Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 3828666 | Erythrocyte sedimentation rate, plasma and serum viscosity as measures of disease activity | 1987 Apr | The activity of rheumatoid arthritis was assessed in 96 unselected out-patients by performing a number of clinical measurements and comparing them to ESR, plasma and serum viscosity. It was found that ESR correlated with clinical parameters better than did both plasma and serum viscosity. These tests were repeated 3 months later in 87 of the same patients and again change in ESR correlated with change in disease activity better than did change in plasma viscosity. Plasma viscosity was a consistently more reliable measure of disease activity than was serum viscosity. | |
| 2057713 | [Orthopedic surgery in rheumatoid polyarthritis]. | 1991 Apr | The authors have determined the timing and details of the recourse to surgery in a cohort of 288 non-selected cases of rheumatoid arthritis. This was necessary in one third of the patients after a mean follow-up period of 10 years. The same was true for patients followed up as out-patients as for those hospitalized during the active progress of the disease. Fifteen percent of the patient in the cohort received total replacement of a large joint by a prosthesis. Orthopedic surgery makes a major contribution towards improving the functional prognosis in rheumatoid arthritis. | |
| 2767751 | A practical test and its value in rheumatoid arthritis. | 1989 Feb | A practical test distinguishing some pathological conditions from the healthy state is described and a preliminary study on the value of this test for determining the disease activity in rheumatoid arthritis (RA) is presented. In this disease, the test was found positive in 97% of the cases, while rheumatoid factor (RF) was present in 57%, C reactive protein (CRP) in 83%, and elevated erythrocyte sedimentation rate (ESR) in 93% cases. When the activity of the disease disappeared, the test became negative. This test may be useful in RA for determining the active phase and evaluating treatment. | |
| 3590005 | [The use of contact thermography for evaluating joint inflammation in rheumatoid arthritis | 1987 | The paper is concerned with the results of a study of the hand joints in patients with different variants of a course and activity of rheumatoid arthritis by a method of contact liquid crystal thermography. Methods for assessment of thermography taking account of qualitative and quantitative indices were described. They showed correlation with a degree of disease activity, the presence of the rheumatoid factor, extraarticular symptoms and a time-period. Probable pathogenetic mechanisms of occurrence of characteristic thermographic shifts in rheumatoid arthritic patients were discussed. | |
| 2213765 | Rheumatoid arthritis in a patient with sickle cell disease. | 1990 Jul | Sickle cell disease has various articular manifestations. Coexistent rheumatoid arthritis (RA) and sickle cell disease has been reported rarely. We present a patient with sickle cell disease and seropositive erosive RA demonstrating characteristic radiographic findings of the 2 entities. | |
| 2181947 | Subcorneal pustular dermatosis associated with rheumatoid arthritis and raised IgA: simult | 1990 Mar | A 44 year old white woman with rheumatoid arthritis for 19 years developed subcorneal pustular dermatosis. She had increased polyclonal IgA and IgA rheumatoid factor. After 4 months' treatment with dapsone 100 mg daily the patient had neither skin lesions nor active joint disease. | |
| 2402603 | Influence of oral contraception on the occurrence of rheumatoid arthritis in female sibs. | 1990 | ||
| 3423824 | Bone mass in patients with rheumatoid arthritis. | 1987 | Bone loss was evaluated in 118 patients with rheumatoid arthritis by measurement of the total width and marrow cavity of the second metacarpal bone. Both in men and women a significant increase in width of the medullary cavity could be demonstrated, probably due to bone loss at the endosteal surface. Although a certain increase in the total width of the second metacarpal bone took place in men but not in women, combined cortical thickness and metacarpal bone mass decreased significantly. There was no significant difference in the values in patients on gold treatment and in patients without systemic treatment, while patients treated with steroids demonstrated a significantly greater loss of endosteal bone compared to the other two groups. Some correlation was found between the severity of joint involvement and the measured loss of cortical bone. In summary, the study shows that bone loss takes place in patients with rheumatoid arthritis, being most pronounced in steroid-treated patients, in postmenopausal women, and in patients with more severe joint involvement. | |
| 3602948 | A seventeen-year follow-up of a population survey of rheumatoid arthritis. | 1987 | A population survey was carried out in Stockholm during the period 1965-67 for the purpose of determining the prevalence of rheumatoid arthritis (RA). 239 subjects with RA were found in a random sample of 15,268. In 1983, 17 years later, all the 127 persons still living could be traced, 109 of whom were re-examined. In 95, all the information required to satisfy the New York diagnostic criteria was available, i.e. with radiographs of the hands and feet and a Waaler-Rose test. The number of subjects with involvement of at least 3 joints (criterion No. 2) had decreased from 72 to 36, while the persons with a positive Waaler-Rose test (criterion No. 3) had increased from 9 to 18. The total number of fulfilled criteria showed a reduction from a median of 2 criteria to 1. The Steinbrocker functional class remained unchanged for the group as a whole (median Class 2), with a significant deterioration only in the oldest age-group (from 2 to 3). The knee was most often the single joint in which the disease had started and also the joint which caused the subjects the most inconvenience at the follow-up. Medical records were traced for 85 of the 112 who had died. Among them, 44 cases of RA or polyarthritis were noted. The present study gives a conception of RA in the population, as well as of its development over a long span of time. | |
| 1804381 | Collagen-induced arthritis--characteristics of the animal model and implications for the t | 1991 Jun | Collagen-induced arthritis (CIA) is a chronic polyarthritis induced in mice and rats by immunization with homologous or heterologous type II collagen (CII). In this study, we report on a variety of experiments designed to elucidate the characteristics of CIA and its potential application in the treatment of human disease. The notable results were as follows: Both mouse anti-human-CII monoclonal antibody and a mouse T cell clone reactive to human CII were able to provoke arthritis when i.v. injected into naive mice. When injected together, a synergistic enhancement of the incidence and severity of passive arthritis was seen. However, inoculation with irradiated T cells reactive to human CII could suppress the development of active CIA. Given these results and the fact that CIA closely resembles rheumatoid arthritis both clinically and histologically, we suggest that the CIA animal model provides a good tool for studying the potential of T cell vaccination as a means of treating or preventing human autoimmune diseases. | |
| 3666433 | Classification of rheumatoid arthritis: the importance of including data from the siblings | 1987 | A discriminant analysis has been applied to physical and laboratory data on a series of 37 patients with rheumatoid arthritis (RA). Good discrimination was found between RA when it was associated with organ-specific autoimmune phenomena and when it was not. When data from other members of the families was included there was consistently better discrimination than when using data from the patients alone. The results suggest that future studies of classification of variable diseases should include study of relatives. | |
| 2368368 | [Immunocorrective therapy of patients with rheumatoid arthritis]. | 1990 Mar | The clinico-immunological efficacy is shown of including timoptin, levamysol, sodium nucleinate in the complex treatment of patients with rheumatoid arthritis who received glucocorticosteroids. It was found that employment of immunoregulating agents allowed to correct the immunological insufficiency in patients with rheumatoid arthritis, to increase the treatment efficacy. | |
| 2080687 | [Attempt at staging articular changes in rheumatoid arthritis using magnetic resonance tom | 1990 Sep | Sixty-four examinations of the wrist in patients with rheumatoid arthritis by magnetic resonance imaging using a 0.23 TESLA magnet showed a great sensitivity in detecting proliferative partly exudative or destructive synovialitis, as is common in rheumatoid arthritis. In accordance to the Larsen system for grading rheumatoid arthritis lesions by conventional x-ray, we establish a clinically relevant magnetic resonance grading system which is able to diversify the stages of destruction and inflammative activity in rheumatoid arthritis. | |
| 1856815 | Nocardia asteroides infection complicating rheumatoid arthritis. | 1991 Mar | We describe a case of pulmonary nocardiosis in a patient with rheumatoid arthritis (RA) receiving treatment with combined immunosuppressive agents and prednisone. This infection is still considered rare, hard to diagnose, and difficult to treat. To the best of our knowledge, such a case has not been described in a patient with RA. | |
| 2856595 | Intravenous immunoglobulin treatment of rheumatoid arthritis-associated immunodeficiency. | 1988 | Three patients with rheumatoid arthritis were treated with weekly intravenous injections of immunoglobulin. All three reported definite improvement with treatment. One subsequently dropped out of therapy and experienced recurrence of symptoms. It is concluded that intravenous immunoglobulin is a potentially effective agent in the therapy of rheumatoid arthritis and possibly other autoimmune diseases. Further investigation of its mechanism of action as well as its clinical effectiveness is indicated. | |
| 2740805 | [How will rheumatoid arthritis be conquered? A look into the future]. | 1989 Apr 30 | A look into the future.--The author recalls the different pathogenetic stages presumed to be at the root of rheumatoid arthritis, and then reviews the various theoretical and practical routes which may eventually provide a basic radical treatment for a disease that is still too often poorly controlled. | |
| 2703508 | Non-constrained total shoulder replacement in patients who have rheumatoid arthritis and c | 1989 Apr | The results of twenty-four non-constrained total shoulder replacements that were done in twenty patients who had treatment of rheumatoid arthritis were retrospectively reviewed to determine how those results were affected by the severity of the disease. All of the patients had Class-IV functional capacity, and 92 per cent had Stage-III or IV rheumatoid progression. Nine (38 per cent) of the shoulders had a tear of the rotator cuff. The mean length of clinical follow-up was 4.5 years (range, two to ten years). Preoperatively, all of the patients had disabling pain and limited function. Postoperatively, twenty-two (92 per cent) of the patients had no appreciable pain, and eighteen (75 per cent) had no significant functional limitation (p less than 0.001). Active elevation improved by 88 per cent, and external and internal rotation also improved significantly. Motion, relief of pain, and functional improvement were not significantly greater in the patients who had an intact rotator cuff. Radiolucent lines developed around ten (42 per cent) of the glenoid prostheses, but only two of the prostheses were surrounded by a complete line and were thought to be loose. No revisions were done. We believe that a non-constrained total shoulder replacement affords excellent relief of pain, satisfactorily improves range of motion, and improves function in patients who have severe rheumatoid involvement of the shoulder. However, because motion and function are severely restricted preoperatively, the end-results are not comparable with those that have been reported for patients who have less severe rheumatoid disease. | |
| 2696263 | [Differential diagnostic, prognostic and therapeutic aspects in geriatric patients with jo | 1989 Nov | Diseases of the joints in the elderly are a frequent reason for disability. An initial assessment of the patient is important for selecting the appropriate hospitalization. Exclusion of infections is mandatory. The peculiarity of rheumatic diseases in the elderly, e.g., rheumatoid arthritis, polymyalgia rheumatica, is discussed, as well as the problem of osteoarthritis which shows a progressing disability in only half of the patients. Long-term nursing is required more for polymorbidity than for osteoarthritis. The optimal care is provided by a team composed of nurse, physio- and ergotherapist, and social attendant in close cooperation with the physician; the goal is self-sufficiency and hospital discharge for even the severely disabled patient. | |
| 2285746 | Perspective of the patient with rheumatoid arthritis on issues related to missed medicatio | 1990 Jun | In order to better understand issues surrounding missed medication doses, 140 patients with rheumatoid arthritis in a tertiary care clinic were interviewed about their medication-taking behavior and beliefs. Findings from work in memory and attention and concepts from Ajzen and Fishbein's theory of reasoned action were used to guide the development of questions. Key findings included: (a) some ignorance about their regimen, (b) a tendency to rely just on their memories rather than environmental cues to remember doses, (c) variation in responses to a missed dose, and (d) the use of an inferential process for judging a medication's efficaciousness. These findings suggest several areas that physicians and allied health professionals can investigate with patients to help minimize missed doses. | |
| 2302273 | Subclinical renal dysfunction in rheumatoid arthritis. | 1990 Jan | We studied renal function in 35 patients with chronic, seropositive rheumatoid arthritis (RA), of whom 7 had vasculitis, 10 had hypergammaglobulinemia, and 18 had neither of these 2 conditions. Findings included a decreased glomerular filtration rate in 8 patients, (micro)proteinuria in 11, a defective urine concentration in 10, and increased urinary tubular enzyme levels in 15. These results indicate that subclinical renal dysfunction is common in patients with chronic, seropositive RA. In addition, vasculitis and hypergammaglobulinemia were not identified as risk factors for renal dysfunction in the RA patients studied. |