Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 6770269 | HLA-DR antigens and toxic reaction to sodium aurothiomalate and D-penicillamine in patient | 1980 Aug 7 | To investigate the possible relation between certain HLA antigens and toxicity during treatment with sodium aurothiomalate of D-penicillamine, we studied 91 patients with rheumatoid arthritis. Seventy-one had toxic reactions to either drug or both drugs; the remaining 20 took one of the drugs for at least six months, without toxicity. Nineteen of 24 patients in whom proteinuria developed were positive for HLA-B8 and HLA-DRW3 antigens; 14 of 15 episodes of aurothiomalate-induced proteinura and nine of 13 episodes of penicillamine-induced proteinura occurred in patients with these antigens. All 13 episodes of proteinuria in which urinary protein exceeded 2 g in 24 hours occurred in patients with DRw3. The relative risk of proteinuria during treatment with aurothiomalate is increased 32 times in patients who are HLA-DRw3 positive. No significant associations were found between any HLA antigen and development of skin rashes or hematologic complications. Toxicity during aurothiomalate or penicillamine treatment for rheumatoid arthritis may be under genetic control. | |
| 748909 | [Electrocardiographic changes in rheumatoid arthritis]. | 1978 May | The clinical course of 50 patients with rheumatoid arthritis has been reviewed with special emphasis on the electrocardiographic changes. Thirty two of 50 of these patients presented electrocardiographic abnormalities and two cases had myocardial infarction. Electrocardiographic changes were associated with activity of the sickness. It is possible that the electrocardiovasculars manifestations represent the first manifestation of the rheumatoid arthritis therefore it is convenient to check them the whole time, even in case the patient does not present clinical abnormalities. | |
| 6768887 | Oral chrysotherapy in rheumatoid arthritis: minimum effective dose. | 1980 Mar | We studied the dose-response to a new oral gold compound in 28 patients with definite rheumatoid arthritis, divided in 4 groups of 7 patients, each treated with different doses of auranofin for 3 months. Clinical and laboratory parameters were recorded weekly, and blood gold levels (BGL) measured by atomic absorption spectroscopy. Six and 9 mg daily doses of auranofin were most effective based on clinical and laboratory results. Correlation studies between BGL and percent decrease of humoral measurements, within the 3 months were statistically were statistically significant. Mean BGL, associated with clinical improvement, reached 0.73 microgram/ml, and was accompanied by a 17.6% decrease from initial value of IgG, 17.1% of alpha 2-globulin, 48.9% of RF titer and 25.9% of ESR. | |
| 37682 | [Pathology of pulmonary changes in Wegener's granulomatosis, rheumatoid arthritis and poly | 1979 | Histology of the pulmonary alterations which may occur in Wegener's granulomatosis, rheumatoid arthritis and polyarteritis nodosa is enumerated. 30 own cases with pulmonary lesions are presented. The difficulties of differential diagnosis in lung biopsies are discussed. Both Wegener's granulomatosis and rheumatoid arthritis may terminate in a generalized necrotizing arteritis which cannot be distinguished from polyarteritis nodosa. This as well as various other similarities indicate that these three different disease entities base on an identical hyperergic reaction of the vascular wall. Only the so-called limited type of Wegener's granulomatosis has a relatively favourable prognosis. | |
| 4131601 | Benign rheumatoid arthritis of the aged. | 1974 Mar 9 | A severe type of rheumatoid arthritis which is seen in 25% of cases that present with the disease after the age of 60 is a self-limiting illness. It can be well controlled during the acute severe phase and has a good prognosis. This paper describes 29 patients with this pattern of disease who were separated from a larger group of 110 elderly onset cases. | |
| 3891280 | The use of methotrexate in rheumatoid arthritis. | 1985 May | The use of methotrexate in rheumatoid arthritis is reviewed. Methotrexate, a folic acid antagonist, is sometimes employed in an attempt to symptomatically control patients whose disease does not respond adequately to conventional therapies. Systemic administration of 7.5-15 mg/wk in a "pulse" fashion appears to be effective without precipitating severe adverse effects. However, concern over potentially serious side effects and a lack of well-controlled clinical trials have limited its use to severe, refractory disease. Further studies are needed before its role in rheumatoid arthritis can justifiably be expanded. | |
| 1121636 | Vertical atlanto-axial subluxation in rheumatoid arthritis. | 1975 Feb | In a prospective survey of 476 hospital in-patients with rheumatoid arthritis, vertical atlanto-axial subluxation (AAL) was found in 13 patients (3.7 per cent). All were women with severe rheumatoid arthritis. Neurological signs were found in ten patients, and in seven they appeared to be due to vertical AAL. The signs caused by vertical AAL were diminished pain and temperature sensation in the upper divisions of the trigeminal nerve, sensory loss in the areas supplied by C2, nystagmus and pyramidal lesions. Disabling involvement due to vertical AAL was not found although it may occur and the lesion may be fatal. The lower cervical spine was involved in all patients and severe lesions were seen in nine. The most severe neurological lesions appeared to be due to subaxial subluxation. Corticosteroid therapy may have been a contributing factor in four patients. | |
| 7112057 | [Spinal involvement in chronic polyarthritis]. | 1982 Jun 19 | Rheumatoid arthritis (RA) may involve every segment of the entire spine. In particular, the cervical spine is commonly affected in rheumatoid arthritis. In approximately 40% of RA patients inflammatory changes are observed in the upper inflammatory changes are observed in the upper cervical region. Atlanto-dental dislocation, a common early sign especially in juvenile RA, is radiologically diagnosed by a lateral radiograph of the neck in maximal flexion. The pathological findings in the spine and the corresponding radiological signs and clinical symptomatology are described. | |
| 6966249 | [Infantile inflammatory rheumatic diseases. Diagnosis and differential diagnosis]. | 1980 Mar 6 | An arthritic illness in children may be the expression of quite different underlying conditions. The cause must be searched for by history, clinical examination, and careful consideration of the differential diagnosis. The most important types of arthritis are discussed along with the relevant diagnostic procedures. | |
| 7341027 | Stroke and gangrene: complications of therapeutic plasma exchange therapy. | 1981 | Two patients underwent therapeutic plasma exchange therapy. One patient with advanced rheumatoid arthritis developed a stroke after his fifth exchange. The other patient, with progressive systemic sclerosis, required a below the knee amputation secondary to shunt problems. These cases are presented to caution physicians in selecting patients for pheresis procedures and suggest that major complications can occur with this technique. | |
| 994904 | Rheumatoid arthritis improved by treatment with levamisole and L-histidine. | 1976 Sep 4 | A case of classical rheumatoid arthritis of 12 years' duration, was treated during an exacerbation with levamisole and remission was induced. The findings support the postulate that depressed cell-mediated immunity to an unknown antigen is the primary immunity defect in rheumatoid arthritis, and that the defence mechanism stimulant levamisole is an effective treatment, at least in some cases. The lack of toxicity of the drug is noted, but in this case the blood aspirin level rose while the patient was taking levamisole with an unaltered dose of aspirin. There was some depression of the neutrophil count after five months which responded to a reduced dosage. | |
| 334475 | A comparative study of the long-term efficacy of flurbiprofen and indomethacin in the trea | 1977 | Preliminary results are reported for the first 23 rheumatoid arthritis patients entered in a long-term, double-blind trial to compare the efficacy of flurbiprofen and indomethacin. It was planned that, unless withdrawn, patients from matched pairs received either flurbiprofen (150 mg to 300 mg daily) or indomethacin (75 mg to 150 mg daily) over a minimum period of 6 months, dosage being adjusted to suit exacerbations and remission of disease. In addition to clinical assessments of severity of pain, duration and severity of morning stiffness, joint size and joint score, routine laboratory measurements were carried out, including estimates of serum iron and total iron binding capacity, rheumatoid factor and immunoglobulin levels. This interim report gives the statistical analysis of results from the 17 patients completing from 2 to 4 months of treatment and shows that both drugs were equally effective in controlling disease activity. Withdrawals due to side-effects or exacerbations of disease were similar for both drugs. | |
| 7294583 | [Follow-up study of patients with rheumatoid arthritis over a period of more than 10 years | 1981 | A follow-up study was conducted in 100 rheumatoid arthritis patients, treated over the last 10 years with currently accepted therapy, after a period varying from 10 to 15 years following the onset of the disease: 20 p. cent were in Steinbrocker's stage I, 60 p. cent in stage II, 16 p. cent in stage III, and 4 p. cent in stage IV. When compared with a similar study conducted between 1948 and 1958, results demonstrated that the percentage of patients in stage I had not varied, but that only half as many patients were disabled (stages III and IV), due to insertion of lower limb surgical prostheses. Corticoid therapy had been necessary in 84 p. cent of the patients for variable periods. The 50 p. cent duration of the different treatments proposed during this 10-year period was 12 months for antimalarial drugs, 8 months for gold salts, and 12 months for D-penicillamine. Therapy was still effective after one year in 30 p. cent on antimalarial drugs, 27 p. cent on gold salts, 51 p. cent on D-penicillamine, and 21 p. cent on chlorambucil. Duration of efficacy of basic treatments is too short to cover the long progression of rheumatoid arthritis. New treatments are necessary, as the functional prognosis of this disease has not changed fundamentally over the last 15 years. | |
| 869956 | Surface ultrastructure of rheumatoid articular cartilage. | 1977 Jun | Six rheumatoid articular cartilage specimens, which appeared grossly normal and were shown to be free of pannus when examined under the light microscope, were examined electron microscopically. For comparison, normal-appearing cartilage specimens from 2 patients with meniscus injury and 2 with degenerative joint disease (DJD) were also examined. In all cases the normal-appearing joint surface of rheumatoid cartilage was abnormal. Amorphous-appearing material was present to a depth varying between 6 and 25 micron. Some of this material had the appearance of fibrin deposited at the cartilage surface, but much appeared to represent breakdown products of the cartilage matrix, i.e. degraded collagen and proteoglycan. DJD cartilage did not show similar changes. The findings suggest that the surface of rheumatoid articular cartilage, even when grossly normal in appearance, is degraded by enzymes either present in the synovial fluid or released by polymorphonuclear cells in close contact with the cartilage surface. | |
| 6164344 | beta 2-Microglobulin levels in serum and urine of rheumatoid arthritis patients on gold th | 1981 Apr | The levels of beta 2-microglobulin (beta 2-m) in serum and urine of 24 seropositive patients with rheumatoid arthritis (RA) treated with regular gold (sodium aurothiomalate) injections have been investigated. The values obtained were compared with levels from 20 seropositive patients with RA treated only with nonsteroidal anti-inflammatory drugs and 20 age and sex matched normal controls who had received no medication. A significant increase of urinary beta 2-m levels was found in the gold-treated RA group. No correlation between dose of gold received and the levels of beta 2-m in the urine could be established. There was also no correlation between the erythrocyte sedimentation rate (ESR) or total lymphocyte count and beta 2-m levels in serum or urine. We conclude that serum and urinary beta 2-m levels appear to be poor indices of joint inflammation, but sequential urinary beta 2-m levels may prove valuable in monitoring the development of renal tubular lesions due to gold therapy. | |
| 334184 | On the nature of rheumatoid rice bodies: an immunologic, histochemical, and electron micro | 1977 Sep | The nature of rice bodies was studied, utilizing histochemistry, immunofluorescence, and scanning and transmission electron microscopy. Rice bodies were found to consist primarily of fibrous material, most of which was fibrin with small amounts of collagen. Channels containing a variety of viable cells permeated the rice bodies. Blood vessels occurred in a few rice bodies indicating a former connection with the synovial membrane. Nonvascularized rice bodies might represent a further degeneration of the vascular type. Rice bodies seem to be a nonspecific response to inflammation. | |
| 3863520 | Shoulder replacement arthroplasty. | 1985 | Since 1973 64 shoulders in 56 patients have had a prosthetic replacement at the Oslo Sanitetsforening Rheumatism Hospital, the semi-constrained prosthesis of Lettin/Stanmore was used in 13 cases, the non-constrained prosthesis of Engelbrecht/St. Georg in 10 cases and Neer's type II prosthesis in 41 cases. An evaluation of the results is given. The minimal muscular loosening recommended by Neer is facilitating the postoperative training. The best results regarding function and pain reduction have been obtained by the Neer prosthesis, but the lack of cranial support ("fornix humeri") and the ovalization of the head seem to be responsible for some cases of upward migration of the head of the prosthesis. The ideal prosthesis should be non-constrained and come with different lengths of the neck and at least in two sizes of the head and several sizes of the stem. The glenoid socket should provide a cranial support facilitating the centering. Special problems are met with in juvenile rheumatoid arthritis. A best possible reconstruction of the rotator cuff and the deltoid is mandatory, requiring good technical skill. | |
| 3878238 | Impaired release of a T-cell specific suppressor factor in rheumatoid arthritis. | 1985 Sep | Peripheral blood T cells from patients with rheumatoid arthritis (RA) and scleroderma (PSS) were assessed for their ability to release T-cell-specific suppressor activity (TRSA) upon incubation with a suppressor activating factor (SAF) derived from a human lymphoblastoid cell line (CEM). T cells from 11/20 (55%) RA patients exhibited impaired TRSA release in contrast to 1/12 (8%) of PSS patients. RA patients demonstrating impaired TRSA release exhibited more active arthritis than patients demonstrating normal TRSA release. | |
| 6360510 | Measuring function and health status in rheumatic disease clinical trials. | 1983 Dec | We have summarized the limitations of traditional outcome measures in rheumatology, reviewed the growing field of measures emphasizing the patient's perception of improvement, and provided guidelines for choosing a specific instrument for a clinical trial. Newer measures have measurement properties equal to or surpassing traditional measures, but no one ADL or quality-of-life instrument can be used to assess outcome in every situation as no one test can indicate success of a treatment in a chronic disease. An instrument needs to be judged by the following criteria: Is it metrically sound? Does it fit the socio-demographic characteristics of the target population? Does it measure the specific changes which are likely to be affected by the treatment? Will it capture or measure the expected changes? | |
| 1153766 | Shoulder arthrography in rheumatoid arthritis. | 1975 Sep | Arthrograms of the shoulder were evaluated in 10 patients with rheumatoid arthritis. The arthrographic findings common to all joints consisted of nodular filling defects, irregular capsular attachments, bursal filling defects and visualized lymphatic drainage. Findings unique to the shoulder joint consisted of rotator cuff tear, frozen shoulder, and biceps sheath dilatation. Since the agents used to treat patients with rheumatoid arthritis have profound side effects, it is important to exclude an associated rotator cuff tear and/or confirm the presence of glenohumeral rheumatoid involvement. |