Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 1093287 | Mycoplasma in synovial fluid from the patients with rheumatoid arthritis. | 1975 Jan | Mycoplasma colonies were found on culture of synovial fluid in 14 of 18 cases of rheumatoid arthritis. It was possible to demonstrate the colonies in primary culture medium only by the method of hot water fixation and Giemsa staining. The organisms grown on solid medium were also observed electron-microscopically. | |
| 6880413 | The effect of D-penicillamine on plasma amino acids in rheumatoid arthritis. | 1983 May | The effect of D-penicillamine (DPA; 150 mg/day) on plasma amino acids administered to female patients suffering from rheumatoid arthritis (RA) was observed daily during the first 9 days of the treatment. A statistically significant influence of the oral DPA administration was detected. In comparison to control, a decrease in 12 out of 18 amino acids was found on day 2. Furthermore, for 6 amino acids an increase and a peak concentration on day 6 or 7 were observed. Surprisingly, similar results were also obtained in rats after oral application of DPA. These findings give further evidence for the multifactorial action of DPA. | |
| 689924 | Electron probe X-ray microanalysis of human skeletal muscle involved in rheumatoid arthrit | 1978 Aug 15 | Electron probe X-ray microanalysis in the scanning microscope was used to determine the elemental composition of muscle fibres from patients with rheumatoid arthritis (RA). Quantitative data concerning phosphorus, sulphur, chlorine and potassium were correlated to the fibre type by a routine method based on serial cryosectioning and histochemical staining of adjacent sections. Significantly lowered sulphur values were found in type II A and II B muscle fibres of RA patients as compared to those of healthy controls. Traces of gold were detected in muscles of two patients treated with gold salts. The basis and mechanism for the decreased sulphur content in RA muscles are so far unknown, but may depend on the decreased amount of sulphur-rich potein(s). | |
| 601434 | Preliminary experience with the geomedic total knee replacement. | 1977 Nov | This paper reports preliminary experience with the Geomedic total knee replacement prosthesis. Forty-five prostheses were inserted into the severely damaged knees of 38 patients. Forty-one knees (35 rheumatoid, 6 osteoarthrotic) in 34 patients were available for review by an independent observer, a mean of 18 months (range 4--38 months) post-operatively. The assessment concentrated upon changes in function, pain relief and patient satisfaction, but objective parameters of range of movement and stability were also recorded. There were 23 excellent results, 15 good, 1 fair, and 2 poor. Thus, 93% of operations resulted in definite improvement. Complications occurred following 16 operations, but were mostly minor. One prosthesis dislocated, and there was one case of late infection which was treated successfully. | |
| 235911 | Cerebral vasculitis in rheumatoid arthritis. | 1975 Apr | A 63-year-old man with severe, untreated rheumatoid arthritis and pleuritis developed an unusual neurological syndrome similar to Gerstman syndrome, followed by dementia and blindness, six weeks before his death. An autopsy showed extensive necrotizing vasculitis, resembling polyarteritis nodosa, involving the brain and resulting in numerous infarcts. The disease was most severe in the posterior portion of the cerebral hemispheres. Other organs were only slightly involved. Severe amyloidosis of cerebral arterioles and senile plaques were noted in the areas of brain with most severe vasculitis. Review of literature indicated only six cases of cerebral vasculitis in rheumatoid disease, five of which were treated with corticosteroids. | |
| 1121635 | Ankylosing rheumatoid arthritis. | 1975 Feb | The study concerns the clinical, haematological, serological, radiological and histocompatibility antigenic status of eleven in-patients suffering from long-standing sero-positive rheumatoid arthritis at the Royal Hospital and Home for Incurables in London. The study revealed a striking degree of widespread bony ankylosis affecting the peripheral joints and cervical spine. In large part, this bony ankylosis accounted for the disability but it is considered that the cervical spine ankylosis may protect the spinal cord from damage. The absence of the histocompatability antigen HLA 27 is a useful pointer in the exclusion of Ankylosing Spondylitis. Despite the clinical impression that the disease was inactive, the elevated sedimentation rate (23-66, mean 41 mm) suggests that the rheumatoid process remains active. | |
| 6467719 | Synovial cyst and ulnar nerve entrapment. A case report. | 1984 Sep | A 77-year-old man affected by rheumatoid arthritis demonstrated clinical evidence of progressive ulnar nerve compression that proved to be caused by an extra-articular synovial cyst of the elbow. Conservative measures failed to reduce the size of the cyst or to check progress of the ulnar nerve lesion. Surgical treatment by elbow synovectomy and partial cystectomy was effective. The ulnar nerve lesion healed, and the cyst disappeared. Ulnar nerve compression by soft tissue in continuity with a rheumatoid elbow joint is very uncommon. Only one similar case was found in the English-language literature. | |
| 4045841 | An improved assay for IgG rheumatoid factor: its value in the diagnosis of rheumatoid arth | 1985 Jun | A simple radioimmunoassay suitable for the routine estimation of IgG rheumatoid factors (IgG RF) has been developed. This involves determination of the amount of IgG RF binding to highly purified human IgG Fc on microtiter plates using a radiolabelled F(ab')2 preparation of an antihuman IgG Fd antiserum. A correction for nonspecific binding is made by subtracting sample reactivity with bovine serum albumin. Significantly elevated IgG RF levels were found only in patients with symmetrical peripheral erosive polyarthritis and in some patients with "mixed connective tissue disease." | |
| 6670516 | Prosthetic arthroplasty of the shoulder. | 1983 Dec | Twenty-six patients, 18 with rheumatoid arthritis, underwent arthroplasty of the shoulder between 1973 and 1980, with an average follow-up of 3 years. The Stanmore and Kessel arthroplasties and the Neer hemiarthroplasty were used. Twenty-one patients undergoing 22 elective arthroplasties considered that the operation was worthwhile. Pain was completely relieved in 12 shoulders. Movement was improved in 18 shoulders. The priority of restoring movements which improved independence and self-respect is emphasised; the results were far superior to those obtained by an arthrodesis. | |
| 3984529 | [Indications for emergency operations in rheumatoid orthopedics]. | 1985 Jan | In arthritis surgery "urgent" indications are a relatively subjective definition--apart from few exceptions. The aim of this paper is to give a substantiated classification--under practical aspects--for frequently occurring rheumatoid lesions in all parts of the locomotor system requiring surgical treatment. | |
| 3156991 | Evaluation of clinical and prognostic significance of T cell regulatory subsets in rheumat | 1985 Feb | Phenotypic analysis of circulating lymphocytes and T cell subsets using monoclonal antibodies was performed on 60 patients with rheumatoid arthritis (RA). A significant lymphopenia was observed in RA patients and correlated with the use of disease suppressant drugs (p less than 0.0001). A significant decrease in the number of suppressor/cytotoxic T cells resulted in an increase in the TH/TS ratio in 40% of RA patients. This elevated ratio did not correlate with disease activity, the presence of extraarticular features, autoantibody production or immune complex formation. We conclude that the evaluation of the TH/TS ratio has no diagnostic or prognostic value. | |
| 1126076 | The wrist in rheumatoid arthritis. | 1975 Jan | The wrist is the key joint of the upper extremity and is frequently seriously involved in rheumatoid arthritis. Surgery is often indicated to control the effects of the synovitis which often includes rupture of both flexor and extensor tendons. Early synovectomy is indicated. Tenosynovectomy, synovectomy, distal ulnar resection and transposition of the dorsal carpal ligament beneath the extensor tendons, has been effective in preventing rupture of the extensor tendons. The wrist also has an effect on ulnar drift of the fingers. Transfer of the extensor carpi radialis longus to the extensor carpi ulnaris is recommended in patients who do not have the ability to actively ulnar deviate the wrist. Wrist fusion has proven to be effective in patients with marked destruction, deformity or pain, or where there has been a rupture of both radial wrist extensors. | |
| 6711282 | Total condylar knee arthroplasty. Prosthetic component positioning and radiolucent lines. | 1984 Apr | Prosthetic positioning and overall postoperative alignment were studied in 138 consecutive total knee replacements, using the Insall/Burstein total condylar knee system. Overall alignment was within 7 +/- 5 degrees of valgus in 63 per cent of the knees, while tibial component positioning was within 4 degrees of tilt in any direction in 53 per cent of the knees. A radiolucency index incorporating width and extent of radiolucent zones at the tibia was shown to progress from 3 months to 2 years postoperatively. The radiolucency index 2 years postoperatively was higher with postoperative varus alignment in the rheumatoid arthritis group; a tibial component tilt of more than 4 degrees in any direction increased the radiolucency index in both treatment groups. | |
| 845841 | [Acro-osteosclerosis in the course of sarcoidosis (author's transl)]. | 1977 Feb | The authors report two cases of acro-osteosclerosis occurring during sarcoidosis. Condensation lesions involve above all the distal and proximal phalanges of the hands. Comparison of these cases with those in the literature indicates that these particular types of bone changes in association with sarcoidosis are more common than indicated in the studies of Jüngling (occurrence estimated at 54% of subjects suffering from sarcoidosis with bone localisations). This acro-osteosclerosis is however not specific to sarcoidosis. It is seen in patients suffering from rheumatoid arthritis, Hodgkin's disease and other haematological disorders. It has also been seen in normal individuals in X-rays taken at the time of a traumatic accident. | |
| 6879093 | [Effects of chrysotherapy on various immunological parameters in rheumatoid polyarthritis] | 1983 Apr | The effects of chrysotherapy on various immunological parameters were studied in 60 cases of rheumatoid arthritis, either classical or as defined by the ARA. There was a significant fall in serum immunoglobulin levels and in rheumatoid factor. The serum levels of C3 and C4 did not show any significant modifications. At the same time, the serum albumin level rose, suggesting that gold salts do not inhibit protein synthesis. There was a reduction in the total number of leukocytes, affecting lymphocytes more than polymorphs. Finally, there was no significant modification of the response to mitogenes during chrysotherapy. The increase in the lymphocyte response to PHA coincided with improvement in the disease. | |
| 7470581 | Short and longterm experience with plasmapheresis in connective tissue diseases. | 1980 Dec | Plasmapheresis has been performed in eleven cases with connective tissue diseases, three with systemic lupus erythematosus, three with mixed connective tissue disease and five with rheumatoid arthritis. Plasmapheresis was in all cases instituted as an additional therapy during disease activity which was not under control with conventional modes of therapy. The best results were obtained in systemic lupus erythematosus and rheumatoid arthritis complicated with vasculitis. In mixed connective tissue disease with severe Raynaud's phenomenon, no striking and lasting results were obtained. Plasmapheresis seems to be a valuable adjunct in the management of acute exacerbation of connective tissue disease, especially when it is associated with drugs which can block antibody rebound. | |
| 366143 | A multicentre randomized double-blind study comparing two dosages of levamisole in rheumat | 1978 | A six-centre study was conducted to evaluate the effectiveness and safety of a single weekly treatment with 50 or 150 mg levamisole in patients with rheumatoid arthritis (RA). The results were compared with those of a previous placebo-controlled study, in which 150 mg levamisole was given on 3 or 7 consecutive days each week. The efficacy/side effect ratio is better with 150 mg once weekly than with 150 mg on 3 or 7 consecutive days each week. A reduction of the dose to 50 mg reduces the incidence of idiosyncratic reactions but also reduces efficacy. A single dose of 150 mg levamisole once weekly is therefore recommended as a standard dose in patients with RA. This regimen allows for hematological controls at critical times and, hence, permits recognition in practice of agranulocytosis at the incipient stage. | |
| 4070924 | Borderline-tissues as sites of antigen deposition and persistence--a unifying concept of r | 1985 | In organs of rheumatoid inflammation avascular tissue is nourished by perfusion either directly from the blood stream or by neighbouring blood vessels (borderline-tissue). An open question remains whether this borderline-tissue promotes only the known antigen persistence, or also the first deposition of the pathogenetically important microbial antigen, and subsequently a deposition of immune complexes. The three markers (carbon, latex, and living bacteria) used in this study led to nearly the same pattern of deposition in two groups of organ systems: Organs with clearance function belonging to the mononuclear phagocyte system (MPS); organs with borderline-tissues: joint, kidney, artery, heart valve, and eye. This deposition at the borderline can be observed best in areas of the joint where highly vascularized tissues are adjacent to avascular tissues nourished via perfusion: perichondrium, peritendineum, periosteum, and endo- and perimysium. These localisations of particle deposition correspond exactly with the intraarticular predilection sites of chronic rheumatoid inflammation in man and animals. Our results indicate an easier settlement of corpuscular material in these localisations, which at the same time are unable to eliminate such substances, unlike the organs of the MPS. Our studies seem to support the theory of pathogenetic importance of the borderline-tissues as a localizing factor in the perpetuating rheumatoid inflammation. | |
| 6612174 | The assessment of radiological changes in the hands and wrists in rheumatoid arthritis. | 1983 | Two methods of assessing changes in hand and wrist radiographs, the Larsen Index and Amos Index, were compared and contrasted in 48 patients with rheumatoid arthritis (RA). X-rays were taken before and after 1 year of treatment with remission-inducing drugs and scored independently by three observers using both methods. Single readings of radiographs using the Larsen Index were highly reproducible (intra- and inter-observer correlations greater than 0.90 on all occasions), but reproducibility fell when changes were determined from paired films (intra- and inter-observer correlations 0.47-0.82). Variability was greatest in the proximal interphalangeal and wrist joints. The Amos Index, which assesses erosive progression and not the appearance of single films, was more reproducible (intra- and inter-observer correlations 0.72-0.94); it would therefore be better able to detect small changes in groups of patients. The scoring systems were significantly correlated (r = 0.63; P less than 0.001), and with both different observers scored the films at the same "level'. The Amos Index is simple, reproducible, and does not require standard films. It is the assessment of choice. | |
| 3854165 | Are rheumatoid arthritis and systemic lupus erythematosus inversely related diseases? | 1985 Dec | Although rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) have certain features in common, the literature suggests that the two diseases are inversely related to each other in at least eight major respects, viz., age of onset in relation to reproductive fertility; psychosis; kidney disease; nutritional status; and the differential effects of pregnancy, oral contraceptive use, jaundice, and penicillamine. It is suggested that associated with RA and SLE are differing blood and/or tissue levels of a common but as yet undetermined factor: deficient levels in RA, toxic levels in SLE. |