's disease. No significant difference from the control frequencies of HLA specifities was found in patients with non-gonococcal urethritis. The association between HLA-B 27 and Reiter's syndrome is so marked that tissue typing is a valuable adjunct in the diagnosis of Reiter's syndrome. | |
| 7030234 | Autoantibodies to cartilage and type II collagen in relapsing polychondritis and other rhe | 1981 Oct | Cartilage antibodies were demonstrated by indirect immunofluorescence (IFL) on human fetal cartilage in 6 out of 9 patients with relapsing polychondritis (RPC), in 4 out of 260 patients with rheumatoid arthritis (RA), and in only 1 out of 1016 patients with other disorders. The antibodies were specific for cartilage and evenly stained the whole cartilage matrix. They were predominantly of IgG class and varied in titres from 1:1 to 1:320. Follow-up studies in the RPC patients indicated that higher titres were present during the early acute phase of the disease. Five of the 6 positive cases had developed the disease within the past 12 months, and the 3 negative cases had had the disease for 3 to 7 years when tested. The RA cases showing positive cartilage IFL had no clinical evidence of RPC. Sequential measurements in 2 of the 4 cases showed that these antibodies became detectable some years after the onset of arthritis. Absorption studies with human type II collagen and purified porcine proteoglycan failed to remove the cartilage IFL. Antibodies to human native type II collagen were measured by an enzyme-linked immunosorbent assay. The highest levels were found in the RA sera which also displayed cartilage IFL, but the 2 tests gave discordant results. RPC sera showed the same antibody levels by this method, as did cartilage-IFL-negative RA sera, though both groups had higher mean levels than health controls. The findings that cartilage antibodies are detected in the majority of cases of RPC and only rarely in other diseases suggests these antibodies may play an important role in the pathogenesis of cartilage destruction in RPC. | |
| 3853569 | A baseline study for the development of an instrument for the assessment of pain. | 1985 Nov | This study was designed to establish a foundation for the further development of a pain assessment tool for use in clinical practice. It was earlier reported that there existed a significant difference in the intensity of the words pain, ache and hurt and that each of these concepts had their own specific sensory and affective word descriptors. This study was designed to: 1 find out if the above results could be verified by using subjects with a different background from those included in the previous study; 2 determine the intensity of word descriptors; and 3 determine if patients, nurses and nursing students use the same word descriptors to describe pain-like experiences. Pain assessment tools used were the McGill Pain Questionnaire, a visual analogue scale and a pain, ache and hurt questionnaire. The results of the earlier reported study were confirmed. In addition, a significant difference was found in intensity of the word descriptors. Patients, nurses and nursing students used basically the same word descriptor to describe pain-like experiences. The sensory word descriptors (crushing, sharp, tearing, cutting, penetrating, gnawing, dull, pulling, sore, stinging, pricking and pinching) and the affective word descriptors (dreadful, torturing, killing, unbearable, terrifying, suffocating, exhausting, unhappy, troublesome, annoying, irritating and fearful) are suggested as a foundation upon which a pain assessment tool could be developed for use in clinical practice. | |
| 366719 | Auditory changes associated with moderate blood salicylate levels. | 1978 Nov | Thirty patients with rheumatoid arthritis were randomly assigned to two groups: aspirin and placebo. Aspirin group subjects received five grain ASA capsules and placebo group subjects received lactose placebo for seven days. Blood salicylate level (BSL) and audiological evaluations were performed on Days 0, 3 and 7. BSLs never exceeded 21 mg/100 ml. BSLs during the seven days varied only slightly among aspirin group subjects but dropped consistently in the placebo group. Intra-subject comparison of scores on low versus high BSL days indicated significant differences between mean speech reception thresholds (SRT) scores and pure-tone air-conduction thresholds at all test frequencies for both groups, except at 2000 Hz for the aspirin group. Inter-group differences occurred on SRT and high-frequency pure-tone thresholds. The results indicate that moderate BSLs adversely affect hearing ability. These adverse effects appear to be temporary. | |
| 6377451 | The tissue architecture of synovial membranes in inflammatory and non-inflammatory joint d | 1984 | Tissue specimens of synovial membranes from patients with rheumatoid arthritis (RA) and non-inflammatory joint diseases were analyzed with a panel of monoclonal antibodies directed towards T-lymphocyte subsets and natural killer (NK) cells. In the RA group, mononuclear cell infiltrations in the synovium presented a distinguished pattern as compared to the non-RA group. Inflammatory synovial membranes displayed an increased level of cells recognized by the monoclonal antibodies OKT4 and OKT8, especially attributable to the broadened layer of synoviocytes and to the fibrous synovial tissue. No significant difference in the RA patients was observed with regard to the percentage of OKT4 and OKT8 positive cells in different investigated compartments of the synovium, e.g., diffuse inflamed synovial tissue, fibrous synovial tissue, and perivascular infiltrations. OKT4 and OKT8 positive staining was additionally observed on spindle-shaped cells present in the fibrous and diffuse inflamed synovium. OKT10 binding cells were located in the deeper layers of synoviocytes, in the inflamed synovial tissue, and in one case in perivascular areas, whereas HNK 1 positive cells were scattered in the fibrous synovial and perivascular cells, as well as in lymphocyte clusters of synovium in RA patients. | |
| 6646795 | Development of the Wisconsin Brief Pain Questionnaire to assess pain in cancer and other d | 1983 Oct | This paper reports the development of a self-report instrument designed to assess pain in cancer and other diseases. It is argued that issues of reliability and validity should be considered for every pain questionnaire. Most research on measures of pain examine reliability to the relative neglect of validity concerns. The Wisconsin Brief Pain Questionnaire (BPQ) is evaluated with regard to both reliability and validity. Data from patients with cancer at 4 primary sites and from patients with rheumatoid arthritis suggest that the BPQ is sufficiently reliable and valid for research purposes. Additional methodological and theoretical issues related to validity are discussed, and the need for continuing evaluation of the BPQ and other measures of clinical pain is stressed. | |
| 1218826 | [Treatment of pseudarthrosis of the scaphoid bone]. | 1975 | The best therapy for pseudarthrosis of the scaphoid bone is still contested. Various operative techniques are reviewed and our experience with 129 operations is discussed. | |
| 106859 | Identification of hydroxyapatite crystals in synovial fluid. | 1979 Apr | A semiquantitative technique employing (14C) ethane-1-hydroxy 1, -1-diphosphonate (EHDP) binding has been used to detect crystals, presumably hydroxyapatite, in human synovial fluid samples which were handled to prevent the formation of artifactual mineral phase. Binding material was found in 29% of non-inflammatory and in none of inflammatory joint fluids. Nuclide binding material was strongly correlated with the presence of CPPD crystals and with radiographic evidence of cartilaginous degeneration. | |
| 7089270 | The Haglund syndrome: initial and differential diagnosis. | 1982 Jul | Haglund syndrome is a common cause of posterior heel pain, characterized clinically by a painful soft-tissue swelling at the level of the achilles tendon insertion. On the lateral heel radiograph the syndrome is characterized by a prominent calcaneal bursal projection, retrocalcaneal bursitis, thickening of the Achilles tendon, and a convexity of the superficial soft tissues at the level of the Achilles tendon insertion, a "pump-bump." An objective method for evaluating prominence of the bursal projection is measurement using the parallel pitch lines. This measurement helps to identify patients with Haglund syndrome and patients predisposed to develop this condition, and also to differentiate local causes of posterior heel pain from systemic causes. The parallel pitch line measurement was determined in 10 symptomatic feet and 78 control feet and the results were analyzed statistically. |