Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 6730731 | Concentrations of prostaglandins D2, E2, F2 alpha, 6-keto-F1 alpha and thromboxane B2 in s | 1984 Mar | The concentrations of PGD2, PGE2, PGF2 alpha, 6-keto-PGF1 alpha and TXB2 in synovial fluid from patients with rheumatoid arthritis (RA), Reiter's disease (RD), acute gouty arthritis (GA) and osteoarthritis (OA) were measured by radioimmunoassay. PGE2 was found to be the most predominant prostanoid (pg/ml; Mean +/- S.E.M.): RA 887 +/- 85, RD 870 +/- 71, GA 1064 +/- 155 and OA 665 +/- 71. In patients with OA lower mean levels of all the prostanoids were found than compared to the other groups of patients. Only in patients with RA a slight correlation between PGD2/PGF2 alpha, PGE2/PGF2 alpha and PGE2/6-keto-PGF1 alpha could be demonstrated. No significant correlations between the leucocyte cell counts in the synovial fluid and the prostanoid concentrations were found. In patients with RA developing recurrent knee joint effusions within four weeks after the first sampling significantly lower levels of PGE2 and TXB2 were found in the recurrent samples (PGE2 792 +/- 183; TXB2 179 +/- 33) than compared with the original samples (PGE2 984 +/- 146; TXB2 239 +/- 32). | |
| 2931087 | Intraarticular variation in synovitis. Local macroscopic and microscopic signs of inflamma | 1985 Sep | Multiple biopsy specimens from various parts of the synovial membrane were sampled under direct vision during arthroscopic surveying of the inflamed knee joints of 12 patients with various arthritides. Considerable variation in the macroscopic signs of inflammatory activity was found within the single joint. However, there was a highly significant correlation (P less than 0.001) between local macroscopic signs of inflammatory activity and microscopic signs (by immunohistochemical analysis of the corresponding tissue sample). The profound intraarticular variation in inflammatory activity was seen irrespective of clinical diagnosis. An immunohistologic pattern comprising foci of T helper cells, associated immunoglobulin-bearing cells, and HLA-DR-expressing dendritic cells was not specific for rheumatoid arthritis or any other diagnosis, but was found in the biopsy samples from sites that macroscopically demonstrated maximal inflammatory activity. | |
| 6736090 | Total shoulder arthroplasty with the Neer prosthesis. | 1984 Jul | Of seventy-seven total shoulder-replacement arthroplasties with a Neer prosthesis, I evaluated seventy-three replacements in sixty-five patients at two to six and one-half years after the operation. The operations were performed for the treatment of osteoarthritis, rheumatoid arthritis, and old fractures or fracture-dislocations with traumatic arthritis. Postoperatively there was little or no pain even with vigorous activities in most shoulders, and active abduction improved by an average of 44 degrees, to an average of 120 degrees. The amount of abduction that was regained was related to the original diagnosis and to the amount of rotator cuff disease. Complications developed in thirteen shoulders, and five reoperations were necessary. Eight glenoid components showed radiographic evidence of loosening. Fifty-two of the remaining sixty-five shoulders had some radiolucency at the glenoid bone-cement junction. | |
| 954349 | Pharmacokinetics of naproxen overdoses. | 1976 Sep | In earlier safety studies, naproxen, 600 mg three times daily, was administered to healthy subject without significant adverse effects. Another study demonstrated that single doses of 500 to 900 mg resulted in accelerated renal clearance and a nonlinear naproxen plasma level response after the higher doses. Our report describes the pharmacokinetics of naproxen when administered in single doses of 1, 2, 3, or 4 gm (up to eight times the clinically effective dose in rheumatoid arthritis) to healthy subjects. An increase in urinary excretion rate and continuation of the previously documented nonlinear plasma level response were observed. There were no signs that capacity to conjugate or to excrete the drug was exceeded. There were no adverse effects. | |
| 391117 | Ibuprofen. | 1979 Dec | Ibuprofen was introduced in England in 1967 and in the United States in 1974 as an anti-inflammatory drug in humans. It has weak but definite anti-inflammatory properties similar to those of aspirin, milligram for milligram, but with considerably less adverse effect on the stomach. Ibuprofen is chemically related to fenoprofen and naproxen, but lack of effect for any one in this chemical class of propionic-acid derivatives does not necessarily mean lack of effect for any other in an individual patient. The drug has analgesic properties, probably related to its anti-inflammatory effect. It inhibits prostaglandin synthesis and has no effect on the adrenopituitary axis, making it a nonsteroidal agent. Ibuprofen has been shown to be effective in rheumatoid arthritis and osteoarthritis and is probably effective in ankylosing spondylitis, gout, and Bartter's syndrome. | |
| 89452 | Vitiligo patterns simulating autoimmune and rheumatic diseases. | 1979 Aug 25 | Several variants of generalised vitiligo can be recognised by their cutaneous distribution. In some, certain anatomical regions--e.g., hands--are predominantly affected while the cutaneous depigmentation in other variants shows a similar anatomical distribution to that of the internal structures affected in some of the autoimmune and rheumatic diseases. Five patients have been seen, and three described by others, with vitiligo affecting skin of eyelids and lower front of neck, reminiscent of the anatomical distribution of lesions in thyrotoxicosis with exophthalmos: two of these patients have thyrotoxicosis. Another variant of vitiligo mimicks the anatomical distribution of lesions in ankylosing spondylitis, Reiter's syndrome, and ulcerative colitis and there are cases simulating lupus erythematosus, rheumatoid arthritis, and psoriasis. It is suggested that the parts of the body affected in each vitiligo variant and its corresponding internal disease constitute a set os mosiac patches with distinctive shared characters. These may have morphogenetic functions during embryonic development and be potentially autoantigenic later in life. | |
| 454501 | Cellular immunity in polymyalgia rheumatica and giant cell arteritis: lack of response to | 1979 Jul | Peripheral blood lymphocyte functions were evaluated in 20 patients with active polymyalgia rheumatica (PMR) and/or giant cell arteritis (GCA) by determining the percent of E-rosette-forming cells and by measuring the uptake of tritiated thymidine by peripheral blood lymphocytes after exposure to common infectious antigens and to homogenates of homologous and heterologous artery, muscle, and elastin. Although lymphocytes from patients with PMR and/or GCA were stimulated slightly by artery and muscle homogenates, no differences in lymphocyte responses were found when the results were compared with 22 normal controls and 16 patients with rheumatoid arthritis. The hypothesis that GCA results from a cellular immune reaction to normal or diseased arterial wall antigens is not supported by these studies. | |
| 308806 | Gastrointestinal systemic sclerosis in serologic mixed connective tissue disease. | 1978 Sep | Mixed connective tissue disease is a clinical entity defined by overlapping features of progressive systemic sclerosis, systemic lupus erythematosus, polymyositis, rheumatoid arthritis, and distinct serologic findings. Esophageal dilatation and dysmotility have been the only gastrointestinal manifestations reported. Three patients with serologic findings of mixed connective tissue disease and extensive gastrointestinal involvement compatible with the changes found in progressive systemic sclerosis are presented. Gastrointestinal manifestations of progressive systemic sclerosis are reviewed and were found to be indistinguishable from the findings in these patients. | |
| 227219 | [Angiotensin converting enzyem (ACE) - a blood chemistry parameter in the diagnosis of sar | 1978 | Serum angiotensin converting enzyme (ACE) activity was studied in 50 patients with sarcoidosis (39 active, 11 inactive sarcoidosis), as well as in 50 control patients (34 chronic lung diseases, 9 Hodgkin-disease, 7 rheumatoid arthritis). There is a significant difference (p less than 0.001) of ACE-activity between sarcoidosis patients and controls, and between active (without steroid treatment) and inactive sarcoidosis. Steroid treatment apparently lowers ACE-activity in sarcoidosis, however, without evidence for clinical improvement. Increased ACE-activity was also found in a patient with primary biliary cirrhosis. | |
| 6977354 | Immune complexes in acute pancreatitis. | 1981 Dec | Immune complexes were detected in the sera of ten of 22 patients with acute pancreatitis using a Clq deviation assay. Five of these were positive using a second technique. There was no correlation between immune complexes and clinical or aetiological features of the pancreatitis. Two patients with immune complexes developed a benign and transient pancreatic polyarthritis. Immune complexes may provide one common path in the sequence of pathogenic events that lead to pancreatitis. | |
| 1089597 | Pathogenesis of Salmonella-associated arithritis in the rat. | 1975 Feb | The distribution of joint lesions in rats with Salmonella-associated arthritis (SSA), as determined in a detailed survey, resembles to a great extent the pattern of small joint involvement in human rheumatoid arthritis. Such lesions, though regularly induced in the rat by the intravenous injection of live S.enteritidis, could not be evoked by the heat-killed organisms injected by various routes with and without extrinsic adjuvants. Efforts to transfer SAA from sensitized donors to either normal or primed recipients, employing lymphoid ce-ls from several sources, also failed repeatedly. Two observations, however, virtually exclude the possibility that joint damage in SAA can be the direct result of sustained intra-articular sepsis. First, the inoculation of as many as 10-3 viable inflammation. Second, the incidence of SAA was significantly lower in weanling rats in the adult controls although the growth and distribution of intravenously injected S. enteritidis was virtually identical in the two groups. Together these observations indicate that the joint damage occurring in SAA is determined by the host and not by the infecting organism. From this, it seems fair to conclude that the destructive arthritis characteristic of this syndrome is immunologically mediated. | |
| 6667096 | [Chronic polyarthritis in cystic fibrosis]. | 1983 Nov | In a 8 year-old girl, presenting with cystic fibrosis and severe respiratory failure, a chronic polyarthritis with skin rashes occurred. Rheumatoid factor was lacking in the serum. Antibiotic treatments of the pulmonary infections resulted repeatedly in an improvement of both articular and cutaneous disorders. Thus, the trigger-action of the microbic infection was considered as the inducer of a "reactive arthritis". | |
| 6333070 | [Rheumatoid body cavity effusions in chronic polyarthritis. 5 cases with special reference | 1984 Aug 18 | All of 5 patients with rheumatoid disease presented with the rare complication of rheumatoid pleurisy or pericarditis. The lesion was diagnosed cytologically from effusions by means of the characteristic cellular findings. The unique cytologic picture and possible differential diagnoses are presented in detail. The pathogenesis of rheumatoid serositis and its bearing on follow-up of rheumatoid disease are discussed. | |
| 6427463 | Stroke-like syndrome after gold sodium thiomalate induced vasomotor reaction. | 1984 Apr | Vasomotor reactions after gold sodium thiomalate are well recognized. When they do occur they are rarely a clinical problem. We describe a 50-year-old woman with rheumatoid arthritis in whom a severe postinjection vasomotor reaction was associated with a cerebral vascular accident. | |
| 6715124 | Double pylorus or antro-bulbar fistula. | 1984 | A patient suffering from rheumatoid arthritis and a gastric ulcer was found endoscopically to have a double pylorus. One year later the two apertures were found to be fused and appeared endoscopically like a deformed pylorus. We suggest that this lesion, which is usually acquired but may sometimes be congenital, would be better called antro-bulbar fistula. | |
| 24822759 | Pitfalls in the diagnosis of the simple wrist ganglion. | 1983 Aug 1 | ABSTRACT; A wrist mass, often found to be a ganglion, is a common clinical problem. Any mass is difficult to diagnose by physical examination alone. Reported entities appearing to be wrist ganglions areanomalous extensor muscle bellies, lipomas, neuromas of the posterior interosseous nerve, synovial cysts of rheumatoid arthritis, aneurysm of the radial artery, and others. In addition, the authors are aware of entities not previously reported. This retrospective review of four malignancies and a plexiform neuroma that appeared to be simple wrist masses serves to increase the clinician's awareness of the pitfalls to be avoided in the diagnosis of the wrist mass. | |
| 7239114 | Scleromalacia perforans in ulcerative colitis. | 1981 Jul | Ulcerative colitis is associated with many ocular complications. The only systemic disease currently recognized to be complicated by scleromalacia perforans is rheumatoid arthritis. A 36-yr-old male is described whose long-standing ulcerative colitis was complicated by scleromalacia perforans at a time of disease activity. The scleromalacia was successfully treated with high-dose steroids and total proctocolectomy. | |
| 7268463 | Tibiotalar tilt--a new slant. | 1981 | Classically tibiotalar tilt (TTT) is associated with four conditions: Fairbanks disease, hemophilia, sickle-cell anemia and juvenile rheumatoid arthritis. We have found it to be present in at least 20 other conditions including other dysplasias, developmental conditions such as fibrous dysplasia and a variety of other acquired disorders including various metabolic diseases and following previous trauma. The pathogenesis is controversial, but the most probable cause is related to stress and the blood supply of the distal tibial epiphysis. The differentiation of TTT from pseudotibiotalar tilt is also discussed. | |
| 7408308 | Fatigue fracture of the pelvis after total knee replacements: report of a case. | 1980 Jun | Fatigue fracture of the pelvis in a 66-year-old woman with rheumatoid arthritis was recognized after bilateral total knee replacements. The fatigue fractures occurred sequentially and bilaterally in the superior and inferior pubic rami. Satisfactory recovery occurred in response to conservative treatment. The fracture of the right superior ramus failed to unite. Fatigue fracture should be suspected if there is pain in the pectineal region after knee arthroplasty. | |
| 227095 | [A differential diagnosis of sural phlebitis: popliteal cysts. Value of ultrasonography (a | 1979 May 18 | Two cases are reported of popliteal cysts simulating sural phlebitis, one in a patient with lupus, the other during the course of rheumatoid arthritis. Diagnosis is based upon the following signs: sudden onset of pain, sometimes after effort, and in the knee rather than in the calf, and more especially ecchymosis occurring in the internal supramalleolar region. The decision as to whether anticoagulant treatment should be instituted must be based on the certitude of the diagnosis, and this can be obtained in an atraumatic manner by ultrasonography of the popliteal fossa as shown by iconography. |