Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 6650168 | Secondary systemic amyloidosis with Hodgkin's disease. | 1983 Sep | A case of Hodgkin's disease with amyloidosis in various organs in a 68-year-old Japanese man is reported. The initial sign was dysuria followed by diarrhea, melena, and ileus. There was no history of pulmonary tuberculosis or rheumatoid arthritis. Autopsy findings suggested that Hodgkin's disease may have been the initial disease in development of secondary systemic amyloidosis, followed by dysuria and paralytic ileus. | |
| 6946762 | Pseudoaneurysm of the left ventricle. | 1981 Aug | A case study is reported of a patient with rheumatoid arthritis who developed a pseudoaneurysm of the left ventricle after inferior myocardial infarction. The clinical diagnosis was confirmed by radionuclide cardiac blood pool imaging and by contrast ventriculography; the aneurysm was successfully excised. | |
| 7245044 | Actinomycosis of the common bile duct presenting as chronic cholecystitis. | 1981 Jul | Actinomycosis of the common bile duct can masquerade as cholecystitis. This is the first report of a case. The bacteriologic and pathologic characteristics are described. This opportunistic saprophytic organism took advantage of 15 years of prednisone therapy for rheumatoid arthritis. The actinomycosis was successfully treated with tetracycline-deoxycycline for 6 weeks. | |
| 7127912 | Preferential rheumatoid factor reactivity with disulphide bond altered IgG in radioimmunoa | 1982 Aug | Rheumatoid factor (RF) antibody populations were purified by immunoabsorption from rheumatoid arthritis patients' sera and from rabbit hyperimmune anti-streptococcal sera. On the basis of the particular affinity matrix from which the RF were eluted, the antibody populations were classified as being preferentially reactive with either mildly reduced and alkylated (MRA) or native, intact, homologous (with regard to species) IgG. Immune complexes formed between these RF preparations and IgG were characterized by their susceptibility to polyethylene glycol (PEG) precipitation. The two RF specificity populations were incubated in the presence of 125I-labelled MRA and intact homologous IgG preparations. The resultant complexes were subsequently precipitated in the presence of 0-20% (w/v) PEG. From the data generated by incubation of a constant amount of RF in the presence of either intact or MRA IgG, the amount of complex precipitated over the range of PEG concentrations examined was greatest when the form of IgG used for immunoadsorption was also used as the radiolabelled antigen. When a constant concentration of PEG was used and the concentration of the IgG antigen and RF were separately varied, precipitable complexes were formed at lower concentrations of each variable when radiolabelled antigen homology, with respect to the affinity matrix, was maintained. Therefore, although cross-reactive, the two RF specificities were clearly selective with regard to their affinity for a given form of IgG. | |
| 6153936 | Histopathological studies of the labial salivary glands in patients with Sjögren's syndro | 1980 Mar | Labial salivary gland biopsy specimens from 111 patients evaluated for Sjögren's syndrome (SjS) were examined histopathologically with particular attention to the degree of lymphoid cell infiltration with or without the formation of epimyoepithelial islands, fibrosis and atrophy with fatty replacement. These cases were divided into groups, and the histological findings were compared. In definite cases, "positive" findings of more than one focus of lymphoid cells per lobule were seen in about 80%, this value closely coinciding with the reports in Europe and America. Epimyoepithelial islands and hyaline-like substance were also found in the cases with severe lymphoid cell infiltration. Cases of probable SjS connective tissue disease and some other conditions showed lymphoid cell infiltration to a lesser degree. It seems likely that fibrosis and atrophy with fatty replacement are not closely related to SjS. In several cases of definite SjS, labial salivary gland examinations after more than a one year interval were performed on two occasions, and the clinical and histopathological changes were investigated. | |
| 4001878 | Hypokalemic paralysis in Sjögren's syndrome secondary to renal tubular acidosis. | 1985 | A 62-year-old woman with Sjögren's syndrome, distal renal tubular acidosis and hypokalemic muscle paralysis is described. The sicca syndrome was nearly subclinical and went unrecognized for several years. The main and first manifestation to be expressed was that of hypokalemic muscle paralysis secondary to renal tubular acidosis. In the last decade several reports have appeared indicating that renal tubular acidosis is associated with Sjögren's syndrome. The data in this report support the view that adult onset distal renal tubular acidosis is often a disorder of an autoimmune disease, frequently that of Sjögren's syndrome. The complications to renal tubular acidosis such as hypokalemic muscle paralysis or chronic muscle weakness, nephrolithiasis, and osteomalacia can be avoided if the diagnosis of renal tubular acidosis is made and corrective alkali therapy is maintained. | |
| 6696772 | Labial salivary gland biopsy in Sjögren's syndrome. Assessment as a diagnostic criterion | 1984 Feb | Xerostomia is an unsatisfactory diagnostic criterion for the salivary component of Sjögren's syndrome (SS). To determine the diagnostic usefulness of the presence of focal sialadenitis in labial salivary gland (LSG) biopsy specimens, 362 patients suspected of having SS prospectively underwent a unique LSG biopsy procedure. The pattern and severity of LSG inflammation were compared with measurements of parotid flow rate, and the presence or absence of symptomatic xerostomia, major salivary gland enlargement, keratoconjunctivitis sicca (KCS), and other connective tissue diseases (CTD). LSG biopsy focus scores of greater than 1 correlated more closely with the diagnoses of KCS alone and with KCS plus a CTD than did either reduced parotid flow rate or symptoms of xerostomia (P less than 0.0005 and P less than 0.05, respectively). Focal sialadenitis in an adequate LSG specimen is an objective criterion and a more disease-specific feature of SS than xerostomia or any other feature of salivary disease. The salivary component of SS should be redefined as the presence of LSG focal sialadenitis. | |
| 1221365 | [Correlation between scleroderma and Sjogren's syndrome. Value of systematic biopsy of the | 1975 Dec 27 | Thirty one patients with generalised scleroderma underwent labial biopsy. Sixteen showed a nodular infiltration of the accessory salivary glands indicative of Sjögren's syndrome. In 21, intralobular fibrosis was present. More common in those forms with extensive cutaneous involvement, collagenous fibrosis would appear to be a direct manifestation of scleroderma. The frequency of these abnormalities poses the problem of immunological competence with respect to lymphocytic labial infiltrates in generalised scleroderma. | |
| 4050835 | Long-term low-dose glucocorticoid therapy associated with remission of overt renal tubular | 1985 Oct | Renal tubular acidosis and focal interstitial inflammatory cell infiltrate secondary to Sjögren's syndrome remitted with low-dose glucocorticoid therapy over five and one half years in a patient with associated mild systemic lupus erythematosus. Such response has not been previously documented. This observation may have therapeutic applications for renal tubular acidosis associated with Sjögren's syndrome that deserve further investigation. | |
| 6326298 | [Association of mixed connective tissue disease with Sjogren's syndrome and lupus in 2 HLA | 1984 Apr 5 | Different connective tissue diseases were observed in two HLA--and DR--identical sisters. The daughter of one of the index patients and their father exhibited closely related symptoms. With reference to this familial observation the authors discuss the significance of DR3 which is correlated with immunologic disturbances producing multiple clinical and biological manifestations. | |
| 886553 | Familial CRST syndrome with sicca complex. | 1977 Spring | Two patients, a mother and daughter, each with the CRST syndrome, developed Sjögren's syndrome. Both patients had mitochondrial antibodies, smooth muscle antibodies, and a raised serum IgM without clinical evidence of liver disease. This family constitutes the first record of the familial coexistence of the CRST syndrome with Sjögren's syndrome, and the second evidence of vertical inheritance of scleroderma. It is suggested that patients with the CRST syndrome be studied for Sjögren's syndrome and for autoimmune liver disease. | |
| 2992332 | Neuropsychiatric dysfunction in primary Sjögren's syndrome. | 1985 Sep | Neuropsychiatric complications developed in 40 patients with primary Sjögren's syndrome, none of whom met American Rheumatologic Association criteria for systemic lupus erythematosus. Twenty-five patients had psychiatric abnormalities, the commonest of which were affective disturbances. Of 30 patients tested, 23 had an abnormal pattern in the Minnesota Multiphasic Personality Inventory, the commonest pattern being a "conversion V." In general, patients presented with hysteroid dysphoric features. Of 16 patients undergoing cognitive function testing, 7 showed mild memory impairment with attention and concentration deficits. On clinical evaluation, 27 patients had neurologic abnormalities unattributable to other causes (central and peripheral nervous system in 16 and 19 patients respectively). There was a significant correlation between psychiatric disturbances and neurologic dysfunction, suggesting a possible organic basis for psychiatric dysfunction. The diagnosis of primary Sjögren's syndrome should be considered in patients with unexplained neuropsychiatric illness. | |
| 6494625 | Xerotrachea and interstitial lung disease in primary Sjogren's syndrome. | 1984 | 22 patients with primary Sjogren's syndrome were prospectively studied for respiratory system involvement with clinical, roentgenological and functional parameters. 12 patients (55%) had respiratory manifestations. In 10/12 (83%), respiratory symptoms occurred before or concomitantly with the classical symptoms of Sjogren's syndrome. There were two distinct forms of respiratory involvement: xerotrachea, manifested by dry cough without other symptoms and negative roentgenological and functional evaluation and diffuse interstitial lung disease manifested by dyspnea with or without dry cough with bibasilar rales, compatible chest roentgenogram, restrictive pattern in spirometry and/or hypoxemia. Xerotrachea was more common in patients with glandular form of Sjogren's syndrome (3/10) and diffuse interstitial lung disease in patients with extraglandular form (6/12). None of the 22 patients had pleurisy or other forms of respiratory involvement. Antibodies to Ro (SSA) and La (SSB) antigens were more common in patients with the extraglandular form of the syndrome but did not correlate with diffuse interstitial lung disease. | |
| 989035 | Pulmonary manifestations of Sjögren's syndrome. | 1976 Sep | A review of 343 patients with classic Sjogren's syndrome seen at the Mayo Clinic from 1967 through 1974 revealed pulmonary involvement in 31 patients (9 percent). Cough dyspnea, recurrent pneumonitis, and pleuritic pain were the primary complaints. Chest roentgenographic features included diffuse interstitial patterns, diffuse alveolar patterns, and pleural effusions. Laboratory studies revealed hypergammaglobulinemia in 16 of 22 patients tested, and 23 of the 31 patients had positive tests for anti-nuclear antibody, rheumatoid factor, or lupus erythematosus cells. Pulmonary function tests showed a restrictive ventilatory impairment or low diffusion capacity (or both in all 18 patients studied. Pathologic diagnosis included the full range of pulmonary lesions described in Sjogren's syndrome syndrome, ie, lymphocytic interstitial pneumonitis, pseudolymphoma, malignant lymphoma, diffuse interstitial pulmonary fibrosis, and bronchopneumonia. The clinical pulmonary diagnosis included diffuse interstitial fibrosis, recurrent pneumonitis, pleural effusions, and suspected lymphoma or pseudolymphoma. We conclude that pulmonary lesions occur in Sjogren's syndrome more frequently than previously reported. | |
| 6859056 | Primary Sjogren's syndrome and autoimmune hemolytic anemia in sisters. A family study. | 1983 Jun | Familial primary Sjogren's syndrome is infrequently reported despite a strong association with a genetically determined factor, HLA-DR3. Although autoimmune hemolytic anemia occurring with secondary Sjogren's syndrome has been well-documented, its association with primary Sjogren's syndrome has not previously been well-recognized. Thus, the unique occurrence of primary Sjogren's syndrome and autoimmune hemolytic anemia in two sisters prompted investigation of other family members for autoimmune diseases and serologic phenomena and their relationships to HLA genotypes. Serologic analysis (antinuclear antibodies, anti-single-stranded DNA, biologic false-positive result for syphilis, and rheumatoid factor) and HLA-A, B, C, and DR typing were performed in 19 relatives in the kindred. Although HLA-DR3 occurred in those affected with Sjogren's syndrome and thyroid disease, there was no consistent segregation of HLA haplotype with serologic abnormalities in other relatives. These data suggest that there are other, non-HLA-linked, factors contributing to the autoimmune diseases in this family. | |
| 6208003 | [Chronic increase of amylase in primary sicca syndrome]. | 1984 Oct 19 | Pancreatitis had been erroneously diagnosed in a 50-year-old female patient with primary sicca syndrome with chronic salivary-gland-caused increase of amylase of 5 years' standing. Differentiation of amylase into isoenzymes showed clearly increased salivary amylase with normal pancreatic amylase. Little is known on the increase of amylase in Sjögren's syndrome. Unresolved increase of amylase of non-pancreatic origin should thus also lead to consideration of sicca syndrome. | |
| 6252617 | [Mixed cryoglobulinaemia and benign monoclonal gammopathy in Sjogren's syndrome (author's | 1980 Sep 8 | The authors report a case of Sjögren's syndrome associated with Raynaud phenomenon and mixed IgM-IgG cryoglobulinaemia. Three years after the onset of this association:--Immunoelectrophoresis of the serum showed a monoclonal IgM (lambda) protein, --the level of the mixed IgM-IgG cryoglobulinaemia had increased from 28 mcg/ml up to 12 mg/ml and its IgM component was monoclonal (lambda) with anti-IgG activity. Search for amyloïdosis and for a malignant lymphoma was negative. Such an association of a benign monoclonal gammopathy, mixed cryoglobulinaemia and Sjögren's Syndrome has only exceptionally been reported in the literature. | |
| 529328 | Sjogren syndrome presenting as pulmonary pseudolymphoma: report of a case. | 1979 Jul | A case of pulmonary pseudolymphoma and Sjogren syndrome is presented. Unusually, the lung involvement preceded the salivary disease by more than two years. The initial gammopathy and abnormal serologies are more consistent with uncomplicated Sjogren syndrome, but were present when the pseudolymphoma was solely apparent. | |
| 4053442 | Effect of the intra-articular injection of lutetium-177 in chelator liposomes on the progr | 1985 Jul | The treatment of rheumatoid arthritis by radiosynovectomy has been restricted by the difficulty of preventing leakage of the radioisotope from the joint cavity. We have previously shown that this leakage can be reduced to very low levels by delivering the radioisotope in liposomes containing the lipophilic chelator, 3-cholesteryl 6-[N'-iminobis-(ethylenenitrilo)tetraacetic acid]hexyl ether. The present study investigates the effectiveness of the beta-emitting isotope lutetium-177, delivered in chelator liposomes, in treating an experimental arthritis in rabbits. Chelator liposomes containing 0.35 mCi, 0.175 mCi Or 0.087 mCi of the isotope were injected into the synovial cavities of the knees of rabbits with an established experimental arthritis. The retention of the lutetium and the progress of the arthritis were followed for 47 days, and samples of the joint tissues were taken for histology at the end of the experiment. Results showed that losses of radioactivity averaged less than 1% per day over 47 days and that joints treated with 0.175 mCi showed significant reductions in both diameter and surface temperature compared with controls treated with a non-radioactive preparation. Post-mortem histology revealed that, whereas control joints showed a highly active synovitis, synovia of joints treated with 0.175 or 0.35 mCi lutetium-177 had very little inflammatory activity. Although some joints which had received 0.35 mCi showed signs of damage to the articular cartilage, this damage was not apparent wih either of the two lower doses. We conclude that, in this animal model, chelator liposomes complexed with a suitable radioisotope are capable of effecting an efficient synovectomy. | |
| 6999158 | Demonstration of antibodies to double-stranded DNA by the Crithidia luciliae immunofluores | 1980 May | All of 627 sera positive for antinuclear antibodies (ANA) among 1,862 sera received during a three-month-period for routine examination of ANA were tested for antibodies to native double stranded (ds) DNA by the Crithidia luciliae kinetoplast immunofluorescence test. Eighty-seven (14%) of the ANA-positive sera had antibodies to dsDNA. These sera were derived from 73 patients. Forty out of 73 patients with dsDNA antibodies in their sera had the clinical diagnosis SLE. Among the other 33 patients there were eight cases diagnosed as rheumatoid arthritis, one case of psoriatic arthritis, four cases of unclassified arthritis, one case of polymyalgia rheumatica, five cases of chronic hepatitis, three cases of chronic glomerulonephritis and 11 cases with various other disorders. Antibodies to dsDNA, even at high titre, were demonstrated both in patients with clinically active and in patients with clinically inactive SLE. |