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Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes

PMID	Title	PublicationDate	abstract
7387792	[Early effect of levamisole on plasma immunoglobulins in rheumatoid arthritis].	1980 Mar 15	In 8 patients affected with rheumatoid arthritis the effects of levamisole administration (150 mg/day once a week) on plasma immunoglobulins were studied. The concentration of IgG, IgA and IgM was measured before and after 15,30,60 and 90 days of treatment. We observed a significant increase of IgG after 30, 60 and 90 days, of IgA after 30 and 90 days, and of IgM after 15 and 30 dyas. Such response is in contrast with previously reported decreased of immunoglobulins most frequently observed after 6 months of drug administration. Therefore, it seems that levamisole at the beginning of its activity on immunocompetent cells enhances rather than decreases the antibody production.
28650	Salazopyrin in rheumatoid arthritis.	1978 Jun	After a 12-week preliminary period of observation 32 patients with consistently active rheumatoid arthritis (RA) were treated for up to 22 weeks with salazopyrin. Seven patients could not tolerate the drug. The remaining 25 patients had a marked improvement in subjective clinical state and significant falls in serum C-reactive protein and the erythrocyte sedimentation rate 6 weeks after treatment began. The improvement was maintained after 22 weeks. The results strongly suggest that further trials with this drug in RA are needed.
6934774	Association of HLA-DRw4 with rheumatoid arthritis in black and white patients.	1980 Nov	The HLA-A, B, C, and DR antigens were typed in 35 black and 35 white Americans with rheumatoid arthritis. The frequency of HLA-DRw4 was increased in both the black and white patient patient groups compared to the race-matched control groups. DRw4 was found in 45.7% of the black patients compared to 14.3% of the black controls (corrected P value < 0.035) and DRw4 was found in 71.4% of the white patients compared to 40.0% of the white controls (corrected P value < 0.035). These data indicate that immunogenetic factors related to DRw4 are important in the development of rheumatoid arthritis in American blacks as well as whites.
6824823	The effect of hyperparathyroidism on the course of rheumatoid arthritis.	1983 Feb	Rheumatoid arthritis and primary hyperparathyroidism have been diagnosed in three patients. This is likely to represent the coincidence of two common diseases but the clinical features are discussed with particular reference to the presence and withdrawal of raised levels of circulating parathyroid hormone (PTH). It is argued that raised levels of PTH potentiate the effects of the rheumatoid disease on bone and joints. Other musculoskeletal features of hyperparathyroidism and the actions of PTH on bone are reviewed.
6660205	Acupuncture and rehabilitation (III) effects of acupuncture applied to the normal side on	1983	In osteoarthritis deformans and rheumatoid arthritis of the knee and in disorders in motility of the knee joint after cerebral hemorrhage and thrombosis, acupuncture was applied to the normal side at the symmetrical part to the lesion and flection-extension exercise and massage on the affected joint were carried out as rehabilitation (Reha) during the time the needles were used. A most remarkable cure rate was obtained in osteoarthritis deformans of the knee when treated with acupuncture on the normal side and flection-extension exercise and massage on the affected part. The cure rate was low in rheumatoid arthritis, and the therapy was non-effective concerning disorders in motility of the knee joint after cerebral hemorrhage or thrombosis. The improvement rate, however, was extremely low in osteoarthritis deformans and rheumatoid arthritis of the knee after the acupuncture on the affected part of the affected side with Reha on the affected part of the affected side, or Reha on the lesion, and these means of therapy were completely non-effective concerning disorders in motility after cerebral hemorrhage or thrombosis. Our previous reports No. 1 and 2 accord with the evidence obtained in this study that the acupuncture on the normal side and Reha on the affected part of the affected side produced most remarkable effect in osteoarthritis deformans of the knee. The low improvement rate in rheumatoid arthritis and non-effectiveness concerning disorders in motility of the knee joint after cerebral hemorrhage or thrombosis may be explained by differences in morphology of the diseases.
685511	[Effect of D-penicillamine on zinc levels in blood and urine of patients with chronic poly	1978 May	In 6 female patients with classical rheumatoid arthritis D-penicillamine was administered in a daily dose of 250--500 mg for 3 weeks. The only additional antiphlogistic treatment was Indomethacin (100--150 mg daily). At the beginning and during the trial blood levels and the urinary excretion of zinc were determined using both neutron-activation analysis and atomabsorption. The results showed an increase of the urinary zinc excretion during the whole trial, a decrease of blood concentration of zinc until the 2nd week of treatment followed by an increase during the 3rd week above the level of the controls obtained before D-penicillamine therapy was started.
483941	[Analysis of the causes of death in patients with rheumatoid arthritis].	1979 May 1	The post-mortem examinations performed from 1943 to 1977 in Tartu were examined for the frequency of rheumatoid arthritis as cause of death. Here was the result that since 1968 in increasing number this clinical picture was observed and that during the last five years it appeared in 1.4% of the cases. As cause of death in patients whose basic disease was rheumatoid arthritis most frequently and uraemia was found either on the basis of an amyloidosis of the kidneys or of a chronic glomerulonephritis. Also the number of fatal complications among a long-lasting glucocorticosteroid therapy is not unconsiderable.
7129267	Ankle fusion for degenerative arthritis secondary to the collagen diseases.	1982 Jul	This study reviews the arthritis clinic population of Rancho Los Amigos and a private practice limited to foot and ankle to determine the number of ankle fusions performed for collagen diseases. Rheumatoid arthritis was found to be the most common disease with ankle involvement severe enough to require fusion. From 8020 clinic visits in a 2-year period there were 61 total hip replacements, 56 total knee replacements, and no total ankle replacements. Three ankle fusions were performed. In a private practice out of 90 patients seen for ankles painful enough to require fusion, 6 were in rheumatoid arthritics. A successful ankle fusion was compatible with good function of the lower limb. Motion lost through fusion could be restored with a rocker-bottom shoe. Significant complications occurred with ankle fusion.
7020777	Rheumatoid arthritis: a study of relaxation and temperature biofeedback training as an adj	1981 Jun	Rheumatoid arthritis (RA) is a painful systemic disease and is believed to be exacerbated by stress. Relaxation and biofeedback strategies have demonstrated utility in alleviating both pain and stress-related symptomatology, and therefore were tested for efficacy with this disease in a two-phase study. First, 24 patients were taught a relaxation technique and then trained in either temperature elevation or reduction. Second, a group of 15 patients thus trained was compared with 8 others who received traditional physiotherapy modalities. Psychological tests, functional/physical evaluations, as well as measurements related to pain, sleep, and other activities were carried out. Results of the first study revealed significant and positive changes following treatment that were primarily related to pain, tension, and sleep patterns for both groups, but no differential effects were noted between temperature elevation or reduction conditions. This was attributed to both groups having maintained temperature above baseline during biofeedback training. The results of the second study consistently favored the relaxation and biofeedback over the physiotherapy group on the physical/functional indices. The psychological measures tended to remain constant throughout both studies, leading to the conclusion that the effectiveness of treatment was specific to physical functioning rather than to a psychological enhancement of well-being.
646468	Impairment of lachrymal and salivary secretion and cellular immune responses to salivary a	1978 Apr	During a systematic investigation of 100 unselected outpatients with rheumatoid arthritis, 58 were found to have reduced lachrymal or salivary secretion. No correlation could be detected between the presence or absence of secretory abnormalities and the age or sex of the patient, the presence of nodules or salivary duct antibody, or the occurrence of vasculitis. However, there was a significant correlation between diminished salivary of lachrymal flow and the occurrence of cellular immune responses to a protein fraction of normal human saliva, sensitisation being found in 94% of those with impairment of salivary and lachrymal secretion as compared with 33% of those without.
607391	Morphological findings in joint cartilage after osmic acid treatment.	1977	Punch biopsy specimens from the cartilage of the lateral condyle of the femur in 29 patients suffering from rheumatoid arthritis were taken during surgical synovectomy of knee joints and investigated by light or electron microscopy. Eleven patients had never received osmic acid injections in this particular joint, whereas 18 had had such injections 1-24 months prior to surgery. By light microscopy only minor differences could be seen between controls and cartilage treated with osmic acid, whereas with electron microscopy, increased amounts of dark-staining cell debris were visible in samples taken after osmic acid treatment. The perilacunar matrix appeared normal. There was no irregularity of collagen fibres at the surface of the cartilage. It is concluded that osmic acid causes limited superficial damage to the cartilage. The question whether this is of any clinical consequence in the form of subsequent degenerative joint disease, must be solved by clinical follow-up studies.
56015	Radionuclide imaging of the bones and joints of the hand. A definition of normal and a com	1976 Mar	Normal radionuclide patterns of the hand obtained with 99mTcO4 and 99mTc-Sn-EHDP are described and their validity supported by clinical, radiographic, and laboratory examinations performed to exclude articular disease in the control group. Comparison of the 99mTcO4 and 99mTc-Sn-EHDP images in patients with various articular diseases demonstrated higher sensitivity of 99mTc-Sn-EHDP in detection of involved joints; this was also true when the radionuclide images were compared with fine-detail radiographs in patients with rheumatoid arthritis.
6402232	Disease activity and pregnancy associated alpha 2-glycoprotein in rheumatoid arthritis dur	1983 Mar 5	Fourteen patients with rheumatoid arthritis were studied during pregnancy and clinical disease activity and serum concentrations of pregnancy associated alpha 2-glycoprotein (PAG) measured at monthly intervals until parturition. Disease activity diminished during pregnancy in 10 patients (group 1) and increased or remained unchanged in four (group 2). The mean PAG concentration produced by group 1 was 1250 +/- 737 mg/1, which was significantly higher than the mean of 470 +/- 304 mg/1 produced by group 2. Furthermore, there was a highly significant negative correlation coefficient (r = -0.41; p less than 0.001) between disease activity and PAG concentrations during gestation. Since there was no significant difference between the two groups of patients in any of the other serum factors measured, and since PAG has immunosuppressive properties in vitro, the results suggest that this protein may play an important part in inducing the remissions of rheumatoid arthritis which frequently occur during pregnancy.
6976861	Immune complexes in early arthritis. L Detection of immune complexes before rheumatoid art	1981 Jun	Fifty-three patients with early arthritis were studied longitudinally for up to 3 years. During this time, 24 developed sufficient features for definite rheumatoid arthritis (RA) to be diagnosed. The other (arthralgia patients) differed from the RA patients as, in the majority, C-reactive protein and ESR were normal and anti-nuclear antibodies or rheumatoid factors were rarely found. Moreover, in time their signs and symptoms improved or disappeared. Circulating immune complexes were detected in both groups of patients by the platelet aggregation test whereas complexes detected by abnormal Clq-binding activity were found mainly in the RA patients. Platelet-aggregating complexes were usually present in the first samples studied and disappeared in the arthralgia patients with recovery from their symptoms. In the RA patients, Clq-binding complexes appeared simultaneously or later than platelet-aggregating complexes but both tests were positive several months before RA could be diagnosed. These results suggest that immune complexes are one of the first immunological abnormalities to appear in patients with arthritis. Although the constituent antigen and antibody of complexes detected by either test are unknown, their possible nature is discussed.
6612251	Rheumatoid arthritis in a medical information system: how valid is the diagnosis?	1983	In order to validate the Stockholm County Medical Information System with regard to rheumatoid arthritis (RA) we have studied the medical records of 276 cases coded as RA in the medical information system. We searched information on the criteria for RA from (1961) and New York (1966). 18% of the medical records lacked information to the extent that an assessment of the number of criteria fulfilled was not possible. 9% fulfilled only one New York criterion and 7% fewer than three Rome criteria. 47% fulfilled four New York criteria and 35% at least seven Rome criteria. The most complete information on criteria was found in medical records from departments of rheumatology and these had also the highest degree of criteria fulfillment. A comparison is also presented between this sample of cases and a sample of RA persons selected from the general population with regard to fulfillment of criteria.
7097681	Correlation of clinical parameters of disease activity in rheumatoid arthritis with serum	1982 Mar	Serum C-reactive protein (CRP) levels were measured in 99 patients with definite or classical rheumatoid arthritis (RA). At the same time as the serum was obtained, the activity of the RA was assessed by assigning scores to a comprehensive set of subjective, semi-objective and objective clinical features. The results confirmed that the serum CRP concentration closely reflects activity of RA and is of value in its objective assessment. Erythrocyte sedimentation rate (ESR) followed the same pattern as CRP levels but all of the subjective and semi-objective criteria correlated more significantly with CRP levels than with ESR.
7341275	Evaluation of the long-term efficacy and safety of indoprofen in rheumatoid arthritis and	1981	Thirty-seven adult out-patients of both sexes, suffering from classical or definite rheumatoid arthritis (R.A.) or osteoarthritis (O.A.), were given indoprofen 600 mg/day for up to 5 months, in order to evaluate its effectiveness and safety. A significant improvement of joint tenderness (Ritchie) and of functional index (Lee) was rapidly achieved in R.A. patients (12 cases); objective signs of inflammation, moreover, were gradually relieved. In O.A. patients (25 cases) articular pain, motility and swelling all improved in about 90% of cases. A complete set of laboratory tests reflecting blood picture, liver and kidney function, carried out at monthly intervals during the study, failed to reveal any sign of toxicity. Clinical tolerance was generally good.
304637	[Are antinuclear factors a contraindication for penicillamine treatment in patients with r	1978 Feb 3	28 patients with rheumatoid arthritis undergoing treatment with penicillamine were investigated over a period of 7 to 72 months. Antinuclear antibodies were detected in 43% of patients before treatment, and 39% when treatment was completed. In all patients anti-native DNA antibodies were within the normal range. Precipitating antibodies to heat-denatured DNA were detected in 3 out of 16 patients at the end of therapy. There was no correlation between the detection of antinuclear antibodies, antibodies to native or denatured DNA and the occurrence of immunological side effects due to penicillamine (1 patient with pemphigus erythematosus, 3 patients with immune-complex nephritis).
3968097	Synovectomy of the elbow in rheumatoid arthritis.	1985 Jan	The combined procedure of synovectomy and resection of the radial head was performed in thirty-five patients (forty-two elbows) with Stage-III or IV rheumatoid arthritis. These patients were followed postoperatively for a minimum period of two years (average, seven years). The result was graded as excellent in four, good in fifteen, fair in fourteen, and poor in nine elbows. Pain was diminished from the preoperative level in all but six elbows, but motion was not much improved. Synovitis recurred postoperatively in thirteen elbows, but in only five did the destructive process progress to a degree requiring a second operation. We think that synovectomy for relief of pain in the elbow is not contraindicated in the presence of Stage-III or IV rheumatoid disease, but that little improvement of elbow motion can be expected.
121600	Plasma levels of malondialdehyde, a product of cyclo-oxygenase-dependent and independent l	1979 Jan	Plasma levels of malondialdehyde (MDA), indicating the sum of lipid peroxidation dependent and independent of cyclo-oxygenase activity, were measured in rheumatoid arthritis (RA) patients. MDA levels were increased in those patients most severely diseased. Higher levels of MDA correlated with more active RA.