Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 4048760 | Cryoglobulins in cases of rheumatoid arthritis. | 1985 | Clinically diagnosed cases with different grades of rheumatoid arthritis (RA) were studied for (a) cryoglobulin content (b) constituents of cryoglobulins, and (c) rheumatoid factor (RF) titers in sera and cryoglobulins. Of 60 patients, 28 (46.66%) had significantly high levels of cryoglobulins and were mainly distributed in the severe group. Significant amounts of IgG and IgM were found in the cryoglobulins of the 15 cases of RA studied. Ten of these cases had detectable C3 in their cryoglobulins. Of 20 cases of RA, 10 had detectable levels of RF in their cryoglobulins, as shown by the latex agglutination method. There was no significant correlation between the RF titers of cryoglobulins and the RF titers in the corresponding sera or the quantity of IgM and IgG components in them. Since the RF titer in cryoglobulin seemed to indicate the severity of the disease, the use of this parameter is proposed for diagnosis and prognosis of RA. | |
| 6841420 | Unilateral rheumatoid arthritis in hemiplegia. | 1983 Mar | Rheumatoid arthritis is generally a symmetrical polyarthritis characteristically involving small joints. Unilateral disease may occur when limbs are protected by a neurologic defect. Unilateral rheumatoid arthritis occurring in a patient with hemiplegia is here described. | |
| 6816052 | Levels of IgD in patients with rheumatoid arthritis. | 1982 May | It has been proposed that IgD may have a pathophysiological role in certain autoimmune diseases, since antinuclear IgD antibodies were revealed in patients with systemic lupus erythematosus, rheumatoid arthritis and systemic sclerodermia. The studies on the problem of evaluation of serum IgD levels in patients with rheumatoid arthritis (RA) are scanty and their results are controversial. We studied IgD levels in patients with RA in order to demonstrate possible correlations with selected immunologic parameters, and to determine the relevance of IgD quantitation in the diagnosis of RA. We determined IgD levels in 30 patients with classic or proven RA, and in 30 age and sex-matched volunteers. Immunoglobulins of A, M, G classes were also determined. E-rosettes were assayed by the method of Jondal et al. in a modification. The distribution of IgD concentrations in donors revealed two modes, and also showed bimodal distributions in the patients. IgG and IgA levels were practically equal in the IgD-positive patients, but IgM was significantly lower than in the IgD-negative subjects. E-rosette values were also different in these subgroups. IgD-positive patients had significantly higher numbers of E-rosettes (1254 +/- 215), compared to IgD-negative individuals (497 +/- 146). IgD was found more often in the seropositive patients to rheumatoid factor (60%) than in seronegative ones (33%) but the difference was not statistically significant. | |
| 718281 | Costovertebral and costotransverse joint involvement in rheumatoid arthritis. | 1978 Oct | Lesions of the costovertebral (CV) and costotransverse (CT) joints are distinctly unusual in rheumatoid arthritis. The patient presented had dramatic changes in these joints with destruction, ankylosis, and bony overgrowth. This led to a moderate respiratory impairment and a distinctive radiological presentation. | |
| 6979326 | [Pathomorphosis of rheumatic diseases]. | 1982 | Clinico-anatomic analysis of section and biopsy materials (skin, kidneys; synovial membranes of joints, lungs) was performed to study the effect of immunosuppressive and antiinflammatory therapy on the course and morphological manifestations of rheumatic diseases. In rheumatic fever, predominant involvement of valvular endocardium with flaccid asymptomatic course was observed with the lack of vasculitis and myocardial involvement, decreased fatality rate, a shift of fatality and morbility to middle age groups suggesting changes in the epidemiology of the disease and pathomorphosis of this nosological form. In systemic lupus erythematosus and rheumatoid arthritis, treatment of the disease positively affects its clinical, morphological, and immunological manifestations, i. e. partial pathomorphosis (nosomorphosis) occurs. | |
| 1127137 | New approaches to trials of antirheumatic drugs in rheumatoid arthritis. | 1975 Apr | While drug trials can be performed in different designs and sequences, the paramount consideration is careful definition of limited trial objectives such as efficacy, tolerance, and safety. Efficacy variables might include tests for analgesic effect, antiinflammatory activity, or specific antirheumatic action. Unless a drug has remarkable therapeutic effect, double-blind comparison with placebo or a standard reference drug such as aspirin is mandatory. Random assignment of patients to treatment groups must be assured and patients should not receive other antirheumatic drugs unless the trial is specifically designed to study drug interactions. Drug dosage poses a problem because average doses are usually employed. Compliance is monitored by several techniques including measurement of blood levels of test drugs in all study patients. Multicenter trials have several advantages: (1) averaging patient selection, (2) minimizing observer bias, (3) shortening time of trial by rapid entry of patients, (4) entering large number of patients, which can permit examination of "responders" versus "non-responders." Data analysis should employ proper statistical evaluations (nonparametric tests for nonnormally distributed variables). Duration of study period, trials to evaluate drug interactions, and variables used to measure drug effects will be discussed. | |
| 384931 | The antiperinuclear factor. 1. The diagnostic significance of the antiperinuclear factor f | 1979 Jun | In 1964 Nienhuis and Mandema reported the presence of antibodies against cytoplasmic granules in buccal mucosal cells in the serum of 50% of patients with rheumatoid arthritis (RA). Although they reported a good specificity for RA of these so-called antiperinuclear antibodies (APF), their results never threatened the monopoly of the rheumatoid factor as a serological tool for the diagnosis of RA. A re-evaluation with improved immunofluorescence methods showed a frequency of the APF of 78% in 103 patients with RA. The latex test and the Waaler-Rose test were positive in only 70% and 58% respectively of these patients. Only 15% of the RA patients were negative for all 3 tests. Thus, 40% of patients who were seronegative by the traditional methods gave a positive result on performance of the APF test. The high sensitivity of the APF test was combined with a good specificity, for the frequency in patients with other autoimmune diseases or degenerative joint disease and in healthy subjects was low. For the serodiagnosis of RA it seems best to combine the use of the APF test with one for rheumatoid factor. | |
| 7352940 | Metabolic and secretory properties of peripheral and synovial granulocytes in rheumatoid a | 1980 Jan | The metabolic and secretory properties of peripheral and synovial granulocytes of patients with rheumatoid arthritis were investigated with serum- or immunoglobulin-treated zymosan as activators of cell metabolism. During isolation of the synovial cells precautions were taken to prevent in vitro phagocytosis of immune materials present in the synovial fluids. Oxygen uptake, extracellular release of lysosomal enzymes under resting and activated conditions, yield of the isolated granulocytes, and the granule enzyme content of peripheral and synovial cells did not differ significantly from those of peripheral granulocytes from healthy volunteers. In agreement with the biochemical results, intracellular inclusions could be detected in only a few synovial cells with a direct immunofluorescence technique. The possibility that formation of "ragocytes" may be an in vitro phenomenon is discussed. | |
| 6830323 | Consequences of synovectomy of the knee joint: clinical, histopathological, and enzymatic | 1983 Feb | The state of 36 knee joints of 32 rheumatic patients was evaluated after surgical synovectomy, the follow-up period varying from 2 to 39 months. Synovitis was suspected by arthroscopy in 67% and verified histologically in 52%, although in a milder form than at the time of synovectomy. The regenerated synovial tissue was less permeable to serum proteins and contained lower activities of lysosomal enzymes than the excised synovial tissue. Although the number of leucocytes decreased in the joint fluid after synovectomy, the activities of lysosomal enzymes were lowered only slightly, and there was no change in the amount of C3 and C4 components of complement pathway. | |
| 162672 | A long-term double-blind clinical trial of ibuprofen and indomethacin in rheumatoid arthri | 1975 | Two-hundred and eighteen individuals with rheumatoid arthritis were randomly assigned to six months treatment with ibuprofen (900-1800 mg/day) or indomethacin (75-150 mg/day). The drugs were equally effective in the treatment of rheumatoid arthritis while the incidence of indomethacin side-effects was 1.5 times greater than the incidence of ibuprofen side-effects. | |
| 6627762 | Renal biopsy appearances in rheumatoid disease. | 1983 Sep | The renal biopsies of 30 patients with rheumatoid arthritis and clinical evidence of renal disease were reviewed; only patients in whom the intravenous pyelogram was normal were subjected to biopsy, thus excluding those with papillary necrosis and chronic pyelonephritis. Tissue was studied by light, electron and immunofluorescence microscopy. There were 13 cases of mesangial change, 9 of membranous glomerulonephritis, 4 of tubulointerstitial change, 2 cases of focal segmental glomerulosclerosis, 1 case of amyloid and 1 of diffuse proliferative glomerulonephritis with crescents. All 9 patients with membranous glomerulonephritis but only 6 of 13 with mesangial change had received gold or penicillamine. We found no evidence of "glomerulitis" or of a rheumatoid vasculitis. | |
| 931589 | Polyarticular disability: a functional assessment. | 1977 Nov | The purpose of this study was to design and evaluate a system for the functional evaluation of patients with polyarticular disease. A single assessment can be done in approximately 15 minutes. Extensive prior preparation is not required. The evaluation is reproducible and the numerical characterization agrees well with a physician's overall assessment of functional impairment. The subscores can be used independently of the total score to focus on specific areas of disability. Use of the evaluation in other institutions has produced a high degree of reliability. Statistical evaluation has demonstrated areas of weakness that have been eliminated or modified to increase reliability of the system. | |
| 7388707 | Nodular regenerative hyperplasia of the liver: diagnosis by liver biopsy. | 1980 May 24 | Specimens of liver obtained by needle biopsy from two patients with rheumatoid arthritis showed features of nodular regenerative hyperplasia. In one patient the nodularity was apparent on gross examination of the specimen. Portal hypertension was present in the other patient. The cause and pathogenesis of the disorder are poorly understood. | |
| 7288766 | Reticuloendothelial function in rheumatoid arthritis: correlation with disease activity an | 1981 May | Fourteen patients with active rheumatoid arthritis had their reticuloendothelial function tested with clearance of heat damaged radiolabeled autologous erythrocytes. Only 3 of these 14 patients had prolonged red blood cell (RBC) clearance. No correlation was found between RBC clearance and level of circulating immune complexes, disease activity or disease duration. | |
| 402324 | Operative treatment of arthrosis deformans of the temporomandibular joint: a preliminary r | 1977 Feb | If patients with arthrosis deformans of the temporomandibular joint are treated without success by conservative means, operative therapy may be indicated. The type of operation depends on the complaints: a)resection of the auriculotemporal nerve and superficial temporal artery; or b) the same operation in combination with condylar shaving. Twenty-four joints in 14 patients underwent a denervation. Thirty joints in 19 patients were also shaved. The results were very satisfactory. | |
| 3909363 | [Plasma and synovial beta-2-microglobulin. Results of a personal study]. | 1985 Oct | Beta-2-microglobulin was assayed in the plasma and the synovial fluid in 41 subjects with mechanical joint disorders, 27 patients with rheumatoid arthritis and 32 patients with non-rheumatoid arthritis. The plasma beta-2-microglobulin may be raised in all forms of joint disease, especially in the course of rheumatoid arthritis, but its ability to discriminate between rheumatoid arthritis and other forms of inflammatory joint disease is poor. In contrast, for the beta-2-microglobulin level in the synovial fluid, the differences in the means are highly significant between rheumatoid arthritis and non-rheumatoid arthritis. Concentrations of beta-2-microglobulin in the synovial fluid greater than 5.2 micrograms/ml, in this study which excluded patients with renal failure, were 100 per cent specific for rheumatoid arthritis and were found in 52 per cent of cases. However, this result has to be interpreted in the light of the fact that any extra-articular cause for an increased plasma beta-2-microglobulin, particularly renal failure, also causes a rise in the synovial concentration, invalidating the test. For this reason, the authors propose using the value of the beta-2-microglobulin in the synovial fluid minus the plasma beta-2-microglobulin, as a more specific index. | |
| 7152744 | Synovectomy of the ankle joint. | 1982 | Between 1970 and 1979, 123 synovectomies of the ankle joint were performed on 99 patients. Sixty two of these patients (81 ankles) were followed up for an average period of four years. Using Steinbrocker's classification 10 ankles had Stage I disease, 34 had Stage II, 33 had Stage III and 4 had Stage IV. In more than 80% of the joints pain and swelling significantly decreased after operation, with improvement in the range of motion and of the gait pattern. However the procedure did not change the walking distance or dependency upon walking aids, probably because the ankle joint was rarely the only joint of the lower extremity affected by rheumatoid arthritis. | |
| 6419598 | Auranofin: bane or bonanza for the nonrheumatologist. | 1983 Dec 30 | The availability of an oral gold preparation in the treatment of rheumatoid arthritis, with a claim to being effective yet safer than parenteral gold, will most certainly attract the attention of physicians and patients who previously would not have used chrysotherapy. Cardinal clinical features that may be especially helpful to the nonrheumatologist in the diagnosis of rheumatoid arthritis are outlined. The often unpredictable course of rheumatoid arthritis is stressed, emphasizing the need for an adequate trial of nonsteroidal anti-inflammatory drug therapy before instituting the use of a potentially more toxic remission-inducing drug such as gold. The absence of an immediate flare of synovitis, should the use of oral gold be sporadic, will aggravate the problem of patient noncompliance. Techniques to minimize this problem will be noted. Perseverence and careful record keeping by physicians not necessarily comfortable with the long-term management of chronic disease must be part of the therapeutic program. | |
| 6657554 | [Rheumatoid arthritis, obliterating bronchiolitis and D-penicillamine. Apropos of a new ca | 1983 | Over recent years, several cases have been reported of bronchiolitis obliterans, of very rapid onset and serious clinical course in patients with rheumatoid arthritis being treated with D-Penicillamine. After reporting a new case, the authors stress the unusual features of this bronchiolar condition which is probably of iatrogenic origin and irreversible, with death occurring within a few years. The pathogenesis is poorly understood and many questions still remain concerning the relationships between rheumatoid arthritis, the bronchiolar lesions and D-Penicillamine in this disease of pulmonary collagen. The ultrastructural examination and the morphometric examination of this new case suggest the presence of predominantly type III collagen, which is normally present in the lungs in only small quantities. | |
| 6863632 | Red lunulae in a patient with rheumatoid arthritis. | 1983 May | Red nails, a distinctive, dusky red, blanchable erythema of the lunula area of the nail bed, has been previously reported three times in the English language literature, in each instance in association with alopecia areata. An identical case of red nails here in association with "classical" rheumatoid arthritis is reported. |