Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 6158297 | Synovial fluid beta 2 microglobulin and hydroxyproline fractions in rheumatoid arthritis a | 1980 Jun | Fourteen patients with classical and definite seropositive rheumatoid arthritis (RA), 5 patients with microcrystalline arthritis, and 7 patients with osteoarthrosis were studied with respect to markers of newly synthesised collagen (synovial NDOH pro levels); markers of connective tissue resorption (synovial DOH pro and NBH levels); markers of lymphoid tissue activity (synovial and plasma beta 2m levels). Higher amounts of NDOH pro in RA synovial fluid are compatible with the hypothesis of a local connective tissue production as suggested by Uitto et al. on basis of a higher protocollagen proline hydroxylase activity in RA synovial tissue. DOH pro and NBH do not differ significantly in synovial fluid from RA or gouty patients, but the correlations between these forms of OH pro and, respectively, synovial lymphocytes and polymorphonuclear leucocytes are indicative of different processes of connective tissue remodelling in the 2 conditions. Synovial beta 2m levels are a direct function of total synovial lymphocyte counts independently of the type of arthropathy being explored. The ratio of synovial to plasma beta 2m is systematically above unity in RA patients only. | |
| 695999 | [Liver findings in Felty's syndrome. A review]. | 1978 Jul | A reaction of the RES with its organs (lymph nodes, spleen, bone marrow and Kupffer's cells) is not uncommon in rheumatoid arthritis. Although these manifestations are pronounced in Felty's syndrome, reviewing articles about Felty's do not mention liver manifestations. This paper summarises the publications about liver findings in Felty's syndrome. Hepatomegaly, abnormal bromsulfalein tests, raised alkaline phosphatase and transaminases have been stated in many case reports. Among 34 patients, the frequency of hepatomegaly was 68%, of abnormal bromsulfalein tests 27%, of alkaline phosphatase 23% and of transaminases 18%, respectively (52). Alkaline phosphatase and transaminases were raised in almost all of 12 patients (3). The histological correspondence is an infiltration with lymphocytes of sinusoids and portal fields, a portal fibrosis and occasionally a cirrhosis. These histological abnormalities, as well as enlarged lymph nodes and splenomegaly, have to be considered as organic manifestations of rheumatoid arthritis. If the nodular regenerative hyperplasia of the liver, which has been reported also after use of contraceptives, is a manifestation of Felty's syndrome, remains unresolved. | |
| 7028164 | [Use of whole loose connective tissue preparations in immunofluorescence studies]. | 1981 Jul | Evidence has been obtained for potential use of total loose connective tissue film preparations during immunofluorescence studies of antinuclear antibodies of serum from patients with systemic lupus erythematosus, antibodies to cytoplasmic components of fibroblasts of serum from patients with rheumatoid arthritis, antibodies to the surface fibroblast antigen fibronectin, and of certain regularities in IgG binding with mast cell components. As compared with other preparations (cryostat, paraffin sections) used in immunomorphology while applying the methods of labeled antibodies, the total preparations have the following basic advantages: simplicity of preparation and possibility to eliminate the denaturative effects on tissue structures. | |
| 7022479 | HLA-DR and disease associations. | 1981 | Recent data from the literature on the association of HLA-DR antigens with various diseases are presented. These data indicate that many diseases show stronger associations with these antigens than with other HLA-locus antigens. Included in this group are multiple sclerosis (DR2), diabetes (DR3), and pemphigus vulgaris (DR4). In earlier studies other diseases - rheumatoid arthritis and Goodpasture's syndrome, which were not found to be associated with HLA-A, -B, and -C antigens - show associations with DR4 and DR2, respectively. If population association is due to linkage disequilibrium, then the DR locus must be closer to the hypothesized disease susceptibility genes than are other HLA loci. Examination of the family data with appropriate methods of segregation and linkage analysis could clarify the genetic bases of some of these disorders. | |
| 6998793 | Fenbufen, a new non-steroidal anti-inflammatory agent in rheumatoid arthritis, its efficac | 1980 | Fenbufen, a new butanoic acid derivative with anti-inflammatory properties, was evaluated in an open-label study. It was found that fenbufen was an effective anti-inflammatory agent with tolerable and acceptable potential side-effects. Its advantages appeared to be its long clinical half-life and relatively mild toxicity and/or allergic response. | |
| 144508 | A double-blind trial of high versus conventional dosages of gold salts for rheumatoid arth | 1977 Nov | In a double-blind study, patients were randomly selected for treatment using conventional doses (CD; 50 mg) or high doses (HD; 150 mg) of sodium aurothiomalate given weekly by injection. Twenty-three patients were assigned to the CD group and 24 to the HD group. Neither efficacy nor toxicity correlated with serum gold concentrations. Conventional doses were as efficacious as high doses with respect to both rapidity and degree of response. However, side effects were much more frequent and severe in the HD group. Thus there is no reason to recommend a 150 mg weekly dosage regimen. | |
| 6883812 | Cold-precipitable immune complexes in collagen diseases: evidence for the coexistence of m | 1983 Oct | In patients with systemic lupus erythematosus, mixed cryoglobulinemia, and rheumatoid arthritis, the presence of cold-precipitable immune complexes (IC) was investigated by means of two different methods, i.e., the Clq-binding activity (ClqBA) and a competitive enzyme immunoassay, based on solid-phase bovine conglutinin (K). Cold precipitability of IC ranged between 0 and 100% with K and between 0 and 71% with ClqBA. No correlation existed either between the levels or the cold precipitability of the IC measured by the two systems in the same sera. On the whole, cold-precipitable IC were better determined by the K method than by ClqBA and in mixed cryoglobulinemia cryocrit levels correlated with IC levels determined with K, but not ClqBA. These data provide direct evidence of the coexistence of several types of circulating IC in the same serum and that the two methods recognize, at least in part, different IC in the same specimen. It might be hypothesized that different IC present in a serum may have a distinct biological significance. | |
| 7276042 | Total elbow arthroplasty. A five-year experience at the Mayo Clinic. | 1981 Sep | During the five years from 1973 through 1977, eighty Mayo and Coonrad total elbow arthroplasties were performed in seventy-two patients at the Mayo Clinic. Follow-up after at least two years (average, four years) revealed that the results were good in 60 per cent, fair in 16 per cent, and poor in 24 per cent. Pain was a major symptom in 80 per cent of the elbows preoperatively but in only 3 per cent postoperatively. At follow-up, motion had increased: extension-flexion by 10 degrees (average range, 29 to 131 degrees of flexion) and forearm rotation by 26 degrees (average range, 61 degrees of pronation to 59 degrees of supination). Excluding eleven prostheses with loosening for which revision was necessary, there were forty-four complications (55 per cent) after eighty procedures. Of these forty-four complications, eleven were ulnar neuropathies (two permanent and nine transient); four were wound-healing problems; ten, significant triceps weakness; eleven, intraoperative fractures of the medial or lateral supracondylar bone column; seven, deep infections; and one was an ulnar fracture. Although the complication rate was very high, most of the complications occurred during the early years of the study. Follow-up revealed twenty-nine elbows with radiolucency around the components: in twenty-five about the humeral and in four about the ulnar component. Revisions were performed in nineteen (24 per cent) of the eighty elbows: in eleven because of loosening, in seven because of deep infection, and in one because of ankylosis. Intraoperative supracondylar fracture and defective cementing of the prosthesis were important factors contributing to prosthetic loosening. When the arthroplasty was successful, the relief of pain was dramatic, stability was excellent, and the range of motion was superior to that provided by any other procedure currently available. | |
| 1125918 | Treatment of persistent knee effusions with intra-articular radioactive gold. | 1975 May 3 | Patients with a total of 112 chronic knee effusions unresponsive to the usual conservative methods of therapy were treated with intra-articular injections of radioactive gold and followed from 6 months to 5 years. Most patients in the study had rheumatoid arthritis but others had ankylosing spondylitis, psoriatic arthritis, intermittent hydrathrosis and undiagnosed synovitis. After 6 months 81% showed improvement. This figure diminished to approximately 70% at 1 and 2 years, 60% at 3 and 4 years and 50% at 5 years. The mose beneficial results were seen in patients with intermittent hydrarthrosis. Twelve patients with a synovial cyst and/or rupture improved. Patients with thin synovia and anatomic stage I or II disease did best, but those with stage III disease also did well. After the injection 33% of the patients had a reactive synovitis. A variable amount of radioactive material escaped from the knee to the regional lymph nodes and general circulation. | |
| 6176099 | Beta 2 microglobulin in pleural effusions. | 1982 | Beta 2 microglobulin (beta 2m) concentrations in serum and pleural fluid from 64 patients with pleural effusion were studied. The level of beta 2m in pleural fluid was generally twice that in serum. The ratio of pleural fluid beta 2m to serum beta 2m in patients groups defined according to the final diagnosis showed an interestingly high value in tuberculous pleuritis and in patients with rheumatoid arthritis with pleural effusion. There was a positive correlation between the beta 2m and lysozyme contents in pleural fluid, suggesting local and simultaneous activation of different cell lines when the pleura is involved. We suggest that pleural fluid and concomitant serum beta 2m measurements should be taken into consideration when pleural effusion of tuberculous origin is suspected. Furthermore, beta 2m determination might help to differentiate between rheumatoid pleural fluid and pleural involvement due to the other systemic diseases. | |
| 7039147 | [Results of an open study and a controlled comparative study of feprazone and naproxen in | 1981 Dec 31 | The so-called non-steroid antirheumatics have considerable significance in medical armamentarium for controlling polyetiological complexes of diseases. The numerous new developments are designed to reduce the side effects, some of which seem inevitable with increased efficacy. In this two-part study the authors deal with the new Feprazone. Prior to a double-blind randomized comparative study against Naproxen, an open study on effect and tolerance was performed in ten rheumatic patients over three months. In the second part a controlled study was carried out in 30 patients for four weeks following this treatment. The patients half of whom were each given 600 mg Feprazone or 750 mg Naproxen showed a definite improvement in the rheumatic symptoms as compared with their initial situation. A difference in therapeutic efficacy and tolerance was only noticeable in a slight trend in favour of Feprazone. | |
| 266841 | Acute leukemia after azathioprine treatment of connective tissue disease. | 1977 May | A 23-year-old man is reported who had a connective tissue disorder with features of rheumatoid arthritis and systemic lupus erythematosus. Because of the development of severe myocarditis and acute cerebral dysfunction treatment with azathioprine and prednisone was instituted, with dramatic clinical improvement. Ten months later, when a total of some 52 g of azathioprine had been administered, acute myelomonocytic leukemia developed. Although acute myelogenous leukemia has been noted in several individuals receiving immunosuppressive drugs for treatment of lymphoreticular neoplasms, this complication has heretofore been rare in patients given azathioprine for non-neoplastic disease. The present case is documented because of the increasing use of immunosuppressive drugs in treatment of various rheumatic disorders and the need to establish the relationship, if any, between the use of such agents and malignancy. | |
| 834212 | Aspirin-induced depression of renal function. | 1977 Feb 24 | We observed elevation of serum creatinine and blood urea nitrogen and decrease in creatine clearance in patients taking anti-inflammatory doses of aspirin. In 13 of 23 patients with systemic lupus erythematosus increases in serum creatinine ranged from 27 to 163 per cent, and those in urea nitrogen from 42 to 270 per cent. Sequential creatinine-clearance studies, available in 11 of the 13 patients, demonstrated decreases up to 58 per cent. Patients with aspirin-induced changes in renal function were more likely to have active renal disease (P =0.035) or hypocomplementemia (P =0.030). Four of 22 patients with rheumatoid arthritis and two of three normal volunteers also demonstrated biochemical changes. The rate of aspirin-induced alterations was significantly higher in systemic lupus erythematosus (P =0.007) than in rheumatoid arthritis. Aspirin, and other nonsteroidal anti-inflammatory agents, can have a major reversible effect on renal function that may influence the interpretation of clinical data. | |
| 213448 | Activation in vitro of rheumatoid synovial collagenase from cell cultures. | 1978 Nov | Rheumatoid synovial cells dissociated from matrix and adherent to culture dishes released a latent form of collagenase into culture medium. Previous studies have shown that the latent enzyme does not complex with alpha2-macroglobulin and binds to fibrillar substrate. We now show that serum-free culture medium of the synovial cells contains an inhibitor of collagenase as well as latent enzyme; the two were separated on a column of acrylamide/agarose. Latent collagenase (estimated mol wt 45,000-49,000) was transformed by trypsin to active collagenase of approximately equal to mol wt 33,000. When mixed with inhibitor the active enzyme formed an inactive complex again with approximately equal to mol wt 45,000-49,000. The inhibitor(s) itself was found in one major peak of mol wt 33,000-35,000 and several minor peaks eluting with lower apparent molecular weight. Mersalyl, an organic mercurial compound, effectively activated latent collagenase producing an active enzyme with approximately equal to mol wt 33,000. Bacterial collagenase did not activate latent enzyme. We suggest that latent rheumatoid synovial collagenase, as it is harvested from synovial cells in culture, is an enzyme-inhibitor complex. | |
| 6592972 | Penicillamine-induced myositis. Observations and unique features in two patients and revie | 1984 Oct | Dermatomyositis developed during treatment with penicillamine in two patients with rheumatoid arthritis. Both were male without a history of penicillin allergy. Eosinophilia was present at the start of their illness, and HLA tissue typing showed the presence of HLA-DR2 in one patient. One patient was retreated with penicillamine and remained asymptomatic after three years of therapy, and the other was able to take penicillamine in a reduced dosage. | |
| 7033337 | Tarsal coalitions: an instructional review. | 1981 Winter | Tarsal coalitions, the majority of which are congenital, are abnormal unions between two or more tarsal bones. Acquired tarsal coalitions may result from trauma or from rheumatic conditions. Tarsal coalition may cause peroneal spastic flatfoot or rigid valgus foot without peroneal spasm. Surgery is not always essential in the treatment of tarsal coalitions; some patients will respond to conservative treatment. | |
| 6128873 | A pharmacological study of the anti-inflammatory activity of Chinese herbs. A review. | 1982 | A considerable number of Chinese medical herbs have been found to be anti-inflammatory upon screening for the inhibition of acute inflammation and allergic reaction, and for the suppression of adjuvant arthritis. Most of this research has been published exclusively in Japanese, and consequently is little known internationally. In this review, we will introduce the most recent conclusions drawn from current pharmacological research on the anti-inflammatory action of various Chinese medicinal herbs being undertaken in Japan. Due to limitations of space, we mention only herbs showing anti-inflammatory activity in vivo when administered intra-orally, and having low toxicity. We will also introduce some popular Chinese medical prescriptions used in the treatment of arthritis, hepatitis and nephritis and attempt to explain their anti-inflammatory action resulting from the synergistic action of the herbs contained in these prescriptions. All references cited in this review were either written originally in English or have an English abstract. | |
| 1185735 | Hospital-acquired salicylate intoxication. report of a case with psychosis, acidosis, and | 1975 Mar | A case of salicylate intoxication from repeated therapeutic doses of aspirin is reported in an adult with impairment of salicylate elimination. Evolution of acid-base disturbance from respiratory alkalosis to metablic acidosis is documented. Serum salicylate levels during several years of therapy demonstrate the acquisition of impaired elimination of the drug. This case illustrates the practical importance of special features of salicylate accumulation kinetics emphasized in a recent review. | |
| 1123356 | Performance analysis of an ex vivo geometric total knee prosthesis. | 1975 Jan | Studies were made of a well functioning geometric total knee prosthesis, removed at autopsy from a sixty-one-year-old man, which had been used for eight months. The components were firmly embedded in bone with no evidence of loosening. There was significant deformation of the polyethylene tibial component, but no significant wear on the metallic component. Thin layers of fibrous tissue were found in some areas of the bone-cement interfaces. | |
| 7086151 | A quantitative assay for IgA rheumatoid factor. | 1982 | We developed a solid-phase radioimmunoassay capable of detecting nanogram quantities of human IgA rheumatoid factor (RF) in biological fluids. Human IgM RF, IgG RF, IgG, IgA, IgM and whole serum did not significantly interfere with the IgA RF assay. Patients with sero-positive rheumatoid arthritis (RA) had significantly higher concentrations of IgA RF than sero-negative RA patients or healthy adult controls. Concentrations of IgA RF in paired sera and synovial fluids from sero-positive RA patients were comparable. Levels of IgA RF demonstrated a moderately good correlation with levels of IgM RF in sero-positive RA sera (r = 0.673). However, the ratio of IgA RF concentration to IgM RF concentration in sero-positive RA sera varied widely. |