Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 7100272 | Pathomechanics, gait deviations, and treatment of the rheumatoid foot: a clinical report. | 1982 Aug | This article describes the five major foot deformities or problems often seen in patients with rheumatoid arthritis: hallux valgus, pronation of the foot, depression of the metatarsal heads, hammer or claw toes, and tendocalcaneal bursitis or subplantar spur formation. These deformities contribute to the development of common rheumatoid gait deviations such as decreased velocity, cadence, and stride length; poor heel-toe pattern; and abnormal patterns of weight bearing. Nonsurgical treatment for these problems includes joint protection methods, assistive gait devices, orthotic intervention, and physical therapy procedures. Surgical intervention provides stability for the weight-bearing joints of the foot and reduces pain. Consideration of these problems and an early intervention effort may help to prolong the ambulatory status of the patient with rheumatoid arthritis. | |
| 857449 | [Prognostic significance of serum iron level, hemoglobin and rheumatoid factor titre in rh | 1977 Feb 1 | On the basis of the results of a five-year examination of the course on 120 patients with rheumatoid arthritis the authors adopt a definite attitude to the prognostic significance of hypersiderinaemia, anaemia and height of the titre of the rheumatoid factor. With the help of the chi2-test and the rank correlation after Spearman the statistical relations to stage, activity, clinical and radiological progressing as well as to the number of the affected joints were examined. In seropositive patients we found a correlation of the titre of rheumatoid factor and stage. Furthermore a clear correlation existed to clinical and radiological progressing as well as to the number of the affected joints. Early highly positive titres of the rheumatoid factor as an expression of high immunologic activity suggest an unfavourable prognosis in the majority of cases. Constant anaemia and hyposiderinaemia as symptoms of a high basis activity of the disease also showed close relations to the progressing. From this result indications for the early use of important therapeutic measures. For the prognostic judgement of the course of the disease of rheumatoid arthritis it is necessary to have at disposal further methodically simply determinable parameters for the recognition of the basis activity and the immunologic activity. | |
| 3872636 | Stimulation of bone marrow erythropoiesis by T lymphocytes of anaemic patients with rheuma | 1985 Apr | An inappropriate response of the bone marrow is implicated in the aetiology of the anaemia of chronic disease complicating rheumatoid arthritis. T lymphocyte subsets have been shown to inhibit early erythroid development in vitro in association with some cases of bone marrow failure, and an expanded peripheral blood pool of these cells is reported in rheumatoid arthritis. We have studied the role of peripheral blood T lymphocytes in erythroid bone marrow culture from seven normal volunteers and nine anaemic patients with rheumatoid arthritis and found comparable stimulation of growth in both groups. | |
| 6692608 | Rheumatoid arthritis of the cervical spine. | 1984 Jan | The synovitis of rheumatoid arthritis (RA) injures structures in the cervical spine, allowing atlantoaxial subluxation, atlantoaxial impaction, and subaxial subluxation. Spinal cord and vertebral artery injury can ensue. Subluxations are common, but neurologic abnormalities are less so. Patients with RA can die from subluxations but usually do not, although many become worse with time. Nonsurgical management is supportive and designed to lessen pain. Neurologic abnormality is the major indication for surgery. Preoperative skeletal traction is often needed. Posterior fusion is most commonly done for stabilization. | |
| 7347124 | Temporomandibular joint abnormalities in rheumatoid arthritis: comparison of different rad | 1981 | Transantral (infraorbital, transmaxillary) examination of the temporomandibular joint was compared with conventional transcranial examination and lateral tomography of patients with rheumatoid arthritis aged 23 to 83. Abnormalities were most frequently found at tomography, and equally frequent at transantral and transcranial examinations. The various examinations appeared to be rather supplementary. Bone erosion was frequently observed at transantral examination, which appeared to be the preferable radiographic method for detecting arthritis of this joint. Combined with transcranial examination, the method is recommended for the evaluation of temporomandibular joint abnormalities in rheumatoid arthritis if tomographic equipment is not available. | |
| 7161773 | Serum beta-endorphin in rheumatic disorders. | 1982 Nov | Serum beta-endorphin levels have been determined in patients with a wide variety of rheumatic disorders as well as a group of healthy men and women controls. Normal levels of endorphin have been found in patients with juvenile rheumatoid arthritis. Patients with rheumatoid arthritis, osteoarthritis, systemic lupus erythematosus, gout, ankylosing spondylitis, pseudogout and psoriatic arthritis have diminished levels of endorphins. Speculation is offered to explain these changes. Perturbations in endorphins are postulated to be part of the organism's protective mechanism in inflammatory arthritis. | |
| 602913 | The zeta sedimentation ratio (ZSR) and activity of disease in rheumatoid arthritis. | 1977 Dec | Zeta sedimentation ratios (ZSR) and modified Westergren erythrocyte sedimentation rates (ESR) were compared with an independent clinical assessment of disease activity in 100 patients with rheumatoid arthritis. The correlation between ZSR and ESR was good. Both methods correlated well with disease activity. The ZSR was more frequently elevated than the ESR in each category of disease activity, but the differences were slight. In addition to its practical advantages, the ZSR appears to be a satisfactory method for monitoring the activity of rheumatoid arthritis. | |
| 6825538 | Rheumatoid vasculitis of the colon presenting as pancolitis. | 1983 Feb | This report describes a patient with pancolitis resulting from rheumatoid vasculitis. Corticosteroid treatment reduced colonic inflammation but colectomy was required to control hemorrhage. The case illustrates the need to recognize colitis as a manifestation of rheumatoid vasculitis so that new treatment modalities may be employed to achieve a more successful medical management. The appearance of discrete colonic ulcerations following corticosteroid treatment of pancolitis in patients with rheumatoid arthritis should further suggest the diagnosis of intestinal vasculitis. | |
| 7136017 | [Rheumatoid arthritis in people of advanced age]. | 1982 Jul | The special position occupied by rheumatoid arthritis in people of advanced age was studied by drawing on a sample of 39 patients who had developed the disease at the age of sixty and over. In the majority of patients the disease was of acute and monoarticular onset, and the pattern of involvement was more often asymmetrical than in younger patients. In three patients the disease followed a fulminant course. The radiological differential diagnosis was complicated primarily by underlying osteoporosis and concomittant degenerative changes. Laboratory tests produced no significant differences compared with the "classic" form of rheumatoid arthritis. Only the percentage of serologically negative patients was slightly increased. Emphasis is put on the difficult differential diagnosis, especially in cases where the onset of the disease is monoarticular. | |
| 655664 | The cervical myelopathy associated with rheumatoid arthritis: analysis of patients, with 2 | 1978 Feb | The clinical findings in a group of 32 rheumatoid patients with symptomatic myelopathy are described. The myelopathy appeared in late middle age after many years of rheumatoid disease (average duration, 18 years). The most common radiological abnormality was anterior subluxation of C1. Other patterns occurred in about half the cases. The most common neurological findings were those of a mild to moderate spastic paraplegia, often with atrophy of muscles of the hands and sensory changes in the hands. Symptoms originating above the foramen magnum (nystagmus, diplopia, slurred speech) appeared to have a vascular cause and were sometimes associated with upward as well as posterior movement of the odontoid process. Root pain into the arms was not present, and its absence helped to distinguish these disorders from cervical spondylosis. Root pain into the territory of the C2 root was common. Medical or conservative therapy was not effective, and the preferred approach was use of a halo traction device followed by posterior fusion, with or without laminectomy. Pathologically, in 2 autopsy cases, the maximal change had occurred in the central gray matter and adjacent posterior and lateral columns. We postulate that direct pressure caused intermittent compression and narrowing of distal transverse branches of the anterior spinal artery. | |
| 7300997 | Renal pathology in patients with rheumatoid arthritis. | 1981 | We studied 76 patients with rheumatoid arthritis who had autopsies performed at the University of Utah and Salt Lake Veterans Administration Medical Center. The most common pathological finding in the kidney was interstitial fibrosis (46%) and internal proliferation of the arterioles in the absence of hypertension (54% of the cases). Renal amyloidosis was only found in 7% of the patients. Azotemia (creatinine above 2 mg/dl) was found in 9% of the patients but was not clinically significant. In addition uremia was not a frequent cause of death in patients with rheumatoid arthritis. | |
| 414991 | Monoclonal gammopathies in rheumatoid arthritis. | 1977 | A total of 2560 sera from patients with and without rheumatoid diseases were examined for the incidence of monoclonal proteins. The incidence of monoclonal protein was higher (3.3%) in patients with rheumatoid arthritis than with other non-rheumatoid diseases of connective tissue (0.7%). Of 16 monoclonal proteins found in rheumatoid arthritis, 15 were IgG and 1 IgA; 7 sera belonged to the kappa and 9 to lambda type. | |
| 6582273 | Epidemiology of rheumatoid arthritis in developed countries. | 1983 Nov | The epidemiology of rheumatoid arthritis (RA) has been the subject of 4 international conferences during the past 25 years and the current concepts have recently been renewed in detail elsewhere. This paper will focus on the prevalence and incidence of RA in various geographic areas and ethnic groups, temporal trends in incidence rates, and the role of host, and environmental and genetic factors in disease etiology. | |
| 6349514 | Treatment of severe rheumatoid arthritis. | 1983 Apr | The basis for the application of remittive agents in rheumatoid arthritis is still hypothetical and empirical. Immunoreactions may be of pathogenetic significance in rheumatoid arthritis but definite evidence is lacking. Similarly the rheumatoid inflammation may be 'non-specific' or immune mediated. Therefore at present there is no basis for 'guidelines' for immunotherapy. Controlled trials have provided little or no information on the mechanism of action of the remittive agents. Furthermore classical controlled trials have severe limitations and require great resources. Therefore we need a new strategy for controlled trials. The emphasis should be on elucidation of the mechanism of actions of remittive agents with already established clinical efficacy. It is now possible in controlled trials to analyse immunological factors of possible pathogenetic significance, factors in the processes of inflammation and the interaction between the immune system, inflammation and connective tissue. Thereby a proper evaluation of the mechanism of action of remittive agents as well as of pathogenetic factors in rheumatoid arthritis seems possible. | |
| 2869625 | Sulphasalazine in the treatment of rheumatoid arthritis. | 1985 Nov | Recent reports have found sulphasalazine to have a disease-modifying effect in patients with rheumatoid arthritis. We report on the results of an open study of this drug. Sulphasalazine was given to 20 patients with active rheumatoid arthritis (definite or classical by ARA criteria) during a period of 6 months. Response to the treatment was assessed by subjective symptoms and objectively by changes in selected clinical and laboratory parameters. After 2 to 6 months' therapy some of these measurements had improved significantly in 18 patients. Three patients went into remission by preliminary ARA criteria. The treatment was discontinued in two patients because of side effects (toxic-allergic cutaneous reactions). From these results we conclude that sulphasalazine may be a useful second-line drug in the treatment of rheumatoid arthritis. | |
| 6493703 | Scleritis, pericarditis, and aortic insufficiency in a patient with rheumatoid arthritis. | 1984 Aug | A 55-year-old black man developed anterior nodular scleritis in his left eye in November 1981. He had no symptoms of systemic disease, and initial laboratory tests revealed only a positive rheumatoid factor. Fourteen months later he presented with pericarditis and aortic insufficiency requiring aortic valve replacement. Examination of excised valvular and pericardial tissue showed changes compatible with rheumatoid disease. Shortly after the surgery he developed florid rheumatoid arthritis. The clinical course of this patient illustrates how scleritis can be the initial sign of severe systemic disease. | |
| 1031364 | Pertechnetate uptake of joints in rheumatoid arthritis. | 1976 Dec 30 | A new isotopic method for evaluation of inflammatory activity in rheumatoid arthritis is reported. By use of repeated whole body profile scanning a double tracer examination with 99mTc-pertechnetate and 113mIn-transferrin was performed. Total pertechnetate activity and total indium activity were measured over both hands, both feet, the ankles, and over the knee joints. In addition, the extravascular component of pertechnetate uptake and the ratio extravascular/total pertechnetate activity were calculated for these regions. The activity curves were followed up to 2 h after tracer injection in seven female patients presenting with rheumatoid arthritis and in six female controls. The four parameters calculated were compared and statistical analysis revealed the most significant discrimination of both groups for the ratio extravascular/total pertechnetate activity 2 h after injection (P less than 0.002). | |
| 6435401 | Diffuse rheumatoid nodules in skeletal muscle in rheumatoid arthritis. | 1984 | Rheumatoid nodule is an uncommon finding in rheumatoid arthritis (RA). A report is given on a case of RA which lasted for 15 years and nodules appeared diffusely in the skeletal muscles close to the fascia. These nodules had a histological structure similar to that found subcutaneously and a tendency to be confluent with colliquation necrosis resembling what was described in subpleural localization. | |
| 7267469 | Rheumatoid arthritis. Guidelines for office management. | 1981 Sep | Since this chronic inflammatory disease is characterized by a combination of destruction and healing, a two-pronged approach to management that incorporates antiinflammatory drug therapy and physiotherapy is advised. More toxic drugs or even surgery may be tried in stepwise fashion if initial measures fail to relieve symptoms. | |
| 7224683 | Cause and age at death in a prospective study of 100 patients with rheumatoid arthritis. | 1981 Apr | A series of 100 patients with rheumatoid arthritis (RA), first seen in the early months of their disease, have now been followed up for 18 years, and 43 have died. Rheumatoid disease directly caused death in 9, and the disease or its treatment contributed to death in 7. These 16 patients were younger at onset and younger at death than the 27 in whom death was unrelated to RA. Of clinical features noted 1 year after the onset of RA a worse ARA grading and a worse functional capacity were already evident in those 16 patients. Conversely, the 57 still surviving had a better ARA grading and a better functional capacity after 1 year than those who died. The survivors were also significantly younger than the rest at the onset of RA. The death rate throughout the follow-up period was higher in the patients graded as 'classical' than those graded as 'definite' RA after 1 year of disease. |