Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 324568 | Arthritis in Flemish paintings (1400-1700). | 1977 May 7 | A close examination of the hands of people depicted in paintings of the Flemish school showed that in five paintings there were figures with hand lesions resembling those of rhematoid arthritis. Although none of the deformities or swellings are indisputable examples of rheumatoid arthritis, they do at least suggest that the painters must have been confronted with rheumatoid-like lesions in their models. In two other paintings there were signs of rheumatic fever and of temporal arteritis. No arthritic lesions were found in the works of painters of the Italian Renaissance, probably because they are less detailed. The finding of rheumatoid deformities in the Flemish paintings does, however, question the general belief that rheumatoid arthritis is a condition that has arisen relatively recently. | |
| 3881940 | Myeloproliferative disorders in patients with rheumatoid arthritis treated with total body | 1985 Jan 21 | Four patients with refractory rheumatoid arthritis were treated with total body irradiation administered in two sittings, 300 to 400 rads to each half of the body. All four patients had taken antimetabolites prior to receiving total body irradiation, and two continued to use them after total body irradiation. Two patients had taken alkylating agents before, and one had used them after total body irradiation. All patients showed clinical improvement. However, in two patients myeloproliferative disorders developed: a myelodysplastic preleukemia at 40 months after total body irradiation in one and acute myelogenous leukemia at 25 months in the other. Total body irradiation differs from total nodal irradiation in the total dose of irradiation (300 to 400 rads versus 2,000 to 3,000), and in the duration of the therapy (two sittings versus treatment over several weeks to months). Furthermore, the patients in the total body irradiation study frequently used cytotoxic drugs before and/or after irradiation, whereas in one total nodal irradiation study, azathioprine (2 mg/kg per day or less) was permitted, but no other cytotoxic agents were allowed. Rheumatologists may therefore face a binding decision when deciding to treat a patient with rheumatoid arthritis with either a cytotoxic drug or irradiation. | |
| 324485 | Macrophage migration inhibitory factor in rheumatoid pericarditis. | 1977 May | The pericardial effusion in a case of rheumatoid pericarditis was studied to determine whether immune complexes and mediators of cellular immunity, represented by migration inhibitory factor (MIF), were present. MIF-like activity was detected in the pericardial fluid, but only traces of immune complexes were revealed by ultracentrifugation. The MIF-like activity was partially characterized by column fractionation and sugar inhibition tests. The role of lymphokines in the pathogenesis of this case of rheumatoid pericarditis is strongly suggested. | |
| 939432 | The assessment of hand function: Part III--the final analysis. | 1976 Jun | Some common surgical procedures, practised to improve the function of the rheumatoid hand, have been subjected to a prospective and objective evaluation. This analysis has been based on the concept of the assessment of hand function by measurement of individual digital forces and the results clearly justify surgical intervention. In addition, function is improved in those digits belonging to the hand operated upon but not themselves undergoing surgery. | |
| 6430251 | Ischaemic colitis and immune complexes during gold therapy for rheumatoid arthritis. | 1984 Jun | A 35-year-old female with rheumatoid arthritis developed an ischaemic colitis and circulating immune complexes following her fourth injection of sodium aurothiomalate. The immune-complex titres fell rapidly after resolution of the colitis, and a possible association of these immune complexes and the bowel pathology is suggested. | |
| 7123127 | [Serum gastrin in rheumatoid arthritis]. | 1982 Jun | Serum gastrin concentrations under basal conditions and following stimulation were assessed in 40 patients suffering from rheumatoid arthritis (RA) and compared with healthy individuals. The RA groups showed no significant differences in comparison with the control population. These conclusions lead the authors to seek the reasons for the rare instances of confirmed hypergastrinaemia in RA. | |
| 3849467 | Bf and C3 complement types in rheumatoid arthritis. | 1985 | Bf and C3 complement types were studied in 100 male and 100 females patients from northern Sweden with erosive rheumatoid arthritis (RA) and compared with population controls. A significantly decreased frequency of the Bf FS phenotype was found particularly in males and in patients with a family history of polyarthritis. Significant Bf associations were also found with a more severe form of RA (functional classes III and IV) and with high titers of the rheumatoid factor. No significant difference with respect to C3 phenotype and gene frequencies was found between RA patients and controls. Thus, the association between RA and C3F found in some previous investigations was not confirmed. | |
| 822608 | [Refined diagnosis of C-reactive protein for the detection and course control of chronic i | 1976 May 15 | When different methods of demonstration of C-reactive protein are used, results much deviating one from another may be observed. An exact diagnostics based on radial immunodiffusion with large range of recognition allows a quantitative registration of changes of C-reactive protein. The exact diagnostics of C-reactive protein seems to be of advantage especially with regard to comprehension and control of the course of subclinical processes. Together with the blood sedimentation rate the exact diagnostics of C-reactive protein gives the possibility of an improved objectivation of the process activity in chronic inflammatory rheumatic diseases. | |
| 6097789 | [Echocardiography and cardiac localizations of rheumatoid polyarthritis in Africans]. | 1984 Oct | A lot of european authors demonstrate that echocardiography is the best examination to objective cardiac localizations in rhumatoïd arthritis (RA). Leleu, in a recent publication thinks that the rarity of systemic localizations during RA in Africans is characteristic. The authors examine the last 15 patients. They never find cardiac involvement and this seems to confirm the clinical impression about 50 previous cases. | |
| 3970036 | Cancer and rheumatoid arthritis: epidemiologic considerations. | 1985 Jan 21 | Statistical methods used to investigate the epidemiology of cancer in rheumatoid arthritis are reviewed and their relative merits discussed. A cohort analysis of cancer morbidity was carried out on a consecutive series of 489 patients with rheumatoid arthritis seen at the Queen Elizabeth Medical Centre, Birmingham, United Kingdom between 1964 and 1978 and followed to December 31, 1983. Forty-two cancers were observed in the series in comparison with 31.13 expected (p less than 0.05) on the basis of cancer morbidity rates for the West Midlands region. The excess was due to the high relative risk of cancers of lymphatic and hematopoietic tissues (observed = 11, expected = 1.27, relative risk = 8.7, p less than 0.001). The effects of confounding factors, including duration of rheumatoid arthritis and hospital selection on the level and pattern of risk over time were examined. When two cases diagnosed soon after first attendance at hospital were excluded, lymphomas (ICD 200, 201, 8th Revision) showed a pattern of increasing relative risk with time from five years after first attendance. The increasing risk appears to be unrelated to the use of immunosuppressive or cytotoxic drugs. | |
| 6233985 | Rheumatoid arthritis and sterile corneal ulceration. Analysis of tissue immune effector ce | 1984 Jun | Tissue immune effector cells and epithelial surface antigens present in eye tissue of rheumatoid arthritis (RA) patients with sterile corneal ulceration were studied using a large panel of monoclonal antibodies. During periods of active corneal ulceration, conjunctivae and corneas of all RA patients studied contained numerous immune-associated (Ia) antigen-positive tissue macrophages. In 4 of 6 patients, conjunctival or corneal T cell infiltrations were present. In 2 patients, a T cell vasculitis was seen in conjunctival tissue. Conjunctival epithelial cells of all 6 RA patients expressed Ia antigens during active corneal ulceration. These data provide evidence for immune-mediated mechanisms in the pathophysiology of corneal ulceration in RA. Moreover, the expression of Ia antigens by conjunctival epithelial cells may be a useful indicator of disease activity in RA patients with sterile corneal ulceration. | |
| 1241262 | Rheumatoid arthritis of the elbow. Pattern of joint involvement, and results of synovectom | 1975 Oct | Thirty-two rheumatoid elbow joints in 25 patients which had undergone synovectomy and excision of the radial head have been studied from the point of view of pattern of joint involvement and the efficacy of surgery. In this group of patients there was a significant trend towards affection of proximal joints occurring earlier in the course of the disease than distal joints. There was a high incidence of involvement of wrist and knee. There was a positive relationship between dominance and the elbow affected. Pain diminished in all cases after surgery, and there was a significant improvement in hinge movement but no significant improvement in range of forearm rotation though it was less painful. Single lateral approach gave satisfactory exposure and is favoured. Complciations of the procedure were few. | |
| 6326404 | [Determination of gold deposition with a new analytical technic (PIXE)]. | 1984 Mar 15 | By means of proton induced X-ray emission ( PIXE ) we have been able to identify gold deposits in the skin of two patients after gold therapy. There were measured very low concentration of 15 ppm and 6 ppm. | |
| 7131541 | Psychophysiological and cognitive characteristics of ulcer and rheumatoid arthritis patien | 1982 Jun | This study examined differences in the physiological and cognitive response patterns among peptic ulcer, rheumatoid arthritis, and healthy group subjects to two types of stressors-slides of autopsies and imagined scenes involving conflicts and attitudes proposed to be associated with the two psychosomatic disorders. Ten subjects were assessed in each group. Results indicated that the ulcer patients demonstrated a heart rate accelerative trend, while arthritic and normal subjects showed significant deceleration, in response to the aversive slides of autopsies. Ulcer patients also reported paying less attention to the slides, and experiencing more anxiety when viewing them, relative to the other subjects. In response to the imagined scenes, the arthritic patients responded with more heart rate acceleration, apparently because of the greater emotional imagery produced by the scenes in these subjects. Finally, self-report and interview data did not lend support to a derivative of the specificity-of-attitude model of psychosomatic disorders. | |
| 6378494 | Comparison of timegadine and naproxen in rheumatoid arthritis. A placebo controlled trial. | 1983 Dec | A double blind, cross-over design was used to compare the acute effects of timegadine, naproxen and placebo in rheumatoid arthritis. Timegadine appeared to be more effective than naproxen in those variables related to disease activity although there were no statistically significant differences (apart from morning stiffness) where variables were examined individually. There was a tendency to a rise in alkaline phosphatase, and possibly gamma glutamyl transpeptidase, during the 2-week timegadine treatment period. No other biochemical or haematological abnormality was observed. | |
| 1147164 | Patterns of migration of the femoral head in osteoarthritis of the hip. Roentgenographic-p | 1975 May | Characteristic roentgenographic patterns of femoral head migration occur in osteoarthritis of the hip. In a study of 100 patients superolateral migration was noted in 15, superomedial in 48, superior migration of intermediate type in 15, and medial displacement of the femoral head in 22. Correlation with pathologic specimens obtained following total hip replacements and comparison with patterns of femoral head migration in rheumatoid arthritis were accomplished. It would appear that anatomic features of the acetabulum are of prime importance in the determination of the type of femoral head displacement complicating osteoarthritis. | |
| 1202604 | Mycoplasmas and 'diphtheroids' in rheumatoid arthritis. | 1975 | The failure to isolate conventional mycoplasmas from 88 synovial membranes and 119 synovial fluids from patients with proven rheumatoid arthritis using a variety of culture media and techniques agrees with the results of recent workers and suggests that these organisms are unlikely to play a role in the aetiology of the disease. In contrast, 'diphtheroid' organisms were isolated from 27 to 30% of rheumatoid specimens, but not from cultures of non-rheumatoid material. A significantly higher incidence of raised agglutination titres to C. acnes and to a 'diptheroid' isolated from a patient with rheumatoid arthritis in sera from patients with rheumatoid arthritis supports the conclusion that these organisms are present in the joints in such patients, though their role in this disease has yet to be established. | |
| 6697074 | Low density lymphocytes: their relationship to disease activity and to antirheumatic thera | 1984 Feb | The acquisition of low density by lymphocytes is the earliest detectable marker of their activation and may be utilized for the separation and quantification of these cells. Low density lymphocytes (LDL) are found in increased numbers in patients with rheumatoid arthritis compared with healthy controls (p less than 0.05). The number of LDL is raised in patients who failed to respond clinically to gold or D-penicillamine when compared with those who did respond (p less than 0.05), the latter group having LDL values in the normal range. Sequential studies have shown that successful antirheumatic therapy is associated with a return to normal LDL levels (p less than 0.01) and that any alteration occurs by three months. LDL are particularly associated with synovitis and there was a close correlation (p less than 0.01) with the Compound Thermographic Index in the sequential study, as well as with other markers of synovitis, but not with systemic disease. LDL thus appear to be important markers of the synovitis of rheumatoid arthritis and they may represent a population of lymphocytes closely involved in the maintenance of synovial inflammation. | |
| 960708 | [The implementation of a computerized documentation system for the evaluation of spa thera | 1976 Feb 6 | A previously-described documentation system for articular examination was applied to evaluate the results of spa treatment in 20 patients with rheumatoid arthritis during 3 separate treatment periods. Physical joint findings were documented and indices were compiled by means of a computer before, during and after treatment with thermal water the first year, normal water the second year (or vice versa) and without baths at all in the third year. These indices were compared statistically. Each kind of treatment produced a statistically-significant improvement in the disease, there being no significant difference in the results achieved by the 3 therapeutic regimens. | |
| 4069052 | The use of unproven remedies for rheumatoid arthritis in Australia. | 1985 Nov 25 | It is important for a medical practitioner to be aware of his or her patient's use of non-prescribed, unproven remedies. This is especially so in a chronic relapsing disease of unknown cause such as rheumatoid arthritis. We selected 90 consecutive patients with classic or definite rheumatoid arthritis who attended the rheumatology clinic of a teaching hospital in 1982. The patients were asked about their previous or current use of an unproven remedy; 82% had used more than one unproven remedy since the diagnosis was made and 52% were currently using an unproven remedy. In all, 352 separate unproven remedies were used, with a mean of 4 +/- 0.3 remedies per patient. Avoidance of a particular food substance or use of a copper bracelet were the most common of such remedies. Fourteen per cent of remedies were deemed to be useful and 3% were felt to have resulted in an adverse effect. |