Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 3361326 | Preliminary results of total wrist arthroplasty in rheumatoid arthritis using the Trispher | 1988 | Thirty-two patients underwent 38 arthroplasties for advanced rheumatoid arthritis and marked soft tissue losses. Seven wrists required repair or transfer of at least one tendon for rebalancing. All patients were improved by the implants. Thirty-four of the 38 patients were improved beyond the functional level of a painless wrist arthrodesis. Overall, there were 23 excellent, 10 good, 3 fair, and 2 poor results. The average wrist score was 90.3 points, and the average arc of motion was 38 degrees. There were three cases of migration of the third metacarpal stem and nine cases of lucency about the stems, three of which were progressive or greater than 1 mm. There were no deep infections. There was one reoperation for persistent pain and one for component loosening. There were no cases of implant failure. These results indicate that this total wrist arthroplasty is a safe, reproducible procedure for radiographic class III and IV rheumatoid disease and should be considered a first line of therapy for that group. | |
| 3701724 | Further observations on the response of synovial lymphocytes to viral antigens in rheumato | 1986 Feb | Synovial lymphocyte responses to viral antigens were measured in repeated tests over periods of up to 3 years in 4 patients with rheumatoid arthritis, one of whom was rheumatoid factor positive. Consistent responses to adenovirus, mumps and cytomegalovirus were demonstrated. Responses of peripheral blood lymphocytes were almost always much less than synovial lymphocyte responses. Synovial lymphocyte phytohemagglutinin responses were greatly reduced and usually less than synovial lymphocyte antigen responses. | |
| 1974723 | Degree and extent of response to sulphasalazine or penicillamine therapy for rheumatoid ar | 1990 Apr | An attempt was made to audit the clinical usefulness of sulphasalazine and penicillamine in patients with rheumatoid arthritis (RA) managed in a routine out-patient setting with assistance from general practitioners and to ascertain whether clinically significant differences can be shown between these two 'second-line' agents. The degree and extent of change in, and the usefulness of, various parameters of disease activity were also evaluated. Two hundred patients with active rheumatoid arthritis were randomly allocated to either sulphasalazine or penicillamine and monitored for a minimum of two years. Fifty-one percent of the 102 patients who received sulphasalazine continued treatment for two years, compared with 40 per cent of the 98 patients allocated to penicillamine. The proportion of patients stopping therapy because of adverse reactions or due to lack or loss of effect was similar in the two groups. There was no difference between the two groups in the extent of improvement in clinical and laboratory variables at one and two years. The majority of patients showed improvement in most measured parameters; very few showed global improvement. The degree of improvement varied with the parameter assessed, being greatest in relatively easily measured variables such as duration of morning stiffness and ESR, and least for functional index. The effect and toxicity of these two agents in this setting was as anticipated. No clinically relevant difference could be demonstrated between the two drugs. | |
| 3945916 | [Total lymphoid irradiation in chronic polyarthritis--a new therapeutic concept]. | 1986 Jan | Eleven patients with refractory rheumatoid arthritis were submitted to a total lymphoid irradiation up to a dose of 20 Gy. A constant improvement of clinical symptoms was observed in four out of the eleven patients already during the treatment and in the other patients not later than two months after. The frequency of attacks decreased and the number of joints involved in the attack was reduced. Morning rigidity and joint swellings decreased. One patient developed joint empyemas 4 and 26 months after the treatment. Four patients died in the meantime. In two patients the cause of death were renal insufficiency and a postoperative cardiogenic shock associated with generalized amyloidosis. The third patient died because of a toxically induced left cardiac decompensation with sepsis that could not be controlled by antibiotic drugs and multiple joint empyemas. The fourth patient developed an abscess after surgical treatment of a Kaposi syndrome. She died three months later from acute left cardiac decompensation. The therapy induced a lymphocytopenia with decrease of T helper lymphocytes and unchanged number of T suppressor lymphocytes. The constant therapy results of total lymphoid irradiation in primary chronic polyarthritis is probably due to this modification in the immune regulation. | |
| 2232443 | [A study on the relationships of discomfort, self-esteem, personality and life satisfactio | 1990 Aug | The purpose of this study was to investigate the correlation of discomfort, self-esteem, personality and life-satisfaction in persons with rheumatoid arthritis and to provide basic data to help them attain a better quality of life. From Jan. 27 to Feb. 24, 1988, 53 patients, registered at a rheumatic clinic at one general hospital in Seoul, were accepted as subjects for this study. The instruments used for this study were a discomfort scale and life-satisfaction scale developed by the researcher, Rosenberg's Self-esteem Scale and Wallston and Wallston's Multidimensional Health Locus of Control (MEILC) Scale. The reliability of the scales were tested by Cronsbach's alpha. The collected data were analyzed by the SAS program using unpaired t-test, ANOVA, and Pearson's Correlation Coefficients. The results were as follows: 1. There was a significant difference in the subjects perceived discomfort level (t = -3.49, p = .0010) between the onset of the disease (14.87 +/- 9.02) and the present (19.87 +/- 8.44). 2. There was a significant correlation between the MHLC-internal score and the MHLC-chance score (r = -.4366, p = .0011). 3. The findings related to the demographic variables regarding the MHLC scores were as follows: 1) Regarding sex, there was a significant difference for the MHLC-internal score (t = 4.2572, df = 15.2, p = .0007) between male (32.13 +/- 2.47) and female (27.56 +/- 4.17). But the MHLC-chance score for male (15.13 +/- 2.85) was lower (t = 3.153 9, df = 21.8, p = .0047) than for female (19.47 +/- 6.29). 2) Regarding educational background, the MHLC-chance score for the below-high school group (20.52 +/- 5.81) was higher (t = 2.5450, df = 51.0, p = .0140) than the college graduate group (16.41 +/- 5.76). 4. The average Self-esteem score was 26.87 (S.D. = 5.29) and there was a significant correlation between the Self-esteem score and the MHLC-chance score (r = .3122, p = .0026). 5. It was found that the subjects' Discomfort score was correlated with the Self-esteem score (r = -.3788, p = .0051) and the Life-satisfaction score (r = -.3570, p = .0087). It was also found that subjects' Self-esteem score was correlated with the Life-satisfaction score (r = .4474, p = .0008). | |
| 3663255 | Systemic lupus erythematosus with Jaccoud's arthropathy mimicking juvenile rheumatoid arth | 1987 Sep | We describe a girl who presented at age 5 with objective signs of arthritis and was initially diagnosed as having juvenile rheumatoid arthritis. Over the following years, she developed slowly progressive joint deformities indicative of Jaccoud's arthropathy. When she was 11 years old, symptoms typical of systemic lupus erythematosus appeared, accompanied by anti-DNA antibodies. This case illustrates that in children also, Jaccoud's arthropathy may be a precocious manifestation of systemic lupus erythematosus. | |
| 3942847 | Rheumatoid arthritis: treatment which controls the C-reactive protein and erythrocyte sedi | 1986 Feb | One hundred and fifty consecutive patients with active, rheumatoid arthritis were assessed and treated with gold, D-penicillamine, chloroquine or dapsone. Four groups were selected from these patients. Group I consisted of 60 patients who did not complete 12 months' therapy. Group II consisted of patients in whom ESR and C-reactive protein (CRP) fell to less than 30 mm/h and less than 20 mg/l, respectively, and remained at these levels between 6 and 12 months. In group IV the ESR and CRP fell but remained greater than 30 and greater than 20, respectively, during the same period. Group III patients had variable ESRs and CRPs between 6 and 12 months. In groups II, III and IV there was a significant deterioration (p less than 0.01) in the hand and foot radiographs from 0 to 6 months. Between 6 and 12 months the radiographs in groups III and IV continued to show significant radiological progression (p less than 0.01), but those of group II did not alter. These results suggest radiological deterioration continues during the first 6 months regardless of clinical response but thereafter, further deterioration is less likely to occur when the ESR and CRP are consistently controlled. | |
| 2256737 | Rheumatoid factors specific for active rheumatoid arthritis. | 1990 Nov | To measure rheumatoid factors specific for patients with rheumatoid arthritis an enzyme linked immunosorbent assay (ELISA) was developed to measure rheumatoid factors in human serum that bind a cross-reactive determinant shared on human and other mammalian IgG. Rheumatoid factors that cross link human IgG and sheep IgG in a double binding ELISA were almost completely specific (greater than 99%) for rheumatoid arthritis in assays of 108 sera from patients with rheumatoid arthritis compared with 231 sera from patients with other connective tissue diseases and 365 sera from healthy subjects and patients without these diseases. Moreover, positive tests occurred primarily in patients with active arthritis (r = 0.68). In contrast, these rheumatoid factor autoantibodies were not detected in sera from most of the patients with other autoimmune diseases, including patients with systemic lupus erythematosus. These results show that rheumatoid factors identified in human sera by the double binding test are specific for active rheumatoid arthritis. | |
| 3426291 | Concurrence of rheumatoid arthritis and systemic lupus erythematosus: report of 11 cases. | 1987 Nov | The concurrence of rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) has been reported infrequently. Eleven patients are described here with both RA and SLE, in whom the diagnoses were separated by one to 24 years. Because of the difficulty in diagnosing RA occurring subsequent to SLE, only patients with classical RA as their initial diagnosis were included. Further difficulties arise because arthritis is common to both diseases and may be deforming in SLE, antinuclear antibodies (ANA) are not uncommon in RA, and rheumatoid factor (RF) may be seen in SLE. Nonetheless, judicious application of the American Rheumatism Association (ARA) criteria allows both diagnoses to be made in the individual patient. In our patients there was erosive arthritis in nine, rheumatoid nodules in five, and urinary abnormalities in 10. Serological evidence of RA and SLE with positive RF and ANA and raised DNA antibodies was universal, all patients had haematological evidence of SLE, and all but one decreased serum complement levels. These cases suggest that the concurrence of RA and SLE is not as rare as previously considered and may occur more often than expected by chance alone. | |
| 1866241 | [Various indices of collagen metabolism in children with rheumatoid arthritis]. | 1991 | To study collagen metabolism, 113 children aged 3 to 14 years afflicted with rheumatoid arthritis and 43 conventionally normal children were examined. The patients were examined for free and protein-bound hydroxyproline in the blood serum and synovial fluid and for total hydroxyproline in diurnal urine. The blood serum and synovial fluid showed a decline of free and a rise of protein-bound hydroxyproline, more marked in severe rheumatoid arthritis, its higher activity and damage to numerous joints. Excretion of free and total hydroxyproline with urine was significantly lower than in the normal children whatever the form of rheumatoid arthritis, its activity or number of the joints involved into the process. In view of the lack of hydroxyprolinuria in the sick children, the authors discuss a hypothesis of a potential initial decrease of collagen formation in children afflicted with rheumatoid arthritis, suggesting its relationship to the "ligand pathology". | |
| 1711712 | [Synovial angiogenesis]. | 1991 Apr | Synovial angiogenesis, the formation of new capillaries from pre-existent capillaries, is a constant feature of synovial inflammation. Strictly regulated, it normally disappears after recovery from the acute episode. However it may persist during chronic synovial inflammation and then participates in pannus development in RA. This is the result of biochemical events which have contributed to breakdown of the extracellular matrix and cartilage in association with activation or secretion into this micro-environment of angiogenic factors. Relations with immunocompetent cells (lymphocytes and monocytes) suggest that this final common pathway may be partially dependent upon stimulation by the antigen. The development of treatment aimed at inhibiting angiogenesis could offer additional therapeutic hope in rheumatoid arthritis. | |
| 3155356 | Abdominal microaneurysms in rheumatoid arthritis. | 1988 Jun | A 55-year-old man presented with systemic vasculitis complicating long-standing classical rheumatoid arthritis (RA). Digital and cutaneous vasculitis, together with widespread microaneurysms on both renal and coeliac arteries, were found. The simultaneous presence of these different patterns of vasculitic lesions in a single patient, affecting small as well as medium size vessels with aneurysm formation, emphasizes the value of angiographic studies in evaluating RA. | |
| 2528634 | The origins of depressed mood in rheumatoid arthritis. | 1989 Jun | Most studies that have considered depressed mood in patients with rheumatoid arthritis have failed to analyze the relative contribution of psychological, social and disease state variables. Using multivariate statistical analyses we identified the role played by demographic, disease related, disability and social variables. Together these variables accounted for 44% of the variation in depressed mood. Demographic factors, disability measures, disease duration, social isolation and economic deprivation all made significant contributions to the explanation of depressed mood. The results of our study underline the importance of examining a wide range of factors in order to consider their relative influence on psychological state. | |
| 2256738 | Judging disease activity in clinical practice in rheumatoid arthritis: first step in the d | 1990 Nov | An investigation of clinical and laboratory variables which might form the basis for judging disease activity in clinical practice was made by six rheumatologists in a prospective study of up to three years' duration of 113 patients with early rheumatoid arthritis. Decisions to start treatment with slow acting antirheumatic drugs were equated with moments of high disease activity. If treatment with slow acting antirheumatic drugs was not started or if the slow acting antirheumatic drug remained unchanged for at least one year or if treatment was stopped because of disease remission, this was equated with periods of low disease activity. Two groups, one with high and one with low disease activity according to the above criteria, were formed. Factor analysis was performed to enable easy handling of the large number of clinical and laboratory variables without loss of information; this resulted in five factors. Next, discriminant analysis was done to determine to what extent each factor contributed to discrimination between the two groups of differing disease activity. Finally, a multiple regression analysis was carried out to determine which laboratory and clinical variables underlie the factors of the discriminant function, resulting in a 'disease activity score'. This score consisted of the following variables: Ritchie index, swollen joints, erythrocyte sedimentation rate, and general health, in declining importance. The rheumatologists' decisions to prescribe slow acting antirheumatic drugs, or not, were mainly based on articular symptoms. | |
| 2009128 | Arthroscopic synovectomy of the knee for rheumatoid arthritis. | 1991 | Arthroscopic synovectomy for rheumatoid arthritis was carried out on a total of 96 knees. The period of follow-up observation varied from 2 to 4 years. The technique was without major complication. There were statistically significant decreases in pain and synovitis over the 4-year follow-up time. The range of movement was maintained. Arthroscopic synovectomy was at least a valuable palliative procedure for uncontrolled synovitis of the knee. | |
| 2750493 | Failure of the Wadsworth elbow. Nineteen cases of rheumatoid arthritis followed for 5 year | 1989 Jun | Nineteen Wadsworth elbow prostheses were inserted in 15 patients with rheumatoid arthritis during the 4 years 1979-1982. The patients were followed prospectively for an average of 5.7 years. Five elbows were revised because of mechanical loosening and one because of deep infection. Of the remaining 13 prostheses, there were radiographic signs of loosening in 8 cases. | |
| 3789825 | Scanning electron microscopy of rheumatoid arthritis peripheral blood polymorphonuclear le | 1986 Nov | Peripheral blood polymorphonuclear leucocytes (PMNs) were isolated from six normal individuals and from 27 patients with rheumatoid arthritis (RA) by the Ficoll-Hypaque rapid single step centrifugation technique, fixed in suspension, and examined by scanning electron microscopy (SEM). In addition, four of the preparations from normal individuals and eight from patients with RA were examined by transmission electron microscopy (TEM). Most PMNs in preparations from normal subjects were spherical, unpolarised, and had their surface membrane elaborated into irregular ridges and small ruffles; they contained few phagocytic vacuoles and large numbers of electron dense primary and secondary granules. A minority of the cells were non-spherical, polarised, and had portions of their surface membrane elaborated into ruffled pseudopodia. In contrast, preparations of RA PMNs frequently contained fewer unpolarised PMNs and a higher number of polarised PMNs than did preparations of normal PMNs. Some preparations of RA PMNs also contained substantial numbers of spherical cells whose surface was covered mainly by bulges and blebs. Concurrent examination by TEM showed that RA PMNs frequently contained more phagocytic vacuoles and fewer electron dense primary and secondary granules than normal PMNs. The morphological and ultrastructural changes seen in RA PMNs resembled those which normal PMNs are known to undergo on exposure to C5a in vitro, during adherence to endothelial cells in vivo, or during phagocytosis in vivo or in vitro. Our observations, therefore, provide a useful morphological correlation to those in vitro studies in which differences in the functional activity of RA and normal PMNs have been shown. The possibility that the difference seen between RA and normal PMNs is artefactual and does not represent the genuine in vivo states of these cells is discussed. | |
| 3262030 | A survey of renal function in outpatients with rheumatoid arthritis. | 1988 Jun | The acute renal side-effects of nonsteroidal anti-inflammatory drugs are well documented. These include interstitial nephritis, hyperkalaemia, renal tubular acidosis, fluid retention, hypertension and nephrotic syndrome. The long-term effects are less well known. We have carried out a cross-sectional survey of an unselected out-patient population with definite or classical rheumatoid arthritis to determine the prevalence of renal problems in this group. Thirty-four patients (20%) were shown to have an abnormality as defined by our criteria but in the majority this was transient or had been previously recognised. Thirteen patients (8%) had a persistent unexplained abnormality but only 1 had merited renal biopsy using established criteria (Patient 1). We conclude that the long-term use of NSAID's is associated with relatively few renal side-effects. | |
| 3944159 | Silicone-rubber implant arthroplasty of the metacarpophalangeal joints for rheumatoid arth | 1986 Feb | Forty-six patients with rheumatoid arthritis underwent metacarpophalangeal-joint arthroplasty of the index through little fingers on 210 joints in fifty-five hands using the Swanson-design silicone-rubber spacer. The patients were followed for two to eight years (average, five and one-quarter years). They were evaluated both preoperatively and postoperatively for range of motion, deformity, subjective sense, grip strength, and prehension. In the initial postoperative evaluation, the majority of patients expressed a strong subjective impression of improvement. Ulnar drift improved from the preoperative average of 25 degrees to less than 5 degrees. The preoperative average extension deficit decreased from 56 to 10 degrees, while the average range of motion increased from 17 to 51 degrees. In the long-term postoperative evaluation, the average ulnar drift had increased to 12 degrees, the average extension deficit had increased to 22 degrees, and the average range of motion had decreased to 39 degrees. Grip strength and prehension did not significantly improve at either evaluation. There were no fractures of the prosthesis and no patient had synovitis. We have found the procedure to be useful for the correction of deformity, increasing range of motion of the fingers, and improving the patient's sense of well-being. | |
| 2691150 | Introduction to orthopaedic surgery in rheumatoid arthritis. | 1989 Sep | Surgical treatment of rheumatoid arthritis dates back some fifty years to when rheumatology developed into a separate branch of medicine. An interdisciplinary approach to rheumatoid arthritis was then introduced at a few specialized centres. By refining the surgical techniques, increasing the number of surgical options to be more precisely defined, this fifty years' experience in the surgery of rheumatoid arthritis has led to the good results that can be achieved today. The goals of the surgical treatment of rheumatoid arthritis are pain relief, improvement of joint motion or stability and correction of deformities. In addition, progression of the disease is likely to be halted in the operated joint. Operations may be classified as either preventive or reconstructive; sometimes they are both. Surgery is indicated when medical treatment fails to adequately check progression of the disease. Absolute indications include tendon ruptures, nerve compression, instability of the cervical spine associated with neurological symptoms, and severe deformities. |