Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 675174 | Tissue atrophy and subcutaneous edema of the rheumatoid hand. A roentgenographic study of | 1978 | Soft tissue radiography of the hands using a mammographic immersion technique was performed on 119 patients having definite or classical rheumatoid arthritis and on 123 controls of matching age, sex and professional distribution. The grade of soft tissue atrophy in the hands was visually estimated from the radiographs and the combined cortical thickness of the second metacarpal shaft and skin thickness of the lateral side of the hand were measured. The stage of chronic edema in the absence of synovitis was estimated. Local bone cortical thickness and skin thickness have a highly significant correlation to the estimated atrophy grade. Soft tissue atrophy of hands is a sign which appears in chronic rheumatoid arthritis, especially in elderly females and has a clear correlation to the number of other irreversible radiographic signs in the hands. The incidence of moderate or advanced atrophy was 21% in rheumatoid patients. Chronic edema was found in 16%, mostly in connection with atrophic changes. A lymphatic origin of this sign is suggested. | |
| 6794868 | [Chronic polyarthrosynovitis in the goat: histological and physicochemical study of an ani | 1981 Sep 28 | The aim of this paper is to describe clinical pattern and pathogenesis of spontaneous chronic polyarthritis observed in Swiss goats. Roentgenograms, histologic findings, ultrastructural study and microprobe analysis of synovium samples show apatite microcrystal deposit ion. Thus this spontaneous goat disease may be related to apatite microcrystal deposit ion disease in man, so called crystallopathic-hydroxyapatite rheumatism. | |
| 6610751 | Antibody to rheumatoid arthritis associated nuclear antigen (RANA) in familial rheumatoid | 1984 Jun | A search was made for the presence of antibody to the rheumatoid arthritis (RA) associated nuclear antigen (RANA) in the sera of 57 affected and unaffected members of 10 families with multiple members affected with RA. While anti-RANA was frequently observed among the seropositive affected individuals with definite or classical RA (60%), it was less frequently observed among those family members who had incompletely expressed disease, and rarely among normal close family members including those sharing haplotypes with the affected index case. An HLA haplotype containing B8, DR3 was more frequently seen among anti-RANA positive (61%) than anti-RANA negative (44%) RA patients. These data do not support a primary early role for the Epstein-Barr virus related antigen RANA in the etiology of RA. They may indicate a possible influence of the complete haplotype HLA-B8, DR3 on the expression of anti-RANA in established RA. | |
| 6581669 | Temporomandibular joint involvement and dental occlusion in a group of adults with rheumat | 1983 Oct | The temporomandibular joint (TMJ) and dental occlusion were investigated clinically and radiographically in 59 patients aged 23-83 (mean, 58) years with general joint disease. Forty-nine had rheumatoid arthritis (RA), mostly of long duration. The patients were divided into four groups by type of dentition. Radiographic TMJ abnormality was found in about 4 of 5 patients with RA, in both the dentate and the edentulous group. The abnormality was mainly destructive with productive signs, but in the edentulous group erosive and asymmetrical changes occurred more often. Almost complete restriction of the condylar translation and severely restricted mouth opening (less than or equal to 30 mm) rarely occurred, although the translatory motion was restricted in several patients. Many of these had a satisfactory mouth opening (greater than 40 mm). Occlusal changes-various degrees of anterior bite opening-were reported by about one fourth of both the dentate patients and the complete denture wearers. One patient had occlusal contact on the second molars only. Anterior bite opening occurred only in patients with radiographic TMJ abnormality, including 5 of the 6 patients with complete mandibular head destruction. | |
| 956245 | The Shiers arthroplasty of the knee. | 1976 Aug | Thirty-one patients with rheumatoid arthritis were reviewed after Shiers arthroplasty of the knee joint for which the main indication was intractable pain. Seven patients had the operation done to both knees. This review was done to assess the long-term results two to seven years later. All patients were clinically and radiologically assessed, and our results showed that pain and instability recurred within eighteen months. Thus it is likely that a prosthesis which allows rotation, and in which the bearing surfaces are metal on plastic, will replace the Shiers prosthesis. | |
| 6512801 | Predictors of outcome at two years in patients with rheumatoid arthritis. | 1984 Dec | The prognostic value of clinical and laboratory measures in 72 patients with rheumatoid arthritis (RA), seen initially within 18 months of disease onset, in predicting function outcome after a further two years was assessed. Limitation of wrist extension was associated with a slow disease onset, a high articular index and a high latex titre. A reduction in global functional capacity, as measured by the Stanford Health Assessment Questionnaire, was associated with a high initial articular index and a high latex titre. Neither outcome was associated with the initial level of acute phase reactants nor with patient or physician's initial assessment of disease activity. It is concluded, first, that factors predicting early disability outcome in RA are not identical to those associated with continuing disease activity; and secondly, that patients' and physicians' judgment of disease activity at diagnosis do not carry any prognostic value for functional outcome two years later. | |
| 6800538 | Circadian variation in disease activity in rheumatoid arthritis. | 1982 Feb 20 | Disease activity in rheumatoid arthritis as measured by repeated estimation of joint pain, stiffness, articular index, and grip strength was shown to have a circadian rythm, maximal activity being seen between 0200 and 0400 and minimal activity in the early afternoon. This variation in disease activity may be related to circadian alterations in immune and inflammatory responses (such as immune complexes and neutrophil function) dependent on alterations in circulating concentrations of steroids. The circadian variation in disease activity has important implications in assessment of patients, prescription of drugs, and performance of drug trials. | |
| 377474 | Deposits of immunoglobulins and complement in skin of patients with rheumatoid arthritis. | 1979 | Immunopathological studies on skin biopsies from 88 patients with rheumatoid arthritis showed that one-third of them had deposits of IgM and/or C3 in the walls of small vessels immediately underneath the dermal-epidermal junction. The deposits in the vessel walls which may reflect subclinical immune complex vasculitis could be correlated to the occurrence of IgG-rheumatoid factor in the serum, but not to IgM-rheumatoid factor, other extra-articular manifestations, or to the occurrence of circulating immune complexes demonstrated by the complement consumption test or the thrombocyte aggregation test. Two untreated patients had granular deposits in the dermal-epidermal junction. Five out of 50 patients developed deposits in the dermal-epidermal junction during treatment with levamisole, penicillamine, or azathioprine, as observed by serial skin biopsies. | |
| 1112093 | Rheumatoid arthritis in a dog. | 1975 Jan | Rheumatoid arthritis was diagnosed in a 5-year-old Golden Retriever. Diagnosis was made on the basis of historoclinical, laboratory, and radiographic findings, a positive rheumatoid factor titre, and compliance with the American Rheumatism Association criteria for diagnosis of rheumatoid arthritis in man. Satisfactory remission was obtained with buffered aspirin. | |
| 3929938 | Screening for antimalarial maculopathy in rheumatology clinics. | 1985 Sep 21 | Ophthalmoscopy and three tests of visual function were undertaken in 39 patients with rheumatoid arthritis receiving treatment with antimalarial drugs and in a control group of 16 patients with rheumatoid arthritis who were not receiving such treatment. Visual contrast sensitivity, macular threshold to red light, and central visual fields to red targets were not significantly different in treated patients and controls. There were no abnormalities in visual acuity, but 11 of 76 eyes of treated patients showed minor macular abnormalities on ophthalmoscopy that were not seen in control patients, suggesting that ophthalmoscopy may be the most sensitive measure of early drug toxicity. Five rheumatologists were able to identify 52 of 65 minor changes detected by an ophthalmologist. These studies, and a critical review of published reports, suggest that in clinical practice antimalarial drugs can be administered safely to patients with rheumatoid arthritis without the need for repetitive routine examination by an ophthalmologist or the use of complicated physiological tests. Recording of visual acuity in each eye and ophthalmoscopy by the prescribing doctor may be all that are required to detect early antimalarial maculopathy. | |
| 6796009 | Biochemical indices of response to hydroxychloroquine and sodium aurothiomalate in rheumat | 1981 Oct | Biochemical and clinical changes have been monitored in 30 patients with rheumatoid arthritis treated with either hydroxychloroquine or sodium aurothiomalate over a period of 6 months. Acute-phase reactants improved in both treatment groups, while serum sulphydryl and serum histidine improved only in the gold-treated patients. Correlation matrices were constructed from mean clinical and biochemical data at successive clinic visits. Correlations obtained with gold were more frequent and of a higher level of significance than those obtained with hydroxychloroquine at the doses we studied. This lends support to the use of correlation matrices as a screening test for potential long-term antirheumatoid activity of drugs in man. | |
| 3875717 | Clinical features, autoantibodies and HLA-DR antigens in rheumatoid arthritis. | 1985 Apr | HLA-DR4 was associated with seropositive but not seronegative disease in 105 Caucasians with rheumatoid arthritis (RA). There were no clinical or radiological differences between DR4 positive and negative RA groups, although 7 of 8 patients with early disease onset (less than 30 yr) were DR4 positive. High rheumatoid factor (RF) titers were more frequent in DR4 negative RA. A plot of the frequency distribution of RF titers in DR4 negative disease showed a bimodal distribution with seronegative and high titer groups. HLA-DR3 was not associated with high RF titers but was associated with high titers of antinuclear antibodies. | |
| 155621 | [Baker cysts: an accompaniment of chronic diseases of the knee joint (author's transl)]. | 1979 May | One hundred and twenty one Baker cysts demonstrated by arthrography have been analysed. Morphologically one must distinguish between distension cysts and dissection cysts. Distension cysts are more common with various diseases of the knee joint (68% of all cysts). Dissection cysts (32%) are found particularly with inflammatory-rheumatic diseases and are rarely of degenerative or post-traumatic origin. Acute rupture of the cyst was observed on ten occasions. Repeated rupture, which had only been suspected previously, was demonstrated by arthrography in four patients. It is pointed out that Baker cysts may imitate the features of acute thrombophlebitis. | |
| 6264593 | Sensory neuropathy in rheumatoid arthritis: an electroneurographic study. | 1981 | In a selected series of twenty-three RA patients, aged from 23 to 56 years, mean 41, the neurophysiological functions of six sensory nerves were measured and the results were correlated with clinical and laboratory data. Significant changes in the functions of one or more nerves were found in 10 patients, 2 of whom had no symptoms of clinical neuropathy. There was a highly significant correlation between neurophysiological symptoms and clinical neuropathy symptoms, although the combination of the clinical and electrophysiological findings was variable. On the other hand, there was no significant correlation between neurophysiological/neurological findings and clinical/laboratory data (age, sex, duration of disease, stage of disease, rheumatoid factor and erythrocyte sedimentation rate). Manifest or sub-clinical mono-neuropathies in n. medianus were found in 5 patients. In the light of these results it would seem in order to recommend the inclusion of an electro-neurophysiological examination of the medianus nerves of RA patients in routine diagnostic procedures. | |
| 504949 | [Lymphocyte populations in the blood and synovial fluid in rheumatoid polyarthritis. Impor | 1979 Jul | We have studied the synovial and blood lymphocyte populations of 18 patients with rheumatoid arthritis. Two methods have been used: the membrane markers (E rosette, active E, EA, EAC) and lymphocyte electrophoresis. The authors find no significant difference beteween the blood populations of the patients with the PR and that of the controls. On the other hand, the study of the synovial fluid shows a large number of lymphocytes T forming active rosettes having an electrophoretic mobility of about 1,10. In order to explain the presence of lymphocytes with high affinity for sheep red cells, and having a reduced electric charge in the synovial fluid, we propose two explanations: the first one is a selective filtration through the synovialmembrane of a physiological T subpopulation; the second one is a general modification of the lymphocyte membrane in relation with a stimulation or an intraarticular cellular alteration. In the discussion we report the arguments in favour of the two hypothesis. | |
| 6084372 | Distribution of mast cells in human synovial tissue of patients with osteoarthritis and rh | 1984 Nov | Mast cells are demonstrated in synovial membranes of patients with osteo-arthritis and rheumatoid arthritis using a new staining principle based on interaction of heparin in mast cell granules with peroxidase labeled avidin. It was found that mast cell numbers in the subsynovial layer of patients with rheumatoid arthritis were significantly lower than those in patients suffering from osteo-arthritis. This decrease can be mainly attributed to patients with rheumatoid arthritis whose synovitis was characterized by a distinct histomorphological pattern consisting of lining cell ulcers and granulation tissue. However, when mast cell numbers in rheumatoid arthritis and osteo-arthritis patients were compared without respect to mast cell distribution in the subsynovial layer or the stratum fibrosum, no statistical differences between the diseases could be observed. | |
| 4081998 | [Changes in the functional state of the cardiovascular system as an indicator of the gener | 1985 | Multimodality clinical and physiological studies on the CVS in patients with rheumatoid arthritis (56), deforming osteoarthrosis (97) and systemic scleroderma (29) before and after various mud application procedures during the entire course of treatment showed that the CVS sensitively responded to the mud effect. As to the nature and expression of reactions peloid applications produced a general effect on the body; the most informative reactions were hemodynamic effects, changes of indices of intervalograms and the capillary blood flow. The hemodynamic effect was of a hypodynamic type of the CVS adaptation response to mud therapy. The author proposed that these indices should be used as tests for working out methods of control of the process of mud therapy and for other practical problems of pelotherapy. | |
| 370768 | [Critical study of techniques for the detection of "light" rheumatoid factors (author's tr | 1978 Dec 30 | In a number of cases of true rheumatoid arthritis, it is not possible to demonstrate the presence of 19 S "heavy" rheumatoid factors by the Waaler-Rose and globulin latex techniques. However, in some of them, 7 S rheumatoid factors are suspected. Three techniques for the detection of these "light" rheumatoid factors are described and critically evaluated. The authors report their own experience of the immuno-absorption and indirect immunofluorescence technique performed on 156 sera from RA patients. Immuno-absorption is not felt to be a reliable technique on several grounds. Indirect immunofluorescence is of value only in the diagnosis of seronegative rheumatoid arthritis where it provides information in addition to that offered by classical techniques. It is positive in 53.3% of seronegative rheumatoid arthritis sera. | |
| 1258567 | [Clinical and histopathological findings in mycoplasmal polyarthritis of rats. III. Course | 1976 Jan | Clinical, microbiological and histological findings of the late phase of experimentally induced Mycoplasma-polyarthritis in rats are described. Investigations were carried out between the 7.-30. week and between the 54-61. week p.i. M. arthritidis could be reisolated from affected joints regularly up to the 7th week p.i. Thereafter until 12th week only occasional recovery was possible. The healing process of affected joints dominated signs of arthritis which could be confirmed histologically as a purulent process. The alterations of carpal and tarsal joints were divided into purulent, chronic deforming and chronic minor lesions. The findings derived from investigation of joints and parenchymatous organs during the course of the disease are discussed. | |
| 7224682 | A prospective study of the radiological changes in the cervical spine in early rheumatoid | 1981 Apr | The cervical spine radiographs of 100 patients with early rheumatoid disease were studied annually, on a prospective basis, for a mean follow-up period of 7 years 2 months. Atlantoaxial subluxation developed in 12 patients. The subluxation was more frequent in females, more severe in patients with progressive, seropositive, erosive rheumatoid disease, and more marked in patients treated with oral corticosteroids. Subaxial subluxation, affecting upper cervical disc levels, occurred in a further 20 patients. Three patients developed vertical subluxation. The mobility of the cervical spine affects the degree of subluxation achieved, and when assessing serial films for subluxation it may be necessary to measure the cervical spine flexion before deciding whether subluxation has progressed or not. Over 80% of the patients with subluxation developed the first evidence of subluxation within 2 years of disease onset. Subluxation in the cervical spine is not, therefore, a late complication of rheumatoid disease. During the follow-up period none of the patients developed neurological signs. |