Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 2539618 | [Magnetic resonance tomography of the craniocervical junction in chronic polyarthritis]. | 1989 Apr | Magnetic resonance imaging and conventional radiographs and tomograms were correlated in 61 patients with chronic polyarthritis. Radiographs of the occipito-cervical junction only demonstrated bone lesions, erosions were detected on conventional tomograms. MRI was adequate for demonstration of bone abnormalities and soft tissue lesion and was especially suitable for detection of complications at the cervical spinal cord. | |
| 2237676 | [Intra-articular rheumatoid nodules of the knee joint]. | 1990 Apr | Intra-articular rheumatoid nodules found in 6 knee joints of 4 patients with rheumatoid arthritis were reported with histological findings. All patients were women, ranging in age from 32 to 61 years, with 6 to 41-year history of rheumatoid arthritis. The masses were exclusively in the anterolateral aspect of the joint. Snapping occurred when the joint was flexed by 20 degrees in four joints and by 60 degrees in two. The masses had the sizes of a thumb tip to index-finger tip, and were elastic and soft. Histologic examination of the masses revealed the typical formation of rheumatoid nodule in two joints. Myxomatous degeneration and granulation tissue consistent with rheumatoid arthritis were found in two joints. Perivascular fibrosis and myxomatous degeneration were mainly demonstrated in two joints which had developed masses two months before excision. | |
| 2877856 | Assessing the progression of joint damage in rheumatoid arthritis. | 1986 | Joint damage in rheumatoid arthritis can be assessed by plain radiographs of the hands and wrists. There are a number of established methods that give reproducible scores which relate to increasing joint damage by measuring erosions and loss of joint space. Only 3 placebo-controlled trials have shown convincing evidence that gold or cyclophosphamide reduce the rate of progression of joint damage. Most placebo-controlled studies have failed to show a beneficial effect of slow acting antirheumatic drugs on radiological joint damage progression. However, comparative studies or analyses of cohorts of patients taking slow acting antirheumatic drugs show comparable amounts of progression for patients receiving gold and other drugs in this category. In addition, patients who show a clinical response also have less radiological progression after 6 months' therapy. In these circumstances, sulphasalazine produces comparable rates of radiological progression to those produced by gold and penicillamine. There are many problems associated with the use of radiological assessments to determine the progression of rheumatoid arthritis; thus, this method should not be deemed the most important technique by which to measure the success of therapy. | |
| 2353153 | Significance of rheumatoid factor isotypes in seronegative rheumatoid arthritis. | 1990 | In a cross-sectional study of 124 patients with definite or classical rheumatoid arthritis (RA) and negative agglutination assays, rheumatoid factor (RF) isotypes were measured using an ELISA technique. Elevated levels of IgA-RF were found in 55 patients (44%), IgG-RF in 99 (80%), and IgM-RF in 20 (16%). The levels of IgA- and IgM-RF correlated with each other (P less than 0.001). Elevated levels of IgM-RF were associated with a more severe disease course. Elevated levels of IgA-RF correlated with the occurrence of bone erosions. The results of this study suggest that in patients with RA and negative agglutination assays, both IgM- and IgA-RF are markers of disease severity. | |
| 3397965 | Patient outcome following inpatient vs outpatient treatment of rheumatoid arthritis. | 1988 Apr | To assess the short and longterm efficacy of intensive inpatient treatment of active rheumatoid arthritis (RA), 16 patients, the test group, admitted to a hospital based rheumatic disease unit (mean length of stay 12.4 days) were studied, using clinical and laboratory variables. The comparison group was similarly evaluated, using 10 outpatients with active RA to whom hospitalization was recommended, but refused by the patients. Both groups were studied intensively over a 12-week period. In addition, a 2-year followup was performed on 12 test group inpatients and 8 comparison group outpatients, using the same variables plus a functional status questionnaire. Health care costs were determined for both groups and corrected for a 1985 dollar value. The test group showed significant improvement in morning stiffness, pain, and joint score, whereas the comparison group improved only in pain score during the initial 12-week period. At 2 years, the test group and the comparison group showed significant improvement in morning stiffness, pain, grip strength, and joint score. The comparison group initially had a somewhat lower index of disease activity. The test group maintained their initial improvement and none required rehospitalization. Functional status scores were similar for both groups. Health care costs were initially higher for the test group ($5,065); followup care cost for the test group was $99 less/year than the comparison group over 2 years. Hospitalization on a rheumatic disease unit brought about prompt, sustained improvement in 2 weeks which required nearly 2 years to achieve in the comparison group. Such hospitalization of uncomplicated RA seems warranted to decrease disability and increase the quality of life. | |
| 3501276 | Older age onset rheumatoid arthritis with or without osteoarthritis. | 1987 Dec | The clinical features of a group of 79 patients with older age onset rheumatoid arthritis (ORA) were compared with those of a group of 414 patients with younger age onset rheumatoid arthritis. The ORA group contained approximately equal numbers of men and women, were less rheumatoid factor positive, had a raised erythrocyte sedimentation rate, lower HLA-DR4 positivity, and a tendency towards larger joint involvement at the onset of the disease. These features have been reported by many authors except for the lower DR4 positivity. Of these features, the lower prevalence of rheumatoid factor positivity and the tendency towards larger joint involvement at the onset were characteristic of a subset of patients with ORA who had had osteoarthritis before the onset of rheumatoid arthritis. It is suggested that osteoarthritic large joints may be susceptible to the occurrence of rheumatoid synovitis at the onset of the disease, but that the osteoarthritis inducing factor may be negatively related to the progression of rheumatoid arthritis. | |
| 1947898 | Functional improvement and costs of hip and knee arthroplasty in destructive rheumatoid ar | 1991 | Functional improvement and costs were analysed in 54 patients after 23 hip and 31 knee arthroplasties. All patients had destructive RA (ARA criteria 5-8). Mean stay at the surgical department was 15 and 26 days respectively, regardless of preoperative locomotion status, sex, or age, but additional in-patient rehabilitation was significantly longer after knee than hip arthroplasty (11 days and 4 days, respectively). Subjective and objective status as evaluated with total locomotion score showed significant improvement 6 months after operation. The degree of over-all improvement was equal for men and women, for all age groups, and for the different score groups. Quality of life improved with pain relief, improved sleep, and improved walking ability. The mean total costs were 34,902 SEK for hip and 56,200 SEK for knee replacement, including in-patient rehabilitation. Costs for home help were reduced from 693,600 SEK to 479,400 SEK. Severely disabled patients showed satisfactory improvement, but did not reach the functional level achieved by patients who were less disabled at the time of operation. Costs were not significantly higher for the former category. | |
| 3453966 | Rheumatoid arthritis in the metacarpophalangeal joint. | 1987 Feb | A case is presented illustrating some of the basic principles in the development of deformity in the rheumatoid hand. Swanson flexible implant arthroplasties of the second through the fifth metacarpophalangeal joints are described and postoperative care and follow-up discussed. The authors conclude that surgery plays a crucial role in the early treatment of the rheumatoid hand. | |
| 1946927 | Rheumatoid arthritis: workload and outcome over 10 years. | 1991 Jun | Rheumatoid arthritis remains a chronic disabling disorder in which medical and surgical intervention may provide amelioration but not cure. In this study a cohort of 123 rheumatoid patients were followed for a period of 10 years from the time of prescription of their initial second-line agent. The workload involved in managing articular, extra-articular and intercurrent disease in these patients has been documented and outcome in relation to continued use of 'disease modifying' therapy evaluated. At 10 years 24 patients (20 per cent) had died and 7 (5 per cent) were not traced; of the 92 (75 per cent) who were assessed, three had become wheelchairbound, two for reasons other than rheumatoid arthritis. Seventy-one per cent of patients required joint surgery, 36 per cent management of peptic ulcer and 45 per cent experienced major episodes of sepsis. Analysis of the results in the 92 patients who were evaluated at 10 years showed significant improvement in Ritchie articular index, pain score, morning stiffness, haemoglobin, platelets, ESR, total globulins, IgG and IgM. Grip strength and Lee functional index showed a trend towards deterioration which did not reach significance. Sixty-seven (73 per cent) of the 92 patients remained on a second- or third-line agent at 10 years (median duration of treatment 107 months); 25 (27 per cent) were not receiving such therapy (median duration of second- and third-line therapy 13 months). The group remaining on treatment showed significant improvement similar to that of the total study group. Those not on treatment improved only for articular index; Lee functional index deteriorated significantly. There was a correlation between area under the curve for ESR over 10 years and radiological progression of disease in hands (r = 0.29, p = 0.026) and in knees and hips (r = 0.3748, p = 0.012) over the 10 year period. Radiographic score correlated well with Lee functional index at the outset and at 10 years and also with the change in the radiographic score over the 10-year period. Unlike the results of previous studies, there was no morbidity from vertebral collapse; this may be related to the low dose of corticosteroids in this cohort (seven patients received systemic corticosteroids). Thus while the aim of treating patients for prolonged periods with second- or third-line therapy was achieved in the majority with no overt evidence of cumulative toxicity, sustained medical and surgical intervention was and will be needed in order to minimize disability in these and other patients with rheumatoid arthritis. | |
| 3211504 | Bilateral epibulbar rheumatoid nodulosis. A new ocular entity. | 1988 Sep | A 61-year-old woman, whose rheumatoid arthritis had been quiescent for 9 years, developed a crop fo 16 painless bilateral episcleral rheumatoid nodules without any flareup of her joint disease. Biopsy of the lesions disclosed lymphocytic and plasmacytic infiltration within the conjunctiva, overlying palisading granulomas with elongated epithelioid histiocytes, multinucleated giant cells, and central necrobiotic degeneration of the collagen of the episclera and superficial sclera. The rheumatologic designation for the development of groups of subcutaneous nodules in inactive rheumatoid arthritis is rheumatoid nodulosis. This report is the first description of this entity in the ocular adnexa. | |
| 1947303 | Rheumatoid arthritis of the cervical spine. | 1991 Aug | This article discusses the pathologic and radiologic changes in the cervical spine that occur with rheumatoid arthritis. The relevance of radiologic evaluation using radiographs, conventional tomography, myelography, computed tomography, computed tomography-myelography, and magnetic resonance imaging is discussed. Magnetic resonance imaging is the pre-eminent radiologic modality in the examination of cervical rheumatoid arthritis. | |
| 3533082 | Group therapies for rheumatoid arthritis. A controlled study of two approaches. | 1986 Oct | An important unanswered question about rheumatoid arthritis (RA) is how the patient's psychological or emotional state relates to disease activity and functional status. No controlled studies of psychotherapeutic interventions in RA have been reported. To test the hypothesis that a psychosocial intervention would lead to improvement in functional status or disease activity, 57 RA patients were randomly assigned to 1 of 3 groups, which received: 1) conventional group psychotherapy; 2) group assertion/relaxation training; or 3) no treatment (control group). Patient and physician questionnaires collected at baseline, immediately after the interventions, and 12 months after baseline provided outcome data on functional status, social and psychological adaptation, psychological symptoms, and disease activity. There were few outcome measures for which either treatment resulted in significantly higher scores than were seen in controls, though more improvement did occur among patients who received conventional group psychotherapy. | |
| 2015015 | Anterolateral rupture of popliteal cysts in rheumatoid arthritis. | 1991 Mar | Popliteal cysts occur commonly in both normal and arthritic knees. Most cysts are formed by distension of the medially situated semimembranosus bursa. Popliteus bursa distension occurs uncommonly as a lateral popliteal cyst. Two cases of rupture of lateral cysts which produced symptoms related to the anterolateral lower leg are reported. The difficulty of diagnosing the condition because of this unusual site of inflammation and subsequent management problems are discussed. | |
| 3145661 | [The concept of basic therapy of chronic polyarthritis with D-penicillamine: clinical expe | 1988 | Rheumatoid arthritis is a chronic lifelong disease, facts which must be considered when concepts of therapy are developed. This paper reports retrospectively analyzed results of long-term therapy using D-penicillamine. One-hundred-sixteen patients were selected for critical analysis from among 257 treated patients. Judgment was made according to the parameters: inflammation activity, radiological progression, remission rate, clinical outcome-measurement. The results show that the clinical course of the disease is influenced by the treatment and they confirm the need for long-term therapy with an emphasis on immunomodulation. | |
| 2200786 | Complete heart block in rheumatoid arthritis. | 1990 Jun | A case of rheumatoid arthritis with complete AV heart block is reported. The relevant literature is briefly reviewed. | |
| 2075371 | The neo-synovial membrane of patients with active rheumatoid arthritis at resynovectomy. H | 1990 | Neo-synovial membranes, which formed after "primary" synovectomy in 21 patients with rheumatoid arthritis (RA), were studied at resynovectomy. The clinical, histomorphological, and immunohistological data were compared with data derived from "primary" synovial membranes from RA and osteoarthritis (OA) patients. The clinical data suggest a less active rheumatoid inflammatory response after synovectomy. Histomorphologicaly, the synovitis in resynovectomized neosynovial membranes of RA revealed no qualitative differences when compared with synovitis in the "primary" synovium. However, the degree of the inflammatory rection evaluated by the different parameters was found to be distinctly lower. The immunohistological data correlated with these findings. | |
| 1847487 | [Intralymphatic administration of open radionuclides in complex treatment of rheumatoid ar | 1991 | A new method was developed for the treatment of patients with rheumatic arthritis using therapeutic effect of radioactive colloid aurum in the lower limb lymphatic vessels. Altogether 50 patients with various degrees of activity and stages of disease were treated. A positive therapeutic effect was observed in 84%. The method of endolymphatic radiotherapy with radioactive colloid aurum made it possible to give up cytostatic and glucocorticoid therapy and to reduce a dosage of nonsteroid antiinflammatory drugs. | |
| 2473207 | Liver biopsy findings in patients with rheumatoid arthritis undergoing longterm treatment | 1989 Apr | Ten histological criteria were evaluated semiquantitatively in the liver biopsies of 60 patients with rheumatoid arthritis (RA) before initiation of methotrexate (MTX) and were compared with 40 biopsies taken during MTX treatment (mean cumulative dose 1.322 mg). Mesenchymal changes (Kupffer cell proliferation, portal tract infiltration) and parenchymal alterations (nuclear variability, ballooning, fatty infiltration) were very common without statistically significant difference between the 2 groups. Slight periportal and/or portal fibrosis was present in 25% of patients without statistical difference between groups. Central fibrosis occurred in 13.5-12.5%. We conclude that liver abnormalities in RA are not related to MTX treatment. | |
| 2512936 | Cost-effectiveness of inpatient and intensive outpatient treatment of rheumatoid arthritis | 1989 Dec | Women with active rheumatoid arthritis who were judged to be in need of hospitalization were assigned at random to receive inpatient therapy (n = 35) or intensive outpatient therapy (n = 36). All relevant costs of treatment were measured. At 19 weeks, clinical outcomes, as summarized in a pooled index, were significantly better in the inpatient group (pooled index units: inpatient 0.72, outpatient 0.25; F[1,69] = 10.9, P = 0.002). Inpatient therapy produced a sustained three-fold increase in efficacy, at a 2.5-fold increase in cost to society. | |
| 2360423 | Operations for the unstable cervical spine in rheumatoid arthritis. Sixteen cases of subax | 1990 Apr | Sixteen patients with seropositive rheumatoid arthritis were operated on for subaxial subluxations. Four of the patients had slight, but progressive, tetraparesis, and 5 had severe or total tetraparesis; they were operated on 1-4 months after the first signs. Seven patients were treated for severe neck and shoulder pain. Nine patients had subluxation at the C3-4 level, the most common site, and 3 patients also had an atlantoaxial subluxation. Patients with cord compression were treated with posterior laminectomies and fusions that relieved the tetraparesis. Two patients died during the early postoperative period: 1 of a cardiac infarction and the other of pneumonia. During 4 (1.5-9) years' follow-up, 3 patients had new subluxations at other levels. |