Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 636667 | [Enzyme, enzyme-histochemical and immunohistological studies in chronic erysipelas polyart | 1978 Mar | The chronic Erysipelas-polyarthritis in pigs has been considered an animal model resembling human rheumatoid arthritis. Fifteen specifically pathogenfree (SPF) pigs 45 days old were experimentally infectec with strain T 28 of Erysipelothrix rhusiopathiae-bacteria. During the subsequent 32 weeks several enzymatic, immunohistological and microbiological parameters were monitored. Compared to 5 age and sex matched healthy controls the infected pigs showed increased activity of plasma acid phosphatase starting 4 weeks after the infection. Acid phosphatase activity was usually enhanced in synovial fluid of chronically ill animals. Histochemically increased activity of acid phosphatase, beta-glucuronidase and beta-acetylglucosaminidase was found in lining cells and fibroblasts of the synovial membrane of chronically diseased joints. Immunohistochemically Erysipelas-antigen was demonstrated in the synovial membrane even of those inflamed joints from which no living bacteria had been isolated. The microbiological and immunohistochemical results correlated positively with the enzymehistochemical data. The release of lysosomal enzymes from cells of the synovial membrane in chronically diseased joints due to the influence of Erysipelas-bacteria and the possible implications of persistent bacteria on the perpetuation of chronic Erysipelas-polyarthritis are discussed. | |
| 4015026 | Rheumatoid factor seroconversions in relation to clinical rheumatoid arthritis. | 1985 | Two blood samples were taken with an interval of five years in a continuing epidemiological study of a rural population with an age range of 40-64 at the commencement. Paired sera from 1805 subjects were tested for rheumatoid factors using Waaler-Rose and latex tests. Simultaneous conversion in both tests from negative to positive occurred in seven cases and from positive to negative in eight cases, corresponding to 20% of the Waaler-Rose positives. The mean Waaler-Rose titre in the cases converting to positive was nearly four times higher than in the cases converting to negative. Five subjects developed Waaler-Rose-positive rheumatoid arthritis after the baseline survey. In three of them, positive rheumatoid factor reactions were observed to precede the joint disease; in two others the chronological order could not be established. | |
| 822802 | Nuclear fibrous lamina in the rheumatoid synovium. | 1976 Apr | Biopsy specimens of synovial membrane were obtained from patients with rheumatoid arthritis and from patients with nonrheumatoid conditions. Comparison of the mean thickness of the lamina in the rheumatoid and nonrheumatoid groups showed a statistically significant thickening of the lamina in the rheumatoid group (rho less than .01). There was no statistically significant difference in the thickness of the lamina before and after chrysotherapy. | |
| 6583817 | Clinical and immunogenetic studies in rheumatoid arthritis from northern India. | 1983 | A total of 258 patients with classic rheumatoid arthritis seen over a 7-year period were included in this study. The majority of the patients had relatively mild disease at the time of presentation. The incidence of extraarticular manifestations such as subcutaneous nodules, vasculitis, amyloidosis and pulmonary involvement was low although one or two pulmonary function test parameters were abnormal in some. Seventy patients were tested for all three subclasses of rheumatoid factors - IgM, IgG and IgA. Of these, 23 patients had all three whilst four had only IgG. The 62 patients who had most typical and severe manifestations were typed for four major HLA loci A, B, C and DR. Of these 42 (67.7%) had DR4 antigen while DR3 antigen was detected in 14 (22.6%). | |
| 3875567 | Lymphocytapheresis in the treatment of rheumatoid arthritis: clinical and immunological st | 1985 May | Six patients with Rheumatoid Arthritis (RA) have been treated with lymphocytapheresis after their disease proved unresponsive to conventional therapy. Clinical improvement, measured evaluating articular swelling, morning stiffness, and muscle weakness, was observed in four of the six patients. From the cellular point of view lymphocytapheresis induced (1) T cell depletion without modification of lymphocyte subsets in the peripheral blood, (2) improvement of lymphocyte responsiveness to lectins, autoantigens and alloantigens. All together these data suggest that therapeutic leukapheresis modifies the immune responsiveness in humans, possibly facilitating the process of cell to cell cooperation. | |
| 6651364 | The hand radiograph as a diagnostic discriminant between seropositive and seronegative 'rh | 1983 Dec | Although traditional teaching emphasises that 70-80% of patients with rheumatoid arthritis have positive serological tests for rheumatoid factor, a review of the evidence suggests that the seronegative group has distinctive characteristics. In a blinded and controlled evaluation of hand and wrist films we correctly identified the serological status of 43 out of 46 patients satisfying the ARA criteria for 'definite RA'. The radiographic appearances of the seronegative group differed significantly from those of the seropositive group in (1) degree of juxtalesional osteosclerosis (p less than 0.001); (2) the relative absence of classical subchondral erosions (p less than 0.001); (3) presence of new bone formation (p less than 0.001); (4) more fusion (p less than 0.001); (5) more asymmetrical joint involvement (p less than 0.001); and (6) predominant carpal involvement (p less than 0.001). The nature of the destructive process, as defined radiologically, may be different in patients with seropositive rheumatoid arthritis from that seen in individuals with so-called 'seronegative rheumatoid arthritis'. | |
| 6522880 | [Glomerular nephropathies in untreated rheumatoid arthritis. Review of the literature apro | 1984 Nov | Two cases of classical rheumatoid arthritis complicated by the development of a glomerulopathy independently of drug treatment are presented. Renal biopsy showed membranous glomerulonephritis in one case and fusion of foot processes in the second. The literature is reviewed and the possible relationships between rheumatoid arthritis and these glomerulopathies are discussed. The authors conclude to the absence of causal relationship between these two diseases. | |
| 6574363 | Genetic predisposition to two rheumatic diseases. | 1983 Jun 8 | The co-existence of ankylosing spondylitis and rheumatoid arthritis is uncommon and usually occurs in a male with a long history of back pain followed by the appearance of clinical features of ankylosing spondylitis, while features of rheumatoid arthritis develop in the third or fourth decade of life. Recently, histocompatibility (HLA) antigens have partially elucidated the genetic factors predisposing to both diseases. We report a patient with ankylosing spondylitis and rheumatoid arthritis who had the associated HLA genes. | |
| 2863874 | Rheumatoid arthritis and schizophrenia: are they mutually exclusive? | 1985 Aug | The relationship between schizophrenia and rheumatoid arthritis has been explored in a number of studies. It has been claimed that the two disorders are mutually exclusive. Review of the literature indicates that the two conditions seldom coexist. The underlying mechanisms responsible for the infrequent coexistence of schizophrenia and rheumatoid arthritis are far from clear. However, various hypotheses have been proposed to explain the negative correlation between the two diseases. | |
| 6854921 | An autopsy case of rheumatoid arthritis with an involvement of the cardiac conduction syst | 1983 Jun | A case of rheumatoid arthritis with an involvement of the cardiac conduction system was described. The patient was a 65-year-old man who had a 15-year history of classical rheumatoid arthritis combined with an advanced atrioventricular (AV) block resulting in Adams-Stokes seizure. Prior to the occurrence of the AV block, a complete right bundle branch block with a left axis deviation and a first-degree AV block were found on an electrocardiogram (ECG). The histological examination of the conduction system according to the serial sectioning method disclosed that the branching portion of the His bundle and anterior fascicle of the left bundle branch were replaced by the scarring tissue and that the penetrating portion of the His bundle, the AV node and the right bundle branch had rheumatoid granulomatous lesions. The extent and localization of the lesions in the conduction system were well correlated with the findings on the ECG. | |
| 6808066 | Auranofin therapy in rheumatoid arthritis. | 1982 Aug | Gold is well established as an agent to suppress progressive rheumatoid arthritis. Until recently, gold could only be given parenterally. An orally absorbable gold compound, auranofin, has been undergoing clinical trials in the last 6 years. Auranofin has some effects on the immunologic system, demonstrated in vitro, that differ from its parenteral counterpart, GST. Auranofin appears to have clinical effectiveness in rheumatoid arthritis that approximates that of parenteral gold. Although gastrointestinal toxicity is more frequent with auranofin, renal toxicity is distinctly less frequent than with parenteral gold. There is preliminary evidence that auranofin may have a disease-altering capability, as measured by serial radiographs, similar to that of parenteral gold. | |
| 60622 | Oral zinc sulphate in rheumatoid arthritis. | 1976 Sep 11 | A preliminary trial of oral zinc supplementation was conducted in twenty-four patients with chronic, refractory rheumatoid arthritis. Zinc sulphate (220 mg three times daily) or placebo capsules of identical appearance were added to pre-existing therapy for 12 wk. This double-blind trial was followed by an open 12-wk period when all subjects took zinc. During the double-blind phase, zinc-treated patients fared better than controls with regard to joint swelling, morning stiffness, walking time, and the patient's own impression of overall disease activity. The indices and joint tenderness also improved with zinc treatment in both groups of subjects during the second 12-wk period. These encouraging results indicate that oral zinc sulphate deserves futher study in patients with active rheumatoid arthritis. | |
| 846388 | The pseudothrombophlebitis syndrome. | 1977 Mar | Sixty-two patients with popliteal or calf synovial cysts defined by arthrography are presented, of whom 34 had the pseudothrombophlebitis (PTP) syndrome. While the clinical manifestations of PTP may closely mimic thrombophlebitis, including the presence of calf pain, swelling and warmth, and a positive Homans' sign, the helpful descriminating features include the presence of inflammatory joint disease (91%), concomitant pain and swelling of the knee (94%), a demonstrable knee effusion (91%) and the absence of deep venous tenderness or cord. Except for seven patients with large intact Baker's cysts, the PTP syndrome was associated with synovial cyst dissection (18 patients), rupture (5 patients), or both (4 patients). Of those with arthrographically demonstrated Baker's cysts, only 27 (44%) had a palpable mass in the popliteal fossa and another 4 (12%) a mass in the calf. Popliteal fossa pain was noted in 22 (35%). Thus, clinical features are far less sensitive than arthrography in the diagnoses of both synovial cysts and pseudothrombophlebitis. Among patients with rheumatoid arthritis there were no differences in the severity or duration of disease or the extra-articular features in patients with and without synovial custs or the PTP syndrome. The therapeutic implications of pseudothrombophlebitis are of major significance with respect to the avoidance of anti-coagulation and the prompt response to intra-articular corticosteroids. Possible mechanisms of synovial cyst formation and unusual presentations of synovial cysts are discussed, and the literature is reviewed. | |
| 6515290 | Serum glycoproteins and synovial fluid in seropositive and seronegative rheumatoid arthrit | 1984 Oct | An increased level of glycoproteins (seromucoid, protein-bound hexoses, protein-bound hexosamines, protein-bound sialic acids) was found in the blood serum from patients with rheumatoid arthritis (RA) as compared with healthy individuals. Higher glycoprotein content was observed in the seropositive RA patients than in the seronegative ones. Higher levels of glycoproteins was also observed in the synovial fluid from seropositive RA patients than in the seronegative ones. | |
| 6536399 | Rehabilitation of the person with arthritis of the ankle and foot. | 1984 Aug | When combined with skillful pharmacologic management, applying the full stock of biomechanical principles available to the rheumatoid foot and ankle is very effective in avoiding the need for surgery and slowing or preventing deformity. The general principles of arthritis rehabilitation also help restore function. When good medical management, joint protection, exercise, and energy conservation techniques are combined with psychosocial vocational therapy as needed, the crippling loss of function so often seen in the past can be largely avoided. | |
| 849360 | Intracellular collagen fibers at the pannus-cartilage junction in rheumatoid arthritis. | 1977 Mar | Sections of the pannus-articular cartilage junction from a patient with rheumatoid arthritis (RA) were prepared for electron microscopy. Cells at this interface contained membrane-bound collagen fibrils, apparently in various stages of digestion. Previous studies have demonstrated intracellular collagen fibrils at sites of very active and rapid collagen resorption. It is suggested that at certain times in certain patients with RA, phagocytosis of cartilage collagen fragments and subsequent intracellular digestion may serve as a supplemental pathway to extracellular collagen degradation. | |
| 4001890 | Lack of corneal chrysiasis in rheumatoid arthritis patients undergoing oral gold therapy. | 1985 | Corneal chrysiasis is a common consequence of parenteral chrysotherapy in patients affected by rheumatoid arthritis. Concerning the factors and conditions that could be determinant for the gold accumulation in the cornea, there are contradictory opinions. Total or weekly gold dose and its accumulation quota, and the frequency of drug administration, seemed to be parameters to which corneal chrysiasis could be related. Since all these parameters are completely different during oral gold therapy, previous investigations on corneal chrysiasis are inapplicable to patients undergoing oral treatment. This study, performed on rheumatoid arthritis patients treated with auranofin, orally administered for 8-34 months, did not reveal any appreciable corneal deposits of gold. | |
| 999734 | Coagulation abnormalities in rheumatoid disease. | 1976 Nov | Forty-one patients with rheumatoid arthritis, including 6 with acute vasculitis, 13 with chronic vasculitis, and 22 without vasculitis, were studied for evidence of intravascular coagulation and fibrinolysis (ICF). The mean plasma fibrinogen levels were elevated in all groups. The fibrinogen, platelet count, and fibrin split products were usually elevated in acute vasculitis. Fewer patients on corticosteroids had abnormal coagulation tests. Active plasmin was detected in 12 patients primarily with chronic vasculitis. Plasminogen activator activity was not diminished in vascular endothelium of normal appearing skin of those patients with or without vasculitis. None of the patients demonstrated decompensated intravascular coagulation and fibrinolysis. The results suggest overcompensated ICF occurring in rheumatoid arthritis, but rheumatoid patients with vasculitis cannot be clearly distinguished from those without vasculitis on the basis of the usual tests performed for coagulation and fibrinolysis abnormalities. | |
| 3878877 | Autoimmunity to native type II collagen--a distinct genetic subset of rheumatoid arthritis | 1985 Oct | HLA phenotypes were determined in 60 Caucasoid patients with rheumatoid arthritis (RA) and normal serum antibody levels to native type II collagen. Antigen frequencies were compared with 52 patients with RA who had elevated antibody levels to native type II collagen. Both RA groups were compared with 163 healthy controls. A clinical comparison of both RA groups yielded few differences, except a decreased incidence of rheumatoid factor and a positive family history of RA and radiologically, increased osteosclerosis in the RA group with elevated antibodies to native type II collagen. HLA-DR4 was increased and HLA-DR7 was decreased in the RA group with normal antibody levels to native type II collagen. A comparison of both RA groups showed an increased incidence of HLA-DR4 in the normal antibody group, whereas HLA-DR7 was increased in the elevated antibody group. In the elevated antibody group the majority of patients possessed either HLA-DR3 or DR7 both of which are in strong linkage disequilibrium with HLA-DQw2. This immunogenetic data suggests that RA patients with autoimmunity to native II collagen form a distinct genetic subset of RA. | |
| 1084529 | Adjuvant arthritis in T lymphocyte depleted rats. | 1976 Jun | Markedly T lymphocyte depleted rats were prepared by thymectomy, irradiation, and repopulation by bone marrow hematopoietic and lymphoid cells. Such rats had persistent T lymphopenia of about 20% of normal. When T depleted and normal rats were injected with adjuvant, all animals developed arthritis but with slightly less severity in the T depleted animals. Such experiments, and other observations, suggest a complex immunological mechanism in the pathogenesis of adjuvant arthritis in the rat. |