Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 7390153 | Psychiatric consultation among hospitalized arthritis patients. | 1980 Jun | Fifty consecutive psychiatric consultations on 48 patients over an 18-month period in an arthritis hospital are analyzed. The range of psychiatric disorders and their relationship to characteristics of the patient population, such as age, sex, and medical diagnosis, are described. Approximately 2% of patients admitted to the hospital during this period elicited psychiatric consultation. This rate is one-third of the consultation rate of an acute medical and surgical hospital serviced by the same consultants. The relative distribution of psychiatric diagnoses--depression 59%, personality disorders and drug abuse 15%, psychosis 10%, conversion reaction 10%, and "other" 6%--was similar to that encountered in an acute general hospital setting. Although depression was the most prevalent psychiatric problem, it was severe enough to elicit consultation only in 1% of the total hospitalized population; its severity did not correlate directly with the severity of rheumatoid arthritis, the most common medical diagnosis encountered. Neither a particular medical illness nor sex accounted for a disproportionate share of the psychiatric consultations. | |
| 7086771 | Proquazone (Biarsan) in the treatment of juvenile rheumatoid arthritis. A segment I study. | 1982 Jan | Thirty-three patients with JRA were treated with proquazone during a 4-wk open-labeled, non-controlled trial. Increasing doses started at 400 mg/m2/d up to 800 mg/m2/d, not to exceed 960 mg/d. Oral administration was 4 times/d. One patient did not complete the study because an erythematous rash developed. Efficacy analysis showed significant decreases in the total number of active joints, the number and severity of joints with tenderness and LOM, DMS, and travel time (in all cases p less than .05). The drug appears to be similar in efficacy and safety to other NSAID that have been studied in children. | |
| 3874248 | The study and manipulation of experimental autoimmune disease using T lymphocyte lines. | 1985 Jul | Autoimmune diseases include entities of varied clinical expression such as juvenile onset diabetes mellitus, rheumatoid arthritis, multiple sclerosis, and thyroiditis. Nevertheless, these autoimmune diseases have a common origin; they are caused by clones of lymphocytes that specially attack the individual's own body components. To study autoimmune processes, we have isolated and grown as long-term cell lines the T lymphocytes that mediate several different experimental autoimmune diseases in rats or mice. These cell lines have increased our understanding of pathogenesis, but perhaps more importantly, it appears that suitably attenuated lines can be used to immunize the individual animal against its own autoimmune cells. Thus, autoimmune cells can be used as vaccines to prevent or treat the autoimmune process. | |
| 6969065 | Immunoblasts in synovial fluid and blood in the rheumatic diseases. | 1980 Aug | Synovial fluid studies have been made on 43 patients with rheumatic disease. Lymphocytes separated by a 2-stage procedure were examined for the presence of activated large lymphoid cells or immunoblasts. Such immunoblasts were found in 19 of 21 patients with classical rheumatoid arthritis and 7 of 10 patients with seronegative polyarthritis, including patients with Still's disease, psoriatic arthritis, and ankylosing spondylitis. No immunoblasts were seen in synovial fluid from osteoarthrosis or in the inflammatory but nonimmune synovial fluid from crystal-induced arthritis. The presence of immunoblasts showed a correlation with the lymphocyte count in the synovial fluid but not with the total white cell count. Preliminary studies confirm the spontaneous metabolic activity of these cells by autoradiography and show them by scanning electron microscopy to have a villous surface membrane. Simultaneous peripheral blood studies showed a lower incidence of immunoblasts than in the synovial fluid. It is suggested that these cells originate in the synovial membrane. In view of the known migration characteristic of immunoblasts these cells may be important in the spread of immune arthritis as well as being markers of disease activity. | |
| 4722043 | Effects of salicylates on blood changes in mycoplasma arthritis in rats. | 1973 Feb | 1. The polyarthritis produced in rats by i.v. inoculation with Mycoplasma arthritidis was made more severe by salicylates.2. The infection increased the erythrocyte sedimentation rate (ESR), serum lysozyme, counts of total white blood corpuscles, polymorphonuclear cells and lymphocytes, haemolytic serum complement (CH 50) and its component C3. Salicylates enhanced the rise in ESR, CH 50 and C3, but suppressed the rise in lymphocytes and even induced a fall.3. Salicylates did not interfere with the development and action of metabolic inhibition antibodies against M. arthritidis, and did not promote the growth of M. arthritidis.4. Rats treated with salicylate during the first infection acquired the same immunity to reinfection as did infected controls.5. Salicylates did not render rats susceptible to M. fermentans which is non-pathogenic to rats, but may be involved in human rheumatoid arthritis. | |
| 6810443 | [Soluble SS-A, SS-B and RNP antinuclear antigen antibodies in 66 cases of pure or associat | 1982 May | In a prospective study, 66 patients fulfilling the criteria of Sjögren's syndrome were evaluated from the standpoint of the presence of soluble SS-A, SS-B and RNP specific nuclear antigen antibodies. There were 25 cases of pure Sjögren's syndrome and 41 cases of this syndrome associated with a connective tissue disease. Anti SS-A antibodies were found in 10 per cent of cases and anti SS-B in 21 per cent, without there being any significant difference in prevalence between pure and associated forms of Sjögren's syndrome. Three patients simultaneously showed anti SS-A and anti SS-B antibodies, four had only anti SS-A and eleven anti SS-B. Amongst the forms associated with a connective tissue disease all of the latter were represented with an equivalent prevalence. 18 per cent of the patients had anti-RNP with a majority of associated forms of Sjögren's syndrome. In this population of 66 patients with Sjögren's syndrome, no clinical manifestation appeared to be correlated with the presence of anti SS-A and SS-B antibodies. Amongst the laboratory features, only cryoglobulins were significantly more frequent. | |
| 402431 | Cryoglobulinemia in a patient with Sjögren's syndrome, and factors of cryoprecipitation. | 1977 Mar | The IgGK cryoglobulin in a patient with Sjögren's syndrome showed deviations from normal IgG involvine its amino acid composition as well as its carbohydrate components. The heavy chains showed abnormal numbers of arginine, threonine, valine and isoleucine residues, and there was an impressive reduction of fucose and hexose components. The carbohydrate deficits appear to be the reason for the incomplete solubility of the isolated IgGK(Ru) at 37 degrees C. with completion at 52 degrees C. | |
| 6731702 | Sclerosing cholangitis, chronic pancreatitis, and Sjogren's syndrome: a syndrome complex. | 1984 Jun | The disease complex of chronic pancreatitis, sclerosing cholangitis, and Sjogren's syndrome seems to be a well-defined entity with an autoimmune cause similar to that which occurs in primary biliary cirrhosis. Treatment depends on the component of primary sclerosing cholangitis and, more particularly, on the degree of extrahepatic involvement. | |
| 102228 | Increased risk of lymphoma in sicca syndrome. | 1978 Dec | The risk of cancer was ascertained in 136 women with sicca syndrome followed at the National Institutes of Health (NIH). Seven patients developed non-Hodgkin's lymphoma from 6 months to 13 years after their first admission to NIH. This was 43.8 times (P less than 0.01) the incidence expected from the rates of cancer prevailing among women of the same age range in the general population during this time. In addition, three cases of Waldenström's macroglobulinemia occurred in this study group. Eight patients developed cancers other than lymphoma, similar to the number expected based on the rates prevailing in the general population. Patients with a history of parotid enlargement, splenomegaly, and lymphadenopahy had an increased risk of lymphoma. These clinical conditions did not appear to be early manifestations of undiagnosed lymphoma but rather seemed to identify a subgroup of patients with sicca syndrome with marked lymphoid reactivity, who had a particularly high risk of subsequently developing lymphoma. | |
| 6703770 | Sjögren syndrome and lupus erythematosus nephritis. | 1984 Feb | A 9 year old girl with symptoms of the Sjögren syndrome showed interstitial lymphocytic infiltrate on renal biopsy. Two years later she had clinical and biological evidence of systemic lupus erythematosus, associated with a typical glomerulonephritis. | |
| 7113701 | Lymphomatoid granulomatosis (Liebow). | 1982 Jul | An autopsy case with pulmonary lesions analogous to Liebow's lymphomatoid granulomatosis (LYG) and some other unusual pictures were reported. A 29-year-old male who had been diagnosed and treated as Sjögren's syndrome for eleven years because of intermittent swelling of the parotids with diffuse lymphoid cell infiltration and positive serum RA-test, showed several circumscribed densities on the chest X-ray examination which were deemed to be of interlobar pleurisy. On autopsy, the nodular lesions in the lung were composed of angiocentric-angiodestructive lymphoid cell proliferation analogous to LYG. In addition, the present case was characterized by focal glomerulonephritis and splenic trabeculitis which are quite unusual associations in LYG. The relationships of the present case to other similar diseases such as Wegener's granulomatosis, Sjögren's syndrome, primary lymphoma of the lung, etc. were discussed. | |
| 7235395 | Felty's syndrome: effects of splenectomy upon granulocyte count and granulocyte-associated | 1981 May | Clinical parameters and laboratory studies including granulocyte-associated IgG were documented in 15 patients with Felty's syndrome treated by splenectomy. Five patients did not benefit from splenectomy, six responded partially, and four completely. Response to splenectomy could not be predicted from age, sex, splenomegaly, preoperative granulocyte count, platelet count, lymphocyte count, bone marrow lymphocytosis, or granulocyte bound IgG. In contrast, marked elevation in preoperative serum granulocyte binding IgG predicted response to splenectomy. Furthermore, a postoperative fall in serum granulocyte binding IgG was associated with response. Thus, one beneficial effect of splenectomy in some Felty's syndrome patients is reduction of serum granulocyte binding immunoglobulin. | |
| 7281088 | Pulmonary involvement in primary biliary cirrhosis. | 1981 Mar | The association of pulmonary fibrosis and primary biliary cirrhosis (PBC) remains controversial. To determine the frequency of pulmonary fibrosis in PBC, a carefully selected series of 14 PBC patients, seven patients with Sicca complex, and 14 control subjects have been studied. Seven of the 14 patients with PBC had Sjögren's syndrome, four of whom had some clinical evidence of pulmonary disease. Evaluation of ventilatory capacity, gas transfer factor, arterial blood gases, and lung mechanics were performed. Gas transfer was reduced in patients with PBC associated with Sjögen's syndrome and in patients with the Sicca complex. These results suggest that the respiratory, clinical, ad functional abnormalities found in PBC are related to the presence of an associated Sjögen's syndrome. | |
| 98631 | Histochemical study of labial salivary glands in Sjögren's syndrome. | 1978 Jun | Human labial salivary gland biopsies of patients presenting connective tissue diseases associated with Sjögren's syndrome were submitted to a polysaccharide histochemistry study. The normal acinar secretion is an association of neutral polysaccharides with a sulphosialomucin. In Sjögren's syndrome, there is a great reduction in the secretory activity of the acinar cells, but no qualitative change was observed. The pathogenesis of this decreased production and its importance regarding the clinical manifestations of Sjögren's syndrome are discussed. | |
| 309169 | [Association of Sjögren's syndrome and mixed connective tissue disease (Sharp's syndrome) | 1978 | The authors present the case of an adolescent who, despite his youth and relatively unaffected lacrimo-salivary secretion, was classified within the context of Sjögren's syndrom on the basis of paraclinical investigations, in particular the detection of salivary and lacrimal immunoglobulins. During a long course, the progresssive appearance of new lupoid type signs led to further complex immunological examinations, including examination for anti-E.C.T. antibodies. This case would appear to be an incomplete Sharp's syndrome and should be classified amongst the mixed connective tissue diseases. | |
| 876928 | Systemic lupus erythematosus, Sjögren's syndrome and glomerular nephritis. | 1977 Feb | The combination of systemic lupus erythematosus, Sjögren's disease and severe diffuse glomerular nephritis has only rarely been reported. A 14-year-old girl is described with lupus nephritis in whom co-existent clinical and histological features of Sjögren's syndrome were found. These include bilateral parotid enlargement, xerostomia, increased serum amylase, reduced salivary secretion and lymphocyte infiltration of both salivary glands and kidneys. The co-existence of systemic lupus erythematosus with Sjögren's syndrome is discussed together with a consideration of pathogenesis. | |
| 1020742 | The pancreatic involvement in disseminated "collagen" disorders. Studies of pancreatic sec | 1976 Dec | In this study of 66 patients with Sjögren's syndrome and/or scleroderma abnormal pancreatic secretory patterns were observed in 43 patients, 17 of 23 with Sjögren's and 19 of 31 with scleroderma. Pancreatic insufficiency was often associated with depressed gastric secretion and/or abnormal gallbladder function. While in both disorders digestive complaints are attributable to one or more dysfunctions, the pathogenetic factors in scleroderma appear to be more varied and require careful investigation for complete elucidation. Antibiotics, antimetabolites and steroid therapies are also additional causal factors involved in the initiation of gastrointestinal dysfunction and pathology. | |
| 963190 | Salivary immunoglobulin determinations: their diagnostic value in Sjögren's syndrome. | 1976 Feb 10 | Salivary immunoglobulins (IgA, IgG, IgM) determinations are performed on 74 patients with and without Sjögren's syndrome (SS). In normal subjects IgA is the only immunoglobulin detected in saliva by classical immunodiffusion methods. Correlations between the presence of IgG and/or IgM in saliva and other functional and objective clinical parameters and hsitological aspects of minor salivary glands are studied. In SS the prescence of IgG and/or IgM is in close relationship with "sialography index" which is the most reliable clinical investigation. These results point out that salivary immunoglobulins determinations constitute a simple and specific complementary test for SS diagnosis; they may allow the clinicians to observe the progress of the disease or to evaluate effectiveness of drugs. | |
| 6274216 | Peripheral neuropathy in Marinesco-Sjögren syndrome. | 1981 | A case of Marinesco-Sjögren syndrome manifesting cataract, short stature, psychomotor retardation, hypogonadism, and progressive ataxia was described. The result of electrophysiological study reflected the presence of peripheral nerve involvement, which was clearly confirmed by sural nerve biopsy. The conspicuous abnormality observed in the peripheral nerve was the presence of segmental demyelination. The process of axonal degeneration was not remarkable. Results confirmed that Marinesco-Sjögren syndrome is a disorder which may involve both central and peripheral nervous system. | |
| 6166090 | Circulating immune complexes in Sjögren's syndrome. | 1980 Oct | Circulating immune complexes (IC) in patients with Sjögren's syndrome (SjS) were examined using the 125I-Clq binding method. IC were detected in 52% of the patients, and the highest incidences (80%) of IC were observed in SjS patients with systemic lupus erythematosus (SLE). IC were also demonstrated even in 40% of SjS patients without definite associated diseases. Several systemic manifestations suggesting participation of IC and hypocomplementemia were recognized in these IC-positive patients at the time of assay for IC. The levels of IC were positively correlated with both the erythrocyte sedimentation rate (ESR) and serum gammaglobulin in SjS patients. The incidences of IC increased in patients with severe sialographical changes in their parotid glands. The roles of circulating IC in advancement of the disease as well as in the occurrence of systemic manifestations in this syndrome were proven by the present results. |