Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 2781493 | [Myocardial reaction and lung ventilation response to inhalation of the gaseous hypoxic mi | 1989 | The initial and end parts of the ventricular complex of the ECG and the roentgenopneumopolygraphy data were assayed in 22 patients with rheumatoid arthritis before and after inhalation of the gaseous hypoxic mixture (GGS-10) consisting of 90% of nitrogen and 10% of oxygen. After the inhalation of the mixture the area of the ST-T segment significantly increased as compared with the initial data, mainly in the AVR, V2 and V5 leads of the ECG. In addition, individual features of the changes in respiratory pulmonary function were discovered, which directly correlated with the disease stage. | |
| 2359068 | A clinical and biochemical assessment of a nonthiol ACE inhibitor (pentopril; CGS-13945) i | 1990 May | Captopril, which is a thiol containing angiotensin converting enzyme (ACE) inhibitor that has a close structural similarity to D-penicillamine, behaves as a disease modifying antirheumatic drug (DMARD) in rheumatoid arthritis (RA). In order to ascertain whether the DMARD-like properties of captopril reside in its ability to inhibit ACE or in the thiol group, we evaluated pentopril (CGS-13945) in patients with active RA. This recently synthesized drug is a nonthiol containing ACE inhibitor. Pentopril produced little clinical improvement and no biochemical improvement in a group of 15 patients with RA, many of whom were unable to tolerate it because of in-effect or side effects. A reduction in serum ACE activity and a modest fall in blood pressure suggested that the drug was exerting its pharmacological effect. Our study strengthens the argument that the therapeutic benefit of captopril in RA probably lies in its thiol group rather than in its enzyme inhibition properties, and that the thiol group may be the effective moiety in some other DMARD. | |
| 3777878 | [Rheumatoid polyarthritis and interstitial cystopathy]. | 1986 | The authors report a case of interstitial cystitis occurring in association with very active rheumatoid arthritis. Although the association of immune disorders and rheumatoid arthritis is well known, cases of concomitant vesical lesions have only been reported exceptionally. The diagnosis of interstitial cystitis is based on histology and immunofluorescence studies. The pathogenetic hypothesis remains uncertain: is this a primary bladder disease or a systemic auto-immune disease with a urinary tract expression? The success of immunosuppressant treatment in this case of cystitis is in favour of the second hypothesis. | |
| 3054096 | Population analysis of symmetrical erosive arthritis in Ohio Woodland Indians (1200 years | 1988 Aug | The antiquity of the symmetrical peripheral erosive arthritis generally classified as rheumatoid arthritis is extended substantially from previous perspectives based on European, Asian, and African studies. New evidence supports its New World origin and the likelihood of subsequent spread to the Old. | |
| 3457667 | Gallium imaging of rheumatoid pachymeningitis. | 1986 May | A case of abnormal uptake of gallium in the tentorium cerebelli secondary to rheumatoid pachymeningitis is presented. | |
| 3951357 | Parenteral gold therapy in the Felty syndrome. Experience with 20 patients. | 1986 Mar | Most of the patients with the Felty syndrome suffer from such complications as fevers, infections, cutaneous ulcers, and vasculitis. Unfortunately, there are no therapeutic interventions that are predictably beneficial. We report our experience with 20 patients who received parenteral gold therapy for 2 to 114 months (mean, 23.6 months). All had complications of the Felty syndrome. On parenteral gold therapy, 60% had a complete response, 20% had a partial response, and 20% were unresponsive by preselected criteria. No serious complications were encountered. We think that parenteral gold therapy should be considered early, before other agents, in the treatment of this condition. | |
| 3368749 | Evaluation of the rheumatoid shoulder function after hemiarthroplasty and arthrodesis. | 1988 | Rheumatoid arthritis frequently involves the shoulder. In the advanced stages of the disease the preferred treatment has been either arthroplasty or arthrodesis. The functional results of five shoulder arthrodeses have been compared with five hemiarthroplasties. The period of postoperative immobilization was shorter for hemiarthroplasty; both procedures relieved pain, but personal hygiene was easier to manage after hemiarthroplasty. Shoulder arthrodesis with a fixed internal rotation greater than 40 degrees makes it impossible to reach the face and the optimal position would seem to be 20-30 degrees of abduction. 20-30 degrees flexion and 20-30 degrees internal rotation. | |
| 3767468 | Monarticular rheumatoid-like arthritis of seven years' duration following fracture of the | 1986 Sep | We report a patient who developed rheumatoid-like arthritis in an elbow joint following a fracture. The arthritis has remained localised to that joint for seven years. | |
| 3599007 | Multiple tendon rupture at unusual sites in rheumatoid arthritis. | 1987 Apr | A patient with seropositive nodular rheumatoid arthritis taking large doses of corticosteroids developed multiple tendon ruptures around weight bearing joints. The mechanisms underlying this rare complication are discussed. | |
| 2959124 | Determination of IgE rheumatoid factor. Comparison of a solid-phase radioimmunoassay and a | 1987 | A solid-phase radioimmunoassay and an enzyme-linked immunosorbent assay have been developed for the identification of IgE rheumatoid factor (IgE RF). For both, human IgG was used as antigen. Bound IgE RF was detected by means of commercially available rabbit anti-human IgE antiserum and 125I-labelled sheep anti-rabbit IgG as well as monoclonal anti-human-epsilon-chain antibody and horse-radish peroxidase-labelled sheep anti-mouse IgG. The presence of IgM RF did not cause false positive results. Correlation in the results of both assays were significant, the reproducibility was very good. In 50.6% of 79 sera from patients with rheumatoid arthritis IgE RF has been detected with both or one of the methods. Only in 1 out of 12 seronegative rheumatoid arthritis sera IgE RF was identified. | |
| 2101185 | [Physiotherapeutic treatment in the recuperation of rheumatoid hands]. | 1990 Apr | In restoring the rheumatoid hand, the balneo-physical therapy considers the restrain of the painful and inflammatory phenomena, and the prevention and correction of the deforming lesions with the view to restore the muscle prehension. The final aim is the function restoration and the socio-professional readjustment of the patients. The author presents in detail the devices of physical therapy. | |
| 1865421 | Complete reversal of rheumatoid nodulosis. | 1991 May | A woman first seen in 1978 had a history of seropositive rheumatoid arthritis (RA) of 12 years' duration with attacks of palindromic rheumatism for 3 years. She was treated with D-penicillamine, pyridoxine and hydroxychloroquine and serial measurements of her grip strength and proximal interphalangeal joint circumference were taken. By 1987 all her nodules had resorbed completely. Hydroxychloroquine effects probably helped her improvement. Although spontaneous resorption of a rheumatoid nodule is not a rare event, to the best of our knowledge, this is the first instance of complete resolution of all nodules in a patient with RA with the nodulosis variant. | |
| 3294204 | Influence of joint inflammation on chondrocyte function. | 1988 | Chondrocyte metabolism changes dramatically during joint inflammation. This overview summarizes the potential mechanisms underlying cartilage destruction in experimental arthritis models and provides arguments for a role for various inflammatory mediators. The contributions of both proteoglycan breakdown and impairment of chondrocyte function are discussed. | |
| 3340903 | Clinical regression of amyloid nephropathy in a patient with rheumatoid arthritis. A case | 1988 Jan 9 | A 22-year-old woman with active seronegative rheumatoid arthritis responded to intramuscular gold but developed proteinuria which settled when this therapy was stopped. Proteinuria recurred after 2 weeks of penicillamine therapy but settled when this regimen was stopped. Six months later she developed a nephrotic syndrome and rectal and renal biopsies showed evidence of amyloidosis. She was treated with chlorambucil for 1 year and the disease activity was well controlled. There was regression of the nephrotic syndrome and her serum albumin and renal function are normal 6 years later. | |
| 3572938 | What are we measuring? An examination of walk time and grip strength. | 1987 Feb | Are walk time and grip strength measures of disease activity or functional ability? Ninety-two patients with rheumatoid arthritis were examined initially and 12 months later for clinical measures including joint deformity, and answered a functional status questionnaire. Walk time and grip strength were strongly related to joint deformity and functional questionnaire measures, and appeared insensitive in showing changes in disease activity over time. They could serve as objective functional measures in studies primarily directed towards changing functional ability, but appeared to be poor major outcome measures for trials aimed at altering disease activity. | |
| 2487696 | Intraarticular corticosteroid injections: should we rest the joints? | 1989 Jun | To prevent damage in injected joints, it has been our policy to rest them for 48 hours. To test this assertion we randomized 30 rheumatoid arthritis (RA) patients (rest, no-rest). Results in 28 patients (63 joints: 27 rest and 36 no-rest) are presented. Joint evaluation was performed at baseline and at 48 hours (pain/tenderness, swelling and range of motion). Two analyses were conducted, the first included all joints, and the second only joint pairs. In both cases measurements at 48 hours were comparable for the rest and no rest group for both upper and lower extremity joints (pain/tenderness/swelling and range of motion). At a later follow up (average 10 months) there were no differences in any of the parameters examined. Our study suggests that rest is not essential for intraarticular corticosteroids to be beneficial, at least in an inpatient setting. The applicability of our data to an outpatient population remains to be determined. | |
| 3285254 | A double blind comparison of tiaprofenic acid with placebo. | 1988 May 11 | The results of a double blind crossover comparative trial of the nonsteroidal antiinflammatory drug tiaprofenic acid with placebo in the treatment of rheumatoid arthritis are reported. Tiaprofenic acid was confirmed as being an effective drug of this class and no untoward side effects were encountered. Individual response was varied and not related to disease activity. | |
| 2054967 | Relationship between physical impairment, psychological variables and pain in rheumatoid d | 1991 Jan | Forty-two consecutive female rheumatoid patients were given the AIMS questionnaire in order to determine their disability. Twenty-one had a second assessment one year later. Factorial analysis showed that the Italian version fully respects the construct of the original test. In fact four main factors (the physical, psychological, social and pain dimensions) arose, explaining 44.8%, 13.6%, 11.4% and 9% of the total variance, respectively. A close relationship was demonstrated between psychological variables, namely depression, and physical impairment, as shown by the correlation coefficient matrix. In order to determine whether depression might influence the ultimate outcome twenty-one patients were separated into two subsets according to their initial depression (greater than 5, less than 5). After one year, dexterity and pain were significantly worse in those with the highest depression score. This study shows that the psychological variables, in addition to physical impairment and pain, are of utmost importance in the outcome of rheumatoid patients. | |
| 3042074 | The Middlesex Hospital prospective study of early rheumatoid disease. | 1988 | A review of findings obtained from a follow-up study of rheumatoid arthritis implicated a positive rheumatoid factor test as the most useful indicator of subsequent joint erosion. | |
| 3764751 | [Comparative evaluation of the effectiveness of plasmapheresis and lymphocytoplasmapheresi | 1986 | The authors compared 2 methods of apheresis: plasmapheresis (PA) and lymphocytoplasmapheresis (LPA) in 24 patients with rheumatoid arthritis (RA). Both methods were shown to produce a positive effect on a course of rheumatoid process decreasing clinical and laboratory parameters of its activity, improving articular function. Under LPA influence the production of autoantibodies by B-lymphocytes was significantly lowered. PA and LPA were characterized by a more rapid development of the regression of RA symptoms as compared to drug therapy and by a good tolerance of the procedures. On the basis of the results obtained a preliminary conclusion has been made of the greater efficacy of LPA as compared to that of PA. However, the assessment of long-term therapeutic results is required to consider the probable LPA influence on cellular immunity. |