Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 6606400 | HLA B27 related 'unclassifiable' seronegative spondyloarthropathies. | 1983 Dec | Twenty-five patients (22 males and 3 females) are described who had 'unclassifiable' seronegative peripheral arthritis affecting mainly the large joints of the lower limbs with other typical features of spondyloarthropathies such as heel pain, low back pain, and mucosal ulcers. But their disorders could not be diagnosed as any specific spondyloarthropathy such as ankylosing spondylitis, Reiter's disease, etc. The mean age of onset of disease was 21.4 years and 60% of them had mono- or oligoarthritis; 60% had arthritis of only lower limb joints. Knee, ankle, and hip joints were most commonly involved, often asymmetrically (mean degree of asymmetry = 0.28). Minimal radiographic sacroiliitis was present in 4 patients, though 13 had low back pain. HLA B27 antigen was detected in 21 (84%) of these patients and only 5.9% of 118 controls (relative risk 83). In addition to these 25 patients there were 4 others whose only symptom was severe bilateral heel pain: 3 of them were positive for HLA B27. | |
| 6398171 | C3c-binding in inflammatory rheumatic diseases. | 1984 Apr | Sera from 73 patients, 24 with rheumatoid arthritis (RA), 10 with Sjögren's syndrome (SS, 4 with and six without RA), 17 with Reiter's syndrome (RS), 10 with systemic lupus erythematosus (SLE), 9 with Yersinia arthritis (YA), and 3 with mixed connective tissue disease (MCTD) were examined by enzyme-immunoassay (EIA) for the presence of C3c-binding IgG, IgM, and IgA activity (C3cBIgG, C3cBIgM, C3cBIgA). This activity probably consists of immunoconglutinins and immunoglobulin aggregates. Significantly elevated C3cBIgG was found in the sera of patients with RA (p less than 0.01), SS, and SLE (p less than 0.02). C3cBIgM was elevated in SS and SLE (p less than 0.02). C3cBIgA was increased in RA (p less than 0.005), in SS and YA (p less than 0.02). Correlations of C3c-binding with erythrocyte sedimentation rate, hemoglobin, C-reactive protein, IgG-binding onto platelets, serum IgG, IgM, and IgA levels, and with rheumatoid factors of IgM and IgA classes were computed. C3cBIgG, C3cBIgM, and C3cBIgA correlated significantly with each other, but usually not with other laboratory variables. The exceptions were positive correlations of C3cBIgM with IgM-rheumatoid factors in RA (p less than 0.05), and with serum IgM levels in the whole series of patients (p less than 0.05). The use of C3c represents a new principle to detect abnormalities in the sera of patients with inflammatory rheumatic diseases. However, the pathogenic significance of elevated C3c-binding remains unknown. | |
| 7018784 | The arthritic great toe metatarsophalangeal joint: a review of flexible silicone implant a | 1981 Jun | A review of 159 feet with double-stem silicone implants in the hallux metatarsophalangeal (MTP) joint was conducted in two medical centers. The majority of patients had a diagnosis of rheumatoid arthritis. Follow-up evaluations ranging between 18 months and six years indicate that pain relief was present in all cases with most having complete relief of pain. Hallux valgus was corrected in most and a functional range of motion as well as good muscle strength was restored. The stability provided by the procedure has improved the postoperative alignment of the lateral MTP joints from which the metatarsal heads had been excised. Operative technique must be precise and tissues must be handled and prepared for the implant with care. | |
| 941960 | Modified finger exercise board. | 1976 Jul | This article describes constructional and material changes made to a finger exercise board (1), a device that provides the occupational therapist with versatile equipment for resistive exercises for most muscles of the hand. It is particularly effective in the treatment of disabilities that involve multiple muscles of the hand such as is commonly the case in rheumatoid arthritis. The modifications of the board have substantially eased grading resistive tension, and construction has been simplified and its stability increased. Brief additional information is supplied below for use of the exercise board in the treatment of arthritic deformities. | |
| 3994209 | Ibuprofen in the treatment of uveitis. | 1985 Feb | Ibuprofen has gained widespread acceptance for the treatment of rheumatoid arthritis and other inflammatory disorders. We have used ibuprofen in the control of both anterior and posterior uveitis and have found it to be effective in the control of these disorders. | |
| 302835 | [Permanent nail changes following gold therapy]. | 1977 Aug | Following gold therapy in a patient with rheumatoid arthritis a transient rash and permanent nail dystrophy resulted. Following onycholysis of several finger and toe nails the nails showed permanent alterations in form of longitudinal streaks and were extremely thin, soft, and fragile. Intracutaneous tests with the commercial gold solution revealed an allergic reaction of the delayed type. | |
| 7059870 | Juvenile dermatomyositis: medical, social and economic status in adulthood. | 1982 Jan 1 | Eighteen adults were studied an average of 18.5 years after the diagnosis of juvenile dermatomyositis had been made. Persistent weakness was found in six patients and recurrent rash in the classic distribution in seven. Other clinical features present were Raynaud's phenomenon, arthritis and subcutaneous nodules. Minor increases in the serum creatine phosphokinase level were noted in seven patients and did not correlate with the presence of weakness or rash. Educational achievement and employment status were better in this group than in a group of adults with juvenile rheumatoid arthritis or the general adult population of British Columbia. Significant residual disability related to calcinosis and flexion contractures was present in only three of the patients. | |
| 1241500 | [Complications in chloroquin therapy]. | 1975 | Chloroquine and hydroxychloroquine are widely used in diseases of connective tissue, especially in rheumatoid arthritis and systemic lupus erythematosus. However, various side effects are reported in many publications. In general these side effects are less important, e.g. those on the gastrointestinal tract and drug exanthema. Disorders of the haemopoetic system, the central nervous system, and peripheral neuromyopathy are rare. Only few reports exist about fetal damage. In contrary, severe problems result from eye complications such as reversible keratopathy and mostly irreversible retinopathy. If, however, chloroquine is administered, the necessity of exakt dosage and periodic ophthalmologic controls has to be stressed. | |
| 6356904 | Reappraisal of the use of methotrexate in rheumatic disease. | 1983 Oct 31 | Methotrexate has been available for clinical use since 1951. Initially, it was utilized as a chemotherapeutic agent, but it has since been widely used in the treatment of such nonmalignant disorders as psoriasis and, more recently, experimentally in psoriatic arthritis and polymyositis. Its mechanism of action is imprecisely understood but it appears to involve both anti-inflammatory and immunosuppressive effects. Controlled pilot studies are underway using methotrexate in patients with severe rheumatoid arthritis. | |
| 7378087 | Studies on the nucleation of monosodium urate at 37 degrees c. | 1980 May | Factors influencing the nucleation of monosodium urate (NaHU) were studied with supersaturated solutions of sodium urate at physiologic conditions of temperature, pH, and ionic strength. Spontaneous nucleation of NaHU did not occur at urate concentrations of 5 mM (84 mg%) in the presence of 140 mM Na ion. Addition of synovial fluids from gout patients greatly enhanced nucleation, whereas fluids from degenerative joint disease patients moderately enhanced nucleation, and fluids from rheumatoid arthritis patients had only a slight effect. Hyaluronic acid and purines minimally enhanced urate crystallization, whereas other connective tissue components had no effect. | |
| 6710280 | Rupture of Baker's cyst mimicking deep-vein thrombosis. | 1984 Apr 21 | Synovial effusions of the knee may produce a Baker's cyst which can dissect downwards or rupture. The synovial fluid released on rupture of such a cyst in patients with rheumatoid arthritis or calcium pyrophosphate disease is highly irritating to tissues and may produce a clinical picture mimicking deep-vein thrombosis. | |
| 1194959 | Increased 99mTc-polyphosphate muscle uptake in a patient with polymyositis: case report. | 1975 Dec | A patient with well-documented rheumatoid arthritis and polymyositis displayed abnormal muscle uptake of 99mTc-polyphosphate during routine bone scanning for occult malignancy. The regions of increased uptake corresponded to the areas of clinically active inflammatory muscle disease. On serial scans the degree of muscle labeling correlated well with both clinical and laboratory indices of disease activity. | |
| 3900373 | [Synovial cysts of the hip. Diagnosis by x-ray computed tomography]. | 1985 Jun | Report of eleven synovial cysts of the hip, associated with osteoarthritis or rheumatoid arthritis, whose the diagnostic problems have been resolved by computed tomography. This technique is proving so efficient in the diagnosis of nature and extension that the other radiological examinations become useless. | |
| 841046 | Pseudotibiotalar slant: a positioning artifact. | 1977 Mar | Pseudotibiotalar slant is a positioning artifact which duplicates a finding recently reported as a new observation in the ankles of patients with sickel cell anemia and the configuration of tibiotalar slant described in juvenile rheumatoid arthritis, hemophilia, and multiple epiphyseal dysplasia. The configuration was produced on radiographs of the author's ankle by flexion of the knee and external rotation. It is a nonspecific finding which should prompt inquiry into the possibility of ipsilateral knee and/or hip abnormality. | |
| 25026378 | Relating passive movement treatment to some diagnoses. | 1974 Sep | When a patient is referred for treatment by passive movement, diagnosis is not the only factor which determines the kind of treatment movement to be used: the presenting symptoms and signs will also have much influence. There are, however, diagnoses which completely direct, or restrict, the kind of treatment to be used. The diagnosis of torn medial meniscus of the knee is one, particular manipulative techniques being required for this complaint. Another example is rheumatoid arthritis, in which the ligamentous tissue undergoes change and is weakened, thus restricting the strength of techniques. The importance of diagnosis can be seen from the above examples. | |
| 6610053 | HLA antigens in black and white patients with juvenile arthritis: associations with rheuma | 1984 Apr | HLA typing for -A, -B, -C, -DR, and -MT antigens and simultaneous studies for the presence of 19S IgM rheumatoid factor (RF), hidden 19S IgM RF, antinuclear antibodies (ANA), and immune complexes (IC) were performed on 24 black and 80 white patients with juvenile arthritis (JA) of different onset types. HLA-DRW6 (p less than 0.05) was associated with pauciarticular onset and early onset pauciarticular black patients. HLA-DR4 was found in both blacks and whites with chronic disease (p less than 0.01) and with the presence of RF (p less than 0.05) and hidden RF (p less than 0.05). In the whites, HLA-DR5 (p less than 0.05) and DRW8 (p less than 0.001) were associated with pauciarticular onset and early onset pauciarticular patients. HLA- DRW8 was also associated with white JA patients with iridocyclitis (p less than 0.001) and black (p less than 0.01) and white patients (p less than 0.001) with the presence of ANA. HLA-MT2 was demonstrated in all 24 black patients (p less than 0.001) and in 54/80 white patients (p less than 0.001). HLA-MT2 was associated with black (p less than 0.01) and white (p less than 0.001) patients with early onset pauciarticular disease and the presence of iridocyclitis in white patients (p less than 0.001). The association of HLA antigens in black JA patients has not been reported before. | |
| 2937722 | Comparison of some procedures detecting circulating immune complexes. | 1985 Dec | Tests for circulating immune complexes were performed by means of 1) plain polyethylene glycol (PEG) precipitation (PEGprec), 2) immunoelectrophoresis of PEG precipitates (IEpp), 3) anti-antibody (AA) inhibition test with sera (AA-Is), and 4) AA inhibition test with PEG precipitates (AA-Ipp). The tests were performed with 156 pathological sera from patients with myasthenia gravis, syphilis, adenocarcinomas of the gastrointestinal tract, rheumatoid arthritis and systemic lupus erythematosus, and 51 normal sera from blood donors. PEGprec was positive with 76 sera, IEpp with 84 sera, AA-Is with 64 sera, and AA-Ipp with 74 sera. Comparison of results in all four tests showed high degree of correlation; all p values were below 0.005. The lower sensitivity of AA inhibition tests was due to the fact that these tests detect only complexes formed by IgG but not by IgM, whereas the remaining two tests detect complexes formed by antibodies of both these immunoglobulin classes. When sera of patients with rheumatoid arthritis and SLE were removed from the material studied, the four tests showed about equal sensitivity. PEGprec gave positive results with two normal sera and the remaining tests were negative with all these sera. It appears that the simultaneous application of PEGprec, IEpp, AA-Is and AA-Ipp will give sensitive and reliable procedure for detecting circulating immune complexes. | |
| 3891199 | Correlation plasma levels, NSAID and therapeutic response. | 1985 Jun | A regular control of nonsteroidal anti-inflammatory drug (NSAID) plasma levels may be useful to avoid undesirable side-effects to monitor therapeutic progress to see if patients are complying with their prescription. Trying to establish a relationship between the plasma concentration of a drug and its clinical effects requires a few prerequisites which may or may not be fulfilled according to the NSAID (e.g. a drug acting by itself, a reversible action, no tolerance to the drug, a highly specific and sensitive enough analytical method of the drug, similar free drug concentrations in the plasma and at the receptor sites,...), the most important of them-which is also probably the most difficult to fulfil in the case of rheumatic diseases-being that the clinical effect of the drug must be easily measured. In fact, the evidence for a good correlation between clinical effects and drug plasma levels are very scarce in the field of NSAID. The best correlation was obtained with salicylates for which ranges of plasma concentrations needed for observing therapeutic effects in rheumatoid arthritis as well as in juvenile rheumatoid arthritis have been established. Similar correlations have been made for side effects such as tinnitus or headaches as well as for toxic manifestations of salicylism. However, many individual variations have been described and there is considerable overlap between therapeutic and toxic concentrations. According to different authors there are or there are no correlations between phenylbutazone plasma levels and either is therapeutic or its side-effects.(ABSTRACT TRUNCATED AT 250 WORDS) | |
| 6571260 | Pharmacokinetics of indomethacin i.m. in blood, synovial fluid, synovial membrane, muscle, | 1984 | Nonsteroidal anti-inflammatory drugs are an important part of the therapy of rheumatoid arthritis. For optimal dosage it would be necessary to know the levels of such compounds in inflamed tissue and not only in blood because the drugs inhibit prostaglandin synthesis in all cells of the body. In the present study, the levels of indomethacin in blood, synovial fluid, synovial membrane, muscle, fat, bone and spinal fluid of patients with rheumatoid arthritis have been measured at 1, 3, 6, and 12 hours after administration of 50 mg indomethacin (Amuno, Merck Sharp & Dohme). At 3, 6, 9 and 12 hours after administration levels in synovial fluid and tissue were higher than in blood but the differences were not significant. Levels in the other tissues investigated did not differ much from blood. In experiments with carrageenan-induced inflammation in rabbits, levels of indomethacin in blood and exudate have been measured after administration of 7.5 mg/kg i.v. Between 3 and 8 hours after administration levels in exudate were significantly higher than in blood. From the time course of indomethacin in blood compared to synovial fluid or exudate and from the comparison of the elimination half lives it can be concluded, that the transport of indomethacin into the inflamed area is mainly a process of diffusion. | |
| 4204728 | Characterization of a human acute phase protein found in association with rubella virus in | 1974 Mar 1 | A precipitating antigen, rho, was first detected in the blood of persons with rubella and in rubella virus-infected cell culture fluids (1). Partially purified antigens from both sources were examined and shown to have similar properties, although antigen from serum sedimented more heterogeneously, with estimated coefficients from 15 to 21 S, while that from culture fluids sedimented in the 11-14 S region. In each case, antigen was located in the beta-1 zone after electrophoresis in agarose, and at a density of 1.305 g/ml after centrifugation in CsCl. Stability characteristics were typical of protein antigens. Immunofluorescent microscopy revealed that rubella virus induced the appearance of rho antigen scattered throughout the cytoplasm of infected cells. When cells containing antigen were exposed for 24 h to 5 microg/ml actinomycin D rho was no longer detectable, indicating the probable cellular origin of the antigen. Also, titers in medium of infected cultures showed a reduction after actinomycin treatment, but levels of the virus-specified antigen, iota, were relatively unaffected. Rho appears to be a protein common to man and many animals. In vitro, it was induced by rubella virus and by adenovirus. In vivo, rho titers were shown to be elevated after rubella virus infection and, to a lesser extent, after infection with certain other viruses. High titers were also demonstrated in women late in pregnancy and in patients with rheumatoid arthritis. In man and the chimpanzee, the appearance and decline of rho in the blood after rubella virus infection were temporally similar to the patterns of CRP, although rho seemed to be a more sensitive indicator of infection. The data presented indicate that rho is a newly recognized acute phase protein inducible by certain virus infections and by other unidentified stimuli present prominently in pregnancy and rheumatoid arthritis. |