Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 214047 | A longitudinal study of in vitro tests for lymphocyte function in rheumatoid arthritis. | 1978 Oct | In vitro tests of lymphocyte function have been performed in 61 patients with ;classical' or ;definite' rheumatoid arthritis. In vitro lymphocyte function was assessed by lymphocyte transformation responses to phytohaemagglutinin (PHA), Pokeweed mitogen (PWM), Candida antigen, and herpes simplex type I (HSV1). Follow up data were available after 6 months of treatment in 32 of these patients. Spontaneous lymphocyte transformation was assessed in all patients. Results obtained in patients with rheumatoid arthiritis were compared to those seen in a normal control population. Disease activity of patients with rheumatoid arthritis was assessed using standard clinical methods. Lymphocytes from patients with rheumatoid arthritis showed a similar degree of spontaneous transformation to that seen in normal subjects. In contrast, lymphocytes from patients with rheumatoid arthritis responded less well to PHA and Candida and HSV1 antigens when compared to normal patients. In patients with rheumatoid arthritis the response to PWM was markedly enhanced compared to normals. Clinical improvement was noted in 19 of the 32 patients seen at follow up, all of whom had received gold or penicillamine therapy. The abnormal responses of PHA and PWM seen before treatment became normal in those patients who improved clinically. The responses to Candida and HSV1 antigens not only returned to normal following treatment but were increased above those seen in normal controls. A statistically significant association was seen between clinical improvement and improvement of in vitro tests of lymphocyte function. | |
| 7305692 | Current status of therapeutic apheresis in rheumatoid arthritis. | 1981 Aug | Evidence developed over the years has suggested that lymphocyte depletion and removal of plasma factors can ameliorate rheumatoid arthritis. In our studies of 40 patients, a subset of patients that respond best to 20 therapeutic lymphoplasmapheresis over 11 weeks has emerged. These are functional Class III patients with seropositive, erosive progressive disease who have little deformity. They must be on long-acting agents or cytotoxic drugs during pheresis to prevent antibody rebound. Other studies have since confirmed our work. The major side effects of pheresis are elucidated. Technologic developments will enable selective pheresis procedures to be in widespread use within a few years. | |
| 728355 | Pulmonary and pleural lesions in rheumatoid disease. | 1978 Oct | Lung and pleural involvement in rheumatoid disease is reviewed and discussed. Attention is drawn to the male preponderance, to the frequency with which lung infections occur in rheumatoid patients and to some problems posed in them by infection with mycobacteria. Pleural effusion, pulmonary nodules and fibrosing alveolitis are familiar in association with rheumatoid arthritis. Less familiar associations include upper lobe fibrosis, 'shrinking lung' and mixed pleural and pulmonary involvement. It is suggested that rheumatoid patients display a wider range of intrathoracic disease than seems generally appreciated. | |
| 7067284 | Prosthetic arthroplasties of the shoulder. | 1982 Apr | Twenty-two Neer shoulder arthroplasties were performed in rheumatoid and osteoarthritic patients and followed for a minimum of two years, with an average of four years, seven months. In addition to the Neer humeral prosthesis, eight had Neer glenoid components and seven had a subacromial spacer inserted. Two years postoperation, 11 patients had no pain and eight had only mild discomfort. Shoulder function improved more than 100% compared with the preoperative ratings while the range of motion increased relatively little. There was one failure. Although the hemiarthroplasty group scored similarly to the total shoulder group, total shoulder arthroplasty is preferred because of possible further glenoid deterioration. A subacromial spacer is used if the rotator cuff cannot be repaired. The Neer shoulder prosthesis is recommended for the relief of rheumatoid or osteoarthritic shoulder pain. | |
| 4057188 | Defective reticuloendothelial system C3b mediated clearance in rheumatoid arthritis and va | 1985 Aug | C3b receptor mediated clearance by the reticuloendothelial system (RES) was tested in vivo using autologous C3b coated, technetium labelled erythrocytes in patients with rheumatoid arthritis (RA) and rheumatoid vasculitis. Diminished C3b mediated erythrocyte clearance was found in all patients with rheumatoid vasculitis and some patients with active RA. Normal C3b mediated clearance was found in some patients with previous vasculitis, in remission when tested. These results are consistent with the hypothesis that acquired dysfunction of RES C3b receptors is implicated in the pathogenesis of rheumatoid vasculitis. | |
| 698120 | Erythropoiesis and mean red-cell lifespan in normal subjects and in patients with the anae | 1978 Jul | Recently developed ferrokinetic methods offer a tool to measure effective and ineffective erythropoiesis and mean red-cell lifespan (Ricketts et al, 1975). We have used this tool to investigate erythropoiesis in normal subjects and in patients with the anaemia of active rheumatoid arthritis. In normal subjects the results are comparable with the results published by Cavill et al (1977). In patients with the anemia of active rheumatoid arthritis there appears to be a total and an effective red-cell production as in the normal subjects. The ineffective erythropoiesis in the patients is increased and the produced red cells have a shortened mean lifespan in the circulation. The increased ineffective erythropoiesis is probably due to inadequate supply of iron to the marrow and the shortened mean red-cell lifespan to an extra-corpuscular haemolytic factor. The impaired marrow response to the anaemia of active rheumatoid arthritis has been confirmed. | |
| 6757555 | [New method of isolating components of immune complexes, using the example of rheumatoid a | 1982 Nov 15 | Immune complexes were precipitated under defined conditions using polyethleneglycol. The precipitation was subjected to the first electrophoresis under nondecomposed conditions for immune complexes. In this way IgG can essentially be separated from the immune complexes which remain in the place where they were applied. In a second electrophoresis, the broken immune complexes were fractionated into IgM and IgG bands. These were analysed for antibody activity by means of hemagglutination and immunofluorescent methods. In serum of 20 rheumatoid arthritis patients, we could detect in the IgM fraction of the immune complexes the rheumatoid factor, an antinuclear antibody, and a new unknown antibody directed against cell plasma membranes of human muscle cells and endothelial cells. The importance of this new antibody in the pathogenesis was discussed. | |
| 6211000 | [Histopathogenesis of synovialitis in experimental allergic rabbit arthritis. Comparative | 1982 Jan | The development of synovitis was studied in 64 rabbits with experimentally produced allergic arthritis and in 30 rabbits with experimentally produced non-allergic arthritis. The results are compared with the morphological changes of the synovial membrane in rheumatoid arthritis, especially in early stages, known from the literature. The experimentally produced non-allergic arthritis shows no similarity whatsoever to rheumatoid arthritis. On the other hand, there is a pronounced similarity of the synovitis in experimentally produced allergic arthritis and in the fully developed stage of rheumatoid arthritis. In experimental allergic arthritis this stage is already reached after three weeks while the changes in the synovial membrane in rheumatoid arthritis are only little characteristic over a disease period of up to six months. A subdivision of individual morphological criteria shows special differences in the vascular changes and in the ratio of lymphocytes to plasma cells. In experimentally produced allergic arthritis, there is only initially a thrombovasculitis within the frame of the Arthus reaction whereas in rheumatoid arthritis, especially in the early stages, a proliferative vasculitis is frequently described. Furthermore, in experimentally produced allergic arthritis as compared to rheumatoid arthritis, the plasma cells are preponderating over the lymphocytes, which points to an increased humoral immune response in the animal model. | |
| 415355 | Some characteristics of RA patients with and without side effects due to gold treatment. | 1977 | Gold treatment was initiated in 98 patients suffering from early-stage rheumatoid arthritis. In 30 patients side effects due to gold therapy were seen during the first follow-up year: proteinuria in 6, allergic symptoms in 23, and thrombocytopaenia in one patient. The serum IgM level was higher in patients with side effects. None of the 33 other parameters studied showed any significant differences between patients with or without side effects. | |
| 6826529 | Physical diseases in schizophrenia and affective disorder. | 1983 Feb | Studies of the increased or decreased risk of specific physical diseases in patients with schizophrenia and affective disorder are reviewed. Existing data suggest further examination of the following relationships: (1) the presence in schizophrenics of increased incidence of gastrointestinal cancer and of cardiovascular and infectious diseases, and of decreased incidence of lung cancer and rheumatoid arthritis; and (2) the increased incidence of circulatory, respiratory, and atopic diseases, and of diabetes mellitus among patients with major affective disorder. A majority of the studies reviewed failed to meet methodologic standards necessary to provide conclusive evidence. An ongoing research project which generally meets these standards, the Oxford Record Linkage Study, is described. | |
| 6462997 | Cardiac tamponade in rheumatoid arthritis. | 1984 Jul | A 56-year-old woman with definite rheumatoid arthritis developed cardiac tamponade while her disease was both clinically and serologically inactive. To our knowledge such a complication has been reported only once previously. | |
| 537542 | The naeglerial causation of rheumatoid disease and many human cancers. A new concept in me | 1979 Nov | Man and terrestrial animals live in an environment containing free-living amoebae on the surface soil, in pools, fresh water lakes, rivers and streams. They form cysts, which float in the air and which are continually inhaled and found in the nasopharynx and their trophozoites are present in human and animal faeces. Amoebae of the genus, Naegleria, have been demonstrate; in all human tissues, both healthy and in larger numbers in those taken from cases of rheumatoid disease, in all human cancers and in the unaffected tissues of cancer patients. They can be killed in vitro by a series of different anti-amoebic substances and treatment of active cases of rheumatoid disease by any of these, either causes cessation of disease activity or a temporary exaggeration of symptoms followed by their lessening or disappearance (Herxheimer reaction), indicating the presence of an amoeba in the affected tissues as the causative organism of the inflammation in this disease in subjects genetically sensitive to the organism. Every internal organ may be involved in the inflammatory response in cases of rheumatoid disease and this also ceases with the above treatments. Many of these internal lesions are premalignant, so that infection with the organism either in sensitive subjects or with pathogenic species, appears to be the primary cause of cancer in many cases. The presence in the body of Naegleria represents the source of the constant antigenic stimulation thought to be responsible both for rheumatoid disease and for the development of lymphomata and myelomatosis. | |
| 1013581 | Synovial-fluid pharmacokinetics of ketoprofen. | 1976 | A study was made of the plasma and synovial-fluid levels of ketoprofen after single oral doses of 50 mg and 100 mg given to patients with rheumatoid arthritis. The drug was rapidly absorbed and plasma levels were similar to those seen in healthy volunteers. The mean early plasma half-life of ketoprofen in both volunteers and patients with rheumatoid arthritis was 1.5 to 2 hours. A cumulative effect of ketoprofen was evident in the synovial-fluid of the patients studied. | |
| 629093 | [Behavior of the complement components C3 and C4, C-reactive protein and blood sedimentati | 1978 Jan | 21 male patients suffering since years from classical rheumatoid arthritis were treated with daily thermal baths of 37 degrees Celsius temperature during a 3 week period. To control the activity of the rheumatoid inflammation we used the complement components C3 and C4, the C-reactive protein and the blood sedimentation rate. No changes in the different activity parameters could be found during the course of the treatment. Joint function improved significantly. Therefore the combined treatment of rheumatoid arthritis with physio- and pharmacotherapy is recommended. | |
| 935822 | Soft tissue radiography of the hands in the rheumatoid arthritis. | 1976 | 25 cases of rheumatoid arthritis were investigated radiologically and clinically over a period of 3 months, using soft tissue radiograms of the hands and Lansbury's Activity Index. The soft tissue radiography technique was a new combination using molybdenum target mammographic equipment and immersion of the hands in a 2.5 cm layer of 1:1 ethanol-water solution, in order to reduce the uneven darkening of films. Periarticular oedema and progression of erosive and soft tissue changes were observed in clinically active cases. High scores for joint swelling and erosions were also registered in some clinically inactive cases. Determination of the rapid progression of erosive and soft tissue changes and the determination of periarticular hyperaemic oedema using special radiographic methods appear to be of some value in assessing the activity of rheumatoid arthritis. | |
| 604478 | Serum ferritin levels in anemia of rheumatoid arthritis. | 1977 Winter | Thirty-five anemic patients with rheumatoid arthritis were studied to determine the relationship between serum ferritin levels and body iron status, as assessed by the grading of bone marrow iron stores. The incidence of greatly reduced or absent marrow iron stores was 60%. Peripheral blood smear, RBC indices, serum iron, and iron binding capacity correlated poorly with stainable marrow iron. Serum ferritin levels only correlated approximately with iron stores, and in iron deficient rheumatoid patients the levels were higher than would be expected in patients with uncomplicated iron deficiency. The study shows that reduced marrow iron stores is common in patients with rheumatoid arthritis, and that the serum ferritin concentration may provide a useful indication of reduced body iron stores in these subjects, but only if a range of normal values can be established for this disease. | |
| 71973 | A comparative study of flurbiprofen and indomethacin in rheumatoid arthritis. | 1977 | A double-blind crossover trial of 200 mg flurbiprofen daily and 100 mg indomethacin daily, each given for 2 weeks separated by a 1-week placebo washout period, was carried out in 30 patients with rheumatoid arthritis. The results were analyzed for the 26 patients with complete records. No statistically significant differences were found between the two treatments with regard to subjective impression of pain severity, duration of morning stiffness, grip strength, joint size, haemoglobin and erythrocyte sedimentation rate. When the results for each treatment period were compared to baseline and both drugs considered individually, there was a statistically significant improvement from baseline. During the flurbiprofen treatment period the erythrocyte sedimentation rate showed a statistically significant fall, but not with indomethacin. During the placebo washout period between the active therapies, there was a statistically significant worsening in all parameters apart from the level of haemoglobin and erythrocyte sedimentation rate. These assessments showed little change. Five patients reported side-effects with indomethacin, and 1 with flurbiprofen. No side-effects were reported during the placebo period and although 4 patients were withdrawn, none was withdrawn because of side-effects. Patient preference was for flurbiprofen. | |
| 6696775 | Sexual problems in rheumatoid arthritis and ankylosing spondylitis. | 1984 Feb | In this study, scores on the sexual motivation scale (which measures the tendency to engage in sexual interaction versus the tendency to be averse to sexual interaction) were determined, by interview, in ankylosing spondylitis (AS) and rheumatoid arthritis (RA) patients and compared with the scores of healthy matched controls. AS patients did not score differently from the healthy population, but scores of men and women with RA were more in the direction of sexual aversion than those of healthy men and women. In female RA patients, some relationship was found between disease variables such as joint index and erythrocyte sedimentation rate and the score on the sexual motivation scale. In the second part of the interview, preference for certain coital positions was investigated, and the demand for help with sexual problems was explored. The percentage of RA patients expressing a need for advice was considerably greater than the percentage of AS patients. | |
| 6610047 | HLA antigens in palindromic rheumatism, nonerosive rheumatoid arthritis and classical rheu | 1984 Apr | The frequency of HLA antigens has been investigated in patients with definite rheumatoid arthritis (RA) who lacked characteristic erosive radiographic changes that we called nonerosive rheumatoid arthritis ( NERA ). The frequency of HLA-DR4 in patients with NERA was significantly lower than that in classical, erosive RA. A normal frequency of HLA antigens was also found in patients with palindromic rheumatism (PR). Those of the PR patients who however, developed RA during followup, carried HLA-DR4. The patients with PR, NERA and RA who had familial RA demonstrated increased frequency of HLA-DR4. | |
| 6508086 | Marginal melting of cornea in rheumatoid arthritis. | 1984 Oct | There was marginal melting of the cornea in a patient with inactive rheumatoid arthritis. Conjunctival biopsy revealed vasculitis which disappeared after treatment with topical steroids and systemic steroids and azathioprine. Conjunctival biopsy can serve as a diagnostic tool and for evaluation of treatment in marginal ulceration of cornea associated with rheumatoid disease. |