Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 886557 | Family study of Reiter's disease and HLA B27 distribution. | 1977 Spring | Starting from index patients with confirmed Reiter's disease, a clinical and immunogenetic study was performed on 12 families in which there were further cases of arthritis. Altogether 51 family members were investigated and some information was available on 15 additional members. In most families there were two or three affected members in addition to the proband. The manifestations included acute polyarthritis (16 cases), which frequently followed urethritis or occurred as a complication of Yersinia or Shigella infection, and chronic arthritis (9 cases), either ankylosing spondylitis or peripheral arthritis. The latter characteristically had a remitting course, affecting mainly the large joints. Not a single subject had sero-positive rheumatoid arthritis. The HLA B27 gene was detected in all 12 families, and served as the main indicator of the familial trait for developing arthritis. In individual patients however, the association was not especially close, since there were members with this antigen who did not have arthritis in spite of a seemingly adequate triggering stimulus and others who had arthritis but not the antigen. | |
| 6175158 | Specificity of antibody-dependent lymphocyte cytotoxicity against cerebral tissue constitu | 1982 Jan | In patients with multiple sclerosis (MS) there is not only an antibody-dependent lymphocyte cytotoxicity (ADLC) against basic protein of myelin (MBP), as was demonstrated earlier, but also against encephalitogenic peptide, cerebrosides and gangliosides. The reaction against cerebrosides and gangliosides is not specific for MS; it is also frequently positive in patients with other neurological diseases (OND), syphilis and rheumatoid arthritis. The ADLC against encephalitogenic peptide shows a very high specificity for MS. Out of 35 cases with OND, 23 had a positive result with MBP, but only one with encephalitogenic peptide. Patients with syphilis and rheumatoid arthritis reacted negatively without exception. According to this, the encephalitogenic peptide is a highly specific antigen for MS; MBP shows less specificity. The ADLC against the encephalitogenic peptide shows a markedly increased sensitivity in MS compared with MBP. Specificity and frequency of positive findings with encephalitogenic peptide support the pathogenic significance of the reaction in MS. | |
| 3876905 | Acute leukemia presenting as arthritis in children. | 1985 Nov | The clinical and laboratory features of six children with arthritis as the presenting manifestation of acute leukemia are reviewed. Asymmetric arthritis involving the large joints of the extremities was the dominant clinical feature in all patients. Despite the presence of antinuclear antibody in three patients, other laboratory features, particularly hematologic abnormalities, served as clues to the diagnosis of leukemic arthropathy in most patients. | |
| 95662 | Serologic studies in juvenile rheumatoid arthritis: a review. | 1977 Mar | Careful study of inflammatory and immunologic parameters in JRA and other connective tissue diseases of childhood has contributed to our current understanding of these diseases. Examination of serum for acute phase reactants, and antibodies to immunoglobulin antigens and nuclear antigens, combined with radiologic evaluation of symptomatic joints and, when indicated, examination of joint fluid or synovial membrane, may confirm the diagnosis of JRA. Changes in inflammatory indicators can be used as an index of adequacy of treatment. An ANA positivity in the child with pauciarticular arthritis should always prompt frequent slit-lamp examinations for asymptomatic iridocyclitis. The role played by auto-antibodies in the pathogenesis of JRA is unknown, as is the possible effect of proteins like CRP on the regulation of the inflammatory process in these children. | |
| 1126044 | Serum protein changes in coal workers' pneumoconiosis. | 1975 Apr 16 | Differences from the normal were found in the serum proteins of coal workers suffering from pneumoconiosis which were similar to those in subjects suffereing from bronchitis, cancer and rheumatoid arthritis. The differences consisted of decreased albumin and increased globulin contents, and decreased sulphydryl contents, and decreased sulphydryl contents in both albumin and globulin proteins. These differences caused a reduction in the number of protein sulphydryl groups in serum. In pnemoconiotic coal workers the amount of idsulphide-linked cysteine in albumin increased above the normal, the increase tending to depend on the severity of the pneumoconiosis. Apart from this correlation the above differences could not be used to diagnose the class of pneumoconiosis. | |
| 6977031 | Chronic polyarthritis in inbred C3H/He mice after systemic administration of allogeneic th | 1981 Nov | Chronic polyarthritis was produced in inbred C3H/He mice after intraperitoneal (ip) administration of allogeneic thymocytes of inbred line BALB/c mice. The polyarthritis persisted more than 18 months without additional ip treatment. Histologically, synovial cell hyperplasia, granulation tissue formation, and inflammatory cell infiltration were seen. More than 6 months after the initial administration, range of motion of the affected joints was significantly restricted and the erosive destructions of joint cartilage were found roentgenographically. Thus, this experimentally induced arthritis proved to have many pathologic features in common with human rheumatoid arthritis. | |
| 1247196 | Erysipelas arthritis in swine: concentrations of complement and third component of complem | 1976 Jan | Concentrations of hemolytic complement and of 3rd component of complement were determined in serums and in synovia of normal and arthritic joints in swine affected with arthritis experimentally produced by the inoculation of Erysipelothrix rhusiopathiae. Mean concentrations of complement in arthritic joints were increased from 24.7 to 37.5 50% hemolytic units of complement per milliliter. Third component of complement, expressed as a percentage of the serum concentration, was increased from a mean of 16.9 (normal joint synovia) to a mean of 27.1 (arthritic joint synovia). Also, fast-migrating conversion products of 3rd component of complement were not detected in synovia from arthritic joints. These results are interpreted as indicating a relatively less important role for immune complexes in the pathogenesis of erysipelothrix arthritis than is described for rheumatoid arthritis in persons. | |
| 6431528 | Cervical spine involvements in Reiter's syndrome. | 1984 Jul | Cervical spine radiographs of 38 patients originating from 145 consecutive cases with Reiter's syndrome (RS) were reviewed. Five of these 145 patients (3.4%) had cervical spine manifestations: anterior atlanto-axial dislocation 2, craniovertebral lesions typical for rheumatoid arthritis (RA), spondylitis typical for ankylosing spondylitis (AS) and anterior ossification, one each. Four of these patients were males. Cervical lesions in RS turned out to be rare. These lesions are alone indistinguishable from those of other chronic rheumatic inflammatory diseases. | |
| 6464745 | Simulated Reye's syndrome and salicylate therapy. | 1984 Jul | A 4-year-old girl with juvenile rheumatoid arthritis developed fever, protracted vomiting, disturbance of consciousness and decorticate posture following the administration of salicylate. There were elevated levels of transaminases in serum, hyperammonemia and a fatty liver. However, the fatty droplets were different electronmicroscopically from that of Reye's syndrome. This observation emphasizes the importance of electronmicroscopic observation of the liver in the differential diagnosis between Reye's syndrome and aspirin-induced encephalopathy, because the clinico-pathological findings of intoxication are so similar. | |
| 6688218 | Effect of brand on the serum level of aspirin. | 1983 Jul | The authors present a case of a four-year-old female, treated with aspirin for juvenile rheumatoid arthritis. A generic preparation was given first, but plasma salicylate levels remained significantly below the required therapeutic range. Upon changing to a brand-name product, however, therapeutic levels were achieved after one day. The authors conclude that the source of aspirin used had a marked effect on the serum salicylate level. | |
| 7441662 | SAA amyloid protein levels in amyloid-prone chronic inflammatory disorders. Lack of associ | 1980 Sep | Serum amyloid protein A (SAA) levels were evaluated by a sensitive radioimmunoassay technique in leprosy, juvenile rheumatoid arthritis and chronic osteomyelitis. SAA was elevated in all 3 groups of patients. The level in each of the patient groups did not reflect the presence of secondary amyloidosis. Our study suggests that serum SAA protein levels should not be considered a routine diagnostic test in patients with chronic inflammatory diseases prone to the development of amyloid disease. | |
| 195406 | [Therapy with synthetic ACTH]. | 1977 Apr 1 | With the development of the fully-synthetic preparation (tetracosactide) the therapy with ACTH has again obtained importance. The application in internal medicine above all takes place in rheumatoid arthritis and in bronchial asthma. Advantages and disadvantages are described and the possibility of withdrawal of cortisone is especially emphasized. | |
| 3881511 | Silicone synovitis of the wrist. | 1985 Jan | Foreign body giant cell synovitis and focal bony destruction requiring secondary surgery developed in nine patients after carpal and radiocarpal arthroplasty with silicone rubber implants. Synovitis followed silicone rubber replacement of the lunate in four patients, the carpal scaphoid in two patients, and the trapezium in one patient, trapezial resurfacing hemiarthroplasty in one patient, and total wrist arthroplasty in one patient. All the removed implants were deformed. Some had changed in color from clear white at the time of insertion to yellow-white or deep yellow upon removal. Scanning electron microscopy of a silicone rubber implant of the lunate removed from one patient revealed extensive fibrillation in the capitate fossa. Light microscopy of the synovium revealed hyperplasia and hundreds of fragments of silicone particulate debris throughout the tissue adjacent to the implant. The silicone debris was surrounded by multinuclear foreign body giant cells in the eight patients from whom the synovium was studied. All patients required revision surgery. We believe that in the patients studied, synovitis represented a biologic reaction to the silicone fragments found scattered throughout the synovium for the following reasons: The synovitis found was not present before surgery (except in the patient with rheumatoid arthritis); the synovitis found was not associated with the condition for which replacement arthroplasty was performed (except in the patient with rheumatoid arthritis); synovitis subsided after implants were removed; and synovitis was noted histologically in areas of silicone debris and appeared directly related to silicone seeding. Fibrillation, fragmentation, and local seeding of silicone after carpal or radiocarpal arthroplasty appear related to gradual deformation of the implant, which was the result of repeated compressive loading and shearing. Clinically significant complications of rubber carpal or radiocarpal arthroplasty with silicone rubber implants may develop from silicone synovitis. | |
| 3890777 | Characterisation of non-histone nuclear proteins cross reactive with purified rheumatoid f | 1985 May | In order to examine the interactions between isolated rheumatoid factors (RFs) and cell nuclear antigens we have prepared 10 RFs by affinity chromatography against IgG coupled to Sepharose. Of these, seven cross reacted with cell nuclei on indirect immunofluorescence. The nuclear antigen appeared to be DNA histones by indirect immunofluorescence on rat liver, though on immunoblotting the rheumatoid factors also reacted with three non-histone polypeptides which were identified in the soluble fraction of nuclear extracts. We were unable to show any relationship between these polypeptides and rheumatoid arthritis nuclear antigen. These reactions represent a hitherto unrecognised phenomenon, which extends the range of antigens recognised by rheumatoid factors. We suggest that the immunopathogenic significance of RFs may not be restricted to their reactivity with IgG, and that non-histone nuclear proteins merit further investigation. | |
| 3877342 | Ocular complications in juvenile chronic arthritis (JCA). | 1985 Jul | Fifty-six children with JCA have attended the Rheumatology Clinic at the Royal Hospital for Sick Children, Glasgow, over the past five years. Eleven have monoarthritis, 21 pauciarthritis and 24 polyarthritis. Seven children with pauciarthritis and one with monoarthritis developed ocular complications. Of these six were girls. In six children the arthritis preceded the uveitis. In one child arthritis and uveitis presented at the same time and in another the uveitis preceded the arthritis by one year. All were treated with steroids (7 topically, 1 systemically) and topical mydriatic agents. After an initial response the uveitis persisted as a low-grade inflammation gradually leading to secondary complications and increasing loss of vision. Only two patients enjoy normal vision at present. The importance of routine slit-lamp microscopy in all children with JCA is stressed, especially in those with pauciarthritis and antinuclear antibodies. | |
| 639341 | IgG rheumatoid factor in subacute bacterial endocarditis: relationship to IgM rheumatoid f | 1978 Jan | With recently developed radioimmunoassays, we have been able to study the levels and properties of IgG rheumatoid factor (IgG RF) and IgM rheumatoid factor (IgM RF) in patients with subacute bacterial endocarditis (SBE), as well as the relationship of these autoantibodies to circulating immune complexes. We found significantly elevated amounts of IgG RF and IgM RF in SBE sera. The IgG RF chromatographed on Sepharose 6B as an intermediate complex, indistinguishable from the pattern seen in rheumatoid arthritis. RF levels peaked later in the course of SBE than did levels of circulating immune complexes. With antibiotic treatment RF levels declined, although not as fast nor as completely as circulating immune complexes. These results suggest that both IgG RF and IgM RF in SBE may be part of a polyvalent antibody response to elevated levels of circulating immune complexes which do not themselves contain RF. | |
| 6650473 | Budd-Chiari syndrome in a patient with Sjögren's syndrome. | 1983 Dec | A case of Budd-Chiari syndrome associated with obstruction of the inferior vena cava is reported. The case was complicated by Sjögren's syndrome and chronic thyroiditis. A marked prolongation of activated partial thromboplastin time, due to circulating anticoagulant, was noted. Interrelation of thrombosis of the inferior vena cava, circulating anticoagulant, and Sjögren's syndrome is suggested. | |
| 1088913 | Sjögren's syndrome. | 1975 Jan | The diagnosis of Sjögren's syndrome, a multi-systemic disease, is often difficult. Sialography is useful; however, biopsy of labial salivary glands is a simple procedure that aids significantly in arriving at a positive diagnosis. Treatment of the disease is usually on the basis of symptoms. | |
| 4468195 | Immunological and virological studies of cultured labial biopsy cells from patients with S | 1974 Oct | Labial salivary gland tissues from twenty-five patients were cultured in vitro for virus studies and for use as target cells in cellular and antibody-mediated cytotoxicity assays. Fourteen patients had definite Sjögren's Syndrome (SS), four had possible SS and seven did not have SS. No evidence for the presence of a virus in the cultured cells or after chemical treatment of the cultured cells was obtained. Tubuloreticular structures were present in three of the original biopsies but were not seen in the corresponding cultured cells, although in two of these cell lines rare bundles of intranuclear microfibrils occurred. The significance of these structures is unknown. Autologous serum and autologous lymphocytes were not cytotoxic for the cultured cells. | |
| 7146853 | [Results of arthroscope studies of knee joint effusions of unknown origin]. | 1982 Oct 2 | 174 knee joints with non-traumatic effusion have been examined by arthroscopy. In 71 cases synovial biopsy was performed. 43% of the knees had cartilaginous damage of the patella or tibiofemoral joint, 19% had an old meniscal and/or ligamentous tear and 33% a "non-specific" synovitis. The remaining 5% comprise 5 patients with pigmented villonodular synovitis, 3 patients with gout, one with synovial tuberculosis and one with a hemangioma of synovial membrane. Arthroscopy serves for early recognition of degeneration of hyalin cartilage and meniscal lesions, while synovial biopsies are also largely non-traumatic. Endoscopic evaluation of synovial membrane is more difficult. Mechanical irritation produces proliferation of synovial villi, while bacterial and rheumatoid inflammation leads to exudative and necrotic changes. The differences are obvious in marked inflammation but difficult to recognize in the beginning of any process. Arthroscopic and histological examination determines the etiology of synovitis only in pigmented villonodular synovitis and synovial tuberculosis. In the other forms of synovitis it is only possible to determine the stage and intensity of inflammation but not the etiology. The diagnosis of rheumatoid arthritis in particular is seldom secured by arthroscopy. |