Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 580708 | Transient pseudoleukocytosis caused by cryocrystalglobulinemia. | 1978 Apr | A patient with Sjögren's syndrome and cryoglobulinemia was found to have pseudoleukocytosis when a leukocyte count was performed on an electronic particle counter. This apparent increase in the leukocyte count was found to be caused by spontaneous crystallization of the cryoglobulin. Further studies showed that this phenomenon was transient. Disappearance of the spontaneous crystal formation without a change in the level of cryoglobulin suggests the possibility of an interaction between the cryoglobulin and a plasma component. Factors affecting spontaneous crystallization of cryoglobulins and the laboratory as well as the clinical implications of pseudoleukocytosis are discussed. | |
| 6583338 | Gallium-67 scanning in Sjögren's syndrome: concise communication. | 1984 Mar | We performed gallium-67 scans in 12 patients with primary or secondary Sjögren's syndrome (SS). Salivary-gland uptake of gallium-67 was noted in four of five patients with primary SS. Pulmonary uptake was observed in ten of 12 patients. Chest radiographs were essentially normal in all patients, although 60% complained of significant dyspnea with exertion. The gallium-67 scan may prove to be a sensitive noninvasive diagnostic test for lung and mediastinal involvement by either primary or secondary SS, and for salivary-gland involvement in primary SS. | |
| 1138436 | The association between HL-A antigens ankylosing spondylitis and sacro-iliitis. | 1975 Feb | The second series antigen W27 has been found to have an increased frequency in ankylosing spondylitis (82 per cent of 17 patients) and juvenile rheumatoid arthritis (Still's disease) (29 per cent of 24 patients). Three family studies are presented, including one in which the antigen W27 occurs both in the absence and the presence of ankylosing spondylitis. It is suggested that this family illustrates that the relationship between W27 and sacro-iliitis is affected by non-HL-A genes. The development of clinical disease depends upon the coincidence of several factors in one individual, some of which are genetically controlled by two or more loci which are not necessarily linked. | |
| 1092507 | Synovectomy of the hip in juvenile rheumatoid arthritis. | 1975 Jan | Review of the results of subtotal and complete synovectomy of 9 hips in 5 female patients with subluxation or progressive joint destruction (roentgenographically) than any 2 years showed improvement or retention of joint motion in 4 patients. Complete synovectomy, performed in 7 hips, necessitated surgical dislocation of the joint, but there was no evidence that this surgical dislocation comprised the proximal femoral blood supply. The mildest synovial and cartilagenous changes were present in the patient who has bilateral partial synovectomies. At follow-up these hips showed more severe destruction evaluated during a minimum of the hips treated by total synovectomy. No postoperative dislocations occurred. Synovectomy of the hip may be useful for progressive hip involvement in younger patients whose skeletal immaturity contraindicates major reconstructive procedures. | |
| 6857171 | Prognosis in juvenile rheumatoid arthritis with systemic onset. A follow-up study. | 1983 | Thirty-three patients with systemic onset JRA were followed up for 4 to 24 years (median 10 years). None had positive RF or ANA. Most patients developed polyarthritis. Cardiac involvement occurred in 14 patients (42%). Cardiac prognosis was good for pericarditis but seemed to be worse for myocarditis or perimyocarditis. Three patients contracted renal amyloidosis (9%). Severe growth retardation was observed in 39 per cent. Half of the patients had low activity or were in remission after in average 5.9 years' duration of the disease. Seventy per cent of the patients were in a good functional state. Patients with less than average radiological progression during the first 5 years of disease and those with onset of disease after the age of 5, seemed to have a better functional prognosis. | |
| 850826 | Pulmonary dirofilariasis: another coin lesion. | 1977 Apr | A 67-year-old woman with a long history of debilitating rheumatoid arthritis developed a peripheral coin lesion in the lower lobe of the left lung. A wedge resection was done and pathologic study revealed noncaseating granuloma secondary to rheumatoid infection with Dirofilaria immitis, a nematode. Although rare, canine dirofilariasis should be considered in the differential diagnosis of coin lesions. | |
| 1098480 | Arthritis in the prehistoric Southeastern United States: biological and cultural variables | 1975 Jul | Recent research shows that a bacterial life form, Erysipelothrix insidiosa, can produce rheumatoid arthritis in deer, swine, and dogs, and that a number of animals, including man, birds, and fish, may be infected by the organism. Examination of the archaeological record suggests that both cultural and biological variables may be interrelated in the maintenance of some forms of arthritis over long periods of time in geographically disparate populations. Re-examination of Cherokee folk beliefs concerning arthritis suggests that they had some recognition of this connection, and it also suggests that they had some recognition of this connection, and it also suggests that the term "magical" may relate more to the world view of the observer than to any actual inability of preliterate peoples to draw causal relations on the basis of their own intimate knowledge of their environments. | |
| 4012184 | Polyarthritis in MRL lpr/lpr mice. | 1985 | Mice of the inbred strain MRL/MpJ-lpr/lpr are affected by a systemic autoimmune disease and a spontaneously occurring polyarthritis. To characterize the arthritis a histopathological study was performed on the joints of the four limbs and of the spinal column of 7, 16, 22 and 28-week-old animals of both sexes. Polyarthritis, the severity of which increased with age was detected in all mice. Proliferation of the synovial lining cells, already evident in 7-week-old animals, was the initial lesion. In the majority of cases infiltrates containing lymphocytes with a few plasmocytes, histiocytes, polymorphonuclear neutrophils and eosinophils were detected later on. The most pronounced changes were observed in the hind-paws, the fore-paws, the knee and hip joints, paired articulations being symmetrically involved. A pannus was seen at the most in 10% of the joints leading to limited and superficial destruction of the cartilage. Rheumatoid nodules were not seen. From 16 weeks of age deposits of unknown nature, often surrounded by phagocytosing macrophages and/or neutrophils, were observed in the articular and/or extra-articular connective tissue and in the vessels. There was a positive correlation between their presence and the intensity of the arthritis. The articular lesions in our study differ from those in rheumatoid arthritis because they lacked the specific and characteristic histological features of the human disease. | |
| 4087270 | Studies on the effect of low dose methotrexate on rat adjuvant arthritis. | 1985 Oct | Adjuvant arthritis in rats was induced by the intradermal administration of Freund's complete adjuvant. When these immunized rats were treated orally with low doses of methotrexate (150-600 micrograms/kg/week) a statistically significant suppression of paw inflammation was observed. This low dose of methotrexate was comparable to that used in the treatment of human rheumatoid arthritis (RA). Our results are the first demonstration of the efficacy of low dose methotrexate in an animal model of human RA. | |
| 3926892 | Structural similarities in the kappa light chains of human rheumatoid factor paraproteins | 1985 Sep | The monoclonal antibody (MoAb) 17.109 recognizes a cross-reactive idiotype (CRI) associated with the light chains of Waldenstrom's macroglobulins with rheumatoid factor (RF) activity. The MoAb also reacts with a proportion of IgM-RF molecules from the sera of rheumatoid arthritis and primary Sjogren's syndrome patients, and from the sera of seropositive normal human subjects. In the present experiments, we used affinity chromatography to purify the 17.109 CRI-positive immunoglobulin from serum and have analyzed the isolated material by Western blotting. The purified 17.109 CRI-positive material from the sera of rheumatoid arthritis patients, Sjogren's syndrome patients, and normal subjects contained exclusively kappa light chains, and had demonstrated RF activity. In every case the 17.109 CRI-positive isolates reacted with antibodies against synthetic peptides corresponding to both the conserved second and third complementarity-determining regions (CDR) of the monoclonal kappa IgM-RF paraprotein Sie. The binding was inhibited specifically by the free peptides in solution. The antipeptide antibodies did not react appreciably with unfractionated human immunoglobulin. The data establish that the 17.109 CRI-positive immunoglobulin from diverse human sera have similar or identical second and third light chain CDR. These results suggest i) that the MoAb 17.109 identifies the protein product of a single or a very few V kappa genes, ii) that the ability to make kappa light chains with the 17.109-associated variable region is widespread in the human population, and iii) that the 17.109-defined kappa variable region segment is associated with IgM-RF autoantibodies. | |
| 6679857 | An experimental polyarthritis associated with systemic antigen excess in immune rabbits. | 1983 | Rabbits were immunized with bovine serum albumin and later challenged intraperitoneally with the same antigen. Polyarthritis, characterized by synovial lining layer hyperplasia and leukocyte infiltration, was conditional on animals having excess free serum antigen in the presence of circulating immune complexes (IC). Nonimmune controls did not develop polyarthritis following antigen challenge. Data are presented that strongly suggest that synovitis was triggered by deposition of IC in the synovia. During the chronic phase of polyarthritis the synovium was clear of antigen but there was marked retention within joint fibrocartilage, suggesting that antigen, immobilized locally, may maintain the chronic synovitis. CLINICAL RELEVANCE: There are several animal models in which experimental arthritis has been induced by antigenic challenge. The resemblance of the lesions to those of human rheumatoid arthritis has provided the rationale for studying the immune events associated with the onset of acute and maintenance of chronic phases of experimental arthritis. | |
| 6230445 | Immune complex mediated destruction of cartilage in antigen-induced arthritis of rabbits. | 1983 Dec | Antigen-induced arthritis of rabbits is used as a model to study pannus-free destruction of cartilage in rheumatoid arthritis (RA) by transmission and scanning electron microscopy, incorporating plain and immune labeling techniques. During the acute "arthus" phase of the RA, immune complexes form and persist in these tissues. We observed the progressive formation of electron dense material rich in immune complexes within a millimicron of the hyaline cartilage surfaces that preceded erosion and loss of surface tissue. Polymorphonuclear neutrophils congregated at the cartilage margins to engulf immune complexes at and within the cartilage surfaces. The changes occurred in regions of hyaline and fibrocartilage free of pannus. Immune complex formation appeared to be a central feature of the cartilage destructive changes, and may be central to mechanisms of tissue loss and similar to those observed in RA. | |
| 313212 | Arthritis associated with jejunoileal bypass: clinical and immunologic evaluation. | 1979 Jul | Arthritis is a common complication of small bowel bypass, occurring in 5-20% of the postsurgical patients. Thirteen patients with arthritis related to jejunoileal bypass were studied. These patients had a symmetrical polyarthritis, and 8 also had extraarticular connective tissue disease manifestations. Immunologic evaluations were done on these patients and on a control group of 12 age- and sex-matched postintestinal bypass patients without arthritis. The incidence of positive ANA, rheumatoid factors, immune complexes, and antibodies to intestinal flora was the same in both groups. Patients in both groups showed similar changes in numbers of circulating T and B lymphocytes. More patients in the group with arthritis than in the control group had elevated IgA levels (38% versus 8%), but the difference was not significant (P less than 0.05). This study demonstrates that immunologic abnormalities occur after jejeunoileal bypass irrespective of the onset of arthritis or related symptoms. No specific immunologic abnormalities could be associated with the arthritis occurring after small bowel bypass. | |
| 6721667 | [Prognosis of the systemic forms of juvenile chronic arthritis. Apropos of 100 cases]. | 1984 Feb | The records of 100 children presenting with systemic juvenile rheumatoid arthritis were studied retrospectively. The precocity of onset and intensity of initial extra-articular signs did not seem to be correlated with a more severe outcome. On the other hand, the number of arthritides present during the first 6 months seemed to be associated with a different prognosis: the oligo- or abarticular forms generally had a better prognosis. In girls, onset was earlier and remissions were twice more frequent than in boys. Contrary to all other joints, the hip was susceptible of a radiological improvement in 25% of cases. Joint disabilities, especially of the wrist, were initially related to inflammation and pain; secondarily, they were chiefly related to the anatomic evolution, resulting in fusion of the joint spaces. At the last clinical examination after a 10 year's evolution, half of patients were in clinical remission, either without articular sequellae, with sequellae, the most severe of which being the hip involvement; 25% of patients still had systemic symptoms; 25% presented with polyarthritis with persisting biological and articular inflammatory signs. | |
| 1156457 | Osteoarthritis of the trapezioscaphoid joint. | 1975 Jul | Isolated osteoarthritis (OA) of the trapezioscaphoid (TS) joint is little recognized. Nine cases that were examined clinically and radiologically are described. Of these 4 had isolated TS OA, 3 also had generalized OA, and 2 also had rheumatoid arthritis. Symptoms and signs, including pain in the wrist and thumb base, radial and volar swelling, and tenderness over the scaphoid, allowed distinction from other causes of pain at the thumb base. A wrist-working splint was beneficial in relieving pain. | |
| 4057192 | Weather and arthritis symptoms. | 1985 Aug | In a one month prospective, double blind study of 70 patients (35 with rheumatoid arthritis [RA], 35 with osteoarthritis [OA]), severity of rheumatic symptoms was compared to changes in daily weather conditions using a visual analogue scale. The majority of patients (62%) believed that various aspects of weather aggravated their symptoms. There was no difference in age, sex, diagnosis or perceived symptom severity between weather sensitive and weather insensitive patients. No significant correlation was found between symptoms of any patient group or individual and any of 13 combinations of weather features. These results suggest that contrary to the belief of the majority of patients with RA or OA external weather conditions do not significantly influence the day-to-day symptoms of arthritis. | |
| 1129574 | [Articular complications of Kahler's disease. Results of a survey of 1953 cases of plasmoc | 1975 Jan | The authors confirm the great rarity of joint complications in patients with Kahler's disease. Among the records of 1953 cases the following complications were the only one found: 2 cases of proved articular amylosis, 2 cases of probable articular amylosis, 3 cases of possible articular amylosis, 20 cases of arthropathy that were impossible to classify, 27 cases of compression of the median nerve in the carpan canal, 6 cases of gouty arthritis, and 3 cases of septic arthritis. The data on symptoms obtained in the course of this enquiry are in conformity with the data in the literature. Articular amylosis often takes on the appearance of a polyarthritic syndrome of progressive installation and extension, involving in particular the hands and the wrists, but sometimes involving in a symmetrical bilateral manner the elbows, the shoulders, and the knees. The affected joints are swollen, stiff, and painful. Local signs of inflammation are, however, often absent. The deformations characteristic of rheumatoid arthritis do not develop. The joints do not show radiological signs for most of the time. In addition, it is not possible to detect the rheumatoid factor in the serum. The arthropathies can also assume an oligo-articular topography. Articular discharges are very frequent: they are usually of a mechanical nature. Whatever the clinical appearance, an exact diagnosis can be established only by means of anatomo-pathological examination of the synovial membrane or of certain para-articular amyloid nodules. Myelomas complicated by amyloid articular deposits are often light chain, with only little increase in the erythrocyte sedimentation rate, discrete hyperproteinaemia, moderate medullary plasmocytosis, and rare or limited radiological lesions. The carpal canal syndrome is either isolated or included within the framework of a polyarthropathy. Compression of the median nerve is due to amyloid infiltration into the synovial sheath of the tendons of the finger flexors, proof of which is not always easy. Gout is rare despite the frequency of hyperuricacidaemia caused by renal insufficiency. Septic arthritis is often caused by renal insufficiency. Septic arthritis is often caused by pneumococci to which those with a myeloma appear particularly suceptible. | |
| 817556 | [Morphological points of departure for the therapy of rheumatic diseases]. | 1975 | Pathogenic mechanisms of several rheumatic diseases are reported. Besides signs of nonspecific inflammation there are characteristic features in some rheumatic disorders: in rheumatoid arthritis one can find mesenchymoid proliferation and - in seropositive cases only - necrosis ot tissue. In ankylosing spondylitis osseous metaplasia of the intervertebral discs, in psoriatic arthritis, osteoclastic and in osteoblastic changes without inflammation. In fibrositis syndrome, however, there was no evidence of inflammation, but one may detect local muscular lesions and proliferation of fibroblasts. Pain in osteoarthritis is always caused by secondary inflammation. Due to this data, the possibilities of treatment are discussed, especially those of nonsteroidal drugs. | |
| 386961 | Synoviorthesis with erbium-169: a double-blind controlled comparison of erbium-169 with co | 1979 Aug | Intra-articular injections of erbium--169 citrate and methylprednisolone acetate in hand joints were compared in a randomly selected double-blind trial. The patients included 21 with rheumatoid arthritis and 3 with psoriatic arthritis, and the design was an intrapatient comparison. No difference between joints treated with the radioisotope or steroid was observed in the year following injection. | |
| 7352963 | [Cause of arthritis in childhood. Relation to age, sex and affected joints]. | 1980 Jan | In a retrospective study (1963--1976) out of 514 children with the general diagnosis of arthritis, the diagnoses most frequently established were; pyogenic arthritis (45.9%), rheumatic fever (18.7%) and juvenile rheumatoid arthritis (17%). Less frequent were tuberculous arthritis (5.8%), systemic lupus erythematosus (3.9%), hemophilic hemarthrosis (2.1%), and other connective tissue diseases (1.5%). Age of onset was significantly lower in patients with pyogenic arthritis. Pyogenic, tuberculous and hemophilic arthritis in most cases were characterized by large joint monoarthritis. Acute polyarthritis was common in rheumatic fever. Chronic polyarthritis was a frequent feature in the other cases. It is concluded that age of onset, number and site of affected joints, as well as evolution time may be useful in the diagnosis. |