Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 6152006 | Copper response to rheumatoid arthritis. | 1984 Dec | Rheumatoid arthritis can be divided into two syndromes, one a potassium deficiency, the other an inappropriate copper requirement seriously affecting the elastin tissues through reduced lysyl oxidase cross linking. The malfunction in copper may arise from the steroids which regulate potassium, which reduces those steroids, and through that, increases the copper response to the needs of the immune system. It is a mechanism which may have evolved to help fight potassium wasting infections. | |
| 7100770 | A functional study of the rheumatoid elbow. | 1982 Aug | A clinical and functional study of rheumatoid elbows has been done to discover the magnitude and frequency of disabilities caused by elbow problems. Pain and weakness were found to affect all activities which were tested, with adjacent joint involvement, flexion deformity, and lack of supination causing significant disability. Instability was not a frequent problem. The frequency of functional disabilities, linked to severe pain, suggests that the development of an elbow joint replacement would be worthwhile. | |
| 7361059 | [Results of surgery of the rheumatoid forefoot. Apropos of 64 cases]. | 1980 Feb | The authors analyze the outcome of 64 operations of different types of rheumatoid conditions in the foot. Of all the techniques used, plantar re-alignment, according to the technique of Lelièvre was the most often used, regularly providing satisfactory results. | |
| 136142 | Effect of antirheumatic drugs on neutral protease from human leucocyte granules. | 1976 Sep | The inhibitory effect of 38 antirheumatic and other agents on purified neutral protease from human polymorphonuclear leucocytes has been studied by determining the decrease in enzyme activity on Z-Ala-NPH as substrate. Analgesics, salicylates, cytostatic agents and steroids, as well as D-penicillamine, colchicine, allopurinol, chlorzoxazone and chlorpromazine, either had no effect on neutral protease or inhibited it only to a very small extent. Typical antirheumatic agents like gold and pyrazolone derivatives suppressed the activity of the enzyme at a concentration of 10(-5)M. The two sulphonated polysaccharides Arteparon and pentosan polysulphate (SP 54) were the most potent inhibitors of neutral protease (inhibition down to 10(-8)M). Increasing concentrations of various inorganic salts gradually suppressed the effect of some otherwise effective drugs on neutral protease. The drugs were completely ineffective at a salt concentration of 0.5 M. At physiological concentrations, however, this effect was insignificant. Inhibition of neutral protease may be one way in which some antirheumatic drugs exert a therapeutic effect in rheumatic diseases. | |
| 6114188 | [Experiences gained with knee endoprostheses (author's transl)]. | 1980 | Authors report on their experiments and observations with knee endoprostheses. On reason of the high price of imported prostheses the home production of implantates is urged. They reported in a preliminary paper in 1977 on the insertion of the first knee prosthesis made in Hungary. Since this time in 36 instances have been inserted without complication their titanium-polyamid and stainless steel-polyamid sledge type prostheses (a total of 42 pairs of 32 patients). After 2 years follow up the results can be classified as "very good". A new improved model of knee prosthesis is under elaboration. | |
| 849362 | Activators and inhibitors of fibrinolysis in rheumatoid and nonrheumatoid synovial membran | 1977 Mar | Histochemical studies of rheumatoid and nonrheumatoid synovial membranes revealed lowered fibrinolytic activity at sites of chronic inflammatory infiltrates and deposits of fibrin-like material (FLM). Inhibition of fibrinolysis occcurred over these areas and was always inversely related to the fibrinolytic activity. Hence the low fibrinolytic activity of these chronically inflamed tissues seems to result from the presence of inhibitors of fibrinolysis. Such inhibitors in FLM deposits may be responsible for the prolonged persistence of these deposits in the rheumatoid joint. | |
| 311199 | Alpha-1-antitrypsin phenotypes in rheumatoid arthritis and systemic lupus erythematosus. | 1979 Feb | Alpha-1-antitrypsin phenotypes were determined in 37 patients with rheumatoid arthritis and 40 patients with systemic lupus erythematosus. No significant increase in non-MM phenotypes was found. It appears that alpha-1-antitrypsin phenotypes neither predispose to the development nor enhance the severity of the two rheumatic diseases. | |
| 666874 | The infectious etiology of rheumatoid arthritis. New considerations. | 1978 Jun | Several possible mechanisms of chronic inflammatory arthritis that might be initiated by infectious agents are discussed. Some recent information on mycoplasma infections, long-term virus infections, and shed bacterial components provides the bases for new experimental approaches. Currently, evidence of involvement of mycoplasma or viral agents in rheumatoid arthritis is tenuous. Chronic peptidoglycan-immune-complex formation is a consideration that has been discussed, but only recently pursued in depth. It may well be that experimental studies on the infectious etiology of rheumatoid arthritis will be revitalized through an appreciation of the bacterial antigen load in the gastrointestinal tract. The perimental vehicles for testing this possibility are available and should be directly applicable at the clinical level. | |
| 6362407 | Rheumatoid arthritis: relationship with HLA-D. | 1983 Dec 30 | Understanding of the genetic component of rheumatoid arthritis has been greatly enhanced by the discovery of the association of risk for development of this disease with certain histocompatibility antigens. The HLA-D region, at the centromeric end of the HLA gene complex, on the short arm of chromosome number 6, is concerned with important functions in the regulation of the immune response. The products of the HLA-D region (DR, SB, MT, and the like) function as "restriction elements" for antigen presentation, mediators of immune response and immune suppressor genes, stimulators of graft rejection, and of other allogenic effects. Rheumatoid arthritis is associated with Dw4 and DR4 in Caucasians. The association with DR4 has been observed also in Blacks and Orientals. HLA-DR4 is associated with more severe, rheumatoid factor-positive disease. Clinical and genetic heterogeneity has been revealed by studies of patients with juvenile arthritis. Conditions often associated with rheumatoid arthritis and also thought to have an immunologic basis, such as Sjögren's syndrome, Felty's syndrome, and rheumatoid vasculitis, and reactions to medications, such as gold and penicillamine, reveal an interesting spectrum of immunogenetic relationships. Thus, HLA studies have shed light on the classification of patients with rheumatoid diseases. In view of the role of HLA-D in the immune response, these studies are expected to further our understanding of the mechanism underlying predisposition for development of rheumatoid arthritis and related conditions. | |
| 6699831 | Detection and clinical significance of IgE rheumatoid factor. | 1984 Feb | High serum IgE rheumatoid factor (RF) levels (greater than 100 ng/ml) were found using solid phase sandwich ELISA in 11 of 20 patients with rheumatoid arthritis having significant extraarticular symptoms (rheumatoid vasculitis) and only in 23 of 142 usual rheumatoid patients without such symptoms (p less than 0.01). A significant influence of other classes of RF and non-RF IgE on the ELISA for IgE RF was not observed in sera with levels of IgE RF over 50 ng/ml. The levels of IgE RF were not closely correlated with those of other classes of RF and total IgE. This study suggests that IgE RF might be one of the factors necessary to produce extraarticular rheumatoid vasculitis. | |
| 644356 | Multiple pneumococcal pyarthrosis complicating rheumatoid arthritis. | 1978 May | Pneumococcal pyarthrosis was documented in seven and ten joints, respectively, in two patients with rheumatoid arthritis. The recognition of multiple pyarthrosis superimposed upon rheumatoid arthritis can be difficult. The present cases are compared with eight previously reported cases of pneumococcal arthritis in patients with rheumatoid arthritis. | |
| 4023991 | Thoracoscopic, histological, and clinical findings in nine case of rheumatoid pleural effu | 1985 May | A characteristic thoracoscopic picture of a granular parietal pleural surface was found in nine patients with rheumatoid pleurisy. Characteristic changes could be identified histopathologically in material obtained by biopsy. The rheumatoid pleural effusion resolved within an average of 14 months and no serious complications developed after the pleurisy. It is concluded that in rheumatoid pleural effusion a positive diagnosis can be made by thoracoscopy, preferably supported by the identification of microscopic structural changes in the parietal pleura. | |
| 654904 | A case of septic arthritis in multiple joints due to Bacteroides fragilis in a patient wit | 1978 Feb | A case of arthritis in multiple joints due to B. fragilis ssp. fragilis is described. The patient was a 55-year-old man badly disabled by rheumatoid arthritis. The patient's immune response to the isolated strain was studied and a significant titre reduction during the course of the disease was observed. The serum antibodies of the patient cross-reacted with heterologous strains of B. fragilis ssp. fragilis. It is suggested that indirect immunofluorescence tests against a certain number of B. fragilis strains could be performed with serum from a patient in whom an infection with B. fragilis is suspected. | |
| 6507603 | Bilateral wrist dislocation in an above knee amputee with advanced rheumatoid arthritis. A | 1984 Dec | The ambulatory difficulties of a patient with long standing rheumatoid arthritis with an above knee amputation and bilateral wrist dislocations has not been previously reported. Although wrist fusion did in fact increase his hand strength, control and stability, he still lacked sufficient hand strength and grip to don and doff the prosthesis, nor could he use assistive devices in order to become an independent ambulator. The results of wrist fusion and attempts at ambulation are discussed. | |
| 6751243 | Zinc sulphate in rheumatoid arthritis. | 1982 Oct | To assess the antirheumatic activity of zinc sulphate, 27 patients with active rheumatoid arthritis took part in a 6-month, randomised, double-blind, between-group trial of oral zinc sulphate versus placebo. Twelve patients on zinc and 9 on placebo completed the trial, but no significant antirheumatic activity of zinc sulphate was demonstrated. | |
| 4032401 | Remission in rheumatoid arthritis. | 1985 Apr | Four hundred and fifty-eight patients whose clinical data had been prospectively entered into a rheumatic disease databank were studied for remission utilizing remission criteria of the American Rheumatism Association and criteria modified for chart review. During the period of observation 86 of 458 or 18.8% had at least one remission by investigators' assessment on chart review and 18.1% by application of ARA criteria. Patients were followed for 1131 patient years and remission occupied 97 patient years. For patients achieving remission this period represented 34.5% of their followup duration. The median length of remission was 10 months. Nineteen (18.6) percent of gold treatment courses and 16.7% of penicillamine courses resulted in remission. Fourteen (13.6) percent of patients who never received remittive therapy also had remissions. The ARA Preliminary Criteria for Clinical Remission in Rheumatoid Arthritis displayed a sensitivity of 80.2% and a specificity of 96.2% in this population. In patients receiving remittive therapy, female sex, disease onset before age 60, and early development of erosions were associated with decreased proportion of remission. | |
| 6979345 | [Tissue autoantibodies during therapy with levamisole for rheumatoid arthritis]. | 1982 Apr 15 | In 20 patients affected with rheumatoid arthritis, tissue autoantibodies were studied during a year of treatment with levamisole. Before therapy, antinuclear antibodies were present in 11 cases, anti-thyroid microsomes in 1 and anti-smooth muscle in 6. During therapy, autoantibodies remained almost unchanged in all patients, thus indicating that levamisole does not influence this aspect of humoral immunity in rheumatoid arthritis. Furthermore, no correlation was found between autoantibody pattern before treatment and effects of levamisole on clinical course of disease. | |
| 7041915 | Genetic predictors of patient response and side effects in the treatment of rheumatoid art | 1982 Apr | Clinical, laboratory, genetic, and radiologic studies were evaluated for 18 patients with rheumatoid arthritis who were treated for a mean of 16.6 months with a regimen involving supplementary aspirin and piroxicam, an investigational, nonsteroidal antiinflammatory agent. Although improvement in disease activity was seen, progression was evident on successive radiographs. Disease activity was not associated with the presence of any of the genetic markers. Peptic ulcers developed in 33% of patients, all of whom had type O blood. ABO blood typing may therefore be useful in patients with rheumatoid arthritis before consideration of therapy with potentially ulcerogenic drugs. | |
| 6842484 | Computerized tomography in evaluation of atlantoaxial subluxation in rheumatoid arthritis. | 1983 Feb | Nineteen patients with rheumatoid C1-C2 subluxation of greater than or equal to 5mm were studied by computerized tomography (CT). CT demonstration of spinal cord compression as defined by loss of posterior subarachnoid space was present in 11/19 (CT+) and absent in 8/19 (CT-). Fourteen patients were examined by a blinded neurologist. Cord compression by CT correlated better with clinical neurologic status than did routine radiographic studies. Absent superficial abdominal reflexes and history of bladder dysfunction correlated highly with cord compression by CT. Two CT+ patients developed neurologic deterioration requiring spinal fusion. Our data suggest that CT is a useful, noninvasive adjunct in management of patients with rheumatoid C1-C2 subluxation. | |
| 997657 | [Possibilities and limits of the morphological diagnosis of rheumatoid arthritis]. | 1976 Aug 15 | For the morphological diagnostics of rheumatoid arthritis only the judgment of the synovial membrane is of practical importance. Based on the experience gleaned on more than 2,000 synovectomy preparations the following evidence concerning the possibilities and the limits of the morphological diagnostics and the judgment of activity can be enunciated. 1. A certain histological diagnosis of the rheumatoid arthritis is possible only when rheumatoid granulomas or their equivalents are proved. 2. A probability diagnosis results from a definite combination of symptoms of proliferative and exsudative reactions of the synovial membrane. Especially the absence of proliferative signs decreases the degree of probability of the diagnostic evidence. 3. Seropositive and seronegative cases do not reveal any differences in histological respect. The possibility of the class-specific determination of rheumatoid factors by means of an immunofluorescence test and the fact the seronegative cases showed IgM and IgM rheumatoid factors, when this test was used, demands an examination of this evidence. 4. As to the synovial membranes of large joints in the same membrane so distinctive local differences of the findings may exist that thus the value of the needle biopsy is restricted. Only positive findings may be evaluated diagnostically. 5. Apart from a diagnosis the histological findings of the synovial membrane also allow a judgment of the local activity. The basis activity and the actual activity are differentiated. The basis activity is regarded as an expression of the immunological activity, the actual activity as an expression of the inflammatory activity. There are no unambiguous relations to the total clinical activity. Differences in the behaviour of the activity between seropositive and seronegative cases are not to be proved. A revision of this evidence under the aspect of the class-specific proof of the rheumatoid factor is necessary. |