Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 451488 | Clinical assessment of disease activity in rheumatoid arthritis. | 1979 | A new experimental design was developed to study the value of clinical parameters of disease activity in patients with rheumatoid arthritis. Ten patients with classical rheumatoid arthritis were examined by five senior doctors in a department of medical rheumatology. In spite of an attempt to make the clinical examination as uniform as possible the inter-observer variation among the doctors was greater than the variation among the patients, for the following parameters: joint pain at rest, joint tenderness and joint swelling. An acceptable inter-observer variation in relation to patient variation was found for 1) a combined registration of joint pain at rest or on movement, 2) duration of morning stiffness, 3) grip strength, 4) subjective well-being as indicated on a visual analogue scale, 5) fingertip--palm distance, and 6) maximum flexion-extension in elbows, wrists and knees. The variation from morning to afternoon and from day to day was negligible. It is concluded that registration of elaborated articular scores is useless in the daily routine in rheumatological departments when different doctors examine the patients. | |
| 3887910 | Stress management and mutual support groups in rheumatoid arthritis. | 1985 May | Stress management and mutual support groups are employed widely in chronic illness, although their efficacy has not been established. To determine the effect of these measures on morbidity and psychologic health in rheumatoid arthritis, 105 patients meeting diagnostic criteria for rheumatoid arthritis were evaluated for depression, life satisfaction, functional disability, and indicators of disease activity. Patients were randomly assigned to one of three groups: (1) stress management; (2) mutual support; (3) no intervention (control). After completion of 10 weekly sessions, identical tests were performed for all patients in the intervention and control groups. Patients in the intervention groups showed greater improvement in joint tenderness than did the control patients but did not differ significantly from the patients in the control group in any of the other outcome measures. | |
| 24426 | Alclofenac and D-penicillamine. Comparative trial in rheumatoid arthritis. | 1978 Feb | Forty-six patients with rheumatoid arthritis, 22 receiving D-penicillamine and 2j alclofenac, took part in a 6-month single-bind external observer trial to compare the efficacy and toxicity of these drugs in the treatment of severe rheumatoid arthritis. Both drugs were active and similar in their efficacy at 6 months as judged by clinical and laboratory measurements. Penicillamine was active therapeutically by 3 months, one month before alclofenac. 9 patients, 8 on alclofenac and one on D-penicillamine, had to stop treatment because of lack of effect or toxic effects. Skin rashes within the first week of treatment were a major problem with alclofenac and led to 6 withdrawals. | |
| 6663593 | The mucin clot test and the synovial fluid rheumatoid factor as diagnostic criteria in rhe | 1983 Dec | We evaluated the diagnostic usefulness of 2 synovial fluid (SF) tests viz the mucin clot test (MCT) and the rheumatoid factor (RF) test in rheumatoid arthritis (RA). SF was obtained from 140 patients, 60 with RA, 80 with other articular diseases. The sensitivity and specificity of the MCT in RA were 76% and 49%, respectively; the positive and negative predictive values (PPV, NPV) were 52% and 73%. The sensitivity and specificity of SF RF were 63% and 91% respectively compared with corresponding values of 75% and 87% for serum RF; PPV and NPV were 89% and 69%, and differed little from values obtained for serum RF. Our results suggest that RA diagnostic criteria should be revised to exclude the MCT, and that the detection of RF in SF in addition to its determination in serum is unnecessary in establishing a diagnosis of RA. | |
| 4038365 | The clinical features of elderly-onset rheumatoid arthritis. A comparison with younger-ons | 1985 Sep | Patients with elderly-onset rheumatoid arthritis (EORA) may represent a clinical subset of individuals who differ prognostically and therapeutically from patients with younger-onset disease (YORA). In order to test this hypothesis, we reviewed the records of 212 patients with rheumatoid arthritis and grouped them according to age at onset above or below 60 years old. Seventy-eight EORA patients and 134 YORA patients with disease duration of less than or equal to 10 years were used for a comparison of presenting features and disease outcome. Abrupt onset occurred somewhat more frequently in EORA, but was not associated with a significantly different clinical course than was an insidious presentation in this older group. There were no differences between the EORA and YORA groups in terms of mean initial joint score, although the scores for the YORA group had wider variation. An initial clinical presentation resembling polymyalgia rheumatica (PMR) was 4 times as frequent in EORA. Elderly patients were less likely to have subcutaneous nodules or rheumatoid factor at disease onset. At the final examination, the EORA patients had lower joint scores and higher health assessments despite similar courses of treatment. These outcome differences persisted when patients with PMR-like presentations were excluded. Multivariate analyses indicated that joint scores and disease duration made important contributions to a better outcome of EORA, whereas PMR presentation and abrupt onset did not. After an adjustment was made for these 4 features, age at onset was an important contribution to joint score outcome. These results confirm the existence of important differences in onset, clinical features, and prognosis between patients with EORA and those with YORA. | |
| 4070964 | An assay for estimating the cytotoxicity of synovial fluid from patients with rheumatoid a | 1985 Nov | The joint is the prime site of involvement in rheumatoid arthritis: the synovium showing lymphocytic involvement and damage. The synovial fluid shows evidence of inflammation such as increased neutrophils and raised CRP. Application of a cell-free extract of serum or synovial fluid from patients with rheumatoid arthritis, or serum from normal individuals on to 111indium oxine radiolabelled endothelial cells and fibroblasts, promotes the release of the isotope as a result of cell damage and death (cytotoxicity). In paired samples, synovial fluid was consistently more cytotoxic than rheumatoid serum. There was no difference in the cytotoxicity of rheumatoid serum or normal serum. These results demonstrate the presence of soluble factors in synovial fluid, which are capable of destroying cells, typical of those found in the synovial cavity, in blood vessels and in connective tissue generally. This system may prove to be a useful model of inflammatory damage. | |
| 6166256 | Significance of laminar antikeratin antibodies to rat oesophagus in rheumatoid arthritis. | 1981 Jun | Antikeratin antibodies reacting in a laminar distribution with keratinised rat oesophagus were found in the sera of a proportion of patients with rheumatoid arthritis but not in healthy controls. In rheumatoid arthritis (RA) the proportion of sera exhibiting this reactivity varied with the site tested in the rat's upper alimentary tract. There were 36.4% of 99 patients with RA who gave positive reactivity to the middle third of the rat oesophagus. This antikeratin reactivity was related to the occurrence of other antitissue antibodies (to reticulin, gastric parietal cells, smooth muscle, mitochondria, or nuclear components) in the same patients with rheumatoid arthritis. It was not related to the duration of early morning stiffness, the Ritchie index, the erythrocyte sedimentation rate, certain acute phase proteins (haptoglobin and C-reactive protein) nor to the levels of haemoglobin or immunoglobulins. Antikeratin antibodies were not specific for rheumatoid arthritis and also occurred in 50% of 16 patients with progressive systemic sclerosis. | |
| 6347304 | Bed rest, activity and the inflammation of rheumatoid arthritis. | 1983 Aug | Seventy-five patients with rheumatoid arthritis have been studied in order to assess the relative contributions of bed rest and planned activity on the observed improvement in arthritis during hospitalization. The benefit of bed rest was less than expected; only a third of patients showed significant improvement. A similar number improved during planned activity and although bed rest was superior the advantages were small. The features of those patients who responded to bed rest or planned activity showed small but important differences indicating that more careful selection to one or other regimen may increase the number of patients benefiting from hospitalization. | |
| 4009567 | Total knee replacement in osteoarthritis and rheumatoid arthritis. | 1985 Jul | Between 1974 and 1983, 187 total knee replacements were performed in 163 patients at four East Kent district general hospitals. With few exceptions pain was the most common indication for the operation and it produced complete or almost complete relief in 90% of cases. The most frequently used prostheses were the Attenborough, Stanmore and Geomedic. | |
| 1157693 | [Psychological tests of patients with chronic rheumatoid arthritis(author's transl)]. | 1975 Sep 12 | 27 women with rheumatoid arthritis had elevated depression and social introversion scores in the Minnesota multiple phasic personality inventory (MMPI) tests, whereas their somatic activity appeared reduced. Age of the patient at time of investigation apparently had no influence on the degree of psychological changes, but was reflected in an increased social introversion. Most important for the degree of psychological impairment was the height of the ARA index, which correlated positively with the neurotic triad as well as the psychasthenia scale in the MMPI. An elevation of the neurotic triad is common in many somatic disease. Patients with rheumatoid arthritis had an additional, introversion and depression, and decreased somatic activity. | |
| 1252261 | Coexistence of ankylosing spondylitis and rheumatoid arthritis. | 1976 Jan | Ankylosing spondylitis and rheumatoid arthritis share many common features. However the presence of rheumatoid factor, histologically classic rheumatoid nodules, and the histocompatibility cell wall antigen (HLA-B27) helps distinguish one from the other. Two cases are reported in which these features established the coexisting diagnoses of ankylosing spondylitis and rheumatoid arthritis. | |
| 628753 | Gray scale ultrasound in the evaluation of rheumatoid arthritis of the knee. | 1978 Mar | Gray scale ultrasound at a frequency of 5.0 MHz was used as part of a study to evaluate the results of yttrium-90 injection as therapy for rheumatoid arthritis of the knee. Popliteal cysts, suprapatellar effusions and synovial thickening in the suprapatellar pouch were demonstrated and ultrasound studies were correlated with the clinical and arthrographic findings. Gray scale ultrasound can be a useful adjunct in the evaluation and follow-up of rheumatoid arthritis of the knee. | |
| 1198073 | Ultrastructural and histochemical studies of muscle in rheumatoid arthritis. | 1975 | Muscle biopsy material from 12 patients with rheumatoid arthritis was investigated by electron microscopy. Degenerative changes and atrophy of the muscle fibres were observed. The periphery of the fibre was indistinct and showed an increased content of lipofuscin granules and remnants of myofilaments. Mitochondria were frequent in the subsarcolemmal regions, but between the myofibrils these were rarer than in healthy subjects. The triads were often swollen and displaced. Capillaries were more frequent than in normal material; the endothelial cells and especially the basement membrane showed pathological changes. Satellite cells were frequent and are regarded as an indication of regeneration. | |
| 6497919 | A critical review of compliance studies in rheumatoid arthritis. | 1984 Nov | Nineteen studies of treatment compliance in rheumatoid arthritis (RA) patients have been critically appraised to assess the magnitude and determinants of noncompliance in this population. Deficiencies in study methodology undermined the possibility of firm conclusions on the influence of various factors on compliance in RA populations. Nevertheless, it is apparent that noncompliance with treatments for RA is a major problem that hitherto has not been widely considered. Compliance with prescribed drug regimens varied from 16% to 84% among these studies. With physiotherapy regimens, compliance rates varied from 39% to 65%, while for splint-usage, rates varied from 25% to 65%. No consistent correlation has been demonstrated between compliance and age, sex, treatment side effects, disease severity, or drug dose frequency. Gaps in our present day knowledge have been detailed and the need for further research is outlined. | |
| 6372082 | Radiological assessment. | 1983 | The criteria for an ideal radiological assessment system for rheumatoid arthritis (RA) were considered and an historical review made of existing systems. In response to their relative shortcomings a new points system is proposed in which several parameters for joint changes may be measured either separately or together. This would allow far greater sensitivity, reproducibility and comparativity , particularly in clinical trials. | |
| 6669870 | The use of 'alternative treatments' by patients with rheumatoid arthritis. | 1983 | In a study of 199 patients with rheumatoid arthritis, 68% were found to have tried 'alternative treatments'. Some treatments (acupuncture and faith healing) gave subjective benefit in nearly half those who tried them and were considered to be better than others (such as copper bracelets). No adverse reactions were reported. 'Alternative treatments' play an important role as self prescribed therapy in rheumatoid arthritis and their use should not be ignored nor underestimated. | |
| 6424587 | HLA DR antigens and disease expression in rheumatoid arthritis. | 1984 Apr | Ninety-four patients with rheumatoid arthritis who possessed one or more of the HLA DR alloantigens 2, 3, or 4 were studied to investigate the genetic influence on disease severity and prognosis. In those with a disease duration of less than 10 years radiological damage was less in patients with DR2 than in those without this antigen. When current joint scores were compared, patients with this antigen had less evidence of disease than patients with DR3 or 4, DR3 patients having the highest scores. The presence of nodules and Sjögren's syndrome were less common in the DR2 patients. Variability in response to disease modifying drugs according to the patient's HLA DR antigen status may explain these differences. It is concluded, however, that possession of HLA DR2 may be an indicator of good prognosis in patients with rheumatoid arthritis. | |
| 1055004 | Rheumatoid arthritis of the temporomandibular joint. | 1975 Mar | An investigation into the involvement of the temporomandibular joint in rheumatoid arthritis is described. There is evidence to show that is is affected in two-thirds of all cases of the disease, and this figure agrees broadly with other recent studies. The clinical and radiographic presentation is discussed and its relationship to degenerative disease (osteoarthosis) of the temporomandibular joint is shown. The clinical course of this manifestation of rheumatoid arthritis is proposed and a line of treatment is suggested. | |
| 818380 | Studies of rheumatoid arthritis among a tribe of Northwest Indians. | 1976 Mar | Thirty-six women from a Northwest Indian population known to have an increased prevalence of rheumatoid arthritis were studied. The course of the clinical disease was that of erosive rheumatoid arthritis with characteristic involvement of metacarpophalangeal and wrist joints. Rheumatoid factor and antinuclear antibody tests were frequently positive, and reactions to gold therapy were more frequent than in other rheumatoid populations. Viral antibodies were similar in the rheumatoid and the control groups. HL-A W24 and HL-A BW40 were increased in both the diseased and the control Indian populations. | |
| 534318 | Effect of fasting and lactovegetarian diet on rheumatoid arthritis. | 1979 | 16 patients with classical rheumatoid arthritis (RA) selected at random underwent fasting for 7--10 days, followed by a 9-week period on a lactovegetarian diet. 10 RA patients acted as controls, taking normal diet. Pain, stiffness, medication, and clinical and biochemical findings were recorded before fasting, on the first day after the conclusion of the fasting period, and at the end of the lactovegetarian period. After fasting, 5 of 15 patients showed objective signs of improvement, compared with only one of the controls. The fasting patients showed reduced pain, stiffness, consumption of analgetics, several clinical variables, and serum concentration of orosomucoid. At the conclusion of the lactovegetarian diet period only one Diet patient showed objective improvement. No differences were found between the Diet patients and the controls concerning symptoms, drug consumption, or clinical and biochemical variables. We conclude that fasting may produce subjective and objective improvements in RA, though of short duration, but the findings of this investigation do not indicate that lactovegetarian diet has any beneficial effects. |