Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 3970038 | Review of United States data on neoplasms in rheumatoid arthritis. | 1985 Jan 21 | Relatively sparse literature developed during the past 30 years that sought to characterize the relationship of rheumatoid arthritis to neoplasms. The past decade has seen added concern over possible oncogenic effects of cytotoxic agents now used to manage some patients with rheumatoid arthritis. Acquisition of unambiguous data is complicated by the fact that the cumulative incidence of cancer in the general population exceeds 30 percent, and that most studies have insufficient patient numbers, duration follow-up, and attention to age, sex, race, or known etiologic agents. Thus, it is not surprising to find reports that cancer incidence is high, low, or unchanged in rheumatoid arthritis. Although equally ambiguous data were accumulated concerning potential neoplasm-inducing effects of cytotoxic drugs, concern is justified in relation to increased frequency of bladder cancer after cyclophosphamide and acute leukemia following alkylating agents. | |
| 941802 | Lymphocyte depletion in patients with rheumatoid arthritis. | 1976 Feb | Sixteen patients with severe rheumatoid arthritis, marked inflammation of the synonvial membrane and high rheumatoid titer were cannulated by the thoracic duct for a period rangin between 82 up to 100 days. The patients being not under any medication during that time. Quantitative and qualitative analysis of the lymphocytes were performed, as well as responses to mitogens, rheumatoid factor, circulating antibodies and delayed hypersensitivity. By the 14th day nearly all the patients had a partial or almost complete remission of their disease. No complications were observed. These results will be discussed. | |
| 596151 | The hallux and rheumatiod arthritis. | 1977 | The purpose of this report is to consider involvement of the great toe by rheumatoid arthritis, defining significant deformities, describing clinical patterns and discussing the pathomechanics of these findings, in what is an ongoing disease. 200 consecutive patients admitted to hospital with classical or definite rheumatoid arthritis were screened for pain or deformity of the great toe. Feet that had undergone previous surgery or had other underlying pathology were excluded from the series. 194 feef were found to have halluceal involvement. Although hallux valgus was the commonest deformity it was found in combination with other significant deformities in many cases. Hallux rigidus was an important lesion in this series as was interphalangeal hyperextension. Other important lesions encountered were metatarsus primus varus and medial rotation of the toe; their relationship to hallux valgus is discussed. | |
| 495569 | Actinomycotic pulmonary abscess in an immunosuppressed patient. | 1979 Oct | The clinical history of a patient with rheumatoid arthritis and bacteriologic findings from a pulmonary abscess occurring during prednisone therapy are presented. Direct transthoracic aspiration of the lesion yielded a pure culture of Actinomyces odontolyticus. This is believed to be the first case of a deep visceral infection with this organism, an inhabitant of the normal mouth and gums. Immunosuppression of the host probably played a role in establishment of the infection. | |
| 6731018 | Vertical dislocation of the C1 and C2 vertebrae in rheumatoid arthritis. | 1984 | In a retrospective analysis of 450 patients with rheumatoid arthritis the cervical films were reviewed to detect vertical dislocation of the C1 and C2 vertebrae. A frequency of 10 per cent was found among all patients and of 24 per cent among those with cervical arthritis. The authors' method of measuring vertical dislocation at conventional radiography turned out to be superior to the method of McGregor , especially in cases with severe dislocation. The vertical dislocation was shown to be preceded by a horizontal dislocation and the appearance of vertical dislocation diminished or abolished the horizontal dislocation. Progression occurred in many cases and was combined with erosions of the atlas and axis. In more than half of the patients there was also contemporaneously a subaxial dislocation. Neurologic symptoms were more often occurring in patients with a severe vertical dislocation and in patients with spinal stenosis at the C1 level. | |
| 1251270 | The heart in rheumatoid arthritis: an echocardiographic study. | 1976 Jan 3 | An echocardiographic study of 44 patients with active rheumatoid arthritis was carried out by means of a Picker ultrasonic laminograph. A posterior pericardial effusion was found in 14 patients (32%) and pericardial thickening in 5 (11%). The maximum amplitude of the anterior cusp of the mitral valve was reduced in 18 patients, and the diastolic (EF) slope was abnormal in 17 patients. The posterior cusp movement and left ventricle diameter were normal. The over-all incidence of cardiac involvement in these patients was 73%. The incidence of heart abnormalities given by echocardiographic diagnosis of cardiac manifestation of rehumatoid arthritis correlates well with the incidence derived from postmortem studies. | |
| 1234410 | Controlled trial of synovectomy of knee and metacarpophalangeal joints in rheumatoid arthr | 1975 Oct | In a multicentre study patients with rheumatoid arthritis judged by prevailing criteria to be suitable for synovectomy of the knee or metacarpophalangeal (MCP) joints were randomly allocated to one of two groups. One group had the operation, the other was observed without operation from a notional corresponding date. 3 years later the outcome of synovectomy was compared with that of observation without synovectomy. Synovectomy of the knee was followed by significantly less pain and tenderness, smaller effusions, and smaller and less frequent erosions and geodes. By contrast, MCP joints were no better clinically or radiographically than those treated conservatively. The results have been compared with those of two other controlled trials, one concerned with the knee and MCP joints, the other only with MCP joints. In the present trial results were more favourable in the knee but comparable in the MCP joints with those reported in the first of these two trials but less favourable in the MCP joints than those observed in the second. | |
| 100121 | Chrysotherapy. Suppression of immunoglobulin synthesis. | 1978 Sep | Forty-four subjects with classic or definite rheumatoid arthritis who were on individualized chrysotherapy were observed for changes in serum protein electrophoresis, immunoglobulins, and circulating lymphocyte counts. By paired variate analysis, significant declines from pretreatment values were recorded for the following--electrophoretic protein fractions: gamma, alpha-1, alpha-2, (P less than 0.05); immunoglobulins: IgM--53% (P less than 0.001), IgG--37% (P less than 0.01), IgA--34% (P less than 0.001). Rheumatoid factor decreased in 29 of 39 subjects, 15 becoming seronegative (P less than 0.001); circulating lymphocytes decreased by 27% (P less than 0.001). The maximal suppressive effect on IgG and IgM was not achieved until the third and fourth years of therapy by sustained weekly administration of gold sodium thiomalate (one year cumulative dosage, mean 2106 mg, range 1065-2,885; greater than or equal to 4 year cumulative dosage, mean 8747 mg, range 5,385-15,160 mg). An immunosuppressive effect is suggested by these results. | |
| 6197976 | Association of HLA-DR4/Dw4 and DR2/Dw2 with radiologic changes in a prospective study of p | 1984 Jan | Patients admitted to a prospective study within a year of onset of suspected rheumatoid arthritis showed a positive correlation between HLA-Dw4 and the eventual severity of peripheral radiologic changes. Dw4 and DR4 were strongly associated with severity of erosions when analysis was restricted to each of the following: patients with erosions, those under 50 at onset, and all females. Relationships were consistently stronger with Dw4 than with DR4. Another D-related specificity, MT3, was positively correlated and Dw2/DR2 negatively correlated with erosions. | |
| 6516449 | Lyme disease: a unique human model for an infectious etiology of rheumatic disease. | 1984 Jul | Lyme disease is a complex immune-mediated multi-system disorder that is infectious in origin and inflammatory or "rheumatic" in expression. Through its epidemiologic characteristics, large numbers of a seasonally synchronized patient population are readily available for prospective study. Lyme disease has a known clinical onset ("zero time"), marked by the characteristic expanding skin lesion, erythema chronicum migrans, and a clearly defined pre-articular phase. At least some manifestations of the disorder are responsive to antibiotics, and the causative agent--a spirochete--is now known. These advantages make Lyme disease unique as a human model for an infectious etiology of rheumatic disease. | |
| 947592 | The relationship between erythrocyte superoxide dismutase activity and erythrocyte copper | 1976 Jun 15 | A quantitative assay for erythrocyte superoxide dismutase activity using the xanthine-xanthine oxidase-nitro blue tetrazolium system which is applicable to clinical material is described. The in-batch precision of the method is 3.5% and the between-batch precision is 8.8%. Employing this assay, erthrocyte superoxide dismutase activities were measured in 50 normal subjects and in 50 patients with rheumatoid arthritis. There was no significant correlatiion between superoxide dismutase activity and erthrocyte copper concentration. Erythrocyte copper was lower in female rheumatoid patients than in normals. This difference was not accompanied by a difference in superoxide dismutase activity. | |
| 2862321 | Difference in cartilage proteoglycan level in synovial fluid in early rheumatoid arthritis | 1985 Jul 20 | Cartilage proteoglycans were measured, by the use of an enzyme-linked immunosorbent assay, in synovial fluids obtained from 109 unselected patients attending an outpatient rheumatology clinic because of inflammation of the knee. The content of proteoglycans in synovial fluid was inversely related to the degree of joint destruction shown on X-ray. The proteoglycan concentrations in knee-joint exudates were higher in patients with reactive arthritis than in patients with rheumatoid arthritis having synovitis of corresponding duration and lacking radiological evidence of cartilage destruction. The measurement of proteoglycan levels may therefore be useful in differentiating between the two conditions. | |
| 623684 | Shoulder swelling in rheumatoid arthritis secondary to subacromial bursitis. | 1978 Jan | A patient with rheumatoid arthritis was seen whose main complaint was marked swelling of the shoulders. Surgical exploration revealed the swelling to be secondary to subacromial bursitis; the glenohumeral joint appeared normal. | |
| 3906995 | [Chlorbutin, azathioprine, D-penicillamine and levamisole (decaris) in the treatment of pa | 1985 | The authors studied and compared the action of chlorbutin, azathioprin, of large and mean doses of D-penicillamine and levamisole with that of nonsteroidal antiinflammatory drugs (NAID) on rheumatoid arthritis systemic manifestations in 186 patients treated with these drugs for more than 3 months. It was shown that the basic drug compared very favourably with NAID. The cytostatics and levamisole were discovered to be highly efficacious. The authors believe that if the patients are afflicted with alveolitis and rheumatoid nephropathy, this should be regarded as indication for use of chlorbutin and levamisole. | |
| 309707 | Schizophrenia and rheumatic disease. A study on the concurrence of inflammatory joint dise | 1978 Oct | The coincidental occurrence of schizophrenia and rheumatoid arthritis is considered to be low in relation to the prevalence of the two diseases. In the present study, data from the patient statistics prepared by the Swedish Social Welfare Board were examined for the occurrence of rheumatic disease in schizophrenic patients. With the aid of the statistics and of questionnaires, 58 case-records were collected and studied. Very few cases were found of co-existing schizophrenia and inflammatory joint disease, rheumatoid arthritis in particular. There were, however, some cases of genuine schizophrenia and definite seropositive rheumatoid arthritis in the same patient. Rheumatoid arthritis is possibly uncommon also in combination with other psychiatric diseases that require hospital care. The ankylosing-spondylitis cases were over-represented in relation to the rheumatoid-arthritis cases included in the statistics from psychiatric care. Most of the 13 ankylosing-spondylitis patients whose case-records were studied had schizoaffective psychosis or atypical psychosis. The results of the investigation should be confirmed by epidemiological studies; this may contribute to the understanding of the aetiology of rheumatoid arthritis and of schizophrenia. | |
| 6336224 | Analysis of T-cell cultures and clones from a patient with classic rheumatoid arthritis--e | 1984 | Using lectin-free IL-2 as the only initial stimulus, bulk cultures and T-cell clones were established from synovial fluid (SFL) and peripheral blood lymphocytes (PBL) of a patient with rheumatoid arthritis (RA). The cloning efficiency of growing bulk cultures was 3%-4% as evaluated by Poisson statistics and was not enhanced by the addition of autologous synovial fluid or serum. The majority of the cloned T cells expressed the OKT8+ phenotype; several clones were OKT4+ and one clone expressed OKT8+ and OKT4+ antigens. None of the cloned T cells exhibited high NK or lectin-dependent cytotoxicity, although bulk cultures had high NK activity. In primed lymphocyte typing responses, bulk cultures and two T-cell clones established from rheumatoid SFL and PBL showed consistent autoreactivity, which we have never before observed with MLC-derived bulk cultures and T cell clones. One of the autoreactive rheumatoid T-cell clones (B25) was found to provide strong helper activity to autologous B cells in the absence of mitogen. Attempts to reveal reactivity of RA-derived T-cell clones to microbial antigens have so far only been successful with Mycoplasma pneumoniae preparations. Careful analysis of this reactivity revealed, however, that Mycoplasma pneumoniae induces a stimulator cell-dependent mitogenic effect rather than an antigen-specific MHC-restricted T-cell proliferation. | |
| 84076 | Small inclusions in the cytoplasm of leukocytes in LE cell tests. | 1978 Winter | Small homogeneous basophilic and eosinophilic particles varying in size from 0.7 to 3.0 micra were seen in cytoplasm of monocytes and polymorphonuclear cells of leukocytes in LE cell tests. The aim of this investigation was to determine their frequency and diagnostic significance. Inclusions were found in one-third of LE cell tests on patients with rheumatic diseases and were not observed in normals. In 19.1% of 161 patients with SLE, they were present before LE cells were found. Sixty-eight% of patients who had particles had SLE, 8% had rheumatoid arthritis with LE cells, and 3% had nonrheumatic diseases. | |
| 800970 | A double-blind crossover comparison of tolmetin sodium and phenylbutazone in the treatment | 1976 | A double-blind crossover study was carried out in 24 patients with rheumatoid arthritis to investigate the relative efficacy of tolmetin (1600 mg/day) and phenylbutazone (400 mg/day). Each drug was given for 4 weeks, preceded by a 2-week wash-out period during which patients received paracetamol alone for pain relief. Assessments were made of duration of morning stiffiness, grip strength, articular index, joint size, and degree of pain. Both drugs produced significant improvements compared to paracetamol, particularly in pain relief and, apart from morning stiffness, tolmetin proved equally effective as phenylbutazone. Three patients (2 on tolmetin and 1 on phenylbutazone) were withdrawn because of side-effects. In general, however, both drugs gave rise to only minor side-effects. | |
| 1110995 | Bone fragmentation in the rheumatoid wrist: radiographic and pathologic considerations. | 1975 Feb | A peculiar pattern of bone fragmentation of the wrist was noted in 16% of 50 rheumatoid patients. This involved erosion of the navicular, distal radius and ulna, carpal fusion, demineralization, and the presence of an elongated bony spicule overlying the radiocarpal joint. Additional examples were found in rheumatoid cadavers. Pathogenesis of the alteration was not entirely clear although contributing factors included extensive pannus proliferation, osseous compression and fracture. The fate of the detached spicules, their relationship to "fistulous rheumatism", and the differential diagnosis are discussed. | |
| 4066893 | Formal education as a marker for increased mortality and morbidity in rheumatoid arthritis | 1985 | Increased mortality and morbidity was seen in association with lower formal educational levels in 75 rheumatoid arthritis (RA) patients over 9 years. Nine of the 20 patients with 8 or fewer years of education had died, compared to 10 of 34 with 9-12 years of education, and only one of 21 with more than 12 years of education. Among survivors with functional capacity data available from baseline and 9 year review, declines greater than 20% were seen in 8 of 10, 13 of 21, and 9 of 19 patients in the three education categories. Overall, 79% of grade-school educated, 43% of high-school educated, and 20% of college-educated patients had either died or declined more than 50% in functional capacity. Patients of different formal educational levels were similar at baseline in age, duration of disease, measures of functional capacity, number of involved hand joints, number of severe radiographic changes, use of gold, oral corticosteroids or other therapies, and associations between formal educational level and disease course are not explained by these variables. Formal educational level appears a simple quantitative marker which identifies a surrogate or composite variable associated with increased mortality and morbidity in RA. |