Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 6340698 | Fibrin and fibronectin in rheumatoid synovial membrane and rheumatoid synovial fluid. | 1983 Apr | Normal synovial membranes and synovial membranes from patients with classic rheumatoid arthritis were investigated for the presence of fibrin and fibronectin by an indirect immunoperoxidase technique. In normal synovial membranes, fibronectin was found around the monolayer of the synovial lining cells. Staining was most intense on the surface and beneath the lining cells, but not detectable in the cytoplasm. Fibronectin was also found in the cytoplasm of the endothelial cells. No staining for fibrin was found in the normal synovial membrane. In synovial membranes from patients with rheumatoid arthritis, large amounts of fibronectin were found around the multilayer of synovial lining cells, in the cytoplasm of the endothelial cells, and in argyrophilic fiber-rich connective tissue. In superficial areas denuded of synovial lining cells, high amounts of fibronectin were found incorporated in fibrin. In some areas with noninjured synovial lining cells, fibrin was also found, but in this case no fibronectin was incorporated. No fibronectin was found in connective tissue in areas with infiltration of inflammatory cells. After treatment of normal and rheumatoid synovial membranes with hyaluronidase, fibronectin was still present around the lining cells but the staining was found to be more distinct. This study relates the presence of fibrin and fibronectin in the rheumatoid synovial membrane to the high amount of these proteins, recently described, in rheumatoid synovial fluid. It also suggests that fibronectin present in the synovial membrane is produced and secreted by the endothelial cells. | |
| 6480068 | Non-steroidal anti-inflammatory drugs in rheumatoid arthritis. Effects on clinical paramet | 1984 Jun | Fourteen patients with classical or definite rheumatoid arthritis were studied for the effect of piroxicam treatment on clinical parameters and cellular immunity. The treatment caused reduced disease activity as assayed by an augmented grip strength, reduced total stiffness, reduced duration of morning stiffness and reduced Ritchies articular index. No effect of the treatment was observed on the percentages of T8 and T4 positive cells nor on the natural killer (NK) cell activity in the peripheral blood mononuclear cells. In contrast, the treatment led to a reduction in the total amount of rheumatoid factor. Since rheumatoid factor is mainly produced locally in the inflamed synovial membranes, our results suggest an effect of piroxicam on the immune system locally but not in the peripheral blood. | |
| 1273600 | Prospective study of the early course of rheumatoid arthritis in young adults: comparison | 1976 May | The early course of newly diagnosed RA among young adult patients (16-44 yr) is described from results of an ongoing study with a mean follow-up of 3.4 yr. Study diagnosis was based on the judgement of experienced rheumatologists, and data on several hundred variables were obtained on entry and annually for the purpose of defining patterns of onset and course of disease. Race and sex factors, as well as certain entry manifestations, e.g., RF, were found to correlate with onset and course patterns. Females, and especially white females, had significantly greater numbers of swollen upper extremity joints than males at entry and at last observation, with increased likelihood of developing bone erosions. At entry, RF positive patients differed only on few articular manifestations from RF negative patients, but had a higher frequency of positive ANA at entry and more subcutaneous nodules and bone erosions during follow-up. Seropositive white females at entry had significantly more swollen upper joints than their seronegative counterparts, but with no difference found at last follow-up. White females of each serogroup had more joint involvement at last examination than patients of other race-sex groups. Males had more acute onset, especially under age 30, with significantly greater improvement in arthritis and in ESR than did females. The majority (55%) of patients entered as seropositive, converted to seronegative during follow-up, and no correlation of either joint swelling or erosions was noted with this phenomenon. At last visit, RF positively did not correlate with bone erosions, but patients developing bone erosions had higher frequency of ANA and higher mean serum complement levels at last examination. The following entry factors were found to correlate significantly with a better outcome: maleness, acute onset under age 30, less swollen upper joints, and negative RF. Type of drug therapy tended to reflect severity of arthritis, rather than vice versa, and functional capacity improved significantly from entry to last evaluation in both males and females, even though the latter had stable or progressive arthritis. Further study is necessary over long intervals and in wider age range to more adequately interpret the biologic implications of findings of this ongoing study. A better understanding of the pathogenesis of RA may be derived from critical studies of the contribution of host factors, e.g., sex, and other variables predisposing to the development of RF positivity (and ANA), subcutaneous nodules, and bone erosions, particularly in systematic ongoing studies of patients with early diagnosed disease. | |
| 6651896 | Synovial fluid lactic acid in septic and nonseptic arthritis. | 1983 Dec | We determined lactic acid levels by the lactic dehydrogenase method in synovial fluid of 41 patients with various rheumatic diseases, to test the concept that significantly elevated values were diagnostic of septic arthritis. Nine patients had septic arthritis, 15 rheumatoid arthritis (RA), and the remainder miscellaneous conditions. In another 9 patients with different rheumatic diseases, including 1 with septic arthritis, synovial fluid lactic acid was determined by both the lactic dehydrogenase and gas-liquid chromatography methods. There was a wide scatter of values among patients with septic and nonseptic inflammatory arthritis, and much overlap occurred. We could not differentiate septic arthritis from RA on the basis of synovial fluid lactic acid levels. Results were similar with both procedures for determining lactic acid levels. | |
| 3863515 | Correction of swan-neck and boutonnière deformities. | 1985 | Rheumatoid arthritis frequently affecting the hand is a progressive and disabling illness. The delicate and precis digital motor mechanism is frequently affected by this disease and the consequences are devastating, with marked functional impairment. This paper discusses two of the most frequent digital deformities: the swan-neck and boutonniere. The pathophysiology, and classification according to the evolution grades of these deformities are presented. Practical application of various surgical techniques, each worked out and proven over 30 years of experience and a great number of cases treated is described. Unfortunately, the results are still modest in relation to the destruction created by this progressive pathology. However, we rely on certain modern techniques and thus obtain considerable functional improvement. The elastomer or silicone rubber prosthesis, implanted with sophisticated techniques and delicate handling of tissues is one of most significant innovations. | |
| 6601934 | Coexistence of Reiter's syndrome and rheumatoid arthritis in a genetically susceptible ind | 1983 Apr | A patient is presented who had features of Reiter's syndrome for 10 years before developing features of rheumatoid arthritis. Diagnostic criteria for both diseases are fulfilled, and HLA typing revealed the presence of both B27 and DR4 antigens. The coexistence of Reiter's syndrome and rheumatoid arthritis appears to have occurred in an individual genetically susceptible to both diseases. | |
| 6188190 | [Radiologic and clinico-serological correlates in rheumatoid arthritis]. | 1983 Mar | In a study of 86 patients with rheumatoid arthritis a valid statistical correlation can be found between the entity of the osteo-articular lesions of the hand and wrist shown by radiography to a high definition and some clinical and serological parameters. The results indicate a good correlation with a large part of the considered parameters (anatomical stage, functional class, duration of the disease, VES, gamma-globulins, serological activity) and confirm the validity of the high definition radiographical study in the follow-up of the disease. | |
| 4090522 | [A rare form of rheumatic lung disease]. | 1985 Dec 20 | Rheumatic changes of the lung are not usual findings, but may accompany rheumatoid arthritis in the form of interstitial fibrosis or pleurisy. The extent of the rheumatic changes depends on the duration of the illness. Necrobiotic nodules in the lung are found very rarely indeed, but if so then usually in the lower lobe of the lung. A case of necrobiotic nodules in the upper lobe of the lung is described. | |
| 7051253 | Anatomic separation of the suprapatellar pouch spares its involvement by rheumatoid synovi | 1981 | Synovectomy of the knee was performed in a 27-year-old female with seropositive rheumatoid arthritis of 6 years duration. At surgery the suprapatellar pouch was found to be separate from the rest of the knee joint, where direct access to articular collagenous tissues remained. The suprapatellar pouch, presumably separate from the knee cavity since birth, was free of disease. The rest of the joint lining, and synovium of the forefoot joints, that had been operated on at the same time, had gross and histological evidence of severe rheumatoid synovitis. The sparing of this suprapatellar pouch by rheumatoid disease is not easily explained, especially since its origin and nature are similar to other synovial parts of the knee that were actively involved. These latter areas had direct access to articular collagenous tissues. The findings of this case question the predilection of rheumatoid arthritis for synovium, and suggest that synovium and articular collagenous tissues are requisites of chronic rheumatoid arthritis. | |
| 6941687 | Treatment of rheumatoid arthritis with levamisole. | 1980 | Levamisole has been shown to be an effective, penicillamine-like drug. Its action is slow, it improves extra-articular features of the disease and reduces ESR and rheumatoid factor titre. Comparison with penicillamine has shown the two drugs to be comparable in effectiveness. Experience with different dosage regimes of levamisole suggest that 150 mg weekly is the optimal dose. It is as effective as larger doses and with fewer adverse reactions. Problems with levamisole have included neutropenia and rashes. The latter are sometimes severe and vasculitic. As with penicillamine some of the late complications of levamisole appear to be associated with immune complex deposition. | |
| 6713984 | Bronchiolitis in rheumatoid arthritis. | 1984 May | Bronchiolitis in association with rheumatoid arthritis has been reported, to our knowledge, in 18 patients to date. In some cases use of penicillamine has been strongly associated with the development of bronchiolitis. Most of the reported cases are described as having marked irreversible airways obstruction and hyperinflation. We describe a patient with rheumatoid arthritis whose respiratory tract symptoms began during gold therapy. Physiologic studies showed marked lung hyperinflation without pathologic findings in forced dry spirometric study. On open lung biopsy a mild degree of granulomatous bronchiolitis was found. Immunofluorescent microscopy showed IgM- and IgG-containing plasma cells in the bronchiolar walls. | |
| 6524203 | [Electrophysiologic correlates of generalized shifts in neurodynamics among rheumatoid art | 1984 | Objective electrophysiological correlates of generalized neurodynamic disturbances were studied in 80 patients with rheumatoid arthritis (RA). The results obtained indicate considerable changes in the level of alpha-activity (AA) and marked restitution of the interzonal paired and multiple correlation of AA in RA. | |
| 433943 | Prognosis in rheumatoid arthritis. A longitudinal study of newly diagnosed younger adult p | 1979 Mar | The course of rheumatoid arthritis was analyzed in 50 newly-diagnosed adults followed prospectively for an average of over five years. Eighteen patients had no swelling and no erosion (outcome 1), 22 patients had swelling without erosion (outcome 2) and 10 patients had erosion (outcome 3). Computer-assisted data screening and multivariate analytic technics were employed to derive a simple index from entry data which correlated closely with the patients' subsequent articular course. The index included six entry items: positive rhematoid factor; two or more swollen upper extremity joints on examination (2 points each); history of Raynaud's-like symptoms; malaise or weakness at the onset of arthritis; white race and female sex (1 point each). This index was 80 per cent accurate over-all in classifying patients into the three mutually exclusive articular outcome categories. Zero to 2 points on entry predicted no swelling, 3 to 5 points swelling without erosion and 6 to 8 points the development of bony erosion. Although results must be qualified to this patient population in the early stages of disease, the analytic approaches developed promise to assist with a broad range of clinical research and medical care delivery problems. | |
| 679484 | Serum glycylproline p-nitroanilidase activity in rheumatoid arthritis and systemic lupus e | 1978 Aug 15 | Glycylproline p-nitroanilidase activity in serum of patients with advanced rheumatoid arthritis or with systemic lupus erythematosus but with normal hepatic function was found to be significantly lower than that of normal adult controls. Decrease of this enzyme's serum activity was more pronounced in systemic lupus erythematosus. A significant inverse correlation was observed between the enzyme activity and the duration of rheumatoid arthritis. | |
| 725829 | Aortic valve replacement in rheumatoid aortic incompetence. | 1978 Oct | Rheumatoid aortic valve disease is uncommon. and there are few reports of valve replacement in this condition. Aortic valve replacement and partial pericardiectomy was performed in a patient with acute rheumatoid aortitis and aortic incompetence. Previous reports suggest that any patient with rheumatoid arthritis who develops cardiac symptoms should be carefully assessed for surgically treatable involvement of the pericardium or heart valves. | |
| 7074865 | Two-dimensional electrophoretic analysis of human leukocyte proteins from patients with rh | 1982 Apr | Human leukocyte proteins from more than 150 patients with rheumatoid arthritis, together with age- and sex-matched controls, were analyzed by use of the ISO-DALT technique in two-dimensional polyacrylamide gel electrophoresis. Patients with ankylosing spondylitis, polymyalgia rheumatica, psoriatic arthritis, calcium tendinitis, post-infectious arthritis, and asymmetrical seronegative arthritis were also included as positive controls. Synthesis of several proteins, referred to by number as members of the "Rheuma" set, is shown to increase in the leukocyte preparations from patients with classical rheumatoid arthritis. Several of these proteins are specific to monocytes or granulocytes; others are of unknown cellular origin, but appear to be unique to rheumatoid arthritis. The Rheuma proteins appear to be indicators of disease activity, because their increased synthesis can be correlated with sedimentation rate and other clinical indices of rheumatoid disease activity. | |
| 3875351 | Different populations of rheumatoid adherent cells mediate activation versus suppression o | 1985 Aug | Adherent cells from synovial tissue of rheumatoid arthritis patients were fractionated on Percoll density gradients and analyzed to determine phenotypes, effects on allogeneic T lymphocyte proliferation, and production of prostaglandin E2 (PGE2). Cells expressing HLA-DR predominated in all fractions, and esterase-positive cells were enriched in light fractions. Heavy cells were potent stimulators in the mixed lymphocyte reaction and produced little PGE2, whereas light cells suppressed the mixed lymphocyte reaction and produced a large quantity of PGE2. These results suggest that macrophage-like synovial cells that suppress T helper lymphocyte activity are generated secondary to synovial lymphocyte activation in rheumatoid arthritis. | |
| 1210467 | [Heridity of progressive chronic polyarthritis - study of the course]. | 1975 Nov 1 | In an analytic epidemiological study 30 relations of patients with progressive chronic polyarthritis with positive rheumatoid factor and 127 relations with negative rheumatoid factor were after-examined concerning their clinical and serological behaviour 6 years after the primary recognition with the aim of an evidence concerning the hypothesis of an hereditary causal factor in progressive chronic polyarthritis. It was revealed that only in 14 of 30 persons with positive primary rheumatoid factor the rheumatoid factor could further be proved, on the other hand 14 relations who had at first a negative rheumatoid factor now, however, reacted with a positive rheumatoid factor. It could be confirmed, that the seropositive forms of the progressive chronic polyarthritis have a stronger hereditary trend to the formation of the rheumatoid factor than the seronegativeones and that after the 50th year of life there exists a significant persistence of the seropositivity. In the group of relations who were seropositive 6 years ago developed a definitive and probable progressive chronic polyarthritis each as well as a further probable progressive chronic polyarthritis in the group of relations who became seropositive only in the period of observation. On account of the changing seropositivity and the only rare appearance of a progressive chronic polyarthritis on the basis of this investigation of hypothesis of the rheumatoid factor as first (premorbid) symptom of a progressive chronic polyarthritis is to be refused. | |
| 7387304 | Salivary gland dysfunction in systemic lupus erythematosus and rheumatoid arthritis. Diagn | 1980 Jul | Salivary scintigraphy employing radionuclides has proved to be an accurate, reproducible method for demonstrating salivary gland involvement in Sjögren's syndrome. A prospective study was undertaken of 24 consecutive patients bearing a diagnosis of systemic lupus erythematosus (SLE), 78 consecutive patients bearing a diagnosis of classic or definite rheumatoid arthritis, and 18 control patients. Clinical of Sjögren's syndrome did not necessarily correlate with abnormal scintiscans. Extensive involvement, with greatly abnormal scintiscans (class 3 and 4), was found most consistently in patients who had SLE and who were seronegative for rheumatoid factor Salivary gland scintigraphy may ultimately serve as an adjunctive procedure for the diagnosis of this disease. | |
| 7377865 | Radioactivity studies on 2 synovial specimens after radiation synovectomy with yttrium-90 | 1980 Feb | Synovial membranes surgically removed from the knees of 2 patients who had received radioactive yttrium-90 silicate have been examined. Autoradiographs showed that in both cases the activity was unevenly distributed over the synovium. One of the specimens, removed 7 weeks after administration of the isotope, was found to contain a slight degree of radioactivity, attributable in part to a long-lived radioactive contaminant. |