Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 3489975 | HLA-DR antigens in rheumatoid arthritis. A Swiss collaborative study; final report. Swiss | 1986 | In two separate Swiss multicenter studies on HLA antigens in rheumatoid arthritis, we found an increase in HLA-DR1 and DR4 and a decrease in HLA-DR5 and DR7, when compared with normal controls. Both seropositivity and latex-titers were inversely related to the presence of DR5 and DR7. There was no relationship with the presence of DR4. No significant relationship was found between HLA antigens and particular features of rheumatoid arthritis such as extraarticular manifestations, prognosis, response to slow-acting antirheumatic drugs, side effects with slow-acting antirheumatic drugs. | |
| 2790892 | [New findings on the pathogenesis of rheumatoid arthritis]. | 1989 Jul 21 | In the submitted review the authors present some new findings and approaches pertaining to the pathogenesis of rheumatoid arthritis (RA). First they describe cells participating in the development of the articular inflammation and mediators which transmit signals between these cells and which may lead to their activation. The authors mention the immune complex role of rheumatoid factors and some new theories on their development. They describe effector substances directly responsible for the resulting damage and emphasize their final role in the entire cycle preceding the inflammatory reaction in which lymphocytes, macrophages, polymorphonuclear leucocytes and dendritic cells participate. The possible role of viruses in the aetiology of RA is also mentioned. In the conclusion the authors present the sequence of mechanisms which lead to the development and maintenance of the chronic inflammatory reaction which develops probably on the background of the persisting autologous mixed lymphocytic reaction. | |
| 2715999 | Legionnaires' disease in a patient with rheumatoid arthritis treated with cyclosporine. | 1989 Jan | We report a patient with long-standing rheumatoid arthritis (RA) treated with cyclosporine A; she developed a flare of her arthritis and evidence of vasculitis, cavitary pulmonary disease, nephritis and hepatitis, and was found to have Legionella pneumophila serotype I infection. Cyclosporine is a relatively new and investigational therapy in RA. Thus, it is important that any unusual complications in patients with RA treated with cyclosporine should be documented. | |
| 2287756 | [Effect of rheumatoid arthritis complicated by urinary tract infections on the activity of | 1990 | In 26 patients suffering from rheumatoid arthritis complicated by urinary tract infections the normal lysozyme activity has been observed in the blood serum. After 14 days lasting therapy with nonsteroid antiinflammatory drugs no changes in the enzyme activity have been observed. | |
| 2799303 | Methotrexate treatment of rheumatoid arthritis: effects on radiological progression. | 1989 | Radiological progression was evaluated in 15 patients with rheumatoid arthritis (RA) treated with methotrexate (MTX). Prior to MTX treatment, all the patients had failed on other slow-acting agents and all showed radiological deterioration. For each patient, three sets of radiographs of hands and wrists were evaluated: prior to MTX treatment while on other slow-acting agents, at the beginning of MTX treatment, and at the most recent evaluation on MTX. Two experienced radiologists evaluated the radiographs independently. The rate of radiological progression was calculated by dividing the change in radiological score by the number of months between sets of radiographs. The mean time from film set one to two (period one) was 29.4 months and from set two to three (period two) 32.5 months. The mean rate of radiological progression for period one was 0.576 and for period two, 0.381. Eight patients showed decline in radiological progression during MTX treatment. | |
| 3403596 | Clinical aspects of osseointegration in joint replacement. A histological study of titaniu | 1988 Aug | In an experimental clinical study, 25 implants of pure titanium were inserted into the proximal tibia of 11 volunteer patients, four with rheumatoid arthritis and seven with osteoarthritis. The implants were removed from five weeks to 24 months later and detailed histological analysis was performed. The implants generally healed with direct bone-metal contact, showing so-called osseointegration. Only one of the 21 implants which had been in place for over five months did not show osseointegration, probably because of inadequate primary contact with bone. The presence of rheumatoid disease did not prevent osseointegration, but accompanying osteoporosis seemed to be a risk factor. | |
| 2233556 | [Rehabilitation of the rheumatoid hand]. | 1990 | Treatment of patients suffering from rheumatoid arthritis is complicated and it consists mainly of applying general measures, medical therapy, physical therapy and rehabilitation, and, if necessary, surgical - orthopedic measures. The treatment is conducted as team work and it lasts for years. The chronic and evolutionary character of the disease requires a rather dynamic effort against the onset of joint deformation as well as the constant follow up of the evolution of the disease, and the local condition of the joints. Within the examined group of a hundred patients with classical and definitive rheumatoid arthritis, formed deformations of hand joints were registered in 72% of patients by means of clinical examination. Preventive measures against joint deformation make an integral part of rheumatoid arthritis patient treatment. Their application starts from the moment when the diagnosis is made and lasts as long as the disease does. | |
| 2289328 | Clinical evaluation of radiographic progression in rheumatoid arthritis. | 1990 Nov | Four rheumatologists and 2 radiologists utilized 3 reading techniques to evaluate clinical radiographic progression in selected serial hand and wrist films from 5 rheumatoid arthritis patients. The carpometacarpal radio determinations were the most internally consistent; global assessment and total erosion + joint space narrowing scores showed the best between-method correlations; and the erosion + joint space narrowing scores depicted most sensitively the progression over time which was not affected by immunomodulating agent or non-steroidal anti-inflammatory agent therapy. In this study, instructed, non-experienced readers detected rheumatoid radiographic progression utilizing readily available scoring techniques. | |
| 3651314 | Bronchocentric granulomatosis and rheumatoid arthritis. | 1987 Apr | We report a 42-year-old patient with an 11-year history of rheumatoid arthritis (RA) who presented 8 years later with haemoptysis and was found to have multiple pulmonary opacities with histological features of bronchocentric granulomatosis (BCG). The association between BCG and RA is discussed and the literature is reviewed. | |
| 2617370 | [A case of progressive systemic sclerosis accompanied with rheumatoid arthritis]. | 1989 Aug | A 37-year old man was suffered from Raynaud's phenomenon, sclerodactyly, and polyarthritis involving knees, shoulders, and hands. Recurrent skin ulcers were present in finger tips. Laboratory studies showed positive RA test, antinuclear antibody (nucleolar type), and anti-Scl 70 antibody. So diagnosis of progressive systemic sclerosis (PSS) was made. Progressed destructive arthritis with rheumatoid nodules developed in the patient. The joint destruction was severe and he was satisfied with the criteria of the American Rheumatism Association (ARA). This patient appears to be an overlapping case of PSS and rheumatoid arthritis (RA). | |
| 2190292 | [Assessment of the course of chronic polyarthritis]. | 1990 May 8 | In the following review the classical clinical and radiological parameters of rheumatoid arthritis are discussed. In our own study we made a prospective follow up of 29 patients with rheumatoid arthritis (104 years of disease) comparing the clinical and laboratory data with the radiological findings. Finally we investigated in another population with rheumatoid arthritis (315 patients) the question of quality of life using a structured questionnaire. | |
| 3316441 | [Significance of the serum rheumatoid factor-like substance in the induction of arthritis | 1987 Jun | Rabbits immunized with heat-killed Escherichia coli 0:14 for 8-10 months developed lymphocyte infiltration in the synovium at a significantly (p less than 0.05) higher rate (61.1%, 22 of 36 knees) than animals immunized for 4 months (31.3%, 10 of 32). Serum rheumatoid factor-like substance (RFLS) was positive (RAHA-titer more than 80) as early as 3 weeks after the initial treatment. After 15 weeks of immunization 90.9% (20 of 22 rabbits) of the animals were RFLS positive. Lymphocyte infiltration in the synovium of knees was observed more frequently (81.8%, 9 of 11 rabbits) (p less than 0.05) in the group with positive RFLS earlier than 8 weeks following immunization than in that with RFLS only after this period (18.2%, 2 of 11). These observations suggest that the long viability of serum RFLS and certain factors inducing early RFLS synthesis might be important in producing arthritis in rabbit immunized with E. coli. | |
| 2570886 | [Role of orthopedic surgery in the management of rheumatoid arthritis]. | 1989 | After describing a few pathological and clinical characteristics of the rheumatoid arthritis author outlines some of the cares connected with the operative treatment of these, in the majority severe cases. The more frequently used operations and their results to be expected are described. | |
| 3583649 | Bony ankylosis in rheumatoid arthritis. Associations with longer duration and greater seve | 1987 Apr | Hand and wrist radiographs of 203 patients with rheumatoid arthritis were examined for bony ankylosis. Forty-eight patients (23.6%) showed ankylosis, including 34 with more than one joint fused. The distribution of ankylosed joints was 32.4% midcarpal, 29.5% common carpometacarpal, 15.8% radiocarpal, 15.8% proximal interphalangeal, and 6.5% metacarpophalangeal. Patients with ankylosis had significantly higher radiographic erosion, joint space narrowing, and malalignment scores than those without ankylosis (all P less than .001). Patients with ankylosis had significantly longer duration of disease (P less than .001) and physical examinations showed more limited motion and deformity (both P less than .001). More patients with ankylosis had subcutaneous nodules (P less than .05). Functional testing with grip strength and the button test revealed poorer performance in patients with ankylosis (both P less than .001). Questionnaires revealed patients with ankylosis had more difficulty with activities of daily living (P less than .001) and had more limited activity (P less than .01); physicians estimated more limited functional capacity (P less than .001). Thus, radiographic bony ankylosis was a relatively common feature of rheumatoid arthritis, and a marker of patients whose disease was clinically, radiographically, and functionally more severe. | |
| 2348421 | Health status assessment in rheumatoid arthritis. I. Further work on the validity of the s | 1990 Apr | In a cross-sectional, longitudinal study, 99 women with rheumatoid arthritis (RA) completed a well established health status measure, the Sickness Impact Profile (SIP), for diagnosis specific evaluation. Using traditional and self-reporting data, we examined SIP relationships that described physical functioning. They related closely to clinical measures. Psychosocial functioning measured by SIP related specifically to mental health and arthritic pain. Importantly, the SIP was sensitive to 1-year pre and posttreatment changes showing both improvement and deterioration. When applied to patients with RA SIP categories could be more appropriately aggregated, e.g., Home management included in the Physical dimension and Communication omitted from the Psychosocial. | |
| 3818749 | Excision of the distal ulna in patients with rheumatoid arthritis. | 1987 Mar | The results of excision of the distal ulna in 34 wrists of 25 patients with chronic rheumatoid arthritis of the distal radio-ulnar joint were reviewed. Rest pain had been cured or relieved in 77%, pain on pronation-supination in 86%, and limitation of pronation-supination in 90%, while 88% of the patients graded the result as excellent or fair. Despite this marked relief of symptoms, function of the upper limb was improved in only 25% of patients and remained unchanged in 60%. Ulnar subluxation of the carpus had occurred in 24% but seemed to be related to the destructive disease process rather than to the operation itself. The length of ulna resected was not related to the outcome of the operation. | |
| 3804599 | Lay beliefs about the causes of rheumatoid arthritis: their implications for rehabilitatio | 1986 | This paper reports research based on interviews with 29 people with rheumatoid arthritis of at least 5 years duration. One of the topics covered was the respondents' understanding of the cause of their condition in the light of continuing medical uncertainty about aetiology. The evidence suggests that, in developing explanations, individuals will combine elements of medical knowledge with "common-sense" beliefs derived from other sources. The difference between lay and professional concepts contributes to communication problems and, in situations of chronic illness, communication may be one of the most potent components of rehabilitation. It is suggested that better appreciation of the individual's beliefs about causality could help to overcome the difficulties. | |
| 3408339 | Hand splint for rheumatoid arthritis patients during gait training after joint replacement | 1988 Aug | Rheumatoid arthritis patients have multiple joint problems, often making it difficult to use gait aids after a joint replacement in the leg. To address this problem, we designed a hand splint with a hook on the palmar side for use with parallel bars. Patients put these splints on both hands and they can walk holding the bars with the hooks. Best suited for using this splint are rheumatoid arthritis patients who are unable to hold parallel bars without marked pain in the hands or fingers, contracture of the wrist joint, or dislocation of finger joints. Several patients have tried this splint, which worked safely and satisfactorily during exercise. | |
| 2084233 | Identifying subclasses of patients with rheumatoid arthritis through cluster analysis. | 1990 Dec | Nonhierarchical cluster analysis was used to classify 92 patients with rheumatoid arthritis drawn from a community rheumatology practice into 5 groups on the basis of biochemical measures and disease indices. The major differentiating variables were the number of active joints, number of damaged joints, overall disease activity, extraarticular complications, and history of joint surgery. Although the 5 subclasses were equivalent on measures of psychological functioning, they differed systematically on such health outcome measures as mobility, physical activity, and dexterity. Relationships between the taxonomy produced through cluster analysis and conventional classifications are discussed, and directions for further investigation are noted. | |
| 3085760 | Preliminary evidence for gut involvement in the pathogenesis of rheumatoid arthritis? | 1986 May | 111Indium leucocyte scans were performed on 26 patients with active rheumatoid arthritis. An abnormal localization of radioactivity was observed in the gut of 12 of these patients, generally in the region of the terminal ileum, caecum and ascending colon. No difference was found in the intake of nonsteroidal anti-inflammatory drugs between those with positive and negative scans. Two patients with positive scans were on no medication. These observations suggest the possibility of a primary role for a gastrointestinal lesion in the aetiology of rheumatoid arthritis, although these abnormalities could be secondary or unrelated. |