Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 6512366 | Swanson implant arthroplasty of the wrist in rheumatoid arthritis. | 1984 Oct | Sixty rheumatoid wrists operated with Swanson implant arthroplasty were evaluated after a mean observation time of thirty-three months. Grip function in daily living improved in 60%, pain decreased in 88%, range of motion increased in 83% and grip strength increased in 69% of operated wrists. Significantly impaired function was found in wrists with implant fracture (12%) and in cases with pronounced bone resorption around the implant (23%). Ulnar deviation and carpal collapse were commonly found but did not impair the function significantly. In seven patients the contralateral wrist had been fused and was compared to the arthroplasty. The merits and indications of arthroplasty are discussed. | |
| 103190 | Comparison of penicillamine and gold treatment in early rheumatoid arthritis. | 1978 | In a series of 100 adult patients with definite rheumatoid arthritis of at most 3 years' duration and with no previous penicillamine, gold or systemic corticosteroid treatment, 50 patients were treated with D-penicillamine and 50 with gold for one yar. The dose of penicillamine was 600 mg daily. Sodium aurothiomalate was given 50 mg weekly up to a total of 13 mg/kg and thereafter 50 mg once a month. In both treatment groups a statistically significant decrease in the number of painful and/or swollen joints, an increase in haemoglobin and a decrease in ESR, serum ceruloplasmin-, alpha1-acid glycoprotein-, IgG-, IgM- and IgA levels was observed. All the changes in these clinical and laboratory tests were of the same degree in both treatment groups. In the penicillamine group 12 out of 20 seropositive patients became seronegative and in another 5 the Waaler-Rose titre dropped clearly. In the gold group, 7 out of 16 seropositive patients became seronegative, and the Waaler-Rose titre dropped in another 5. An equal increase in the number of eroded joints in hands and toes was seen in the penicillamine and the gold group. Penicillamine was discontinued because of side effects in 13 patients (26%), and gold treatment in 15 (30%). Proteinuria and/or haematuria were the most common causes of discontinuation in the penicillamine group. | |
| 6503362 | Lack of association of swine flu vaccine and rheumatoid arthritis. | 1984 Dec | On the basis of available incidence rates, about 22,000 new cases of definite rheumatoid arthritis would have developed fortuitously among the 45 million recipients of the swine flu vaccine during the year after the immunization program. No excess has been detected. Proportional morbidity studies among all Mayo Clinic patients and among the active-duty personnel of the US Army showed no increase in the number of cases of rheumatoid arthritis after administration of the swine flu vaccine. These results do not support the claims based on anecdotal reports of an association of the vaccine with rheumatoid arthritis. | |
| 6360509 | Medicine or meddling? use of arthrography in rheumatology. | 1983 Aug | In the wardrobe of diagnostic procedures for the arthritic patient, the arthrogram is like a tuxedo. It produces striking images in black-and-white, it can be slightly uncomfortable, and there are times when it can be just the right thing. However, like the tuxedo, the arthrogram should be reserved for infrequent special occasions. Although arthrography can show changes which are characteristic of arthritis, it can seldom differentiate one type of synovitis from another. It may be useful to determine whether or not a synovial disorder is present, but this will not be necessary for the great majority of patients. Its most important uses are in the evaluation of masses in and around joints, and of the pseudothrombophlebitis syndrome. In selected cases, it may help to elucidate the stage and mechanism of disease. | |
| 6726712 | Study of HLA antigens in ten multiple-case rheumatoid arthritis families. | 1984 Apr | We studied the inheritance of HLA haplotypes in 10 families with more than one member affected with adult onset rheumatoid arthritis (RA). The frequency of DR4 was 81% among these patients. Nine families had DR4 bearing haplotypes and homozygosity for DR4 existed in 4 families. In 6 of these families DR4 positive haplotypes were shared among affected members. All but one of the affected sibs shared at least one haplotype with their index case. Ten percent of the unaffected relatives had rheumatoid factor (RF). HLA-DR4 or associated genes appeared to confer susceptibility for RF production and development of RA. However, these haplotypes were inherited also by many sibs who did not develop any manifestations of disease. | |
| 313074 | D-penicillamine treatment in rheumatoid arthritis monitored by plasma alfa-1-antitrypsin-I | 1979 | D-Penicillamine treatment in rheumatoid arthritis resulted in a fall in plasma alfa-1-antitrypsin-IgA complexes which was significantly more pronounced among responders than among non-responders. Plasma free cystine levels also fell during D-penicillamine treatment, the fall being dose dependent up to a daily dose of 500 mg. Higher doses did not result in further lowering, and no difference was detected between responders and non responders. The dominating sulphur containing aminoacid excreted in the urine was penicillamine-cysteine disulphide, the concentration of which did not correlate to either toxicity or clinical effectiveness, but showed much individual variation. The slow kinetics of change in the complex concentration taken together with in vitro experiments, suggest that the effect of D-penicillamine is more likely to be on the de novo formation of the complexes, rather than on their reduction. | |
| 6520830 | Dose, plasma concentration and response relationships of D-penicillamine in patients with | 1984 Dec | Plasma concentrations were measured in 10 patients with rheumatoid arthritis taking 250 mg, 500 mg and 750 mg of D-penicillamine daily. A disproportionate rise in the dose adjusted area under the plasma concentration vs time curve suggested dose dependent kinetics for D-penicillamine. Marked interindividual variability was seen with pharmacokinetic parameters and no correlations were observed between side effects or response and plasma concentrations of reduced D-penicillamine. | |
| 6140062 | A comparison of platelet count and acute phase proteins in the measurement of disease acti | 1983 Nov | Platelet count (PC) was compared with standard acute phase reactants (ESR, plasma viscosity and C-reactive protein) and clinical measurements to assess its usefulness as a measure of disease activity in 165 patients with active rheumatoid arthritis. Although PC was elevated (greater than 400 X 10(9) 1(-1) in 45% of patients and was seen to fall under the influence of second-line drugs, it was considered to be unsuitable as an indication of disease activity since levels fall for reasons other than disease improvement. | |
| 6673982 | Adrenal response in rheumatoid arthritis treated with long-term steroids. | 1983 | Twenty eight patients who received corticosteroids for rheumatoid arthritis for at least five years were studied. Short synacthen tests were carried out in twenty two of these patients and twelve showed a subnormal response. This response was unrelated to initial or present dose, duration of treatment or activity of disease. Ten patients accepted our offer of steroid reduction. Reduction proved difficult because of patient resistance although the only index of inflammation to worsen was the articular index. We postulate that patient resistance to withdrawal may be due to some factor other than the loss of the anti-inflammatory effect of corticosteroids. | |
| 496449 | Antibody-dependent and PHA-induced cellular cytotoxicity in rheumatoid arthritis. | 1979 Aug | One hundred and thirty nine observations of antibody-dependent cell mediated cytotoxicity (ADCC) were made on 77 with rheumatoid arthritis (RA) and 17 healthy controls. There were no differences in ADCC between these 2 groups or within the RA group with regard to disease activity, duration, seropositivity, or drug treatment. Sixty observations of phytohaemagglutinin induced cytotoxicity were made on 22 patients with RA and 10 healthy controls. Again there were no differences in cytotoxicity between the 2 groups. | |
| 269704 | Orthopaedic surgery and rehabilitation in rheumatoid arthritis. | 1977 Jun | Orthopaedic surgical procedures are episodes in the continuing management and rehabilitation of the patient with rheumatoid arthritis. Well-chosen procedures give excellent relief of symptoms and deformity, and successful management is a prime example of rehabilitation requiring considerable team work from physician, surgeon, therapists, social workers and nursing staff. Team work enables the rheumatologist to be in charge of the overall management of the patient through the clinic with responsibility for general medical care, while the surgeon can take charge during periods in hospital for surgery and the immediate postoperative outpatient care. Cooperation between physician and surgeon eases each of some of the clinical burden that is at present provided by this disease. | |
| 746503 | Solitary rheumatoid nodule of the pleura and rheumatoid pleural effusion. | 1978 Dec | Tserkezoglou, A, Metakidis, S, Papastamatiou-Tsimara, H, and Zoitopoulos, M (1978),Thorax,33, 769-772. Solitary rheumatoid nodule of the pleura and rheumatoid pleural effusion. Pleuropulmonary rheumatoid nodules are rare. We report a case of solitary rheumatoid nodule of the pleura with cavitation and coexisting pleural effusion in a young woman. | |
| 4023587 | Effect of long-term therapy with transfer factor in rheumatoid arthritis. | 1985 Apr | Specific immunotherapy with transfer factor (TF) was used in a chronic experiment in a group of 50 female patients with rheumatoid arthritis (RA) stage I-III. The patients were followed up for 24 months, clinical and biologic examinations being repeated every 3 months. In this period the patients received beside the basic nonsteroid antiinflammatory therapy, one unit TF every week over a period of 6 months then one until TF every month (10 patients) to the end of experiment. Of the 50 patients 15 (30%) did not respond to the therapy and the experiments had to be interrupted after 6 months. Excellent, very good and good results were obtained in 35 patients (70%). In 12 patients the response was good but the dose of TF had to be increased to two units/week in the first 6 months. In 13 patients the results obtained were very good and therapy with nonsteroid products + TF was continued even after the first 6 months. In 10 patients with RA stage I the results obtained were excellent and after 6 months the nonsteroid therapy could be interrupted and the therapy was continued only with one unit TF every month. The study confirmed the fact that specific immunotherapy with TF represents an important adjuvant in the treatment of rheumatoid arthritis (RA). | |
| 409413 | Comparison of two dosage schedules of gold salts in the treatment of rheumatoid arthritis. | 1977 Jul | Two doses of gold sodium thiomalate were compared for their effect on rheumatoid arthritis. Thirty-seven patients with active disease for longer than 6 months were treated with 25 mg of gold sodium thiomalate for an average of 29.6 weeks, then at biweekly or monthly intervals to complete 2 years of treatment. Thirty-eight patients were given more than twice as much gold salt at the same intervals on a flexible dose schedule that produced serum gold levels which averaged 332 microgram/dl during the weekly injection phase. No differences were observed in the therapeutic responses of the two groups. Therefore the minimal dose of gold sodium thiomalate required to induce a response in rheumatoid arthritis is 25 mg or less per week. Serum gold levels in the steady state varied between 95 and 386 microgram/dl and were not related to response. Serum half-life for gold was calculated for patients who had an excellent response and for those who were treatment failures. The rate at which gold disappeared from serum was not related to therapeutic responses. | |
| 4742467 | Immunological studies on the mechanism of gold hypersensitivity reactions. | 1973 Sep 29 | Immunological studies were performed on 12 patients with rheumatoid arthritis who developed reactions to gold. IgE levels were found to be raised in 10 of 11 patients tested at the time of the gold reaction, returning to normal on stopping therapy. Two of 12 patients with gold reactions had positive in-vitro lymphocyte transformation responses to gold.It is suggested that dermatological side effects in particular are mediated by a type I hypersensitivity response. | |
| 3872472 | Interleukin-1-like activities in synovial fluids of patients with rheumatoid arthritis and | 1985 | Interleukin-1 (Il-1)-like activity in biological fluids was measured by their ability to rectify the Il-1-dependent lymphokine production of highly purified T lymphocytes to a recall antigen. Il-1-like activity was found in 9 of 11 synovial fluid (SF) specimens from patients with rheumatoid arthritis (RA) but only in 2 of 11 paired RA sera. In traumatic synovitis, low Il-1-like activity was recorded in 5 of 9 SF specimens, and a similar low activity was found in sera of 4 of these patients. The Il-1-like activity was partly absorbed by an anti-Il-1 antibody. The presence of Il-1 in the SF of patients with RA suggests in vivo activation of monocytes/macrophages. | |
| 71024 | B lymphocyte alloantigens in the study of the genetic basis of rheumatoid arthritis. | 1977 Aug | In order to carry out tissue typing studies in patients with rheumatoid arthritis (RA), 116 sera from pregnant multiparous women were screened for cytotoxicity specific for B lymphocytes. It was possible to identify three sera (M55, M58, M87) which reacted specifically with B cells after absorption with platelets. Each appeared to have a different specificity which was presumed to correspond to an alloantigen marker on the lymphocyte surface. The frequency of these alloantigen markers on B lymphocytes was investigated in patients with classical or definite RA and in controls. One of these, M58, occurred in 32 out of 43 RA patients (74 - 4%) compared with 10 out of 37 controls (27%). This difference was highly significant (P less than 0 - 0005). The relative risk of developing RA is 7 - 85 times greater in those possessing alloantigen M58. The other two B cell alloantigens failed to show any association with RA. The association with M58 may indicate a significant genetic contribution to disease susceptibility in RA. | |
| 451393 | Circumferential measurements in the assessment of synovitis of the knee. | 1979 May | In a quest for a objective assessment of synovitis of the knee, the value of circumferential measurements of the knee at two levels has been tested. Measurement 1 cm above the patella was shown to be more precise and to correlate better with the quantity of synovial fluid aspirated than measurement at mid-patellar level. The size of change necessary for statistical significance frequently exceeded the change likely to be found in clinical practice. The precision of measurement is greater in normal than in rheumatoid knees, and can be increased by using the mean of duplicate measurements rather than a single measurement. In clinical trials, the use of one observer throughout will increase the reliance that can be placed on the changes in measurements. | |
| 6278816 | 99mTc-pertechnetate uptake after total knee replacement in rheumatoid arthritis. | 1982 Feb | In 6 out of 48 non-hinged knee joint replacements in 35 patients, 99mTc04- uptake values were clearly increased compared with a control group. Measurements were performed an average of 3 years (range 9 months - 4 1/2 years) after operation. Four of the six cases showed loosening of the prosthesis at arthrotomy and one showed an infection. Tests for hypersensitivity to the different components of the prosthesis and cement were normal. Histology and immunofluorescence of the synovial membrane obtained at arthrotomy in the four operated patients showed no recurrence of the synovitis. This study indicates that there is no recurrence or only a slight recurrence of rheumatoid synovitis after total knee joint replacement of the geometric type. | |
| 6294814 | Immunoglobulin inclusions in rheumatoid arthritis polymorphonuclear cells: lack of correla | 1982 | A discriminating direct immunofluorescent test has been used to identify immunoglobulin inclusions in polymorphonuclear leucocytes (PMNs) isolated from the blood of patients with rheumatoid arthritis. These inclusions are thought to represent phagocytosed immune complexes, since normal PMNs incubated in RA sera known to contain raised levels of immune complexes developed similar immunoglobulin inclusions. Inclusions did not develop in normal PMNs incubated in normal serum. No correlation was found between the percentage of either RA blood PMNs with immunoglobulin inclusions or normal PMNs developing inclusions after incubation in RA sera, and levels of immune complexes in the corresponding sera. Using heat-aggregated IgG as a laboratory model of immune complexes, a simple relationship has been demonstrated between the uptake of IgG aggregates by normal PMNs and the concentrations of IgG aggregates in the test solutions over a concentration range of 12.5-200 micrograms . ml-1. These results indicate that the C1q- PEG test gives no measure of the actual amounts of immune complexes available in serum for phagocytosis. |