Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 935738 | HL-A 27-associated arthritis. | 1976 May | Seventy-one of 78 patients presenting to routine rheumatology clinics with seronegative arthritis were found to possess the histocompatibility antigen HL-A 27. Four principal components to their arthritis emerged, namely: spondylitis, sacroiliitis, peripheral polyarthritis, oligoarthritis (involvement of one or two large joints). It is suggested that each of these may be influenced by separate genetic determinants. The various combinations in which these occur warrant a unified nomenclature. A small subgroup of patients with HL-A 27-associated arthritis is described in whom the diseases may be especially benign. | |
| 686863 | Somatomedin activity in synovial fluid from patients with joint diseases. | 1978 Aug | The somatomedin activity in synovial fluids from 50 patients with a variety of joint diseases has been studied and compared with the activity in each of the patient's own serum and a standard reference serum (SRS). The porcine costal cartilage bioassay of Van den Brande and Du Caju (1974a) has been used with the isotopes 3H-thymidine and 35S-sulphate. Synovial fluids from most patients with post-traumatic and post-operative effusions, osteoarthritis and arthritis associated with psoriasis, Reiter's disease, and ankylosing spondylitis stimulated the synthesis of DNA and proteoglycans in cartilage. Synovial fluids from patients with rheumatoid arthritis either had impaired capacity to stimulate DNA synthesis, or they inhibited it; a similar, but less evident pattern was observed for proteoglycan synthesis. Some synovial fluids from patients with miscellaneous synovitides stimulated, while others inhibited cartilage metabolism. It is concluded that the synovial fluid from patients with rheumatoid arthritis and from some patients with miscellaneous synovitides contained an inhibitor(s) to DNA and possibly proteoglycan synthesis. The sera from nearly all the patients stimulated both DNA and proteoglycan synthesis, but the somatomedin potency ratios for serum in terms of SRS were generally less than 1.0. There was a significant inverse correlation between the serum somatomedin potency ratio and the age of the patient. | |
| 455206 | Adult-onset Still's disease. | 1979 Jun 23 | Four adults with an illness similar to the systemic variant of juvenile rheumatoid arthritis seen in children (Still's disease) are described. All four had fever, an erythematous maculopapular rash, splenomegaly and arthritis. The arthritis was asymmetric and involved only a few joints simultaneously. Erosive arthritis developed in one patient. Three patients had a sore throat, two had pleurisy and pericarditis, and one had transient abnormalities of liver function. The laboratory features included anemia, leukocytosis and high leukocyte counts in the synovial fluid. High titres of rubella hemagglutination-inhibiting antibody were detected in two patients, one of whom was found to have rubella virus in the urine. Only one patient responded well to therapy with acetylsalicylic acid; the other three were given prednisone therapy, and two continue to require it. | |
| 1087456 | [Demonstration and analysis of immune complexes in rheumatic diseases]. | 1976 Aug 14 | By means of an immunofluorescence technique, immune complexes have been demonstrated in circulating blood leukocytes, in serum and in joint effusions of patients with various rheumatic diseases. Such complexes are present within cell inclusions in about 30% of patients with rheumatoid arthritis (RA). RA patients has immune complexes in serum in 75% of cases and in joint effusions in over 80% of cases. Soluble immune complexes were demonstrated in the serum of about 30% of age-matched patients with degenerative joint disease, while such complexes are present in the serum of only 1.5% of a younger, normal control group. The immune complexes chiefly contain IgG, frequently IgM and only rarely IgA. CO complement component can frequently be demonstrated within such complexes. In RA patients a statistically significant correlation (p less than 0.001) could be established between the presence of soluble immune complexes and erythrocyte sedimentation rate, but no correlation was observed between the presence of such complexes and the Lansbury joint index. The possible pathogenetic role of immune complex clearance by circulating leukocytes in rheumatoid arthritis is discussed. | |
| 6233699 | Lyme disease--a review of the literature. | 1984 Feb | It appears that a tick introduces an agent--presumably a spirochete--into the skin (see Fig. 1). Immune complexes form and become systemic during the rash. Some patients (identified by the presence of cryoglobulins containing IgM, Clq-reactive material, and depressed IgG and IgA levels) then alter their immune response and may develop neurologic, cardiovascular, or joint involvement. Despite systemic clearing in some patients, the immune complexes localize to the joints where a chronic synovitis develops, similar to rheumatoid arthritis. Why the immune complexes localize to the joints is an enigma. It is tempting to postulate that this localization occurs because of an altered immune response in a genetically predisposed group. However, three of 10 patients with chronic arthritis did not have the B-cell alloantigen DRw2. | |
| 973170 | Ruptured popliteal cyst -- an unusual complication of osteo-arthritis: a case report. | 1976 Sep 4 | Synovial rupture produces a syndrome resembling acute thrombophlebitis and it is usually seen in patients with rheumatoid arthritis. The interesting feature reported here is the occurrence of popliteal cyst rupture in a patient with no evidence of inflammatory joint disease. It is important to diagnose this condition correctly and to avoid anticoagulant therapy. | |
| 7401063 | Interference by rheumatoid factor with the detection of C-reactive protein by the latex ag | 1980 May | The concentration of the acute phase serum protein C-reactive protein (CRP) is used as an index of disease activity in patients with rheumatoid arthritis and with other disorders associated with rheumatoid factor (RF). When CRP was determined by the latex agglutination method, RF caused both increased titers for CRP and false positive reactions for CRP. These effects of RF were abrogated by pretreatment of test samples with 2-mercaptoethanol. Detection of CRP by radial immunodiffusion was not affected by RF. Therefore, the clinical relevance of CRP detected in RF positive sera by latex agglutination can be ascertained only following pretreatment of sera with 2-mercaptoethanol or by the use of radial immunodiffusion to circumvent interference by RF. | |
| 1224928 | [Complications in chrysotherapy in 268 patients]. | 1975 | Side effects of chrysotherapy in 268 patients with rheumatoid arthritis, are reported. The incidence of side effects of all drugs used (Sodiumaurothiosulfate, Aurothiopolypeptide, Sodiumaurothiomalate) was approximately equal. The most common side effects were eosinophilia, exanthema, itching, albuminemia and leukopenia. | |
| 7158105 | [The diagnostic value of so-called Reiter cells in joint effusions]. | 1982 | In 1967, Pekin, Malinin and Zvaifler described macrophages with one or more phagocytized granulocytes. These authors declared these cell phagocytes as a characteristic cytologic sign of Reiter's syndrome. Because we could observe this phenomenon in other joint diseases, too, we studied systematically different inflammable and non-inflammable joint effusions for the diagnostic value of these cells. We counted 1,000 cells in each joint effusion and determined the numbers of phagocytizing and the numbers and sorts of phagocytized cells and heterophagic vacuoles with cell fractions, respectively. We concluded that, beside the Reiter's syndrome, other inflammatory joint diseases had these cell changes, too, especially joint effusions in juvenile rheumatoid arthritis. In the other cases we found a reduced number of phagocytizing and phagocytized cells only. Cell phagocytes, including synovial lining cells, are obviously characteristic for early phases of chronic inflammatory or transitory joint diseases with joint effusions. However, cell phagocytes are not a proof for the diagnosis of Reiter's syndrome in joint effusions. | |
| 7455597 | [Effect of a high serum uric acid diet and injections of urate crystals on adjuvant arthri | 1980 Jun | The difference between gout and rheumatoid arthritis was reproduced experimentally in the rat by combining adjuvant arthritis with an oxonate uric acid raising diet and injections of crystals of sodium urate. The factorial experiment using 3 factors confirms the inhibition or arthritis by a uric acid raising diet and shows that the injections of crystals, which preceed the injection of Freund's adjuvant, increase the arthritic lesions in normo-uricemic rats and reduces them slightly in hyperuricemic rats. This effect of the injection of crystals increases gradually with time. | |
| 987888 | Juvenile rheumatoid arthritis. | 1976 Oct | JRA is a multisystem disease characterized by exacerbations and remissions. Recognition of the three modes of onset can important in early diagnosis, identification of extra-articular manifestations, and prognosis. This is a chronic illness that requires consideration of the whole patient, his family, and his place in society, both in the present and in the future. With a positive, comprehensive approach and an awareness of the pitfalls of seeking immediate relief, the physician can help to assure a good functional outcome. | |
| 220714 | [Pseudolymphoma and lymphoproliferative syndromes in Gougerot-Sjögren syndrome (author's | 1978 Oct 18 | Five cases of pseudolymphoma in Sjögren's syndrome were reported. Pseudolymphoma's pathological aspects described by Rothman then Talal are discussed. After recognition of the Sjögren's syndrome and a pseudolymphoma appearance, the risk of lymphomatous evolution enjoin a clinical close attention. Among our five cases, three had a peculiar evolution: one has presented and immunoblastic lymphoma (case 2). In an other case (case 3) the pathological aspect was very near to the angioimmunoblastic lymphadenopathy features. Waldenström's macroglobulinemia was cause of death of the last one (case 5). | |
| 7468188 | Electrophoretic protein pattern of human parotid saliva in Sjögren's syndrome and sialosi | 1980 Sep | The electrophoretic pattern of the basic proteins in parotid saliva was examined in 12 control subjects and 45 patients suffering from xerostomia and parotid swelling of diverse origins. The protein pattern in the control subjects did not differ from the observed in sialotic patients. Characteristic quantitative and qualitative alterations in protein composition were observed in Sjögren's syndrome. The concentration of the protein fractions with a low Rp value showed a considerable increase, while one or two additional protein bands with high Rp value could be detected in these patients. The appearance of these additional protein bands may prove to be a valuable laboratory indicator in the diagnostic work. If they really indicate the beginning of an autoimmune process, the disease could be diagnosed much earlier than by the methods available today. | |
| 1002751 | Joint replacement surgery in patients under thirty. | 1976 Dec | Forty-five patients, twenty-six of them with juvenile rheumatoid arthritis, had sixty-seven total hip arthroplasties. The patients' ages ranged from twelve to twenty-nine years. An over-all good result was demonstrated in 93 per cent of the patients had a poor result, in 6.9 per cent. The average follow-up period was 32.5 months. Careful planning in severely dysplastic joints should be done. | |
| 301982 | Diagnosis and follow-up of children referred to a rheumatic disease unit. | 1977 Jun 18 | Juvenile rheumatoid arthritis (JRA) has become the predominant rheumatic disease of childhood. In a survey of 292 children referred to a rheumatic disease unit over a 5-year period, 94 had JRA and only three had rheumatic fever. At follow-up, of the children with JRA, 70% were found to be in remission with little or no functional disability. Febrile onset of JRA or onset before six years of age were worse prognostic features than pauciarticular or polyarticular onset of occurrence after six years of age. Of 28 children who had either growing pains or psychogenic rheumatism, two were subsequently found to have chondromalacia patellae. None of the other children in this group for whom follow-up information was available had developed organic disease. | |
| 6160248 | Cell-mediated immune responses of synovial mononuclear cells in Reiter's syndrome against | 1980 Sep | Cell-mediated immune responses of cultured synovial mononuclear cells against ureaplasmal, chlamydial, Mycoplasma hominis and mumps antigens were measured by the 3H-thymidine uptake method. Specific responses against ureaplasmal or chlamydial antigens were found in 3 of 4 patients with venereally-acquired Reiter's syndrome, but not in 3 patients with arthritis after episodes of diarrhea and 4 patients with rheumatoid arthritis. | |
| 522813 | [Yersinia arthritis (author's transl)]. | 1979 Nov 9 | Clinical picture and differential diagnosis of Yersinia arthritis are shown by means of three own observations. It is an acute oligoarthritis affecting especially knee- and ankle-joints. The involved joints are very painful, swollen and warm. There may be a history of enteritis or suspicion of acute appendicitis because of lower abdominal pain, but this is not obligatory. The laboratory parameters of inflammation (ESR, C-reactive protein, white blood count, serumproteinelectrophoresis) are changed significantly. Diagnosis is made by serum agglutination reaction (Widal-reaction) against ceesurface antigens (O-antigens) of Yersinia enterocolitica. Almost only people with the HL-A antigen B27 tend to get arthritis during Yersinia infection. The differential diagnosis has to consider reactive arthritis during Salmonella or Shigella infections, acute sarcoidosis, Reiter's disease and rheumatoid arthritis. | |
| 6418269 | Arthritis in Roman Britain. | 1983 Dec 24 | The pattern of arthritis in Roman Britain was investigated by examining the skeletons of 416 adults from the Roman cemetery at Poundbury Camp near Dorchester, Dorset. The mean height of the people was not much less than that of the current British population, and the prevalence of right handedness was similar to our own. There was a high prevalence of osteoarthritis for such a relatively young community, with particularly severe changes in the vertebral column. The pattern of joints affected by osteoarthritis was different from that seen now, but the prevalence of vertebral ankylosing hyperostosis was much the same. Rheumatoid arthritis was seen as often as the expected rat would indicate, given that the population died young, but it was rare. Other forms of arthritis, including gout and ankylosing spondylitis, were not seen. | |
| 7235894 | Myofascial trigger point syndromes in the practice of rheumatology. | 1981 Mar | Pain referred from a muscle can mimic both pain from a joint and radicular pain associated with disease of spinal joints, leading to mistakes in diagnosis and in treatment. When articular disease is present, it predisposes to myofascial trigger point (TP) syndromes. With arthritis, TPs in muscles may result from decreased mobility with prolonged shortening of muscles, from abnormal mechanical stress on muscles and from stimuli arising in diseased joints. During examination for signs of myofascial disorders, the numbers of tender points and of local twitch responses in women with rheumatoid arthritis were twice those found in women free of any rheumatic illness. It is important to consider this high frequency of myofascial syndromes in persons with arthritis, when treating pain or weakness which could be due to the muscles rather than the joints. Conversely, it has been proposed, on theoretical and clinical grounds, that muscular TPs can cause joint disease. This hypothesis has important implications for the treatment of arthritis. | |
| 7368932 | An arthropathic form of osteogenesis imperfecta. | 1980 Mar | A 14-year-old girl gradually developed severe osteoporosis and destructive generalized joint disease, resulting in joint stiffness and anchyloses. She also had moderate hydroxyprolinemia and hydroxyprolinuria. Rheumatoid arthritis was highly unlikely. Anamnestic data revealed two long bone fractures. Collagen biosynthesis was studied in fibroblasts cultured from the patient's skin. Chromatograms of 3H-labelled culture media proteins on ion exchange celluloses revealed an increased ratio of type III collagen to type I collagen when compared with the chromatograms of age-matched control fibroblasts. This finding is typical of certain cell strains in osteogenesis imperfecta. The patient might thus express a new variety of osteogenesis imperfecta with chronic arthropathy. |