Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 6813474 | Analysis of auranofin as a rheumatoid remitting agent. | 1982 Jul | To assess the therapeutic potential of Auranofin (AF), we examined the results of 7 early short term clinical trials involving 104 rheumatoid arthritis (RA) patients; radiographic analyses were performed on 16 of these patients followed for 4 years. This agent suppressed RA in 2/3-3/4 of patients followed for periods up to 1 year; thereafter emergence of RA activity occurred despite maintenance medication. Serious toxicity was nonexistent. Radiographic analyses indicated a minority of patients may have arrested disease demonstrated by lack of erosion progression. Thus, AF has a similar therapeutic profile to conventional chrysotherapy but the drug is more useful because of absence of serious toxicities. | |
| 4055344 | Evaluation of the effects of various anti-arthritic drugs on type II collagen-induced mous | 1985 Aug | A battery of drugs which are commonly used as therapeutic agents for arthritis was tested for effects on the inflammatory and immunological responses of DBA/1J mice, after immunization with type II collagen. All the drugs were tested at more than one dosage. The mice were protected from the development of arthritis by treatment with paramethasone (0.25 mg/kg/day) or cyclophosphamide (5 mg/kg/day). The nonsteroidal anti-inflammatory drugs used in these studies, viz. aspirin (200 mg/kg/day), benoxaprofen (100 mg/kg/day) and naproxen (200 mg/kg/day), had no significant effect on the joint involvement, although naproxen and benoxaprofen at these high doses caused some reduction of immune responses of mice to collagen. Chloroquine (100 mg/kg/day), levamisol (50 mg/kg/day) and gold chlorophosphene (5 mg/kg/day) had no effect on the inflammatory or humoral response, while treatment with D-penicillamine (100 mg/kg/day) led to an early onset of arthritis in mice. These data suggest that the type II collagen-induced mouse arthritis model may not be highly suitable for detection of the traditional nonsteroidal anti-inflammatory class of drugs or the anti-rheumatic drugs, although the possibility remains that some new and novel immunosuppressive agents may be detected with this model. | |
| 608468 | Comparison of technetium uptake in small joints with other indices of inflammation in rheu | 1977 Dec 30 | The uptake of 99mTc in the small joints of the hand has been compared to various other mesures of inflammation in 22 patients with rheumatoid arthritis. The 99mTc uptake in the finger joints can reflect both disease activity at a given time and change in activity over a period of time. The place of Tc uptake amongst other measures of inflammation, from the point of view of the 'relative efficiency' of the assessment method, is rather inferior. In evaluating the effect of antiphlogistic drugs on local inflammation, techneticum uptake may, however, prove more discriminating than grip-strength or the number of painful joints, since the latter measures depend largely on the degree of destruction. | |
| 6614843 | Knee replacement in rheumatoid arthritis. | 1983 Apr | This paper is based on experience gained from 583 primary knee replacements carried out at Harlow Wood Orthopaedic Hospital between 1968 and 1981. Various types of prostheses are discussed in relation to their application at various stages of destruction of the knee joint. Special problems concerning patients with rheumatoid arthritis and the problems of their damaged knee joints are emphasised. A plea is made for continued study which will recognise common factors essential for success. | |
| 730075 | Is hypergastrinaemia associated with rheumatoid arthritis? | 1978 Nov | In an attempt to confirm the reported high incidence of raised serum gastrin levels in patients with rheumatoid arthritis (RA), gastrin concentrations were estimated in 54 patients. Only three patients (6%) had basal hypergastrinaemia. The heptadecapeptide (G17) and total carboxyl-terminal immunoreactive gastrin responses to a standard protein meal were measured by specific radioimmunoassay in these three patients and in nine normogastrinaemic RA patients displaying the same age range. The three hypergastrinaemic patients showed significantly greater and more prolonged G17 and total carboxylterminal immunoreactive gastrin responses to the meal compared with the normogastrinaemic RA patients (P less than 0.02). Two of these three patients agreed to have an acid output study (pentagastrin 6 microg/kg subcutaneously) and gastric mucosal biopsies taken for histology. Both were found to be achlorhydric and to have atrophic gastritis. This study suggests that basal hypergastrinaemia in RA patients is considerably less common than previously reported and, when present, is associated with achlorhydria. In addition, the incidence of achlorhydria in rheumatoid arthritis is similar to that found in a normal age-matched population. | |
| 7458435 | Gold in erythrocytes, whole blood, and plasma during long-term chrysotherapy. | 1980 Dec | The concentrations of gold in erythrocytes, whole blood, cell-rich plasma, and cell-free plasma were investigated in 17 patients with rheumatoid arthritis undergoing long-term chrysotherapy. Gold estimations were performed with a graphite tube atomic absorption spectrophotometer. Significant quantities of gold were found in isolated erythrocytes of 12 patients. There was no correlation between erythrocyte gold and therapeutic response, plasma gold, and gold in whole blood. Nor did gold in whole blood or plasma show any correlation with therapeutic responses and toxic reaction. However, all patients (3) with toxic reactions had a significantly higher gold concentration in the erythrocytes than the patients without toxic reactions. This result indicates that erythrocyte gold estimations could provide a useful warning of impeding toxic reactions. | |
| 849945 | Ipsilateral hip and knee replacements as a single surgical procedure. | 1977 Apr | A total of thirteen surgical procedures were performed on eight patients, all of whom had a history of rheumatoid arthritis. Five patients had bilateral hip and knee replacements and three patients had ipsilateral hip and knee replacements for a total of twenty-six joint replacements. Ambulatory status for all patients was significantly improved and all patients subjectively reported a great reduction in pain postoperatively. Complications included two transient peroneal-nerve palsies in the same patient from which she recovered spontaneously, and one questionable pulmonary embolus which resolved with heparin therapy. The relative advantages of this type of procedure and the indications for and against surgery are discussed. | |
| 103179 | Do penicillamine and Myocrisin act the same way in rheumatoid arthritis? | 1978 | Our observations, as well as similarities between penicillamine and Myocrisin in clinical action and side effects in RA make it not unreasonable to think that thiomalate may have a penicillamine-like effect. Only a controlled clinical trial with thiomalate in RA can provide an answer to this question. | |
| 6395323 | Lack of effect of tranexamic acid on rheumatoid arthritis. | 1984 | In a double-blind controlled study on 45 rheumatoid arthritis patients, no effect of tranexamic acid (Cyklocapron, 4.5 g per day for 6 weeks) was found in terms of subjective or objective parameters of disease activity. Tranexamic acid did not reduce complement activation, measured by plasma concentrations of the complement C3 split product C3d. Immune complex concentrations in serum were also unaffected. We conclude that plasmin inhibitors do not reduce immune complex mediated complement activation, and they should not be used for treatment of rheumatoid arthritis. | |
| 7113312 | [Comparative crossover double-blind study of profenid and indomethacin patients with rheum | 1982 Apr 15 | 38 patients with active rheumatoid arthritis, randomly divided into two groups, underwent a three weeks treatment with profenid (3 capsules + 1 suppositorium) alternatively with indomethacin (3 capsules + 1 suppositorium), which head lasted six weeks in case of each patient. The study was double-blind using a crossover technique. The results show that the efficacy of the applied doses of profenid is similar to that of indomethacin. Profenid is superior to indomethacin with regard to drug tolerance. | |
| 3981518 | Influence of antecedent lymphoid surgery on the odds of acquiring rheumatoid arthritis. | 1985 Feb | The occurrence of rheumatoid arthritis (RA) and the extent of antecedent lymphoid surgeries was examined using case control study methods. Two hundred sixty-four patients with definite or classic RA were considered and 283 patients with rheumatic diseases presumably of nonimmunologic origin were used as controls. The odds for developing RA were found to be significantly higher for patients with multiple lymphoid surgeries (tonsillectomy and adenoidectomy or tonsillectomy and adenoidectomy plus appendectomy) and exhibited a gradient, increasing with more extensive surgery. Significant rank correlations were found in patients with RA between the age at tonsillectomy and the rheumatoid factor (RF) titer. An earlier tonsillectomy correlated with lower titers of RF. A significant decrease of serum RF titer was also seen in patients with RA subjected to tonsillectomy, adenoidectomy and appendectomy. We conclude that antecedent removal of lymphoid tissue from the tonsils, adenoids and appendix constitutes a risk factor predisposing to RA. Moreover, this risk seems related to the quantity of lymphoid tissue removed. | |
| 6590008 | Life threatening cardiac tamponade complicating a case of seronegative rheumatoid arthriti | 1984 Feb | We report the complication of cardiac tamponade occurring secondary to a pericardial effusion in a patient with persistently seronegative rheumatoid arthritis. The frequency and presenting features of this potentially life threatening complication of rheumatoid arthritis are reviewed and management of this complication is discussed. | |
| 4091641 | Knee-joint arthroplasty according to Stanmore. A clinical and radiographic follow-up. | 1985 | Of a total of 56 knee arthroplasties according to Stanmore, a clinical and radiographic follow-up was performed on 38, with mean follow-ups of 36 months for rheumatoid arthritis and 34 months for osteoarthritis. Early complications occurred in nine of 56 cases. Clinically satisfactory results were obtained in 71%. Radiolucent zones of 3 mm or more were found to be associated with clinically verified loosening. | |
| 1180031 | Simultaneous and spontaneous bilateral rupture of the patellar tendon in rheumatoid arthri | 1975 Sep | A case of rupture of the patellar tendon in a patient with rheumatoid arthritis is presented. The age of this patient (27 years) makes this case quite uncommon. The rupture was bilateral, simultaneous and spontaneous. The absence of previous cortisone administration rules out this drug as a cause of the tendon rupture. | |
| 1258545 | [Cytophotometric DNA measurements in mononuclear round cells of synovial fluid]. | 1976 Jan | Cytophotometric investigations were performed on synovial fluid mononuclear round cells in patients with various joint diseases. In nearly all instances only round cells with a diploid DNA-content were found. No increased proliferation could be observed neither in patients with rheumatoid arthritis nor in patients with a high relative number of neutrophilic granulocytes in the synovial fluid. | |
| 4543614 | Leucocyte migration inhibition with aggregated gamma globulin in patients with rheumatoid | 1973 Sep | Soluble aggregates of IgG inhibit the migration of leucocytes from patients with rheumatoid arthritis. Migration inhibition was not related to disease activity or to SCAT titre. In patients with raised IgG antiglobulins there was a correlation with LMT raising the possibility that inhibition could be due to cytophilic antibody on the leucocytes; this does not seem to be the case in patients with normal antiglobulin levels. | |
| 4092477 | Local treatment of necrotizing scleritis with cyclosporin A. | 1985 | A report is presented on an 83-year-old female patient with seropositive rheumatoid arthritis who developed a necrotizing scleritis of the right eye. The clinical course could not be influenced by indomethacin, cysteine, and the cytostatic chlorambucil. Local cyclosporin treatment, however, which was initiated after a 4-week therapy-free period, led to considerable improvement within a few days. The disease disappeared after 6 weeks of treatment. There is no recurrence as yet, the follow-up period being 13 months. | |
| 4050140 | [Enzyme therapy in comparison with immune complex determinations in chronic polyarthritis] | 1985 Mar | 42 patients with definite or classic rheumatoid arthritis were treated with an enzyme mixture (Wobenzym) for 6 weeks. Circulating immune complexes were investigated with a Clq-solid phase RIA in weekly intervals and also rheumatoid factors were determined together with other routine laboratory tests. The condition of patients after therapy was recorded together with amount of circulating immune complexes during treatment. 26 (61.9%) patients improved, 13 (30.9%) patients remained unchanged, and 3 (17.1%) showed impairment. No side effects were observed. Patients who primarily showed no immune complexes or patients who had immune complexes which became negative during enzyme therapy, showed improvement more often than patients which had immune complexes and remained positive during the entire course of therapy. | |
| 7229091 | Interrelationship of chronic eosinophilic pneumonia, bronchiolitis obliterans, and rheumat | 1981 Feb | Three patients with histologically proven bronchiolitis obliterans are presented, two of whom had rheumatoid disease. All three patients had, in addition, clinical and radiological evidence of chronic eosinophilic pneumonia; open lung biopsy in two showed coexistent features of chronic eosinophilic pneumonia and bronchiolitis obliterans. The association of both rheumatoid disease are chronic eosinophilic pneumonia with bronchiolitis obliterans in these patients may simply be coincidental, but the striking similarities between the cases suggest that a real interrelationship of these disease entities may exist. | |
| 4011684 | Rate and range of knee motion during ambulation in healthy and arthritic subjects. | 1985 Jul | The purpose of this study was to determine the relationship between gait velocity and rate and range of knee motion, during ambulation, for healthy and arthritic subjects. The arthritic subjects had either rheumatoid arthritis or osteoarthritis, and all were tested before and after total knee replacement. Healthy subjects ambulated at an average velocity of 80 m/min and demonstrated knee flexion and extension rates of 344 degrees/sec and a range of knee motion of 60 degrees. Gait velocity correlated with rates of knee flexion and extension and range of knee motion. Arthritic subjects ambulated at velocities less than those of healthy subjects ambulating at free speed. Arthritic subjects accordingly demonstrated reduced knee flexion and extension rates and range of knee motion. When compared with healthy subjects ambulating over a comparable gait-velocity range, the arthritic subjects demonstrated reduced rates and range of motion in most instances. We discuss implications for therapeutic intervention to increase gait velocity for arthritic subjects. |