Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 2862470 | Antibodies to proteus in rheumatoid arthritis. | 1985 Aug 10 | Antibodies to proteus species were measured in patients with rheumatoid arthritis (RA) and ankylosing spondylitis (AS) and in healthy controls by a Coombs agglutination method. The titres to Proteus mirabilis were higher in 30 RA patients being treated with gold than in 24 patients with active AS (p less than 0.001), 28 patients with inactive AS (p less than 0.001), and 41 healthy control subjects (p less than 0.001). Control studies with Klebsiella pneumoniae var oxytoca showed high antibody titres only in active AS patients. | |
| 204020 | [Gamma heavy chain disease associated with rheumatoid arthritis. Spontaneous disappearance | 1977 Nov 9 | The authors report the chance discovery in a man aged 53 years with serum positive rheumatoid arthritis, of gamma 3 heavy chain disease. The originality of this case depended on the absence of any detectable lymphoid proliferation and on the transient character of the pathological protein. Only the course after a long follow up will determine whether there is no incipient lymphoid proliferation and whether the heavy chain disease has disappeared permanently. | |
| 6630252 | Reimplantation for the salvage of an infected total knee arthroplasty. | 1983 Oct | We retrospectively reviewed the results in fourteen patients in whom salvage of an acutely infected total knee arthroplasty was attempted between 1970 and 1981 by the implantation of a new prosthesis within two weeks of removal of the infected one. Salvage was successful in six of the seven patients with a low-virulence infection but in only two of the seven patients with a high-virulence infection. Of the eight patients for whom the result was a functioning prosthesis, two had significant restriction of motion and one had moderate pain. If these three patients are eliminated from analysis, the over-all success rate is only 35 per cent (five of fourteen patients). We concluded that the implantation of another prosthesis for the treatment of infection of a total knee arthroplasty should be done with caution, and preferably when the infection has been caused by a low-grade organism and after a waiting period of longer than two weeks. | |
| 7455639 | Resection arthroplasty of the metatarsophalangeal joints in rheumatoid arthritis. A follow | 1980 | The follow-up results 1 to 11 years (mean 5 years) after resection arthroplasty of the forefoot or arthrodesis of the first metatarsophalangeal (MTP) joint performed on 100 patients (179 feet) with classical or definite rheumatoid arthritis are presented and analysed. The main indication for surgery was pain in the damaged and more or less luxated MTP joint. Resection arthroplasty of MTP joints II-V was performed from the plantar approach in 167 feet. The Keller or Mayo operation was performed on the first MTP joint in 129 feet. Arthrodesis of the first MTP joint was done in 17 feet. The proximal joint of the hallux was not treated in 33 feet. According to the subjective assessment, results after surgery were considered good by 49 patients (91 feet, 51%), fair by 44 (76 feet, 42%), and poor by 7 (12 feet, 7%). These 7 patients complained of persistent pain or a disabling deformity of the toes, or both. Although these results were generally satisfactory, the objective results were not good. At follow-up more than 50% of the patients had recidivistic callosities, a hallux valgus deformity, a dorsal dislocation and lateral deviation of the lesser toes, or radiologically observable bony proliferations of the distal ends of the metatarsals--or a combination of these. All patients in whom a proximal or interphalangeal joint of the hallux was surgically or spontaneously fused were satisfied: the stiff joint was painless on walking. When destruction of the first MTP joint is severe and painful, arthrodesis is recommended. | |
| 641915 | Auranofin: an oral chrysotherapeutic agent for the treatment of rheumatoid arthritis. | 1978 Spring | Auranofin, an oral chrysotherapeutic agent, administered at 3.0 mg. b.i.d., p.o. to eight rheumatoid arthritic patients produced improvement in objective and subjective clinical signs, as well as biochemical and immunological parameters. Adverse effects reported were minimal and generally limited to gastrointestinal disturbances. During auranofin administration, gold concentrations in the blood gradually increased to a mean level of 0.70 microgram Au/ml by week 12 of treatment. Daily oral administration of auranofin appears to provide constant blood gold levels over longer periods of time compared to existing parenteral gold therapy and may provide an improved method of controlling chrysotherapy in rheumatoid arthritic patients. | |
| 729381 | The frequency of coronary heart disease and myocardial infarction in rheumatoid arthritis | 1978 | The authors studied the frequency of coronary heart disease (CHD) and myocardial infarction (MI) in 500 rheumatoid arthritis (RA) patients (116 men and 384 women). Almost 75% RA patients received 15.0-50.0 g of acetylsalicylic acid (ASA) monthly for above 4 years. The authors did not find significant differences in the frequency of CHD risk factors in the group of RA patients and in the Polish population of similar age. The authors noted only 2 cases of MI and 2 cases of CHD in 500 RA patients. All these patients received ASA irregularly and in small doses. The morbidity coefficient analysis showed that MI is 3-times less frequent in RA patients than in the Polish population. The authors suppose that long-term ASA treatment is one of the factors reducing the risk of CHD and MI probably by inhibition of the platelet function. | |
| 1095306 | The therapeutic activity of diftalone in rheumatoid arthritis: crossover comparison with i | 1975 | A multi-centre double-blind crossover study was carried out in 70 hospitalised patients with rheumatoid arthritis to compare the activity of diftalone, a new anti-inflammatory agen, with that of indomethacin. Patients received either 750 mg. diftalone or 100 mg. indomethacin daily for 2 weeks and were then crossed over to the alternative treatment for a further 2 weeks. Routine clinical and laboratory assessments of disease activity were carried out before the start of the trial and after each treatment period. The results indicate that both drugs produced a favourable response and that there was no statistically significant difference between them in the parameters measure, except for the erythrocyte sedimentation rate which fell only after the administration of diftalone. Patient and physician assessments on the course of the disease were in general agreement and were favourable to the same extent for both treatments. Both products were well tolerated and there were few reports of side-effects. | |
| 479236 | Joint replacement in non-ambulatory patients. | 1979 Sep | We treated eighteen non-ambulatory patients by multiple operations consisting of total replacement of the hip or the knee, or both. Thirteen patients had rheumatoid arthritis, four had degenerative arthritis, and one had had bilateral resection of the femoral head and neck. The patients were followed for an average of forty months. We devised a classification based on the number of joints involved and a rating scale for function. Good to excellent results were achieved in the patients who had two or three joints operated on (with one exception). Fifteen patients became ambulatory and seven could climb stairs. Seven patients were pain-free. The factors responsible for poor results were significant neural problems and loss of motivation. The presence of severe upper-extremity involvement was not an obstacle preventing walking. | |
| 1131102 | Rheumatoid nodules of the larynx. | 1975 Jun | The clinical presentation and histologic appearance of three cases of laryngeal rheumatoid nodules are the subject of this report. In one of these cases, the lesions differed from the classic appearance of the rheumatoid nodule in that they were strongly reminiscent of granulation tissue or a pyogenic granuloma. These vascular lesions are interpreted as immature rheumatoid nodules. Although there are no clinical clues that would lead to the preoperative diagnosis of rheumatoid nodule of the vocal cord and larynx, the index of suspicion should be high in patients with rheumatoid arthritis who are hoarse. However, overt joint symptoms do not appear to be a necessary concomitant of these lesions. | |
| 929121 | Levels of prostaglandins F2 alpha and E2 and thromboxane B2 in joint fluid in rheumatoid a | 1977 | Prostaglandin F2 alpha (PGF2 alpha), prostaglandin E2 (PGE2) and thromboxane B2 (TXB2) levels were determined by radioimmunoassay (RIA) in knee joint fluid in two groups of patients with classical or definite rheumatoid arthritis (RA). One group had no treatment for one week prior to the study. The second group consisted of patients who developed acute exudative arthritis despite the use of various non-steroidal anti-inflammatory drugs (NSAID). The main metabolites of PGF2 alpha in plasma and urine were measured in the untreated group. The conclusion to be drawn from this study are: 1) Treatment with NSAID effectively lowers PGF2 alpha and PGE2 and TXB2 levels in joint fluid. 2) Signs and symptoms of arthritis may persist in spite of lowered levels of PGF2 alpha and PGE2 in the joint fluid. 3) The main metabolites of PGF2 alpha in plasma and urine are above the low-normal limit in untreated patients. 4) The ratio TXB2/PG was low in untreated patients, suggesting that the thromboxane pathway is quantitatively minor in rheumatoid joint inflammation. | |
| 7257855 | Discriminative power of Larsen's grading system for assessing the course of rheumatoid art | 1981 | In the classification of 18628 joints in 186 patients with rheumatoid arthritis during a follow-up of 3 to 12 years, the discriminative power of Larsen's scoring system was assessed. Obvious radiologic progression did not give rise to a change of grading in 9.5 per cent of the examinations. For investigations with a relatively short observation period, more detailed scoring systems should therefore be used. | |
| 334477 | Flurbiprofen and indomethacin in the treatment of rheumatoid arthritis: a double-blind cro | 1977 | A double-blind crossover study was carried out in 30 patients with rheumatoid arthritis to compare the effectiveness of 300 mg flurbiprofen daily with that of 150 mg indomethacin daily. Each drug was given in random order for 2 weeks, each period being preceded by a wash-out period of 2 weeks during which patients received paracetamol. With the exception of joint size and erythrocyte sedimentation rate, both drugs showed a statistically significant improvement when compared individually to baseline in all of the parameters assessed. There were no statistically significant differences between the two drugs when both treatments were compared. Three patients reported side-effects with flubiprofen and 3 with indomethacin, 1 of whom had to be withdrawn from the trial. | |
| 3867272 | Significance of NSAID serum to response relationships. | 1985 | NSAIDs are given to patients to obtain a therapeutic benefit, and a "therapeutic serum concentration range" would be useful. To define the therapeutic range requires a specific assay, knowledge of the active moiety, confidence that the action of the drug is rapid and reversible, examination of the relationship at kinetic equilibrium, careful and innovative ways to measure clinical response, and elimination of as many potential interfering interactions as possible. When defined, the therapeutic range can help clinicians develop dosing aimed at a usual concentration for response, help define toxicity, and help determine compliance. | |
| 6214630 | HLA haplotypes in a family with multiple cases of rheumatoid arthritis. | 1982 May | Population studies have identified the histocompatibility antigen HLA-DR4 to be a genetic marker of significantly increased risk for the development of rheumatoid arthritis (RA). Family studies are now beginning to elucidate the role of this and other genetic factors in the pathogenesis of RA. We have studied a large family in which the mother and 3 of the 6 children have seropositive RA. One maternal and 1 paternal HLA haplotype contain HLA-DR4. The mother and the 2 children with the maternal DR4 containing haplotype have RA. One sibling inherited neither of the DR4 haplotypes, yet developed RA at age 20. The inheritance of RA in this family illustrates the complexity of the genetic predisposition to this immunologically mediated disorder. | |
| 6205814 | Plasma membrane glycoproteins of cultured rheumatoid synovial fibroblasts. | 1983 Jun | Fibroblast cultures were started from synovial tissue samples of 12 rheumatoid arthritic, 9 non-rheumatoid synovitic and 6 control patients. External galactose units of plasma membrane glycoproteins of confluent cells were labelled using the galactose oxidase-tritiated borohydride method. These surface-labelled cells were analyzed for possible differences in their glycoproteins by electrophoresis in SDS-containing polyacrylamide gradient gels. Total cell lysates were separated into 50-60 polypeptide bands. Fluorography of the gels revealed about 20 labelled plasma membrane glycoproteins. Some strain-specific differences were detected between the samples in all the groups, but no correlation with rheumatoid arthritis could be demonstrated. | |
| 7024339 | Studies in cutaneous immunofluorescence. II. Histological and direct immunofluorescence ob | 1981 Apr | Twenty patients with rheumatoid arthritis (RA) had a biopsy taken from clinically normal skin. These were examined for histological and immunological abnormalities and were compared to those of 8 patients with osteoarthritis (OA). No 'lupus band; linear deposition of immunoglobulin or complement at the dermo-epidermal interface was seen in any patient in either group. Perivascular deposits were seen in 5 out of 20 (25%) patients with RA. These were IgM in all 5 cases with additional C3 in 2 cases (10%) and additional fibrin in one case (5%). No immunoprotein deposits were seen in specimens from any OA patient. 4 of the 5 patients with perivascular immunoprotein deposits had circulating ANAs present and dilutions of 1/256 or higher but normal DNA binding. A sparse perivascular, predominantly lymphocytic infiltrate was seen in 13 out of 20 (65%) patients with RA and 3 of 8 (35%) patients with OA. | |
| 6981476 | Correlation in rheumatoid arthritis of concentrations of plasma C3d, serum rheumatoid fact | 1982 Jun | The concentrations of C3d in the plasma and of C-reactive protein (CRP), immune complexes and rheumatoid factor in the serum were measured in 99 patients with rheumatoid arthritis. Most patients had raised levels, the values of which correlated with disease activity assessed according to a newly described index based on multivariate analysis of subjective, semi-objective and objective features of the disease. There were also significant correlations between the values for plasma C3d and circulating immune complexes, immune complexes and rheumatoid factor, serum CRP and immune complexes, and serum CRP and plasma C3d. Measurement of plasma C3d provides a useful means of detecting in vivo complement activation, which may be involved in the pathogenesis of rheumatoid arthritis, but neither C3d levels nor any of the other variables correlated as closely with disease activity as did the serum CRP concentration. | |
| 698885 | Family studies of ocular manifestations in arthritis. | 1978 Jul | To determine the hereditary and clinical patterns, nine patients from three families with different systemic and ocular rheumatoid diseases were examined ophthalmologically and medically. Three types of HLA-B27 associated anterior uveitis were seen. While HLA-B27 linked genes predispose the carrier to acute anterior uveitis (AAU) frequently recurring or chronic anterior uveitis may develop if an immune-complex disease such as Rheumatoid arthritis coexists. Hereditary factors may dispose patients to rheumatoid episcleritis, scleritis and keratitis. | |
| 646832 | Rapid assessment of 99mTc-pertechnetate uptake in the knee joint as a parameter of inflamm | 1978 Apr | Shortly after intravenous injection of 99mTechnetium-pertechnetate (99mTcO4-)(200 muCi), the activity of the knee joints was studied in patients with clinical arthritis of one or both knees and compared with that in normal subjects. A rest period directly before the study improved reproducibility. The values found shortly after injection were comparable with measurements at the maximum. The significance of the 99mTcO4- uptake in comparison with the histologic findings in cases of doubtful arthritis was examined. | |
| 695995 | [Anemia in chronic polyarthritis]. | 1978 Jul | In 216 patients, the correlation of anemia and activity of rheumatoid arthritis was studied. In 27% a concomitant anemia was found. These findings are congruent with those of other authors. There is a significant correlation between activity of rheumatoid disease and evolution of anemia as well as changes of serum iron level. With reference to the literature possible pathogenetic mechanisms of this type of anemia are reviewed. Therapeutic possibilities are briefly discussed. |