Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 6091837 | Sjögren's syndrome presenting as a severe sensory neuropathy including involvement of the | 1984 Nov | Primary Sjögren's syndrome (SS) can be associated and may present with neurological complications. We describe a 32-year-old woman with a debilitating sensory neuropathy, including trigeminal nerve involvement which was the initial manifestation of this disease. | |
| 7358324 | Reye's syndrome in a child on long-term salicylate medication. | 1980 Mar | A case of Reye's syndrome in a four-year-old child on long-term salicylate medication for rheumatoid arthritis is reported. Severe fatty changes of the liver, lipid vacuolation in the renal proximal tubules, and severe brain oedema were the prominent postmortem findings. Symptoms of a trivial infection and vomiting just before death added to the resemblance of this case to Reye's syndrome. | |
| 6424588 | Blood gold concentrations in children with juvenile rheumatoid arthritis undergoing long-t | 1984 Apr | During an uncontrolled, open-labelled, open-ended clinical trial of auranofin in children with juvenile rheumatoid arthritis (JRA) we obtained serial blood samples for the purpose of assessing gold content. Our objectives were (1) to observe the pattern of blood gold concentrations over a period of time in children undergoing long-term oral gold therapy, and (2) to observe the effect of changing dosage levels on blood gold concentrations. The initial dosage of auranofin was 0.1 mg/kg/day with allowable increases to 0.2 mg/kg/day. A concurrent nonsteroidal anti-inflammatory drug was allowed. Twenty-one patients were enrolled in the study, and we obtained 2 or more serial samples on 13 of the children. At a constant dosage of 0.1 mg/kg/day, steady state blood gold concentrations were attained in 11 to 13 weeks of therapy and, in the absence of a dosage change, remained remarkably constant through extended periods. The blood gold concentration was related to total daily dosage rather than to the cumulative amount of gold received. Increasing or decreasing the dose resulted in a direct effect on concentration. The clinical value of blood gold levels resulting from auranofin therapy in JRA will have to be established through double-blind controlled trials. | |
| 7257857 | Temporomandibular joint space in children without joint disease. | 1981 | Bilateral assessment of the temporomandibular joint space in children without joint disease is reported. Twenty-eight children were examined with conventional radiography and 23 with tomography. High prevalence of asymmetric joint spaces with both techniques indicated that great care should be taken when using narrowing or widening of the joint space as a diagnostic criterion in children with juvenile rheumatoid arthritis. Other signs, such as restricted translation of the mandibular head, and clinical symptoms should be evaluated. | |
| 6614708 | [Hypothyroidism and the Gougerot-Sjögren syndrome]. | 1983 | The signs of Sjögren's syndrome were systematically researched in 36 patients with hypothyroidism (myxoedema with atrophic thyroiditis in 32 cases, Hashimoto's thyroiditis in 4). In a quarter of these patients were noted separately submaxillary glands and/or parotids enlarged, buccal and/or lacrymal sicca syndromes, and antisalivaryy ducts antibodies. The histologic analysis of minor salivar glands revealed foci of lymphocytes and plasmocytes (grades 3 and 4 of Chisholm's classification) in 6 subjects. Similarities between the Sjögren's syndrome and the autoimmune thyroiditis were specified; their association in the same patients might be explained considering the genetic predisposition to these affections. | |
| 7436567 | Cell mediated autoimmune granulocytopenia in a case of Felty's syndrome. | 1980 Aug | A variety of mechanisms have been demonstrated or suggested to explain the neutropenia that accompanies Felty's syndrome. This case report presents with Felty's syndrome with recurrent infections with initially had a clinical response to splenectomy. Eleven years later profound neutropenia recurred. In-vitro evidence for cell mediated autosensitisation of peripheral blood lymphocytes to autologous bone marrow cells was found. The cellular abnormalities improved after high-dose corticosteroids but not lithium. However, there did not appear to be a reduction in the incidence of clinical infections. The finding suggests that granulocytopenia in some patients with Felty's syndrome may be an autoimmune phenomenon. | |
| 921080 | Sjögren's syndrome in progressive systemic sclerosis. | 1977 Nov | Thirty-five consecutive patients with progressive systemic sclerosis were prospectively evaluated for evidence of Sjögren's syndrome. Six of the 35 (17%) were judged to have the disorder. This is a higher prevalence than in most reports, but much lower than that recently reportedly by Alarcón-Segovia and associates (7). An additional 17 of the 35 patients (48%) had significant fibrosis in the absence of sufficient mononuclear cell infiltrates to confirm the diagnosis of Sjögren's syndrome. This group had particularly aggressive scleroderma with serious visceral features, and five died after a short duration of illness. No significant abnormalities were found in biopsies from six patients with the mixed connective tissue disease syndrome, five with Raynaud's phenomenon alone, or in 29 autopsy control subjects who had no evidence of connective tissue disease. Fibrosis in the absence of mononuclear infiltration in minor salivary glands of patients with progressive systemic sclerosis indicates a poor prognosis. | |
| 6444793 | Rheumatoid disease with encephalopathy. | 1980 Jan | A 63-year-old woman developed progressive rheumatoid disease complicated by a confusional state as well as persistent cerebrospinal fluid pleocytosis and hypoglycorrhachia. Neuropathological examination revealed extensive rheumatoid lesions in the cranial dura, falx, and choroid plexus. The choroid plexus has not been affected in any of the 16 previously reported cases of pathologically verified rheumatoid disease of the central nervous system. The findings in this patient support the observations of others regarding the role of the choroid plexus in development of CNS manifestations in systemic immune complex disease. | |
| 7033533 | Uncommon radiological features of chronic arthritis in childhood: a review. | 1981 Dec | Radiological changes depend on the age of onset as well as the pattern of disease present (Ansell & Kent 1977). Seronegative disease tends to be associated with modelling abnormalities of the epiphyses, loss of joint space and the late development of erosions, although an occasional polyarthritis following systemic disease has a very destructive arthritis and overall failure of growth. Pauciarticular disease is associated with growth anomalies of epiphyses and also metaphyses in asymmetrical fashion. In spondylitic children, enthesiopathies are marked and there is a high incidence of hip involvement. Seropositive juvenile rheumatoid arthritis shows a severe erosive arthropathy early, combined with minor growth changes, particularly bony overgrowth in the hands and feet in the early teens. The hallmark of the psoriatic is the asymmetry and, in a few cases, the destructive nature of asymmetrically involved joints. | |
| 6513403 | [Bromhexine in symptomatic treatment of Sjögren syndrome]. | 1984 Oct | In a group of 11 patients with Sjögren's syndrome bromhexine improved tear secretion in 7 cases and salivary secretion in 4. The efficacy of the drug, in particular in patients in whom the syndrome has been present for a short time, was thus confirmed. | |
| 6725901 | Rheumatoid nodulosis of the hand. | 1984 May | Rheumatoid nodulosis is an uncommon variant of rheumatoid disease with distinctive clinical and radiographic characteristics and a favorable prognosis. This is in contrast to the poor prognosis for the severe form of rheumatoid disease with which rheumatoid nodules are often associated. A case of rheumatoid nodulosis of the hand treated with complete resection of the nodules is presented with a 2.5-year follow-up. Fourteen cases of documented rheumatoid nodulosis are reviewed and surgical treatment is recommended for both functional and cosmetic reasons. | |
| 6887174 | Articular manifestations of primary Sjögren's syndrome. | 1983 Jun | Twenty-six of 31 patients with primary Sjögren's Syndrome who had longterm followup and fulfilled strict criteria for inclusion but were otherwise unselected had articular manifestations attributable to this disease. Articular manifestations preceded sicca symptoms in 10, were simultaneous in 7, and followed sicca symptoms in 9 patients. Involvement was polyarticular in the 26, symmetric in 22, intermittent in 21, and continuous in 5. Synovitis was detected in 24, but was usually mild. These articular manifestations of primary Sjögren's syndrome were generally mild and responded readily to nonsteroidal antiinflammatory agents. | |
| 3897533 | A multidot immunobinding assay for autoimmune testing: evaluation for the diagnosis and ma | 1985 Apr | Multidot immunobinding assays were evaluated for applicability to connective tissue diseases. Four groups of human sera [(a) healthy, (b) miscellaneous diseases, (c) rheumatoid arthritis and (d) other connective tissue diseases] were used to obtain profiles comprising antibodies against DNA, various subcellular components and rheumatoid factor (RF). Qualitative correlation with standard tests for antinuclear factor and RF was shown. Statistically significant ranges of titer for groups (c) and (d) were obtained, and monitoring individual patients during the progression of disease was demonstrated. | |
| 7017003 | MRSPAH: a simple microtitre plate test for rheumatoid factors of different classes. | 1981 | A simple and inexpensive microtitre plate test (the mixed reverse (solid-phase) passive antiglobulin haemadherence test, or MRSPAH) has been developed for the measurement of antiglobulins (RFS) of different classes. Results obtained for IgM RF by this test have been compared with results of latex and Rose-Waaler (DAT) tests on rheumatoid arthritis (RA) sera. Levels of RFs of IgM, IgG and IgA classes have been measured by MRSPAH using rabbit IgG as antigen in RAs and normal people. 94% of RA sera tested were above the upper limit of normal for IgM and/or IgA RF. There was a considerable overlap between IgG RF levels in RAs and normals, although the means of the two groups were significantly different. | |
| 4022579 | Trabeculodialysis for inflammatory glaucoma in children and young adults. | 1985 Jul | A modified goniotomy (trabeculodialysis) was performed on 30 eyes of 23 patients with secondary glaucoma due to chronic anterior uveitis. All but two patients also suffered from juvenile chronic arthritis (Still's disease, juvenile rheumatoid arthritis). Trabeculodialysis was unsuccessful in lowering intraocular pressure to below 21 mmHg in 12 (40%) of eyes and successful in 18 (60%) of eyes. Of the 18 successful cases, 5 required no additional medication, but in 13 cases the intraocular pressure could only be maintained at a normal level by concomitant anti-glaucoma therapy. The presence of aphakia, extent of preoperative angle closure, and patient's age had no bearing on the outcome. | |
| 6971106 | T gamma subset specificity of lymphocyte reactive factors in juvenile rheumatoid arthritis | 1981 Apr | Sera from 34 patients with juvenile rheumatoid arthritis (JRA), 31 patients with systemic lupus erythematosus (SLE), and 22 normal controls were studied for microcytotoxicity before and after clearing in the ultracentrifuge. Normal T cells as well as T gamma and non-T gamma subpopulations were used. Before ultracentrifugation all test sera showed apparent T gamma cell specificity in the microcytotoxicity assay where rabbit complement was added. JRA and SLE sera produced much higher proportions of cell killing than normal controls. Ultracentrifugal clearing resulted in marked diminution in microcytotoxicity of JRA and some SLE sera. However, a considerable proportion of lupus sera continued to show T cell subset cytotoxicity after ultracentrifugal clearing. No evidence for significant alteration of T gamma rosetting capacity was recorded when ultracentrifuge-cleared test sera were preincubated with T cells prior to T gamma EA rosette formation. Apparent T gamma cytotoxic specificity in some uncleared JRA and SLE sera may relate to high molecular weight materials (IgM and immune complexes) present in such samples, whereas in others it relates to lymphocyte reactive antibody with subset reactivity. | |
| 7043972 | [Experimental polyarthritis in rabbits induced by Mycoplasma fermentans]. | 1982 Mar | The time course of the distribution of M. fermentans antigen in the body of rabbits infected by a single intraperitoneal injection, as well as morphological and immunological changes occurring in the joints of the infected animals during 12 weeks of observation have been studied. M. fermentans, or its antigen, has been shown to persist mainly in immunocompetent organs and articular tissues, its localization in articular cartilage corresponding to the areas of dystrophic changes. The character of the pathological process in the joints is similar to rheumatoid arthritis in humans, which is confirmed by the results of immuno-morphological studies. The local synthesis of IgG and rheumatoid factor, the deposition of immune complexes and the presence of phagocytes in synovia have been detected. | |
| 6757423 | Possible involvement of group A streptococci in the pathogenesis of psoriatic arthritis. | 1982 Sep | Bacteria have been implicated in the form of Reiter's syndrome, known as reactive arthritis. If bacteria are important in the related spondyloarthropathy psoriatic arthritis, they may be those comprising skin flora. We found elevated levels of antibody to the streptococcal exotoxin antideoxyribonuclease-B in psoriatic arthritis patients in comparison to patients with psoriasis without arthritis, rheumatoid arthritis, other forms of dermatitis, and normal controls. Patients with peripheral arthritis were more likely than psoriatic spondylitis patients to be antideoxyribonuclease-B positive. Streptococci or streptococcal products may be involved in the pathogenesis of psoriatic arthritis in some patients. | |
| 630660 | Division, duplication and neglect: patterns of care for children with chronic disorders. | 1978 Jan | The care of forty-four children with chronic arthropathies (usually juvenile rheumatoid arthritis) was studied by parental interview. The goal was to determine parents' perceptions of how management responsibilities are shared between primary physicians and specialists. Responses to questions about each of nine specific areas of care, ranging from diagnosis and treatment of the chronic disorder to the care of minor, acute illnesses, enabled the investigators to determine which physician had assumed major responsibility for each area. The results suggest a pattern whereby basic care is either divided or duplicated, but with many of the supportive aspects of care neglected in a high proportion of families. A comparison of these results with those of a similar study of children with meningomyelocele provides support for the view that such patterns are typical of the care of most children with chronic disorders. | |
| 685087 | An ultrastructural study of avian synovium infected with an arthrotropic Mycoplasma, Mycop | 1978 May | Live Mycoplasma synoviae cells in agar base medium were inoculated intravenously into 10 2-week-old chickens. Joint tissues were collected over a 3-week period for light and transmission electron microscopy. In infected chickens, membrane-bound vacuoles of intact M. synoviae cells were seen in the cytoplasms of adipose cells. Cytoplasmic lipid-containing inclusions had accumulated in enlarged fibroblasts in tendon sheaths and loose connective tissue. Synovial cells had proliferated and contained increased amounts of granular endoplasmic reticulum and lipid inclusions. No abnormalities were seen in control chickens. Infected chickens were positive and control chickens were negative for rheumatoid factor activity by two serological tests: tanned cell hemagglutination and latex agglutination tests. |