Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 607389 | Effects of cortisol on glycosaminoglycans synthesized by normal and rheumatoid synovial fi | 1977 | Cultivated rheumatoid synovial fibroblasts synthesize hyaluronic acid which has a changed molecular weight distribution in Sepharose 2B gel chromatography, when compared with normal synovial fibroblasts. Cortisol has no effect on the molecular weight distribution of either normal or rheumatoid hyaluronate. However, it does reduce the hyaluronic acid synthesis, by more than 50% in both cell types at low, near physiological plasma concentrations of the steroid. | |
| 7065742 | Rheumatoid arthritis: treatment with azathioprine (IMURAN (R)). Clinical side-effects and | 1982 | A retrospective review of the literature has been carried out to determine laboratory abnormalities occurring in patients with rheumatoid arthritis (RA) treated with azathioprine, in order to establish a profile for this agent in the treatment of this disease. A total of 542 patients in 24 studies, reported in the literature, were given a range of doses of azathioprine for up to four years. Fifteen percent of patients were withdrawn because of toxicity. The two major toxic effects were gastrointestinal symptoms and alteration in blood counts. Clinically significant leucopenia (less than 2500/mm3) occurred in 14 of the total of 93 patients reported to have developed leucopenia. Some adverse reactions, which would have been expected from the use of azathioprine in other diseases, were uncommon, namely significant infections, hepatotoxicity and pancreatitis. Adverse experience with azathioprine in rheumatoid arthritis compares well with other slow-acting, or disease modifying, drugs. | |
| 205120 | Cellular control of collagen breakdown in rheumatoid arthritis. | 1978 Jan | Remodelling of connective tissue and its destruction in rheumatoid arthritis is related to collagenolysis. Study of collagenase released by rheumatoid synovial cels has indicated that the enzyme is released as latent form from adherent synovial cells in culture. As a latent enzyme it is protected from complexing with alpha2 macroglobulin, the principal proteinase inhibitor. Activation in vivo is very likely caused by proteases which destroy or complex with a portion of collagenase responsible for its latency. Recent data suggest that the latent collagenase is an enzyme-inhibitor complex and not a true zymogen. | |
| 7058296 | Measurement of radiographic joint space in the rheumatoid knee: correlation with obesity, | 1982 Feb | A new and highly reproducible method for measuring radiographic joint space in the rheumatoid knee is described. The joint space was measured in radiographs of the knees of 120 patients with rheumatoid arthritis and correlated by computer analysis with age, sex, duration of disease, erosions, degenerative change, therapy and Quetelet's index (an index of obesity). Narrowing of both compartments of the knee correlated significantly with the duration of disease. Narrowing of the lateral, but not medial, compartment showed some degree of correlation with obesity as measured by Quetelet's index, but this did not achieve significance. The presence of erosions was associated with marked narrowing of joint space which frequently occurred early in the course of the disease; three-quarters of the patients showing even moderate erosions had at least one knee compartment narrowed to 2 mm or less and in half of these the changes had occurred in less than 10 years. Joint space narrowing also correlated strongly with degenerative change which was, however, remarkable for its infrequency. | |
| 7310780 | Multiple myeloma and amyloid bone lesions complicating rheumatoid arthritis. | 1981 Sep | Multiple myeloma developed in a woman with a 7-year history of seropositive rheumatoid arthritis (RA). An unexpected finding was the presence of massive amyloid deposits in the left femur and traces of amyloid in the synovium. Detailed histopathologic studies, however, conclusively excluded amyloid arthropathy. Although definitive tissue classification was not possible, this patient in all likelihood had 2 types of amyloid: massive bone lesions of myeloma-associated (AL) amyloid, and focal subsynovial deposits of RA-associated secondary (AA) amyloid. | |
| 6251563 | [Inflammatory rheumatic disorders during the course of secondary syphilis (author's transl | 1980 May 18 | A 46-year-old man presented signs of secondary syphilis, including a skin eruption, multiple adenopathies, and alopecia. The diagnosis was confirmed by positive serological and Nelson's tests. Inflammatory arthritic signs developed in a few joints two weeks after the onset of the skin eruption, affecting mainly the left wrist, right sternoclavicular joint, lumbar spine, and right shoulder and hip joints, which were painful and stiff. Tests for a rheumatic origin, especially urethral smears and HLA B27 antigen, were negative. The articular manifestations disappeared completely after 8 to 10 days of penicillin. Rheumatic disorders from secondary syphilis affect one or several of the large joints, and quite frequently the sternoclavicular joints, the clinical, radiological, and biological characteristics showing no particular features. Diagnosis is based on the exclusion of other causes for the rheumatic disorder, total rapid regression after penicillin alone, and the simultaneous appearance of the affections. | |
| 818601 | Proliferation of synovial tissue cells in rats with adjuvant disease. | 1975 | Proliferation of synovial lining cells and fibroblasts in adjuvant arthritis of rats was investigated by autradiographic methods. As manifestation of the generalized experimental disease increased labelling rates of both cell types were found in all joints. While in the knee joint this cellular proliferation was of a short duration, it progressed in the ankle joint until the joints were destroyed. It is concluded that increased cellular proliferation is an important mechanism leading to joint destruction in adjuvant arthritis. | |
| 695997 | [The distribution of destructive polyarthritic changes in the hand skeleton]. | 1978 Jul | The distribution of common and erosive changes in advanced polyarthrosis is radiologically demonstrated in the hands of 32 patients. 23 of them showed erosive destructions in at least one joint. In general the alterations were symmetrical. Most of the destructions were seen in the distal and proximal interphalangeal joints, especially in DIP II, III, V and PIP III. Usually the thumb was spared. Most emphasis has been put on the differential diagnosis to rheumatoid arthritis and arthritis in psoriasis and gout. A recent concept concerning mechanical factors in the pathogenesis of so called primary osteoarthritis in the small finger joints is discussed. | |
| 655820 | [An analysis of the anatomical changes of the RA forefoot and the biomechanical consequenc | 1978 Apr 18 | Deformities of the forefoot depend on various mechanical factors as well as on the anatomical structure of the foot and the sufficiency of its individual static-dynamics elements. RA affects primarily the small joints and at the some time accelerates the deformative process of the forefoot. Reviewing literature and using his own observations as a basis the author discusses various causes of deformities and conducts an analysis of the biomechanical consequences after the resection of the metatarsal heads. | |
| 3974921 | [Radiographic diagnosis in the early recognition and evaluation of incapacitating sequelae | 1985 Jan 28 | Two observed cases of rheumatoid arthritis, one at an initial, the other at a very advanced stage, form the basis for a detailed report on the radiographic signs of the disease. Particular emphasis is placed on the possibilities offered by the various radiographic techniques for the evaluation of the sequelae of rheumatoid arthritis and for the early diagnosis of the disease. | |
| 641083 | Osteonecrosis of the knee. A clinicopathological study in twenty-eight patients. | 1978 Mar | Specimens from thirty-four knees in twenty-eight patients with histologically proved osteonecrosis were reviewed. Twelve knees had the clinical diagnosis of so-called idiopathic osteonecrosis; eight, osteoarthrosis; and fourteen, rheumatoid arthritis. Pathologically, the necrosis was localized in the subchondral region of the medial femoral condyle in 67 per cent of the knees. There were pathological fracture and collapse and fragmentation of the necrotic segment leading to marked deformities in most cases. The response to necrosis consisted of histiocytic resorption of necrotic material and formation of granulation tissue and reactive new bone surrounding it. The response was relatively less prominent in the knees with degenerative joint disease and rheumatoid arthritis. | |
| 198897 | [HLA system and rhizomelic pseudopolyarthritis]. | 1977 Sep | 26 HLA antigens of the loci A and B were studied in 50 patients with pseudo-polyarthritis and in 300 control subjects without any joint disease. The arthritis was isolated and not associated with temporal arteritis. An increase in frequency of both HLA antigens was noted in the patients studied: HLA-B5 = 24% as against 13% in controls (P = 0.05 and Pc NS). HLA-Bw38 = 18% as against 5.33% in controls (p = 0.002 - Pc = o.05). The rise in frequency of HLA-B5 and HLA-Bw38 was also found in 19 subjects with polyarthritis and temporal arteritis but not in 31 patients with temporal arteritis alone. In this disease, a link with the HLA-B14 antigen was noted in 50 cases (22.9% as against 8.6% in control). These results suggest that arthritis and temporal arteritis although sometimes associated are probably distinct diseases. | |
| 6331972 | Rapidly progressing rheumatoid arthritis: an example of polyclonal B-cell activation? | 1984 Mar | We report the case of a 76-year old woman who presented with a palindromic onset of seropositive rheumatoid arthritis. After suffering from a fulminant pulmonary infection she developed serologic tests for ornitosis, mycoplasma, pneumocystis carinii and low titer yersinia. Also the rheumatoid factor titer increased and the antinuclear antibody test became positive. Clinically, the course of a rather benign polyarthritis changed into a rapidly progressive deforming disease. The course was also complicated by cutaneous necrotizing vasculitis. Further deterioration occurred after a relapse of pulmonary infection, and she died following acute abdominal surgery for perforated sigmoiditis. It is speculated that the clinical course was in part caused by polyclonal B-cell activation. | |
| 241597 | Clinical studies on alclofenac in the treatment of rheumatic diseases: a drug in question. | 1975 | The potential advantage to patients with chronic rheumatic diseases of an effective, non-steroidal analgesic/anti-inflammatory drug which causes insignificant gastric bleeding was a decisive factor leading to the introduction of alclofenac. Short-term double-blind trials showed that alclofenac has analgesic/anti-inflammatory activities equivalent to phenylbutazone, indomethacin and aspirin, but superior to the fenemates and propionic acid derivatives. Long-term controlled studies, ranging from 5 months to 3-1/2 years and using reliable, objective measures revela, however, that patients with rheumatoid arthritis improve in functional status and graduate to less severe classes of disease activity, a phenomenon not observed with either indomethacin or aspirin administered to matched patients over the same periods of time. So far, clinical improvement on alclofenac has been matched only by treatment with gold, D-penicillamine and the immunosuppressive anti-proliferative drugs. This clinical improvement on alclofenac is reflected in haematological and serological indices, and research shows that alclofenac, like these other antirheumatoid drugs, has a pronounced effect upon the acute-phase protein response and the extent to which L-tryptophan is bound to plasma protein. The clinical data reviewed suggest that alclofenac represents an advance in the therapy of the rheumatic diseases. | |
| 7446053 | Hip replacement with the McKee-Farrar prosthesis in rheumatoid arthritis. | 1980 Aug | A follow-up investigation was made of 74 patients suffering from rheumatoid arthritis (RA) who underwent total hip replacement (THR) according to McKee-Farrar during the years 1969-1975. There were 27 bilateral cases. The mean observation time was 47 months (range 9-85 months). The results were graded according to the method of d'Aubigné & Postel. As regards pain relief and increase in hip mobility after THR the results were good, but walking ability was not greatly improved, partly because many other factors besides the state of the hips influence walking ability. In addition to the THRs, 332 other orthopaedic operations were performed on the 78 patients. No correlation was shown between the results and RA serology, age at THR, preoperative classification of hip radiographs, or observation times. A high frequency of migration of the prosthetic components was found. | |
| 7436558 | Plasma zinc and its relationship to clinical symptoms and drug treatment in rheumatoid art | 1980 Aug | Total plasma zinc levels in patients with rheumatoid arthritis on different therapeutic treatments were determined in conjunction with total serum proteins, serum albumin and globulin, and articular index of joint tenderness, erythrocyte sedimentation rate, rheumatoid factor, serum copper, and serum iron. There were significantly lower zinc levels in patients with rheumatoid arthritis on nonsteroidal anti-inflammatory drugs than in patients on levamisole and penicillamine. Zinc levels correlated positively with serum albumin, and there was an inverse correlation between zinc levels and both ESR and globulin concentration in all rheumatoid patients. However, the correlation coefficient varied in the different treatment groups. The results of this study support the hypothesis that low plasma zinc level in rheumatoid arthritis is one of the nonspecific features of inflammation. | |
| 6205812 | Clinical relevance of antikeratin antibodies in rheumatoid arthritis. | 1982 Sep | Antikeratin antibodies (AKA) were found in 38 out of 96 patients with rheumatoid arthritis (RA); they appeared to be quite characteristic to this disease. There was a very low incidence of AKA positivity in the control groups, i.e., 1 out of 62 healthy subjects and 4 out of 158 other patients. With regard to the sensitivity of the test as a diagnostic tool, AKA was found to be weaker than the rheumatoid factor (RF) and the antiperinuclear factor (APF), whereas the specificity was much better than APF and RF. A clear correlation was shown between the titres of AKA and APF (p less than 0.001) and also between AKA levels and inflammation (p less than 0.02). | |
| 3873887 | Lung biopsy in rheumatoid arthritis. | 1985 May | Forty open lung biopsies from patients with rheumatoid arthritis and possible "rheumatoid lung disease" were reviewed in an attempt to correlate histology with radiologic, physiologic, and prognostic variables. A wide variety of histopathologic features was seen, and primary and secondary patterns of injury were recognized. Five different groups based on histologic patterns were identified: pulmonary rheumatoid nodules, usual interstitial pneumonia (UIP), bronchiolitis obliterans with patchy organizing pneumonia (BOOP), lymphoid hyperplasia, and cellular interstitial infiltrates. The finding of rheumatoid nodules as the primary pattern imparted a uniformly good prognosis, whereas the pattern of UIP indicated a poor one. Patients with BOOP had a more favorable prognosis than did patients with UIP, as did patients with lymphoid hyperplasia and/or nonspecific cellular interstitial infiltrates. Consistent correlations between pulmonary function testing and roentgenographic and histologic findings were not found. The term "rheumatoid lung disease" is of no use as a histologic diagnosis because it encompasses a broad spectrum of morphologic changes that carry significantly different prognoses. | |
| 6711144 | [Determination of the phagocytic ability of leukocytes in patients with chronic polyarthri | 1984 Jan | The phagocytic function of leukocytes from peripheral blood of patients with classical rheumatoid arthritis was investigated using nitroblue-tetrazolium reduction of formazan. One control group (A) and two groups of RA-patients were compared. Group B was treated with nonsteroidal antirheumatics, the third group C additionally with low dose steroids (5,0-7,5 mg/d). Reduction to formazan was increased in group B in relation to the control, whereas treatment with cortico-steroids produced decreased phagocytic function of peripheral leukocytes. | |
| 459564 | Total joint arthroplasty. The hand. | 1979 Aug | Joint replacement in the hand has developed on the basis of improved understanding of the pathophysiologic and the biomechanical factors involved in normal and diseased joints. Compromises are required in prosthetic design and surgical reconstruction, but function and appearance in deformed hands are susceptible to surgical improvement. |