Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 4700332 | Onset, early stages, and prognosis of rheumatoid arthritis: a clinical study of 100 patien | 1973 Apr 14 | One hundred patients with "definite" or "classical" rheumatoid arthritis were followed in a hospital clinic from within one year of the onset of the arthritis. The average interval between onset and first attendance was 3.7 months. Onset was commoner in the winter, transient prodromal symptoms being noted in 23, with possible precipitating factors in 14. The serum rheumatoid factor test was positive at some time in 88.The patients were reassessed between eight and 14 years later. Seventeen died during this period, five possibly as a result of the disease or its treatment.The remaining patients had improved as a whole in terms of the blood sedimentation rate, haemoglobin, titre of the rheumatoid factor test, and status of the disease, but there was an overall deterioration in functional capacity. Both the rheumatoid factor titre and the functional capacity at an earlier review could be directly correlated with the outcome, but other factors were not found to influence the ultimate prognosis. | |
| 666870 | Clinical features of the arthritis of mixed connective tissue disease. | 1978 Jun | Seventeen of 19 patients with mixed connective tissue disease (MCTD) had arthritis as a significant initial feature of their disease; 8 were given an initial diagnosis of rheumatoid arthritis (RA) and 4 received chrysotherapy. RA-like hand deformities were present in 35% and contractures and/or persistent loss of joint motion in 47%. Joint radiographs showed abnormalities in 41% and included erosions and/or cysts in 30%. The arthritis of MCTD may be both erosive and deforming and this disease should be considered in patients presenting as RA with unusual features. | |
| 4026417 | Remission of arthritis and radiological improvement after combination therapy for non-Hodg | 1985 Aug | A patient receiving d-penicillamine for rheumatoid arthritis developed a lymphoma, therapy for which resulted not only in haematological resolution but marked remission of rheumatoid disease activity, including radiological improvement. | |
| 1221937 | Fistulization of rheumatoid joints. Spectrum of identifiable syndromes. | 1975 Dec | Eight patients with rheumatoid arthritis developed cutaneous fistulae adjacent to affected joints. Rheumatoid factor was positive in eight patients; subcutaneous nodules were noted in seven. Two patients had features of rheumatoid vasculitis. A spectrum of syndrome characterized by cutaneous fistulae was observed. Three patients showed classical fistulous rheumatism. Four patients developed septic arthritis which subsequently fistulized; in two, infection was associated with total joint replacement. One patient showed a cutaneous sinus accompanying a large calf cyst. A variety of diagnoses must be considered when cutaneous fistulae appear near joints in patients with rheumatoid arthritis. | |
| 4009007 | [Superoxide dismutase and hyperbaric oxygen therapy of the patient with rheumatoid arthrit | 1985 Jan | Cu, Zn-SOD values were measured by enzyme immunoassay in the synovial fluid, leukocytes in the synovial fluid, synovial membrane, and leukocytes in blood of the patients with rheumatoid arthritis. SOD activity, lipoperoxide value in serum, ESR, and Lansbury's index of the patients with rheumatoid arthritis under hyperbaric oxygen (HBO) therapy were also investigated. SOD values of synovial fluid and of leukocytes in synovial fluid from rheumatoid arthritis group were found to be higher than those from osteoarthritis group. No significant difference was found the SOD values in leukocytes of blood and synovial membrane between two groups. In the patients with rheumatoid arthritis under HBO therapy the SOD activity was increased, whereas lipoperoxide values was decreased. Furthermore, ESR and Lansbury's index showed a remarkable recovery. These results suggest that HBO therapy may be an effective treatment for the patients with rheumatoid arthritis. | |
| 596945 | Rheumatoid involvement of the lumbar spine. | 1977 Dec | On stereoscopic examination of the lumbar spines of 6 patients with rheumatoid arthritis and spinal disease we found typical rheumatoid erosions in the apophyseal joints. 2 also had severe asymmetrical disc destruction with associated involvement of the vertebral bodies and scoliosis. In one of these patients who developed Staphyloccocus aureus septicaemia, infection was localized in this part of the lumbar spine. | |
| 432560 | Differentiation between psoriatic arthritis and rheumatoid arthritis: a biochemical and st | 1979 | The differentiation between psoriatic arthritis and rheumatoid arthritis can be clinically difficult if there is no manifest psoriasis of skin or nail. In order to clarify this diagnostic problem, the amino acid patterns in seventy-five psoriatic and non-psoriatic nails have been studied. Using gas--liquid chromatographic techniques and discriminant analysis, a high degree of differentiation (96%) has been established between the normal looking nails of patients with psoriatic arthritis and those with rheumatoid arthritis. This biochemical/statistical approach to the fingernail enhances diagnosis in difficult clinical problems, particularly where there are no overt manifestations of psoriasis. | |
| 728356 | Pulmonary necrobiotic nodules without rheumatoid arthritis. | 1978 Oct | Pulmonary necrobiotic nodules are the least common of the pulmonary lesions associated with rheumatoid arthritis. Histologically they are identical to subcutaneous rheumatoid nodules. Systemic rheumatoid arthritis usually precedes the development of pulmonary nodules. Seven cases where the pulmonary nodule appeared before or without the development of systemic rheumatoid arthritis are described. The typical histological and radiological features of necrobiotic nodules were found in each. In five of the seven the nodules were in more than one site and in five there were cavitating nodules. Spontaneous improvement occurred in one case. Pulmonary nodules preceded systemic rheumatoid arthritis in three cases and in the remaining four cases systemic rheumatoid arthritis has not yet appeared despite prolonged follow-up. In all patients, tests for rheumatoid factor have remained negative. The absence of circulating rheumatoid factor and systemic rheumatoid arthritis cannot exclude the diagnosis in these cases if the histological diagnosis is accepted as conclusive. | |
| 1144520 | Shoulder arthroplasty in rheumatoid arthritis. | 1975 Feb | Replacement arthroplasty for the shoulder in rheumatoid arthritis is an operation which is being performed increasingly often. Several types of arthroplasty may be performed. One type is a true total shoulder replacement which involves replacing both the head of the humerus and the glenoid fossa. In a second type of arthroplasty, the articular surface of the humeral head is replaced. A modification of this type is the addition of a polyethylene spacer. Indictations for surgery, the surgical procedure, and the postoperative management are duscussed. The primary goal in the rheumatoid shoulder is a pain-free joint with a functional range of motion. | |
| 960871 | [Progression of rheumatoid arthritis]. | 1976 Jul 1 | In order to recognize courses with high and low progression in rheumatoid arthritis deviating from former approach the values of a locomotor function test were used which do not belong to the dispersion region for the adequate classes of duration of a disease. With the help of a material of an electronic data processing study of 1,000 cases with ascertained diagnosis correlations between high progression and, among others, following criteria could be ascertained: male sex, old age, early beginning of the disease, manual trades, unfavourable functional values and very much changed laboratory values including high titres of the rheumatoid factor. In this method there was no relation to the duration of the disease, as it was existing with other methods of the determination of progression which were comparatively included into the investigation. | |
| 82030 | Levamisole in rheumatoid arthritis. A randomised double-blind study comparing two dosage r | 1978 Nov 11 | The therapeutic effect of levamisole in patients with rheumatoid arthritis was evaluated in a sixteen-centre double-blind controlled study which compared continuous and intermittent levamisole treatment with placebo for six months. 363 patients with classic or definite rheumatoid arthritis and active disease were evaluated. Continuous and intermittent levamisole treatments were equally effective in controlling disease activity. 20% of patients had important drug-related adverse reactions. The results demonstrated that levamisole is an active drug in patients with rheumatoid arthritis. | |
| 869952 | Increased frequency of HLA-Cw3 and HLA-Dw4 in rheumatoid arthritis. | 1977 Jun | Thirty-nine patients with rheumatoid arthritis were HLA typed for the full range of A and B locus specificities and for Cw3 and Dw4. HLA-Dw4 was significantly more frequent in patients (36%) than in controls (13%). The frequency of Cw3 was also increased, probably because this allele is in linkage disequilibrium with Dw4. | |
| 1257429 | [Synovectomy in rheumatoid arthritis of the knee, radiologic investigations (author's tran | 1976 Feb | Pathologic and radiologic investigations of rheumatoid arthritis are compared with regard to their development. Radiologic demonstration of several cases prior to and following synovectomy shows improvement as well as exacerbation of the disease. An increasing mineral content signifies an improvement of the bone lesion. The mineral content depends on reduction of inflammatory activity, increasing motility, and postoperative discontinuation of cortisone therapy. In some cases various lesions at the border line between bone and cartilage as blurring, notching and destructions are disappearing. Reduction of cartilage accompanied with narrowing of the joint spaces will subside postoperatively, too. We have to suppose a regeneration of cartilage under increasing physical strain by functional stimulation. Following synovectomy the structure of subcartilage spongiosa becomes more organized as a sign of regression of inflammatory activity, improved motility and load capacity. Following synovectomy, exacerbation of radiologic symptoms occur mainly in advanced stages of rheumatoid arthritis. We may often see progression of secondary osteoarthritis existing preoperatively in contrast to clinical recovery. The increasing load capacity may cause an identation of the articular surface in cases of extreme osteoporosis. This might result in a false position. These lesions might necessitate further surgical treatment as possibly total joint prosthesis. Following synovectomy in rheumatoid arthritis of the knee, dissolving radiologic symptoms in addition to improvement of the clinical picture may be observed. The poor results of synovectomy in advanced rheumatoid arthritis favours the of early synovectomy during the proliferative and destructive stage of the disease. | |
| 76118 | Reduction in incidence of rheumatoid arthritis associated with oral contraceptives. Royal | 1978 Mar 18 | Analyses of the frequency of reporting of rheumatoid arthritis have been undertaken as part of the continuing major prospective survey of oral contraceptives. The rate of reporting in oral-contraceptive users (takers) is half of the rate in non-users (controls). The rates for ex-takers and controls are not materially different. The expected rise in the rate of reporting in women over 35 is apparent in controls but suppressed in takers. In the absence of any accountable bias, it is concluded that oral contraceptives protect against the development of rheumatoid arthritis. Although the effect is small, the observation may be valuable in understanding the aetiology of the disease and the mechanism of action of oral contraceptives. | |
| 6480480 | Comparative therapeutics of canine and human rheumatoid arthritis. | 1984 Sep 1 | For a variety of reasons--both medical and medicolegal--a more aggressive approach is taken in canine than in human rheumatoid arthritis. While cytotoxic agents are probably the drugs of choice in the dog, they are normally the last resort of the rheumatologist. On the other hand, the nonsteroidal anti-inflammatory drugs, which are the cornerstone of treatment in man, are of questionable safety--if not absolutely contraindicated--in the dog. Canine rheumatoid arthritis is an uncommon diagnosis, and it is not the intent of this discussion to encourage either the use of cytotoxic drugs or the experimentation with unproven agents in dogs with vaguely defined forms of arthritis. | |
| 999742 | Organic brain syndrome in rheumatoid arthritis following corticosteroid withdrawal. | 1976 Nov | Six patients with seropositive nodule-forming rheumatoid arthritis developed severe central nervous system manifestations consistent with a diagnosis of organic brain syndrome. Organic brain syndrome occurred while 5 of these patients were undergoing corticosteroid withdrawal after prolonged administration. Neuropsychiatric symptoms rapidly cleared, responding to reinstitution of oral or parenteral corticosteroids in large doses in 4 patients, to increase in dosage in 1 patient, and to no drug therapy in the remaining 1. Marked reduction in rheumatoid factor in sera and demonstration of IgM deposits in the choroid plexus in 1 of the patients raised the possibility of immune complex-mediated central nervous system vasculitis. | |
| 385872 | Hypothesis: that rheumatoid arthritis will disappear. | 1979 May | The first unequivocally clear description of rheumatoid arthritis occurred in 1800. It is possible, however, that the disease existed in earlier times and that Emperor Constantine IX Monomachus (circa 980-1055) was a sufferer. The disease is common today in all races throughout the world. The features of rheumatoid arthritis are consistent with its being an infection, perhaps a slow-virus infection. On the basis of behaviour of other bacterial and viral infections, it is possible that we may now expect the current pandemic to disappear. Perhaps by the end of the next century it will be mild and rare or even non-existent. | |
| 6712308 | Lateral subluxation of the atlas in rheumatoid arthritis: a case report and post-mortem st | 1984 Apr | The atlantoaxial joints of a patient with lateral subluxation of the atlas were studied post mortem by dissection. There was severe erosion of the left lateral atlantoaxial joint and an asymmetrical erosion of the cartilages of the median atlantoaxial joint which prevented reduction of the lateral subluxation. The atlantoaxial ligaments were remarkably intact. It is emphasised that osseous factors rather than ligaments confer lateral stability to the atlantoaxial joints and that destruction of these leads to lateral subluxation. | |
| 1224806 | [Pulmonary function and rheumatoid arthritis]. | 1975 Jan | Pulmonary ventilation was studied on 100 rheumatoid arthritics from a medical outpatient clinic, using wholebody plethysmography, spirography, and pneumometry. Findings were normal in 2/3 of the patients; reduced lung capacity was found in only 3-6%. Thus it is doubtful that significant restriction of ventilation is present in chronic polyarthritis. Nevertheless, 1/4 of all rheumatoid arthritis patients have bronchial obstruction with resulting pulmonary emphysema. Whether or not the incidence of respiratory passage obstruction is directly associated with the underlying rheumatoid disease must await further study. | |
| 3865372 | Chlorambucil therapy in rheumatoid arthritis: clinical experience in 28 patients and liter | 1985 Nov | Our clinical experience in 28 patients receiving chlorambucil for rheumatoid arthritis (RA) and the reports on chlorambucil therapy are reviewed. Our study population and other reports generally represent patients with severe RA who had either failed to improve or developed significant toxicity during previous treatment with conventional slow acting anti-rheumatic drugs (SAARDs). Seventy-two percent of patients had a significant clinical improvement during chlorambucil therapy and reports of complete remission are given, although the incidence of remission is unknown. Hematologic complications are often reported, but appeared more frequently in our experience than previously reported. Hematologic toxicity required that chlorambucil be discontinued in the majority of our cases. Two deaths from suspected drug induced malignancies are reported. Although chlorambucil appears to be effective in the control of active RA, the potential for drug induced toxicity and malignancies may outweigh the benefit of continued use of this experimental therapy in RA. |