Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 2281394 | [Megaloblastic pancytopenia in a female patient with rheumatoid arthritis given methotrexa | 1990 | The paper is concerned with the development of megaloblastic pancytopenia in a female patient with grave rheumatoid arthritis. The patient had been given methotrexate (15 mg per week) for a long time, supplemented by amidopyrine (1.0 to 1.5 g/day). The author holds that the development of the above-indicated complication is provoked by both drugs interference into folate metabolism. It is concluded that caution should be taken as to the combined use of methotrexate with non-narcotic analgesic drugs, nonsteroidal anti-inflammatory agents and sulfanilamides. | |
| 2530824 | Non-surgical synovectomy (basic principles). | 1989 | Non-surgical synovectomy is an important therapeutical method, the spreading of which is due to intensive research in the ways of treatment, particularly in rheumatoid arthritis. Various procedures have been worked out to settle pathological changes first on the synovial membrane (synoviorthesis) by intraarticular administration of pharmacological substances. From this point of view, we report on cortisonoids, chloroquine, cytostatic drugs, pyrazolone derivates and antiproteolytic substances. Special attention is paid to osmic acid and radioactive colloids as possible. It is a matter of the physician's skill and further research to find the optimal drug for synoviorthesis so as to introduce it into the long-term and systematic therapeutical programme necessarily required by rheumatoid arthritis. | |
| 3809886 | The role of cartilage canals in the pathogenesis of experimentally induced polyarthritis. | 1986 | Porcine articular cartilage from cases of experimentally induced Erysipelas polyarthritis, a comparative model of rheumatoid arthritis (RA) in man, was examined with different histological and immunohistochemical techniques. The preexisting canals in articular cartilage played a crucial role during the flooding and deposition of arthritogenic microorganisms deep into the cartilage matrix. Subsequently this vascularized tissue mediated the same inflammatory reactions in hyaline cartilage of young animals as seen in other connective tissues. However, these stereotypical responses to injury were modulated by the unique composition and structure of articular cartilage. | |
| 1857426 | The Duke University Arthritis Center. | 1991 May | The Duke University Arthritis Center has brought together both clinicians and basic scientists into a common structure to achieve a singular goal--that of improving the health and welfare of patients with immune-mediated diseases in North Carolina and surrounding states. The structure of DUAC allows new insights gained by basic immunologic research to be rapidly applied to clinical rheumatologic diseases by channelling basic information to the clinical investigative unit in DUAC. Here new treatment strategies are developed and tested and made available to patients when they are judged to be both safe and efficacious. In the DUAC comprehensive clinics, the best treatments available to patients with rheumatologic diseases are provided in a setting designed to be user-friendly to patients and comprehensive in services offered. | |
| 3723453 | Psychological factors associated with disability in arthritis. | 1986 | A sample of chronically disabled arthritic patients was studied in 1981, and again in 1983, using a questionnaire which included attitudinal and mood items. The majority of patients had high pain and disability, and this did not significantly change between 1981 and 1983. The questionnaire was able to significantly discriminate between subjective disability and pain groups. This discrimination was more accurate than that made by orthopaedic surgeons using physical ratings alone, and possible 'good coping' and 'bad coping' profiles emerged. | |
| 2661567 | Historical perspectives on surgery of the rheumatoid hand. | 1989 May | A history of rheumatoid hand surgery is presented, emphasizing the gains made through a team approach. This is not a complete literature review, but the history as the author has personally seen it develop over 40 years and as it affects today's surgical procedures. | |
| 3656303 | Traditional approaches to functional assessment in arthritis. | 1987 Aug | Both clinical rheumatology and medical rehabilitation have traditional functional assessment approaches to patients with arthritis. Drawing from both, a suggested "universe of function" for rheumatic disease patients is presented. The variables included begin with components of the physical examination and continue to maneuvers performed by the patient, mobility, activities of daily living (ADL), upper extremity function, extended living functions, and global assessment instruments. The development of standardized methodologic techniques is greater for some variables, especially ADL. In all, there is a need for a consensus approach so that aggregate data generated in different studies and programs will be more comparable. | |
| 2722312 | The cruciate ligaments in knee replacement. | 1989 | The cruciate ligaments were resected with their bony insertions during total knee arthroplasty carried out in 12 patients with severe rheumatoid or osteoarthritis. The ligaments were examined histologically and biomechanically, using ten specimens from healthy adults as a control. A significant difference was found in the tensile stiffness and viscoelastic properties of the ligaments between the arthritic and the control group. The ligaments in the rheumatoid knees had a distinctly inferior tensile strength compared with the osteoarthritic knees. Total knee replacement, which also replaces ligament function, should therefore be considered in severely damaged rheumatoid knees. | |
| 2049585 | Articular disease severity in rheumatoid subjects with and without Felty's syndrome. | 1991 Jun | Articular disease severity as measured by a radiographic score of hands and feet was compared in rheumatoid subjects with (21) and without (170) Felty's syndrome. Disease duration was a major determinant of joint destruction. When this was taken into consideration radiographic scores were no higher in the Felty's group than in rheumatoid subjects without Felty's syndrome. Immunogenetic associations previously described in Felty's syndrome are unlikely therefore to represent non-specific markers of disease severity and more likely to represent markers of extra-articular disease. | |
| 1757945 | Syringomyelia in a patient with rheumatoid subluxation of the cervical spine. | 1991 Sep | A patient with rheumatoid damage of the cervical spine with cervical cord compression, complaining of a typical syringomyelic syndrome is described. Magnetic resonance imaging revealed cord compression due to an upward displacement of the odontoid peg with a mass of pannus behind the dens, and a syrinx cavity extending from C1 to T1. We postulate that this patient's syringomyelia probably represents a complication of cervical rheumatoid arthritis that has not been described. | |
| 2801089 | [Large articular geode cyst in rheumatoid polyarthritis]. | 1989 | A case of a large bone cyst in the tibial condyle of a patient with rheumatoid arthritis is reported. The etiology and pathology are discussed, and preventive surgical treatment is recommended. | |
| 2123248 | Medical treatment for rheumatic diseases. | 1990 Oct | Rest, physiotherapy, joint protection, patient education and counselling all play an important role alongside drug therapy and surgery in the management of a chronic disorder such as rheumatoid arthritis. Patients expect their physician to take the initiative in integrating the members of the multi-disciplinary team devoted to their care. The physician will also instigate drug therapy. In early disease, an analgesic ('for pain') may supplement a non-steroidal anti-inflammatory drug ('for stiffness'). A variety of such drugs are available with various advantages and disadvantages. For more severe, progressive disease a 'second-line' or disease-modifying drug may be prescribed. Typical examples are injectable gold, penicillamine, antimalarials, sulphasalazine and methotrexate. The prescription of any of these represents a calculated risk: the benefits of treatment have to be balanced against the likely side-effects. A variety of intra-articular treatments are also available for providing some localisation of response and sometimes obviating the need for surgery which should be the subject of close collaboration between the rheumatologists and orthopaedic surgeons. | |
| 3150561 | Use of lectin-immunohistochemistry in joint diseases. | 1988 | The lectin binding pattern of the inflamed synovial tissue of patients with OA (osteoarthritis) and RA (rheumatoid arthritis) were examined with 18 different lectins. The synovial lining cells are heavily stained by PHA-L, WGA, PNA, Con A, MPA and RCA. In the subsynovial layer, WGA, PHA-L and RCA were found to be fairly good monocytic markers. The lectin binding pattern of the lectins under study, however, failed to discriminate between patients with OA and RA. | |
| 1681143 | [Management of varus knee arthrosis by high tibial osteotomy]. | 1991 | Authors made a follow-up of 69 varsus knee arthrosis treated with high tibial osteotomy. Beside the general results the effect of the severeness of the arthrosis before the correction and that of the gain of the axial correction on the result were also investigated. 56 (81 per cent) of the reexamined patient reported excellent or good results. The ratio of the successful operations was even higher in cases in which the femorotibial axis was corrected to physiological valgus (95 per cent). The best prognosis of the osteotomy is in the early stage of arthrosis (Ahlbäck 0-II). In cases of the more advanced process the ratio of the unsuccessful cases increases. In consequence it is stated that the best results can be expected after osteotomies performed in the early stage and leading to the physiological femorotibial valgus position. | |
| 3326561 | Therapeutic application of phenylalanine immunoadsorbent with on-line regeneration. | 1987 Dec | To improve the adsorption capacity of the artificial reticuloendothelial system containing phenylalanine as a ligand, a regeneration method for the adsorbent during plasma perfusion was developed. The adsorbed rheumatoid factor, immunoglobulins, and complements were demonstrated to be elutable from the adsorbent with a 5% glucose solution in vitro. The regeneration method was applied to the treatment of a patient with rheumatoid arthritis. During each plasma perfusion, the adsorbent was regenerated, usually twice, with a 5% glucose solution at a flow rate of 50 ml/min. After each regeneration, the adsorption capacity of the adsorbent was found to be improved by determining the pre- and post-column plasma titers of a rheumatoid arthritis hemagglutination test. | |
| 3489977 | [Joint manifestations in chronic T-cell lymphocytosis and neutropenia]. | 1986 Jun | The authors report the case of a patient suffering from chronic T-cell lymphocytosis and neutropenia (CTLN), detected from seropositive rheumatoid arthritis with attacks of fever. The distinctive features of CTLN, isolated from other forms of chronic T-cell lymphoid leukemias, are recalled. The frequency and nature of joint signs found during this new hematologic entity are described. | |
| 3238360 | Waaler Rose titres may decrease but increase again during chrysotherapy. | 1988 | In 62 patients with seropositive rheumatoid arthritis, treated with gold compounds, the relationship between serological and clinical response was analysed, based on data on the rheumatoid factor (RF) titre, ESR, number of swollen joints and joint tenderness, through 3 years. Three groups were distinguished. The RF titre became normal in 19, remained elevated in 22, became normal and subsequently again elevated in 21. Responders and non-responders to chrysotherapy occurred in all 3 groups. The findings suggest involvement of pathogenetic mechanisms related to IgM-RF, and of pathogenetic mechanisms which are not related to IgM-RF, and which may be responsive or unresponsive to chrysotherapy. | |
| 3299681 | Quality of life in patients receiving auranofin therapy: confirmation of efficacy using no | 1986 | Traditionally, assessment of therapeutic efficacy in patients with rheumatoid arthritis (RA) has been based on objective measurement of disease parameters, such as the number of tender and swollen joints, 10-cm analogue pain scale, or grip strength. More recently, however, it has been realized that these parameters may not provide a true reflection of the impact of disease or therapy on the patient's overall emotional state and ability to function--the "quality of life." Nontraditional measurements of health status have been used by several researchers in order to provide comprehensive data about the benefits of drug therapy. Most recently the Auranofin Cooperating Group conducted a prospective, 6-month, randomized, double-blind, multicenter study that compared auranofin (AF) oral gold with placebo in the treatment of RA. The study was unique in that it assessed the efficacy of AF using a battery of nontraditional health status measures ("quality-of-life" measures) in addition to the traditional parameters used to chart rheumatic disease activity. Composite scores were calculated for 4 distinct dimensions of RA: physical, functional, pain, and global. Pairwise correlations between composite scores ranged from 0.45 to 0.67, indicating that the scores represented different dimensions of the impact of RA. Results indicated that AF effectively improves several dimensions of RA. In addition, it was apparent that several health status measures are sensitive to changes in clinical status. These measures may be useful in future clinical trials of RA, perhaps indicating when DMARD therapy should be initiated. They should also prove useful in drug trials for other diseases. | |
| 3560099 | Unexpected sites of wear in the femoral head. | 1986 Dec | In a study of 637 femoral heads removed surgically because of osteoarthritis, the wear was predominantly on the posterior half in 13.2% and was more than two-thirds posterior in 7.5%. Wear was more than two-thirds anterior in 37.8%. In 36 heads from patients with rheumatoid arthritis, the wear was predominant posterior in 27.8%. No anatomical reason was found for these marked asymmetries, which, from their position, could not possibly be the result of simple weight bearing. The finding underlines the importance of muscular action in the causation of wear. | |
| 2390856 | Retroperitoneal haemorrhage from the superior gluteal artery: a late complication of total | 1990 Jun | A patient with rheumatoid arthritis was admitted with a sudden onset of abdominal pain owing to a retroperitoneal haemorrhage from a false aneursym of the superior gluteal artery. This aneurysm probably developed as a result of a migrating total hip prosthesis. |