Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 646830 | Relationshipp of HLA-Dw3 and HLA-B8 to Sjögren's syndrome. | 1978 Apr | Nineteen patients with Sjögren's syndrome were evaluated for the presence of HLA-B8 and HLA-Dw3. HLA-B8 was found in 57.8% of patients and 20.1% of 96 controls (P less than 0.001). HLA-Dw3 was detected in 73.7% of the patients and 24.0% of controls (P less than 0.0001). Statistical evaluation of the association of both antigens with Sjögren's syndrome revealed that the primary association was with HLA-Dw3 (P less than 0.005). Patients with HLA-Dw3 had a lower mean parotid salivary flow rate (0.8 +/- 0.3 ml/10 minutes/gland versus 5.6 +/- 1.2 ml/10 minutes/gland, P less than 0.0004) and a more intense lymphocytic infiltration into labial salivary glands (focus score 7.2 +/- 0.9 versus 3.4 +/- 0.9, P less than 0.04) than did patients without HLA-Dw3. The difference in the intensity of the lymphocytic infiltration was even more significant when patients with both HLA-Dw3 and HLA-B8 were compared with patients with neither antigen (focus score 7.5 +/- 1.0 versus 2.8 +/- 0.8, P less than 0.02). In addition, all patients with severe keratoconjunctivitis sicca had both antigens. Our observations suggest that a number of genes may interact to determine susceptibility and severity in Sjögren's syndrome. | |
| 579434 | Experience of antioxidant treatment in neuronal ceroid-lipofuscinosis of Spielmeyer-Sjögr | 1977 Nov | A therapeutic trial with antioxidants in neuronal ceroid lipofuscinosis (NCL) of Spielmeyer-Sjögren type is presented. The series consisted of 46 patients, 23 of whom received antioxidants while 23 served as controls. At the start of the trial the patients were classified into two groups on the basis of their IQs. Eleven children, aged 6 1/2 to 12 years, were of low normal or subnormal intelligence (treatment group I). After an observation period of 5 to 6 years a significant change in IQ was seen in 6 children; an improvement was noticed in 2 boys and a deterioration in 4 patients. The IQs were higher, the neurological signs less marked and epilepsy less frequent among the patients receiving antioxidants than among the controls. The therapy did not benefit vision and it was unsuccessful in advanced cases. The results are discussed and compared with those reported by other authors. | |
| 6847258 | Acute polyarticular gout. | 1983 Apr | We report here on 41 male patients with acute polyarticular gout seen in 3 years. Acute polyarticular gout continues to masquerade as other commoner rheumatological disorders such as septic arthritis, rheumatoid arthritis, degenerative joint disease, and even hemiparesis. Almost all of these patients had clues to the diagnosis of acute gout in their medical history. These clues included a past history of intermittent acute gout, prior attacks of polyarticular arthritis, previous hyperuricaemia, and/or obvious tophi. The patients all responded promptly to nonsteroidal anti-inflammatory drugs. We observed serious toxic drug reactions in 8 patients. | |
| 532373 | [Contact thermography in assessing inflammatory joint diseases]. | 1979 Nov | Cutaneous hyperthermia represents a symptom of inflammatory joint diseases and "activated" arthroses. Arthritis and arthrosis may be differentiated by the different distribution and extent of hyperthermia. In an equal number of different joint diseases the symptoms and signs and the course of the diseases were investigated with the aid of contact thermography. The results indicate different exact localisations of temperature changes in the affected joints which together with the clinical findings may make it possible to establish differential diagnostic definitions between arthrosis and rheumatoid arthritis. In the authors' opinion contact thermography is, however, not suited for observations of the course of the diseases. | |
| 7066047 | Activation of the classical pathway of complement by rheumatoid factors. Assessment by rad | 1982 Feb | A simple, sensitive solid-phase radioimmunoassay to quantitate the activation of the classical pathway of complement by rheumatoid factor (RF) is described. RF (purified, in serum or synovial fluid) was bound to reduced and alkylated IgG adsorbed to polyvinyl chloride microtiter plates and reacted with diluted normal human serum (complement). The activation and binding of C4 were quantitated with 125I-Fab'2-anti-C4. Purified, polyclonal IgM--RF was 100- to 1,000-fold more effective than purified IgG--RF in activating complement. The amount of complement activation produced by RF in each of the 57 sera and 2 synovial fluid samples correlated directly with the amount of IgM--RF present. The complement activating abilities of polyclonal IgM--RF in the sera of 15 rheumatoid arthritis patients were homogeneous. This novel technique is readily applicable to the investigation of complement activation by RF in disease. | |
| 4065592 | Effect of bromhexine, ambroxol, and placebo on clinical and histopathological changes in " | 1985 | Hybrids of New Zealand black and New Zealand white mice were used in an animal model for Sjögren's syndrome. The animals were treated with bromhexine (Bisolvon), ambroxol (Mucosolvan), or placebo from their 20th week of life for 10-17 weeks. The parotic glands were examined in a masked fashion by light and transmission electron microscopy after treatment. Significant inhibition of pathological changes in the parotic glands was observed by both methods in hybrids receiving 60 mg/kg bromhexine. Other types of treatment had no effect. In addition, the animals receiving the high dosage of bromhexine had a significantly higher survival rate than other hybrids. | |
| 6231628 | [Gougerot-Sjögren's syndrome. Clinical and biological correlations with the serology of Y | 1984 Apr 7 | An unusual case of Sjögren's syndrome (SS) induced or revealed by a Yersinia pseudotuberculosis serotype IV infection has prompted the authors to undertake a retrospective study of 32 patients with that syndrome. High titers of antibodies to Y. pseudotuberculosis serotype IV (greater than 1/200 th) were found in 4 patients with primary Sjögren's syndrome and Sharp's syndrome. Seven other patients (5 with primary Sjögren's syndrome, 1 with systemic lupus erythematosus and 1 with Sharp's syndrome) had positive serology with low titres, of doubtful significance. Serology was negative in the 20 remaining patients. Nine out of 25 patients had anti-thyroid antibodies, and their relationship with positive Y. pseudotuberculosis IV serology is discussed. The responsibility of the infection in the induction or disclosure of Sjögren's syndrome may be considered. However, since the syndrome frequently develops before serology becomes positive (8/12 cases with a 1 to 6 years' follow-up), an alternative hypothesis would be that diminished digestive defences in Sjögren's syndrome result in an increased frequency of Yersinia infections. | |
| 6428039 | Multinucleate giant cells in sublabial salivary gland tissue in Sjögren's syndrome. A dia | 1984 | The presence of multinucleate giant cells in the sublabial salivary gland tissue in Sjögren's syndrome is an unusual phenomenon which can give rise to differential diagnostic problems. We found in 4 cases of 55 patients with Sjögren's syndrome multinucleate giant cells. In 2 of these 4 patients epimyoepithelial islands were also present. The combination of both multinucleate giant cells as epimyoepithelial islands can mimic the histological picture of a non- caseating granulomatous disease. To discriminate between an epimyoepithelial island and an epithelioid granuloma the immunoperoxidase technique with antibodies directed against muramidase appeared an useful tool. The epithelioid cells contain muramidase whereas the cells in the epimyoepithelial island do not contain this enzyme. Thus, multinucleate giant cells are a rare phenomenon in Sjögren's syndrome, therefore restricting its diagnostic significance. When they occur in Sjögren's syndrome staining for muramidase can be of help to avoid a false positive diagnosis of diseases in which non- caseating granulomatous inflammation occur, such as in sarcoidosis. | |
| 6380205 | Lacrimal and salivary secretion in Sjögren's syndrome: the effect of systemic treatment w | 1984 Jun | In a randomized clinical study, 32 patients with Sjögrens syndrome (SS) were given placebo/bromhexine (Bisolvon) 48 mg daily for 3 weeks. Various ophthalmological and oral variables as well as different proteins in tear fluid and saliva were registered. Bromhexine stimulated the tear secretion significantly, presumably without changing the protein composition of the tear fluid. In saliva the IgM concentration in contrast to other proteins decreased in patients with high pre-treatment values. Bromhexine may be of valuable help in the treatment of some patients with SS. | |
| 6229760 | [Gougerot-Sjögren syndrome. Functional study of the salivary glands by scintigraphy]. | 1984 Feb 4 | One-hundred and twenty patients with sicca syndrome, connective tissue disease or chronic graft-versus-host disease were investigated in the Saint-Louis Hospital Department of Nuclear Medicine. Technetium scanning of the salivary glands was performed in all patients. The results of the scintigraphic study were closely correlated with clinical and histological data in patients with Sjögren's syndrome. This method, which accurately quantifies the salivary function without danger nor discomfort to the patients, has a number of advantages: (a) it is sensitive enough to detect minimal salivary gland dysfunction; (b) it differentiates between parotid gland and submandibular gland involvement and demonstrates asymmetry in pathological processes; (c) it helps in following up patients with Sjögren's disease and in assessing the results of immunosuppressive or anti-inflammatory treatment. | |
| 7330166 | Pulmonary disorders associated with Sjögren's syndrome. | 1981 Summer | Pulmonary disease is recognized to occur as a complication of Sjögren's syndrome and we have studied 17 patients, the majority middle-aged women, with this association. Eight had sicca syndrome alone and nine had Sjören's syndrome in association with a connective tissue disease. Various pulmonary disorders were found: 10 had diseases mainly affecting pulmonary parenchyma (recurrent pneumonia, granulomatous infiltration, pseudolymphoma and fibrosing alveolitis) and six had disorders of the airways (bronchitis, bronchiectasis and asthma). One patient presented with a mediastinal immunoblastic lymphoma. To test the hypothesis that physical factors such as the retention of viscid mucus may play a part in the development of lung disease in Sjögren's syndrome, we have measured mucociliary clearance in patients with Sjögren's syndrome using 99Tc-labelled polystyrene particles. The mucociliary clearance rate was found to be normal from central airways and the whole lung clearance rate was significantly increased in Sjögren's syndrome compared with normal controls. The latter was attributed to the failure of penetrance of the radioaerosol into the periphery of the lung consistent with obstruction of small airways in Sjögren's syndrome. The patients with Sjögen's syndrome and lung disease were characterized by a number of immunological markers irrespective of the presence or type of associated connective tissue disorder. The commonest found were speckled antinuclear antibody by indirect immunofluorescence, antibodies to the acidic nuclear antigen B by counterimmunoelectrophoresis, increased serum DNA binding, increased levels of circulating immunoglubulins, rheumatoid factor in high titre and circulating soluble immune complexes as detected by Clq binding assay. | |
| 910105 | [Gougerot-Sjögren syndrome, connective tissue diseases and autoimmune pathology]. | 1977 Jul | Each of the following conditions has a 4 to 6 percent frequency of association with the Gugerot-Sjögren syndrome: systemic lupus erythematous, scleroderma, autoimmune liver disease (simple biliary cirrhosis and chronic active hepatitis), and Hashimoto's thyroiditis. Association with a nodular periarteritis and a polymyositis is very much more unusual and should be discussed on account of the existence of myositis and the vascularity peculiar to the Gougerot-Sjögren syndrome. Very many true or supposedly autoimmune diseases have been reported in association with the Gougerot-Sjögren syndrome: mixed connectivity, atrophying polychondritis, Reynolds' syndrome (scleroderma plus simple biliary cirrhosis), thrombotic thrombocytopenic purpura, thyrotoxicosis of simple hypothyroidism, and total or partial lipodystrophy. The lacrymal and salivary condition is almost constant during systemic lupus erythematosus, scleroderma, simple biliary cirrhosis and mixed connectivity. From the point of view of autoimmune pathology, the Gougerot-Sjögren syndrome might constitute either an autonomous condition when found in isolation or represent the exocrine glandular expression of a dysimmunitary disease with which it is associated. | |
| 847365 | [Differential diagnosis betwen Gougerot-Sjögren syndrome and sialadenosis using quantitat | 1977 Feb | The symptoms of both Gougerot-Sjögren's syndrome and sialadenosis consist in a reduction of salive and tear production. Sialadenosis is either essential or secondary to the intake of certain drugs. As it is sometimes difficult to differentiate between the two diseases a new quantitative scintigraphic method is proposed, where the activity over the salivary glands is compared with a neutral zone. This method has been validated with control sialography and parotid biopsies and permits an easy differentiation between the two conditions. | |
| 3902479 | Sjögren's syndrome in a child. | 1985 Sep | Sjögren's syndrome is a relatively uncommon condition in the paediatric age group. The youngest child reported thus far was a 5-year-old girl. This article reports the case of a 2-year-old girl admitted for recurrent infections of the respiratory tract with diffuse pulmonary interstitial infiltrations and a progressive swelling of the parotid glands. The clinical features and the results of laboratory investigations, including parotid and hepatic biopsies, chest X-rays and sialography helped to establish the diagnosis of Sjögren's syndrome. Clinical, immunological and genetic characteristics of Sjögren's syndrome are reviewed. | |
| 6492489 | A case of sicca syndrome due to primary amyloidosis. | 1984 Aug | We report the rare occurrence of sicca syndrome associated with primary amyloidosis. A 63-year-old man with apparent keratoconjunctivitis sicca and xerostomia died of the cardiac failure. Neither sialography nor labial gland biopsy revealed findings compatible with Sjögren's syndrome. Macroglobulinemia and a positive Bence-Jones protein were noted in urine testing. Amyloid deposition was demonstrated by Congo red staining on biopsied rectal tissues, and by typical birefringence under polarized light microscopy. At autopsy, the amyloid deposition was identified histochemically in the submandibular gland and the minor salivary glands of oral cavity. | |
| 6207148 | Rheumatoid nodules. A lightmicroscopical study with special reference to fibrin and fibron | 1984 | The presence and localization of fibrin and fibronectin in rheumatoid nodules were studied using an indirect immunoperoxidase technique on tissue specimens fixed in formaldehyde, embedded in paraffin and pretreated with pepsin and testicular hyaluronidase. Three zones characteristic for rheumatoid nodules was recognized. Central area with necrosis, containing at least in part fibrinogen-antigenic material and fibronectin especially in the peripheral part of the necrotic area. Around the necrosis a layer of mesenchymal cells in a palisade arrangement was found. Especially in the external part of this layer fibronectin was demonstrated around and between the cells, where fibrin was absent. Peripherally, a zone of non-specific granulation tissue containing moderate amount of fibronectin decreasing towards the surround mature connective tissue, was seen. In the border of the cellular layer vessels were found in variable amount. In some of the vessels vasculitis was demonstrated with the presence of inflammatory cell infiltration, fibrin deposition and occasionally thrombosis. The pathogenesis of the inflammatory reaction in rheumatoid nodules is discussed. | |
| 7170582 | Pulmonary function in patients with primary Sjögren's syndrome. | 1982 | In 43 women and 3 men suffering from primary Sjögren's syndrome pulmonary function was correlated to various clinical, haematological and serological disease activity parameters. Primary Sjögren's syndrome was defined as the presence of keratoconjunctivitis sicca and xerostomia, in the absence of other well-defined chronic inflammatory connective tissue diseases. Only objective tests were used in the evaluation of the patients [2]. Total lung capacity, residual volume, vital capacity, functional residual capacity and ventilatory capacity were normal. The diffusion capacities measured for CO were significantly reduced compared with the predicted values. This indicates that pulmonary interstitial disease is a common feature of primary Sjögren's syndrome. There was a statistically significant negative correlation between reduced diffusion capacity and previous pneumonia, previous pleurisy, tiredness, dyspnoea, ESR and p-orosomucoid. No correlation was found to certain other clinical disease parameters, the duration of disease or tobacco smoking. | |
| 299979 | Noncirrhotic portal hypertension in Felty's syndrome. | 1977 Feb | A case of Felty's syndrome with nodular regenerative hyperplasia of the liver, presinusoidal portal hypertension, and bleeding esophageal varices is reported. Increased splenic blood flow may be a contributing factor to the development of the regenerative nodules. The portal hypertension is postulated to be a result of intrahepatic vascular compression. | |
| 937368 | Felty's syndrome. Effect of lithium on granulopoiesis. | 1976 Jul | The effect of lithium carbonate upon granulopoiesis was studied in eight patients with Felty's syndrome. Absolute granulocyte counts increased in all patients receiving 900 mg lithium carbonate daily for six weeks. Increased urinary and serum granulocyte colony-stimulating activity was observed in all patients during lithium therapy. A casual relationship between increases in colony-stimulating activity and increased granulocytes is postulated. | |
| 6865623 | Sicca syndrome--diagnostic perplexities. | 1983 Jul | Patients presenting with xerostomia and other signs of Sjogren's syndrome pose diagnostic problems. Many other underlying diseases cause these symptoms and a systematic evaluation is necessary to make an accurate diagnostic assessment. There are immunological tests and histological studies which help make them distinctive and are herein outlined. Patients with this information presenting with sicca syndrome, therefore, can be more accurately assessed and have better treatment regimens instituted. The "sicca syndrome," which is a disorder discussed primarily in the rheumatology literature, is rarely a topic in the otolaryngology literature, although there are often presenting symptoms of this problem in the head and neck. This paper reviews this problem, discusses the confusion regarding terminology, and outlines a practical method of diagnosis for the clinician. |