Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 6976046 | [New pathogenetic aspects of rheumatoid arthritis]. | 1981 Sep 15 | Inflammatory changes in the epiphyseal bones in patients with rheumatoid arthritis are demonstrated which correspond to changes in the bone organ far from pannus. They may be the cause for the demineralisation near to joint (first x-ray sign to rheumatoid arthritis). Further from the analysis of immune complexes of patients with rheumatoid arthritis apart from rheumatoid and antinuclear factors and IgM-antibody against plasma membranes was the result. These two findings are new in the description of the pathogenesis of rheumatoid arthritis. Their possible importance for the development of the arthrosis is discussed. | |
| 7067225 | A remarkable increase of superoxide dismutase activity in synovial fluid of patients with | 1982 Jan | Superoxide dismutase activities in the synovial fluid of patients with rheumatoid arthritis and osteoarthritis were determined by the technique of McCord and Fridovich. The superoxide dismutase activity from the rheumatoid arthritis group was found to be remarkably higher than that from the osteoarthritis group. The high superoxide dismutase activity of rheumatoid arthritis is correlated with the severity of the disease. A significant correlation was also found between C-reactive protein and superoxide dismutase activity. These observations suggest that superoxide dismutase activity is a manifestation of the acute inflammatory stage of rheumatoid arthritis. | |
| 6623151 | Streptococcus milleri empyema. | 1983 Oct | A 58-year-old woman who had recurrent aspiration due to atlantoaxial subluxation, a complication of rheumatoid arthritis, had S milleri empyema. This organism has been associated with purulent disease in previous series, and may be a relatively common but unrecognized cause of empyema. | |
| 7024866 | Ibuprofen and diflunisal in rheumatoid arthritis: a double-blind comparative trial. | 1981 Jul 22 | Both diflunisal (750 mg/day) and ibuprofen (1600 mg/day) were shown to be superior to placebo in the treatment of rheumatoid arthritis in a double-blind cross-over trial. Neither drug affected lymphocyte transformation to plant mitogens. Diflunisal scored better than ibuprofen at the dose levels chosen but the differences did not reach significance. | |
| 905816 | [Synoviorthesis of finger joints using erbium-169. Parameters influencing the clinical res | 1977 Oct 1 | Synoviorthesis of the finger joint with erbium-169 is a beneficial therapeutic procedure which produces reduction of articular pain and swelling in 2/3 of cases. The effect is lasting and shows only slight regression during the first 24 months. However, if the rheumatoid disease is very active, or if the articular lesions are primarily erosive, the results are poorer. No correlation was found between therapeutic results and the radiological findings prior to 169E treatment. Erbium-169 reduces inflammation and leads to progressive articular fibrosis. Any chronic synovitis of interdigital joints resistant to appropriate conventional anti-inflammatory treatment may benefit from radio-synoviorthesis with erbium-169. Erbium-169 synoviorthesis is is technically easy to perform and free of side effects. It is a palliative measure which the authors consider a valuable complement to the classical treatment of rheumatoid arthritis. | |
| 3914701 | A double-blind comparative study of piroxicam and ibuprofen in the treatment of rheumatoid | 1985 Feb | Recommended dosages of nonsteroidal anti-inflammatory drugs have increased considerably since their introduction. The maximum recommended dosage for ibuprofen, a widely prescribed drug for the treatment of rheumatoid arthritis, has increased from 400 mg three or four times a day (at the time of its introduction) to 2,400 mg per day at present. Piroxicam at 20 mg per day was compared with ibuprofen at 2,400 mg per day in 20 patients with rheumatoid arthritis. Both drugs were found to be effective, with similar side-effect profiles. | |
| 4078265 | Rheumatoid wrist reconstruction utilizing a fibrous nonunion and radiocarpal arthrodesis. | 1985 Nov | Rheumatoid arthritic involvement of the wrist severely limits the functional status of the upper extremity. Total wrist arthrodesis, while providing pain relief and reestablishing support, compromises the functional capacity of the hand because of lack of wrist motion. Wrist arthroplasties allow motion, but have not found wide acceptance because of instability and the recurrence of deformity. A technique for establishing an intentional fibrous nonunion between the carpus and the radius was devised 17 years ago. This fibrous hinge gives wrist stability with or without radiocarpal wrist arthrodesis while allowing painless motion at the fibrous radiocarpal hinge and at the less severely involved midcarpal joint. Twenty-three patients have been followed for more than 7 years. All patients whose wrists achieved nonunion had no pain. Twelve of the 19 wrists in which radiocarpal arthrodesis occurred had no pain, and seven had mild pain that did not limit use. | |
| 7081781 | Studies of phagocytic functions in rheumatoid arthritis. II. Effects of serum factors on p | 1982 May | A previous article has shown a diminished phagocytic and intracellular metabolic activity of the polymorphonuclear cells (PMN's) from patients with rheumatoid arthritis (RA). No correlation was found between PMN's functions with either clinical or laboratory expression of disease activity. In the present study the effects of rheumatoid sera on PMN's functions were investigated and the results revealed significant inhibition of phagocytic activity (PA) and nitroblue tetrazolium (NBT) dye reduction capacity of cells from RA as well as from a normal (N) control group. The number of PMN's showing aggregated latex particles on their surfaces was significantly higher in RA patient groups in the presence of rheumatoid sera. PMN's from N and RA groups were lysed in the presence of rheumatoid sera, with more significant destruction of RA-PMN's. No correlation was found between the PMN's function and the amount of circulating immune complexes (CIC's) or rheumatoid factor (RF). Significantly lower concentration of complement (C4) levels and higher IgA mean values were observed in the patient group compared to the standard values. The mechanism(s) underlying the impaired PA and NBT reduction may be due to defective intrinsic cell function as well as the extra cellular effects of blocking or lytic factors present in rheumatoid sera. | |
| 6926809 | Rheumatoid lymphoedema. | 1982 Jun | Bilateral upper limb oedema due to lymphatic obstruction, is an uncommon complication of rheumatoid arthritis (R. A.). We report a case in which a 40 year old male with seropositive rheumatoid arthritis developed gross pitting oedema of the left arm. Lymphangiography showed lymphatic obstruction in both arms; within two months the right arm also became oedematous. | |
| 6604073 | Enhancement of deficient T-cell function in rheumatoid arthritis by tolmetin sodium. | 1983 Jul | The in vitro effect of tolmetin on deficient T-lymphocytes from patients with autoimmune diseases was tested using a mitogen-stimulation assay. For comparison, levamisole was also tested on T-cells in the same assay system in this group of patients. Tolmetin and levamisole both showed enhancement of T-cell function and normalization of mitogenesis in vitro. To evaluate the relevance of these in vitro findings to treatment of disease, four patients who had active rheumatoid arthritis and who had displayed repeated deficiency in vitro of T-cell mitogenesis were studied. After baseline studies, the patients were started on tolmetin at an oral dose of 800 mg/day in divided doses. If no significant enhancement of T-cell function was observed by four weeks, the dose of tolmetin was increased to 1600 mg/day. The results of the clinical study confirmed that tolmetin enhanced T-cell function in vivo as well as in vitro in a manner similar to that which has been reported for levamisole. This normalization of T-cell function by tolmetin was associated with clinical improvement. | |
| 6475553 | Atlanto-occipital dislocation in rheumatoid arthritis. | 1984 | Four cases of atlanto-occipital dislocation are described. Two of the cases were found in a material of 407 patients with rheumatoid arthritis indicating a frequency of 0.5 per cent. All the patients had severe mutilating changes of the peripheral joints as well as of the cervical spine and all developed severe neurologic symptoms. The diagnosis is not easy to set on conventional films so conventional tomography or rather computed tomography is recommended. | |
| 770079 | Clinical assessment of azapropazone in rheumatoid arthritis. | 1976 | Azapropazone was investigated in a 2-week double-blind clinical out-patient trial against placebo in 23 patients with definite rheumatoid arthritis. The drug was given at a dose of 1200 mg. per day before food. At this dose level the drug was shown to have an antirheumatic effect in terms of pain relief, articular tenderness and duration of morning stiffness. | |
| 6769149 | Monocyte function in rheumatoid arthritis. | 1980 | Monocytes derived from peripheral blood of patients with rheumatoid arthritis (RA) had a marked defect in their bactericidal activity against Staphylococcus albus and Listeria monocytogenes; whereas the phagocytic capacity of monocytes from RA patients for both Staph. albus and Shigella flexneri was similar to that of monocytes from healthy subjects. There were no significant differences between the patient and control groups with regard to antibody dependent cellular cytotoxicity (ADCC) of monocyte against antibody-coated EL4 leukemia tumor cells. No correlation was observed between the rheumatoid factor (RF) titer in the serum of RA patients and the ADCC capacity of their monocytes. The ADCC of normal monocytes was reduced markedly following their incubation with serum from RA patients. It suggested that the defect in bactericidal activity in monocytes from RA patients may explain, at least in part, the susceptibility of RA patients to infections. | |
| 7430191 | Total hip arthroplasty in protrusio acetabuli of rheumatoid arthritis. | 1980 Oct | Thirty-five total hip arthroplasties done in twenty-five patients with protrusio acetabuli secondary to rheumatoid arthritis were reviewed. There was an average follow-up of 4.3 years, with a range of three to seven years. The results were rated as excellent or good in 66 per cent, fair in 26 per cent, and poor in 8 per cent. Although 100 per cent demonstrated cementbone interface demarcation around the acetabular component, only 10 per cent showed progression of the line of demarcation to two millimeters and one had acetabular loosening with migration. Eight per cent showed femoral loosening or subsidence; 8 per cent, calcar resorption; and 6 per cent, a receding cortex with cystic changes. Twenty-three per cent had nonunion of the greater torchanter after trochanteric osteotomy. Type-III cement-bone interface demarcation was present around the acetabular component was positioned one centimeter superiorly or medially beyond the anatomical position, as estimated by the method described. In thirteen hips in which the acetabular component was positioned within five millimeters of the anatomical position, no Type-III demarcation was present. Better fixation and position of the acetabular component is achieved by the use of a bone graft or a special titanium perforated-sheet mesh, or both, or by an acetabular shell. The use of three wires improved trochanteric fixation. | |
| 6337662 | X-ray assessment of activity in rheumatoid disease. | 1983 Feb | This review paper examines the limitations of X-ray techniques, and describes the results of the different methods of assessing disease progression including joint involvement in relation to the duration of the disease, and the different methods for scoring joint destruction. The application of the new X-ray technique of microfocal radiography, which produces radiographs of high magnification (x5-x10) and resolution (2 x 10(-5)m object diameter), is described. The techniques, developed by the author, provide the most accurate method of qualitative and quantitative assessment of disease progression in the wrist and hands of rheumatoid patients. | |
| 6602856 | [T gamma lymphocytes in rheumatoid synovial membrane]. | 1983 Mar | The proportion of T lymphocytes with receptors for the Fc portion of IgG (T gamma cells), revealed by mixed rosette assay, was determined in the synovial membrane and peripheral blood of 11 patients with rheumatoid arthritis. The percentage of T gamma cells in the lymphocytic infiltration of rheumatoid synovium was significantly lower than that found in peripheral blood (p less than 0.005). There was no significant difference between the percentage of T lymphocytes in the synovial tissue and that in peripheral blood. Depressed supressor activity of T lymphocytes in rheumatoid synovial membrane might lead B-lymphocytes to blastic transformation to the plasma cell series with consequent production of large amounts of immunoglobulins in the joint. | |
| 671434 | Connective tissue activation. XII. Platelet abnormalities in patients with rheumatoid arth | 1978 Summer | Patients with rheumatoid arthritis frequently have an unexplained thrombocytosis which appears to be related to the severity of the disease process. This report shows that rheumatoid platelets have reduced saline soluble protein per 10(9) platelets, less of a lysosomal enzyme, acid phosphatase, and decreased connective tissue activating peptide (CTAP-III) activity. CTAP-III is a potent connective tissue mitogen, and promotes glycolysis and glycosaminoglycan synthesis, characteristics which make it an interesting candidate for a role as a mediator of inflammation. | |
| 6351234 | [Anti-perinuclear antibodies in the diagnosis and prognosis of rheumatoid polyarthritis]. | 1983 May | Anti-perinuclear antibodies (APN) were studied in 547 subjects, 123 of whom suffered from rheumatoid polyarthritis (RP). They were detected 88 times in the latter group (72 percent). 26 percent of RP were without serological abnormalities when only rheumatoid factors were considered (latex, Waaler-Rose, Waaler-Rose LOR, rheumatoid factors by indirect immunofluorescence). The rate dropped to 10 percent when APN were included. This test is therefore sensitive. It is also specific as APN exists in only 11 percent of non-rheumatoid rheumatological diseases not including psoriasis (42 percent) and in 16 percent of other auto-immune diseases. In addition, there is a correlation (p less than 0.01) between APN level and the evolution of the rheumatoid illness. APN appears early in an illness and is thus of diagnostic and prognostic interest in RP. | |
| 7092519 | Postoperative results of Yoshino total knee prosthesis. A report of 264 arthroplasties per | 1982 | A review was made of 264 Yoshino total knee arthroplasties performed on 154 patients between February 1974 and July 1980. The average duration of the follow-up was 3 years and 2 months. Eighty-six percent were rheumatoid patients. Complications occurred in seven patients. The evaluation results indicated excellent relief of pain and improvement in walking ability. However, pain of the patellofemoral joint was noted in a number of osteoarthritic patients. This implies that a patella implant is necessary in the case of osteoarthritis. In addition, a new surgical technique was performed on "stiff" knees to improve their degree of movement; the average range of movement achieved in these patients was 70 degrees. | |
| 6601314 | Study of HLA antigens in familial and sporadic rheumatoid arthritis. | 1983 Jan | Patients with familial and non-familial (sporadic) forms of rheumatoid arthritis (RA) were studied to investigate possible HLA heterogeneity. HLA-DR4 was present in 75% of familial and 59% of sporadic RA patients. The frequency distribution of A2, B8, B27, Cw3 and DR3 differed somewhat between the two groups; however, the differences were not statistically significant in this small group of patients. Studies of a larger number of patients are indicated to explore the possibility of genetic subgroups in RA. |