Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 2772758 | [Evaluation of the 1987 revised ARA criteria for rheumatoid arthritis in Japan]. | 1989 Apr | Three hundred and sixty two Japanese patients with rheumatoid arthritis (RA) and 455 patients with other rheumatic diseases (SLE 233, PSS 63, MCTD 51, PM-DM 41 Behcet's disease 33 and OA 33) were examined for the evaluation of the 1987 revised ARA criteria for RA. In our cases sensitivity was slightly decreased and specificity was markedly increased 5 out of 7 criterions compared with the results reported by ARA. In the investigation how many number of criterions at least which the patients with RA should satisfy, 4 out of 7 criterions in the 1987 criteria turned out the highest figure in the accuracy (the mean of sensitivity and specificity values). So the patients who satisfied at least 4 criterions were classified to have RA. Sensitivity of the 1987 criteria decreased to 90% although that of the 1958 ARA criteria was 93%. Specificity were markedly increased from 88% to 95% (the 1958 and 1987 criteria, respectively). These results might be based on the revision of the duration of "morning stiffness" (lasting at least 1 hour) and on the deletion of "joint pain or tenderness" which was relatively less specific for RA. | |
| 3430519 | The joint alignment and motion scale: a simple measure of joint deformity in patients with | 1987 Oct | We developed a simple 5 point scale, the Joint Alignment and Motion (JAM) Scale, to estimate joint deformity in patients with rheumatoid arthritis (RA). The scale is based on an estimate of the percent of normal range of motion and joint alignment and requires 5 min to perform when added to a typical joint count. This deformity measure has good interobserver reliability (r = 0.72) and appears stable over time. The JAM score measures joint characteristics distinct from tenderness and swelling and correlates strongly with functional measures (walk time, grip strength and self-reported functional status). Joint deformity should be considered when interpreting functional measures for patients with RA. | |
| 2084246 | Rheumatoid disease resembling lung neoplasia. | 1990 Dec | We describe a 67-year-old man with severe rheumatoid arthritis of long duration. He developed a peculiar extraarticular rheumatoid complication consisting of localized lung consolidation with a pathological costal fracture, together with an abrupt systemic reaction that occurred in the course of immunosuppressive treatment. The diagnosis first proposed was lung cancer with costal metastases. However exhaustive studies performed in the search of malignancy were systematically negative and pathologic studies finally demonstrated bronchiolitis obliterans with organizing pneumonia (BOOP) as responsible for parenchymal lung consolidation with a rheumatoid nodule eroding bone at the level of the rib fracture. These findings, after long followup of the patient, attest to the rheumatoid origin of his bizarre manifestations and definitely rule out a neoplastic etiology. | |
| 2675369 | [Importance of determining the beta2-microglobulin level in biological fluids in patients | 1989 | The level of beta 2-microglobulin (beta 2-MG) in blood and urine was measured in 97 patients with rheumatoid arthritis. In 42 of them, the measurements were made in the synovial fluid. The level of beta 2-MG was found to depend on the process activity, the magnitude of the articular count, and on the disease duration. It was shown that the drug treatment pattern influenced the content of beta 2-MG in blood, urine and synovial fluid. In 12 out of the 97 patients with rheumatoid arthritis, the measurement of beta 2-MG in blood and urine made it possible to determine the involvement of the kidneys into the pathological process. | |
| 2311344 | Histocompatibility antigens (A, B, C, and DR) in Arabs with rheumatoid arthritis. | 1990 Jan | Eighty-five Arab patients in Kuwait with classical and definite rheumatoid arthritis were typed to examine the frequency of HLA-A, B, C, and DR antigens. The results showed a significant increase in the frequency of HLA-A10, B8, B21, and DR3 antigens when compared to an age- and sex-matched control population. HLA-DR3 was present in 34 per cent of the patients compared with 2 per cent of the controls (p less than 0.001). The association of RA in the Arab population with HLA-DR3 rather than HLA-DR4 or HLA-DR1 as reported in other ethnic groups emphasizes further the complexity of the genetics of RA. | |
| 3361535 | The clinical and immunological effects of pulse methylprednisolone therapy in rheumatoid a | 1988 Feb | Marked effects on C reactive protein, circulating immune complexes, rheumatoid factor and immunoglobulin levels were demonstrated in a group of 40 patients with rheumatoid arthritis, who received pulse methylprednisolone therapy, either as sole treatment or in combination with a disease modifying agent. The only patient groups in which these serological changes were maintained were the groups taking disease modifying agents, with the more significant and sustained changes occurring in the group of patients who started a disease modifying agent at the time pulse therapy was begun. No significant effect of pulse therapy on neutrophil or lymphocyte counts or lymphocyte subsets could be demonstrated. Pulse therapy, per se, did not have a significant effect on the results of intradermal delayed hypersensitivity testing in any patient group. | |
| 1954697 | Histopathological study of iron deposit distribution in the rheumatoid synovium. | 1991 Sep | A qualitative and semi-quantitative evaluation of synovial iron deposits in 20 patients with rheumatoid arthritis (RA) and in 12 patients presenting with degenerative and traumatic joint disease was carried out. Ferric iron deposits, abundant and preferentially distributed in the superficial and deeper connective tissue layers in the RA patients, were more limited and prevalently sited in the synovial lining layer in the controls. These results further underline the increase in synovial iron stores found in active RA and the role played by iron deposits in sustaining inflammation, as has been reported in the literature. | |
| 2664987 | [Plasma macroproteins in the evaluation of the effectiveness of therapeutic plasmapheresis | 1989 Jan | In 32 patients with RA before and after lymphocyto- and/or plasmapheresis the authors determined the content of high molecular protein fraction (macroproteins) in the blood plasma. In the consecutive analysis of the body response and procedure effects it was found out that decrease in the level of macroproteins correlated with the changes of immunological status and state of the patients. The index of macroproteinemia can be used for quantitative assessment of plasmacytopheresis effect. | |
| 3361534 | The clinical and immunological effects of pulse methylprednisolone therapy in rheumatoid a | 1988 Feb | The clinical effects of pulse methylprednisolone therapy were studied in 40 patients with rheumatoid arthritis. A response to pulse therapy was achieved in all but 2. The duration of response to pulse therapy alone was relatively short, but could be increased greatly by the concomitant initiation of treatment with a disease modifying agent. | |
| 3199397 | Early detection of carpal erosions in patients with rheumatoid arthritis: a pilot study of | 1988 Sep | A pilot study comparing standard radiography to magnetic resonance imaging (MRI) was performed on the wrists of 10 patients with early (anatomic Stage I or II) rheumatoid arthritis (RA). MRI was found to be superior to standard radiographs in 2 respects: (1) synovial inflammation was impressively demonstrated on T2 weighted images, whereas plain films merely suggested soft tissue swelling; and (2) T1 and T2 weighted images clearly revealed erosions of several carpal bones which were not noted on standard radiographs. Although the expense of MRI currently precludes its routine use in clinical practice, the apparent sensitivity of this diagnostic modality for detecting early changes in RA might make it an invaluable tool for therapeutic decision making or for assessing response in interventional trials. | |
| 2717561 | Thoracoscopy in rheumatoid pleural effusion. | 1989 Feb | In rheumatoid pleural effusion a positive diagnosis can be made by thoracoscopy, preferably supported by the identification of microscopic structural changes in the parietal pleura. Biochemical changes and the finding of the so-called rheumatoid arthritis cells (RA-cells) are non-specific. | |
| 3744718 | Induction of arthritic processes by synovial fluids of rheumatoid arthritis patients in lo | 1986 | Diluted synovial fluids derived from three patients with rheumatoid arthritis (RA) and applied subcutaneously once as a single dose in Swiss mice caused arthritic processes after a long period of latency (10 months). The arthritis-inducing effect was enhanced by storing the original synovial fluids at 4 degrees C for three months. The effects were followed histologically for at least 18 months. In contrast to the theory that RA is based on immunological processes, these preliminary observations support the finding of other authors that a transmissible agent which is rather slow-acting exists in the synovial fluid of RA patients. | |
| 2491400 | [The value of individual laboratory tests in the evaluation of inflammatory activity in rh | 1989 | In 65 patients with definite or classical rheumatoid arthritis (RA), according to ARA criteria, and the active disease, we studied the correlation of the clinical status (the number of the swollen and tender joints) with the following laboratory parameters: sedimentation rate, C-reactive protein, serum iron level, haemoglobin content and the number of erythrocytes, leucocytes and thrombocytes in the peripheral blood. All patients received nonsteroidal antiinflammatory drugs; 25,5% of them were on small daily doses of corticosteroids, and most of them (76,5%) were receiving some of the second-line drugs. The acceleration of the sedimentation rate was the most useful laboratory parameter and was found in 96,9% of the patients, followed by an increased quantity of the alpha-2 globulin, sideropenia and a decreased level of haemoglobin. Increase in the CRP titer was found in this study to be of a rather modest value and was increased in only 40% of the RA patients. | |
| 2397626 | Low-field MRI in the evaluation of rheumatoid cervical spine. Comparison with neurological | 1990 Jul | The usefulness of a low-field magnetic resonance imaging (MRI) instrument in the evaluation of cervical spine abnormalities was studied in 20 patients with rheumatoid arthritis and known anterior atlantoaxial subluxation (AAS) (16 patients) or other cervical spine abnormalities (4 patients). The MRI results were compared with routine plain radiographs and with neurological findings. Three patients had a clinical suspicion of cervical spinal cord compression. This was confirmed by MRI, which additionally detected one more patient with compressive myelopathy. Anterior AAS in MR images was seen in 4 patients, but proper flexion images were not obtained. Atlantoaxial impaction was detected by a recent method of Sakaguchi-Kauppi in 16 patients as compared to 9 patients by the McGregor method and 4 patients by MRI. Most of the clinically important consequences of rheumatoid cervical spine are seen with a low-field MR imager, but detailed bony changes and precise measurements are better evaluated with plain X-rays. | |
| 3396250 | Long-term follow-up of technetium articular index in rheumatoid arthritis patients during | 1988 Jan | The Technetium Articular Index (TcAI) is regarded as a parameter of local inflammation in rheumatoid arthritis (RA). We studied TcAI behaviour during 1-year chrysotherapy in a group of fifteen RA patients. In non-responders TcAI showed a gradual decrease up to the 6th month and a return to baseline values within the second semester of the follow-up; conversely, in response patients TcAI remained unchanged during the entire period of the study, thus showing a paradoxical behaviour probably depending on the recovery of normal physical ability and articular activity. | |
| 2061662 | The Nicolle finger joint prosthesis: a reappraisal. | 1991 May | The Nicolle prosthesis was used to replace 101 metacarpophalangeal joints in patients with rheumatoid arthritis over a ten-year period. Mean active flexion achieved was 30 degrees. Mean ulnar deviation was 27 degrees. 4% of joints had to be removed after a mean interval of 42 months, for infection. None of the implants had fractured. | |
| 2671365 | Clinical characteristics affecting survival in patients with rheumatoid arthritis undergoi | 1989 Jul | A controlled study of the clinical characteristics affecting survival in patients with rheumatoid arthritis (RA) with cervical spine involvement treated surgically demonstrated a strong association between disease severity, the frequency of severe extraarticular manifestations, especially interstitial lung disease, and a decreased probability of survival. These probabilities at 1 and 5 years postoperatively were 74 and 54%, respectively. Death resulted most often from infection or comorbid conditions. All surgery patients with interstitial lung disease died within 28 months postoperatively. In patients with RA undergoing cervical spine surgery, fatality rates appear to be increased in patients with severe extraarticular manifestations, especially interstitial lung disease. | |
| 3620278 | Radiological evaluation of erosions: a quantitative method for assessing long-term remitti | 1986 | 1 The most reliable method for evaluating possible remission-inducing properties in a drug is to measure how well it prevents the appearance of new erosions in serial X-rays of the hands. 2 I have reviewed the literature on the development, over the last 25 years, of a standard method for quantitatively assessing the progress of erosions radiologically. 3 The only drugs thus far shown to be genuinely remission-inducing are cyclophosphamide, high-dose penicillamine, and (most consistently over several decades) gold-thiols, all drugs with life-threatening toxicity. 4 The search for a non-steroidal drug with remission-inducing properties is crucial in our efforts to find a safe drug to control the progression of rheumatoid arthritis. | |
| 2926407 | Nonconstrained total elbow arthroplasty. Development and results in patients with function | 1989 | Twenty-four nonconstrained total elbow arthroplasties (TEAs) in 20 patients with severe disabling functional class IV rheumatoid arthritis were reviewed retrospectively to determine the effects of their disease on the end result. The mean follow-up period was 6 years (range, 2-11 years). All planes of elbow motion improved after surgery (P less than .005), there was a highly significant reduction in pain and improvement in function (both P less than .005) and patient satisfaction was high. The severity of the disease does not appear to affect the end result when a nonconstrained TEA is used, and the results compare favorably with those of other series reported. | |
| 1802492 | Rheumatoid nodules do not predict response to treatment with slow-acting anti-rheumatic dr | 1991 Dec | Rheumatoid nodules have been associated with a poor long-term prognosis. We investigated whether they predict a poor response to treatment with slow-acting anti-rheumatic drugs (SAARDs). Two hundred and twenty-eight patients with rheumatoid arthritis (RA) were treated for six months with a SAARD. Clinical and laboratory assessments of disease activity were made initially and after 6 months' treatment. Patients were divided into two groups according to the presence or absence of nodules at entry. Twenty-one % had nodules before treatment but their response was no different to patients without nodules (79%), both groups showing improvements in all variables. Males were more likely to develop nodules and had a relative risk of 1.7. High titres of rheumatoid factor correlated with nodules and no sero-negative patients had nodules. We conclude that nodules are not predictive of poor response to treatment with a SAARD, despite their presence being associated with a poor long-term prognosis. One possible implication is that SAARDs themselves, despite an early response, may not effect long-term outcome. |