Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 6747426 | Short term review of the De La Caffiniere trapeziometacarpal arthroplasty. | 1984 Jun | We present a short term review of twenty-one De La Caffinière trapezio-metacarpal prostheses inserted into twenty patients with an average review time of fifteen months. Only one case was of rheumatoid arthritis and the main indication for operation was pain. From a functional and symptomatic point of view the results are similar to other series with surgery for trapezio-metacarpal arthritis but due to cup loosening 24% have needed revision, 24% have loose cups and a further 19% have lucent cement lines around the cup. This review draws attention to the worrying frequency of loosening with this prosthesis. | |
| 6098175 | Neutral protease, collagenase and elastase activities in synovial fluids from arthritic pa | 1984 Oct | Neutral protease, collagenase and elastase activities were high in synovial fluids from inflammatory arthritic diseases such as gout, active rheumatoid arthritis and ankylosing spondylitis. The activities correlated well with biochemical parameters such as CRP, ESR and total protein. Values were much lower in a non-inflammatory fluid from a patient with osteoarthrosis. Treatment of fluids with trypsin released both collagenase and elastase. The fluids possessed reserve inhibitory action against these enzymes presumably due to plasma antiproteases being present. The collagenase present was found to possess a MW of 32,700 daltons. | |
| 1071545 | Double pylorus: a complication of chronic gastric ulcer? | 1976 Dec | A case of double pylorus with a chronic ulcer in one of the two channels is described. The patient, a middle-aged man with active rheumatoid arthritis, required partial gastrectomy to allow continued treatment of the arthritis with anti-inflammatory drugs. Detailed histological examination of the surgical specimen revealed features consistent with intramural penetration of an ulcer across the pyloric ring, resulting in a gastro-duodenal fistula. The findings provide further support for the hypothesis that the double pylorus is an acquired lesion, which occurs as an uncommon complication of chronic peptic ulcer. | |
| 1144524 | Glenohumeral joint replacement and postoperative rehabilitation. | 1975 Aug | Prosthetic replacement of the humeral head in patients with severe fractures that detach or crush the articular surface and in patients with glenohumeral arthritis has been done at the Columbia-Presbyterian Medical Center since 1953. Recently, a revised prosthesis for the articular surface of the head of the humerus has been used in combination with a polyethylene glenoid component. This method of total shoulder replacement has been used in patients with rheumatoid arthritis and in other conditions where the glenoid fossa is abnormal. Postoperative physical therapy management is especially important in this unique joint and is explained in detail. | |
| 6872316 | Association of Sjögren's syndrome with C4 deficiency, defective reticuloendothelial funct | 1983 Jun | A case of Sjögren's syndrome with the sicca complex is presented which was associated with persistently low or absent C4 levels, high levels of circulating immune complexes and abnormal reticuloendothelial clearance of damaged or IgG antibody sensitized autologous red blood cells (RBCs). Investigation of normal relatives of the patient revealed low C4 levels and abnormal reticuloendothelial clearance of damaged or sensitized RBCs. HLA, A, B, DR typing revealed a high incidence of the HLA B8, DR3 haplotype and of homozygous null alleles at the C4A locus in the family members. These results suggest that the C4 deficiency and the abnormal reticuloendothelial function in the patient was in part genetically determined and may have predisposed to the development of Sjögren's syndrome. These findings serve to emphasize the possible importance of abnormal macrophage function in the pathogenesis of Sjögren's syndrome and suggest that further investigation of these aspects may increase understanding of this disease. | |
| 7066046 | The incidence of Sjögren's sicca complex in a population of patients with keratoconjuncti | 1982 Feb | A prospective study was performed on patients who came to a university ophthalmology outpatient clinic with the complaint of dry eyes and who were documented to have keratoconjunctivitis sicca (KCS). Of 45 patients studied 1 had primary amyloidosis, and another 10 had KCS with a previously diagnosed connective tissue disease. Of the remaining 34 patients, 19 had KCS alone without xerostomia, and the remaining 15 had KCS in association with subjective or objective xerostomia. Eight of these 15 patients were subsequently shown to have clinical Sjögren's syndrome--sicca complex, and for the majority, serologic and biopsy findings supported this diagnosis. | |
| 7352942 | Correlative histologic and serologic findings of sicca syndrome in patients with systemic | 1980 Jan | We prospectively evaluated 24 patients with systemic lupus erythematosus for clinical, histologic, and serologic evidence of sicca syndrome. Abnormalties suggestive of sicca syndrome in patients with systemic lupus were identified by parotid scan (58%), questionnaire (54%), labial biopsy (50%), Schirmer's test (21%), and parotid flow rate (13%). An increased frequency of autoantibodies to gamma globulin and cellular antigen SS-A was detected in lupus patients with histologic changes on labial biopsy. The serologic findings are similar to those of patients with sicca syndrome alone with the exception of the reduced incidence of anti-SS-B in patients with systemic lupus. | |
| 3158179 | [The quantitative determination of the IgM rheumatoid factor using a solid-phase radioimmu | 1985 | A solid-phase radioimmunoassay capable of detecting nanogram quantities of human IgM rheumatoid factor using a monoclonal anti-mu-chain antibody is described. Human IgG did not interfere with the detection of IgM RF by this method. The small nonspecific binding of nonRF IgM to the human IgG coated tubes utilized in the assay must be corrected for by assaying samples in parallel bovine serum albumin coated control tubes only in cases of deviation of IgM from normal range. 69 coded and randomly arranged sera from patients with rheumatoid arthritis (RA), nonrheumatic joint diseases and healthy adult control subjects were investigated by this method, agglutination techniques as well as RIPEGA. A good correlation between solid-phase radioimmunoassay and agglutination techniques was found. Patients with seropositive RA had significantly higher concentrations of IgM RF than seronegative RA patients or control subjects (mean +/- 1 SD = 133,3 +/- 187,2 micrograms/ml versus 4,7 +/- 6,5 micrograms/ml and 2,2 +/- 4,0 micrograms/ml; resp.). | |
| 220711 | [Hematological manifestations and complications in Sjögren's syndrome (author's transl)]. | 1978 Oct 18 | The main hematological manifestations and complications seen in 18 cases of Sjögren's syndrome are described: a slight anemia of the inflammatory type, a leucopenia, and/or an eosinophilia occur in about half of the patients. One case of auto-immune hemolytic anemia, one of pernicious anemia, 3 of hypoplastic anemia--one of them drug-induced--, and one of thrombocytopenic purpura have also occurred. The clinical and biological manifestations related to the disturbed immunologic status are also frequent: hyperglobulinemic purpura. Raynaud's syndrome due to cryoglobulinemia, rheumatoid factor, anti-nuclear factor. In 4 patients, the disease presented with or evolved into lymphadenopathy and/or splenomegaly; the initial "pseudo-lymphoma" diagnosis corresponded to different aspects or courses: in one cases, malignancy appeared soon, another has evolved in a chronic lympho-proliferative disease, a third one had the histologic features of angio-immunoblastic lymphadenopathy. These various manifestations, which may reveal the Sjögren's syndrome, are discussed in the light of the litterature data. | |
| 6763017 | The pathology of head and neck tumors: the lymphoepithelial lesion and Sjögren's syndrome | 1982 Nov | The clinical disorder Sjögren's syndrome and its putative histologic marker in salivary tissues, the lymphoepithelial lesion, have been and continue to be sources of confusion as well as the subjects of extensive immunologic and pathologic research. At the present time, Sjögren's syndrome is defined as a lymphocyte-mediated exocrinopathy but definition does little justice to the profound immunogenetic basis of the syndrome. This report presents a contemporary review of the lymphoepithelial lesion and the syndrome and presents a hypothesis of pathogenesis based on a graft vs host disease-like disorder. The hypothesis incorporates the immunogenetic, immunoregulatory, and neoplastic aspects of Sjögren's syndrome. | |
| 6610934 | Anti-ribonucleoprotein antibodies in inflammatory rheumatic diseases. | 1984 | Of 472 consecutive patients with inflammatory rheumatic diseases attending a unit responsible for the treatment of rheumatoid diseases, only 12 patients were found to have anti-ribonucleoprotein (RNP) antibodies. Of these, 5 patients fulfilled the criteria for the diagnosis of systemic lupus erythematosus (SLE) and 7 those of rheumatoid arthritis. Joint symptoms were the predominant clinical features and caused severe deformities requiring operations in most cases. One anti-RNP-positive SLE patient died of chronic active hepatitis. | |
| 4057190 | High dose intravenous gamma globulin for Felty's syndrome. | 1985 Aug | High dose intravenous gamma globulin (IV-IgG) was given to 5 patients with Felty's syndrome. The neutrophil count did not change with IV-IgG therapy and no side effects were encountered. We conclude that neutropenia in Felty's syndrome is not comparable to autoimmune hemocytopenia with respect to the response to IV-IgG. | |
| 424141 | Premature ovarian failure and hypothyroidism associated with sicca syndrome. | 1979 Mar | Two cases of premature ovarian failure, hypothyroidism, and sicca syndrome are described. To our knowledge, this association of sicca syndrome and multiglandular deficiency has not been previously reported. The finding of specific organ antibodies, as well as antibodies to nonorgan antigens in the 2 cases studied, supports the hypothesis that these rare clinical conditions may share a common autoimmune pathogenesis. | |
| 365406 | Interstitial immunofluorescence in nephritis of Sjögren's syndrome. | 1978 Nov | A patient with Sjögren's syndrome (SS) developed mild renal insufficiency without significant proteinuria; the diagnosis of interstitial nephritis secondary to SS was made on the basis of history, serological data and renal biopsy. The renal biopsy revealed immunofluorescence of the interstital infiltrates and the importance of this finding in the differential diagnosis of interstitial nephritis is considered. In addition, further studies to detect anti-renal antibodies and circulating immune complexes are reported and the possible interpretation of the results is discussed in regard to pathogenesis. | |
| 268011 | [Salivary calcinosis and the immunologic context]. | 1977 | On the strength of three new cases, it is suggested that the term "calcifying parotiditis" must be replaced by "salivary calcinosis". This suggestion is based on clinical and pathological grounds. An analysis of 11 cases of salivary calcinosis encountered in the last eight years points to clinical analogies between this condition and Gougerot-Sjögren's disease as well as to the fairly frequent involvement of the immune system in the calcinoses. | |
| 52841 | Beta2 microglobulin and lymphocytic infiltration in Sjögren's syndrome. | 1975 Dec 11 | We measured salivary beta2 microglobulin concentrations in 49 patients evaluated for Sjögren's syndrome with a labial salivary-gland biopsy. The salivary concentration was elevated and a significant correlation (P less than 0.001) was found between the concentration and the degree of inflammation seen in the biopsy. Serum concentrations were increased in 135 patients with Sjögren's syndrome. Striking elevations were seen in patients with associated renal or lymphoproliferative complications. Three patients have an increase in serum beta2 microglobulin concentration in association with exacerbation of their disease, and six a decrease after clinically efficacious therapy. These data indicate that determination of beta2 microglobulin in saiva may provide a simple, noninvasive technic for estimation of the degree of local inflammation in autoimmune disease. | |
| 6210468 | Immune complexes: characteristics, clinical correlations, and interpretive approaches in t | 1982 Jun | Immune-complex-mediated injury is thought to play a role in diseases such as rheumatoid arthritis, systemic lupus erythematosus, serum sickness, various infectious diseases, and malignancies. With increased appreciation of the biological and pathological significance of circulating immune complexes has come efforts to develop appropriate techniques for identifying and measuring them. Common approaches exploit such phenomena as the attachment of complement components to antigen-antibody complexes, the presence of specialized receptors for immune complexes at the surface of cells, and the ability of rheumatoid factor to bind with immune complexes. This variety of assay systems for immune complexes has yielded abstruse results in numerous human pathological conditions. Unfortunately, these results seldom correlate with one another in a given disease. Thus, use of a panel of immune complex assays has been recommended. Indirect consequences of immune complex disease may still be appraised and evaluated with some confidence in clinical medicine: measurements of C3 and C4, cryoglobulins, serum viscosity, and turbidity of serum samples. Measurement of immune complexes may be useful in diagnosis, prognosis, and therapeutic monitoring, but it is the characterization of immune complexes that holds the greatest potential for better understanding of disease mechanisms. | |
| 6137196 | Vascular ulcers in scleroderma. | 1983 Oct | Seven patients with scleroderma and either livedo reticularis or atrophie blanche lesions had ulcers of the lower extremity. Livedoid vasculitis, periarteritis nodosa, or endarteritis obliterans lesions were associated with the ulcers. Five patients had livedoid vasculitis, one patient had associated lupus panniculitis, and one patient had rheumatoid arthritis. Four patients had elevated ESRs, four had positive antinuclear antibody tests, and two had positive tests for rheumatoid factor. Patients with scleroderma and livedoid vasculitis or livedo reticularis and ulcers should be examined to rule out underlying vascular disease or endarteritis obliterans. | |
| 7269742 | [Scintigraphic examinations in osseous diseases (author's transl)]. | 1981 Jun | Scintigraphy has been carried out for many years in adequate hospitals with special equipments. Isotopic examinations have been considered to be more and more important; they are applied in cases of pathologic changes of bones and joints or in cases of changes in the surrounding areas. Besides all medical findings, for instance X-ray, laboratory and histological ones, scintigraphic examinations have been applied as a supporting method especially in cases of loose-end endoprosthesis or a periarticular calcifications, rheumatoid arthritis and other rheumatoid diseases of the joints, inflammatory processes, tumourous processes, delayed healing of the bones, pseudoarthrosis and osteoporosis. Of course the scintigraphy is a not specific method but it is extremely important for a complete diagnosis. | |
| 836338 | Lyme arthritis: an epidemic of oligoarticular arthritis in children and adults in three co | 1977 Jan | An epidemic form of arthritis has been occurring in eastern Connecticut at least since 1972, with the peak incidence of new cases in the summer and early fall. Its identification has been possible because of tight geographic clustering in some areas, and because of a characteristic preceding skin lesion in some patients. The authors studied 51 residents of three contiguous Connecticut communities -- 39 children and 12 adults -- who developed an illness characterized by recurrent attacks of asymmetric swelling and pain in a few large joints, especially the knee. Attacks were usually short (median: 1 week) with much longer intervening periods of complete remission (median: 2.5 months), but some attacks lasted for months. To date the typical patient has had three recurrences, but 16 patients have had none. A median of 4 weeks (range: 1-24) before the onset of arthritis, 13 patients (25%) noted an erythematous papule that developed into an expanding, red, annular lesion, as much as 50 cm in diameter. Only 2 of 159 family members of patients had such a lesion and did not develop arthritis (P less than 0.000001). The overalll prevalence of the arthritis was 4.3 cases per 1,000 residents, but the prevalence among children living on four roads was 1 in 10. Six families had more than 1 affected member. Nine of 20 symptomatic patients had low serum C3 levels, compared to none of 31 asymptomatic patients (P less than 0.005); no patient had iridocyclitis or a positive test for antinuclear antibodies. Neither cultures of synovium and synovial fluid nor serologic tests were positive for agents known to cause arthritis. "Lynne arthritis" is thought to be a previously unrecognized clinical entity, the epidemiology of which suggests transmission by an arthropod vector. |