Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 288394 | Drug compliance in outpatients with rheumatoid arthritis. | 1979 Jun | A study of drug compliance was carried out on 108 patients with rheumatoid arthritis. Thirty-nine per cent were non-compliant with their antirheumatic medication, varying from occasional to complete failure to take the prescribed drugs. Compared with those taking their medication regularly, the non-compliant patients had a significantly lower mean active joint count and average pain severity and a significantly higher proportion had not received an adequate explanation of their disease. However, drug default does not appear to be a significant problem in management of rheumatoid arthritis, as over 90% of patients were taking their medications all or most of the time. Patients with this disease appear motivated to taking their medication regularly by the presence of chronic and often severe pain. | |
| 6852662 | Trigger wrist phenomenon in rheumatoid arthritis. | 1983 Feb | Flexor tendon synovitis in patients with rheumatoid arthritis commonly presents with a carpal tunnel syndrome and a concomitant trigger finger. Triggering at the wrist joint is in this disease an uncommon additional feature. In the two cases reported, histological examination of the tissue has indicated that, as well as chronic synovitis, there was a true rheumatoid nodule present at the wrist joint, either pedunculated or fusiform. The passage of the nodule, with a 'Click' from the proximal side of the transverse carpal ligament to the distal aspect, when the fingers are flexed, creates the sensation, signs and symptoms of a trigger wrist. | |
| 3852362 | Effect of exercise on morning stiffness and mobility in patients with rheumatoid arthritis | 1985 Sep | The effects of evening exercises on arthrographic measures of elastic stiffness, subjective ratings of stiffness, and graphic goniometric measures of mobility were examined in 30 patients with rheumatoid arthritis. Measures were obtained on 2 consecutive mornings, one of which was randomly determined to be preceded by evening exercise. Each morning, elastic stiffness and mobility were measured before and after morning exercise. After the final measurements of elastic stiffness and mobility on the second day, patients compared stiffness on the 2 days. Elastic stiffness and subjective ratings of stiffness were less and mobility was greater when evening exercises were performed (p less than 0.001). The relationships between elastic stiffness and subjective ratings of stiffness indicated that the effect of evening exercise was perceived as greater when elastic stiffness was greater, and 21 patients reported less stiffness with evening exercise (p less than .05). | |
| 6406321 | [Shoulder arthrography in rheumatoid arthritis]. | 1983 May | Shoulder arthrography in a patient with rheumatoid arthritis is performed to differentiate between a rheumatoid flare and limitation of motion secondary to tear in the rotator cuff. Accurate diagnosis is important because of the therapeutic implications. The arthrographic findings characteristic of rheumatoid involvement of the shoulder joint are nodular filling defects of the joint, the subacromial and subdeltoideal bursa in case of rotator cuff tear, irregular capsular attachment, contracted joint space and visualized lymphatic drainage. A dilatation of the biceps tendon sheath has not been shown. | |
| 7146243 | Psychologically distinguishable groups of rheumatoid arthritis patients: a controlled, sin | 1982 Sep | Systematic measures of mood and psychological symptoms were obtained for 68 ambulatory arthritis patients on two standard questionnaires, the Brief Symptom Inventory (BSI) and the Profile of Mood States (POMS). We studied two groups of rheumatoid arthritis patients, one positive and the other negative for rheumatoid factor and erosive joint changes. A third group of patients had other forms of arthritis. All were matched for chronicity and functional impairment as well as psychosocial background variables. We found a distinct psychometric response profile that allowed us to sort patients into the three clinical groups with an accuracy ranging from 63% to 100%. | |
| 935824 | Morphological changes in liver biopsies from patients with rheumatoid arthritis. | 1976 | Oxphenisatin is known to induce liver damage and is suspected to cause or perpetuate chronic liver disease. In order to evaluate the hepatotoxic effect of long-term therapy with oxyphenisatin 26 consecutive patients with rheumatoid arthritis were investigated for the presence of liver disease. In all cases, liver biopsy, biochemical liver function tests and determination of Hepatitis-B antigen were performed. Ten patients showed no pathological changes in the liver biopsy and a further 2 had only non-specific changes. Seven patients had fatty liver, 5 passive congestion, one haemosiderosis and only one had cirrhosis of the liver. No correlation was found between the activity of rheumatoid arthritis, and duration of the disease, the drug therapy given, and the liver damage. | |
| 6437348 | Free thiomalate levels in patients with rheumatoid arthritis treated with disodium aurothi | 1984 Oct | Sixteen patients with seropositive rheumatoid arthritis were treated with 20 mg disodium aurothiomalate (Myocrisin) weekly for six months. Disease activity was assessed before and after treatment. Plasma profiles and urinary excretion of free thiomalate were measured in all patients after the initial injection and again at six months in the 12 patients remaining on therapy. No difference was found in plasma levels or urinary excretion of free thiomalate between patients who responded to treatment or who developed toxic reactions and those who did not. | |
| 7094466 | Morton's metatarsalgia due to intermetatarsophalangeal bursitis as an early manifestation | 1982 Jul | Of 50 patients in whom Morton's metatarsalgia was diagnosed during an 18-year period, 12 (24%) had rheumatoid arthritis at the time of presentation. After conservative management had failed, 20 patients had subtotal excision of the intermetatarsophalangeal bursa and associated digital nerve; in two patients, only the nerve was excised. During the follow-up period ranging from two months to 15 years, an additional eight patients developed sero-positive rheumatoid arthritis. Thus, a total of 20 patients (40%) presenting with Morton's metatarsalgia had rheumatoid disease at initial presentation or later developed this disease. Histological changes in the intermetatarsophalangeal bursa consistent with rheumatoid arthritis were found in ten patients. Of these, two were known already to have rheumatoid arthritis, three subsequently developed rheumatoid arthritis, and five do not yet have other evidence of the disease. The evidence suggests that Morton's metatarsalgia is associated with rheumatoid arthritis and is the basic etiology in a significant number of patients. | |
| 1011464 | [Morphologic festures of cardiac lesions in rheumatoid arthritis]. | 1976 Nov | Morphological examinations of the heart in cases of articulo-visceral rheumatoid arthritis revealed in 20 of the 35 conducted observations certain changes attributable to the underlying disease. The following groups of changes were revealed: 1) endocarditis; 2) myocarditis; 3) pericarditis; 4) rheumatoid nodules; 5) valvular sclerosis and mural endocarditis; 6) cardiosclerosis; 7) amyloidosis; 8) coronaritis and coronary sclerosis; 9) adhesions in the pericardial cavity. The severity of cardiac leasion in rheumatoid arthritis is determined by the involvement of the serosa into the pathological process. Inflammatory and sclerotic changes in the myocardium are predimonantly of a subepicardial and subendocardial nature, usually non-accompanied by any clear clinical symptoms, or taking a latent course. Rheumatoid nodules typical of rheumatoid arthritis, and deposits of amyloid masses in the walls of the coronary arteries are noted rarely. Changes in the heart are observed mostly in "septic", subacute rheumatoid arthritis and in Still's disease. Cardiac lesions in rheumatoid arthritis are connected with microcirculatory disorders caused by immunopathological processes. | |
| 898925 | [Rheumatoid arthritis among the rural population of southern Bulgaria (transitory morbidit | 1977 | Examinations of 5021 subjects (2779 females and 2242 males) were carried out with a view to rheumatoid arthritis. En masse examinations of the population over the age of 20 were carried out in eight villages of South Bulgaria. Making use of the Roman diagnostic criteria, rheumatoid arthritis--probable form, was found in 1.47 per cent of the males and 1.40 per cent of the females (mean for both sexes-1.43%), confirmed form (including the classical) in 0.80 per cent of the males and 1.12 per cent of the females (a total of 0.98% for both sexes). With two positive New York diagnostic criteria are 1.12 per cent of the males and 1.30 per cent of the females (a total of 1.21% for both sexes). With three and four positive New York criteria are 0.45 per cent of the males and 0.76 per cent of the females (a total of 0.62% for both sexes). Only 60 per cent of the subjects with confirmed (including the classical) rheumatoid arthritis are with three or four New York diagnostic criteria. The Roman diagnostic criteria define sometimes subjects with polyarthritis as patients with rheumatoid arthritis, whereas New York criteria fail to detect the cases with rheumatoid arthritis with asymmetric joint involvement. | |
| 7313484 | [HLA and rheumatoid arthritis]. | 1981 Nov | In a study on the frequency of the HLA A, B, C and DR antigens seen in 100 controls and 31 patients with rheumatoid arthritis, the authors found a significant increase in the DR4 antigen in rheumatoid arthritis. (50% as against 25%; X2 = 8,5; 0,04 greater than Pc greater than 0,008; RR = 3,43). The other antigens on loci A, B. C and DR are not altered significantly. However the increase in DR4 which does not seem to be related to the severity of the rheumatoid arthritis, seems to be proportional to the level of rheumatoid factor. The authors review literature on HLA in rheumatoid arthritis and the figures for the antigenic frequency of HLA-DR4 are compared with their own results. The findings are of interest especially from a pathogenic point of view. | |
| 7247471 | Plasma viscosity--a new appraisal of its use as an index of disease activity in rheumatoid | 1981 Jun | The suitability of the plasma viscosity (PV) test has been examined in relation to the more commonly used erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) estimations as a diagnostic aid in 120 outpatients with rheumatoid arthritis (RA) and as an index of improvement during subsequent specific antirheumatic drug treatment (60 outpatients). Correlation data based on 7 clinical variables suggest that PV estimations are at least as reliable as ESR and CRP in terms of diagnosis and as indices of improvement. The methodological advantages offered by the PV test lend support to its application in RA. | |
| 7432674 | [Rheumatoid arthritis and the marine climate]. | 1980 Sep 22 | After defining rheumatoid arthritis as a diffuse disease of the connective tissue developing into ankylosis, stress is laid on the need for rehabilitation measures to back up basic medical treatment. The use of physical means is strictly conditioned in R.A. by the scrupulous search for the physiotherapeutic phase of the disease to avoid new acute phases. The marine climate as therapy can be excluded in the classical sense where air and rest are the only treatments. It is useful to associate climatotherapeutic technique and prudent balneotherapy and kinesitherapy, but only after identifying the physiotherapeutic phase of the disease. As criteria of effectiveness of the therapeutic possibilities of a stay by the sea, subjective parameters (pain), objective parameters (joint tumefaction) and serological parameters may be adopted. | |
| 451392 | Patterns of disability related to joint involvement in rheumatoid arthritis. | 1979 May | The relationship between particular disabilities and specific impairments of which these disabilities could be the consequence has been explored. Assessments of performance of activities of daily living (ADL) have been simplified by factor analysis, and the resultant factors have been related to the sites of joint involvement in patients with rheumatoid arthritis. Our preliminary findings on the grouping together of various ADL activities are meaningful in terms of underlying impairments, and at the same time indicate an approach for simplification of ADL assessments so as to enhance their value for research and the evaluation of outcome. The results are entirely consistent with a comprehensive model of disablement. | |
| 7059100 | Psychological care of adults with rheumatoid arthritis. | 1982 Mar | Physicians treating patients with chronic rheumatoid arthritis spend a considerable amount of time dealing with the psychological and social aspects of the disease. The patients' reaction to the disease can be related to age, experience, personality, and environment at work and at home. Common problems include loss of independence and self esteem, relations with family and friends, employment, and management of pain. Physicians should be attentive to the psychosocial aspects of rheumatoid arthritis and recognize their dynamic interactions to minimize their impact. | |
| 3970043 | Multiple primary malignancy as a model for the study of cancer occurrence in rheumatoid ar | 1985 Jan 21 | Research approaches to the study of multiple primary malignancy can be helpful in the study of cancer occurrence in rheumatoid arthritis. Research on multiple primary malignancy suggests that an observed increased risk of cancer in rheumatoid arthritis could be due to shared host susceptibility to both diseases, shared risk factors, rheumatoid arthritis-caused changes predisposing to cancer, biased research, chance, or the therapy used in the treatment of rheumatoid arthritis. All of these factors should be considered before concluding that treatment was the cause. Multiple primary malignancy research suggests that sophisticated analyses are needed in order to evaluate cancer risks following therapy. There may be long latency periods between therapy and cancer onset. Drugs may have been given in various dosages, sequences, and combinations and for different durations. Persons with chronic diseases such as rheumatoid arthritis are often difficult to follow over time; hence, there may be variable follow-up intervals for subjects. All of these problems must be taken into account in analyses of cancer risk. | |
| 719380 | Genetic basis of rheumatoid disease: HLA antigens, disease manifestations, and toxic react | 1978 Nov 11 | Ninety-five patients with rheumatoid arthritis and 200 healthy controls were examined for HLA-D-related (HLA-DR) alloantigens. HLA-DRW4 was significantly more prevalent among the patients and was particularly common in those with a family history of the disease (77% of such patients had DRW4 compared with 34% of controls). Significantly fewer patients than controls had DRW2: patients with this antigen had rheumatoid nodules less frequently and significantly lower titres of rheumatoid factor than patients without DRW2. In contrast DRW3 was significantly more prevalent among severely affected patients with rheumatoid factor titres exceeding 1/1280 and in patients with nodules. There was a significant association between DRW2 and DRW3 and toxic reactions to sodium aurothiomalate and penicillamine. The results suggest that the HLA-DR phenotype is associated not only with susceptibility to rheumatoid arthritis but also with severity of the disease and whether certain toxic reactions to drugs occur. | |
| 7142367 | Histological and immunological study in patients with rheumatoid arthritis showing isolate | 1982 Oct | We report the histological and immunological findings in 20 rheumatoid arthritis (RA) patients with impaired salivary scintigraphy but without sicca complex. This condition was stable over 2-5 years and associated with mild infiltrates on lip biopsies. Increased levels of IgG, immune complexes, and antinuclear antibodies were found in seven patients (35 vs 69% in secondary Sjögren's syndrome). Two of the seven patients later developed xerostomia. The above-mentioned immunological abnormalities may increase the likelihood of developing a clinical impairment of salivary function in patients with an abnormal salivary scintiscan, the latter being a frequent, yet often isolated, finding in RA. Antisalivary duct antibodies were not related to any other parameter of salivary gland involvement. | |
| 4452745 | Nodular, non-cirrhotic liver associated with portal hypertension in a patient with rheumat | 1974 Dec | A patient with rheumatoid arthritis developed portal hypertension and died from bleeding oesophageal varices. The liver was small and showed a nodular, non-cirrhotic pattern similar to that described by Blendis et al (1970 and 1974) in association with Felty's syndrome. This appears to be the first report of a patient with this liver lesion associated with rheumatoid arthritis in the absence of Felty's syndrome. The liver lesions described here are compared with partial nodular transformation and nodular regenerative hyperplasia; in spite of some differences it is not proven that these are distinct entities and further study is required to settle this question. | |
| 4017309 | Plasmapheresis vs total lymphoid irradiation in the treatment of severe rheumatoid arthrit | 1985 Apr | In an ongoing study patients with severe rheumatoid arthritis (RA) who had previously failed conventional therapy including gold salts and penicillamine were randomly assigned on an open basis to a plasma exchange or fractionated total lymphoid irradiation protocol. Nine patients (eight female, one male) with erosive RA of long duration exchanged 40 ml/kg of plasma over a period of two to four weeks. Nine patients (eight female, one male) with similar characteristics, received 2,000 rads to lymphoid tissues in fractionated doses (200 rads each) over 4 to 5 weeks. Treatment was completed in all patients and follow-up ranged from two to twelve months for plasma exchange and eight to sixteen months for radiation. Results of the study showed subjective and objective improvement including morning stiffness, joint score, and pertinent laboratory evaluation in six patients admitted to plasmapheresis with duration of remission lasting as long as seven weeks. Three patients failed to show any improvement in the activity of the disease. Eight patients on the radiation protocol showed a marked decrease in disease activity which has been maintained until the present time. Side effects for the plasma exchange group included mild febrile reactions during the exchange and one non-A non-B Hepatitis. In the radiation group occipital alopecia, loss of appetite and nausea was seen in all patients and severe leucopenia in one (WBC 500/mm3). The present results suggest that both procedures can reduce disease activity in severe RA. Plasma exchange efficacy appears to be short-lived when compared to total lymphoid radiation. The latter was poorly tolerated by all patients submitted to the program. |