Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 122657 | Penicillamine treatment of rheumatoid arthritis: relationship of proteinuria and autoantib | 1977 | Thirty-seven patients were studied before and during treatment with respect to immune status, clinical response and development of adverse effects and autoantibodies. The baseline immune status was not predictive in terms of the above features, apart from the fact that the group of 7 patients developing proteinuria had a tendency to low or subnormal IgG levels. The most marked clinical improvement was recorded in the group who had augmented skin test responses sometime during the treatment period. These patients also had the largest falls in the IgG, IgA and rheumatoid factor. Antinuclear antibody persisted or increased in titre in 38% of patients, but was not associated with poor prognosis or liability to side-effects. Autoantibodies to striational or smooth muscle occurred in 20% of patients, and there was a much higher incidence of proteinuria in this group. We have previously suggested that penicillamine may act by depressing humoral function, leading to augmentation of cell-mediated immunity. Although the present findings suggest that penicillamine does cause humoral depression in some cases, it is not clear how the drug induces the side-effects described. | |
| 10274895 | The effects of patient education on patient cognition and dis-related anxiety. | 1985 Dec | A rheumatoid arthritis patient education program was developed with objectives of increasing patient knowledge base and improving health status. Forty-six rheumatoid arthritis outpatients entered a three-session multidisciplinary education program. Each client was given a cognitive test and the Arthritis Impact Measurement Scale (AIMS) before, immediately after, and at remote follow-up. Data were analyzed to determine the effect of age and disease duration on clients' ability to benefit from group education. The effect of the program on physical and psychosocial parameters was also assessed. There was a significant increase in average cognitive scores between pre- and post-tests which remained at one month follow-up testing. Pre-test cognitive scores correlated positively with disease duration. At immediate post-test a correlation between anxiety scores and physical parameters was seen, which was not present on pre- or follow-up testing. No correlation was found between increase in cognitive scores and overall health status. Multivariate analysis of the AIMS test showed significant improvement in total health score at remote testing. Depression scores significantly improved from post to remote follow-up testing. This study suggests that one 'side effect' of patient education may be a transient worsening of psychological status in patients with greatest disease involvement. | |
| 6332432 | [Psoriasis arthropathica and seronegative rheumatoid arthritis--differential diagnostic co | 1984 Jun 1 | For differential-diagnostic considerations concerning seronegative arthritides two groups of patients with 25 patients each of the disease groups psoriasis arthropathica and serologically negative rheumatoid arthritis were selected. The differentiation of the two diseases was performed by clinical, paraclinical and radiological findings. When there are no typical psoriatic changes of skin and/or nails and there is an empty family anamnesis concerning this dermatosis, respectively, the coordination of seronegative arthritides is considerably rendered more difficult. Here the radiomorphological investigations particularly of the sacroiliacal joint and/or of the spine essentially contribute, since the arthritis of the sacroiliacal joint is to seen in high incidence in psoriasis arthropathica. Out of the number of the paraclinical values the determination of the complement factor C 4 and of immunoglobulin M gets the importance of a sign of differentiation, in which case C 4 in the psoriasis arthropathica and the immunoglobulin M in the seronegative rheumatoid arthritis are statistically significantly increased. The problems of the often difficult differential diagnosis between the two groups of disease can be clarified only by complex clinical examinations, paraclinical parameters and subtile radiodiagnosis. A close interdisciplinary cooperation between experienced dermatologists, rheumatologists and radiologists seems reasonable. | |
| 1126063 | The use of wire mesh in total hip replacement surgery. | 1975 Jan | Metal mesh is helpful in relation to two complications of total hip replacement; namely, migration of the trochanter and fatigue fracture of the medial wall of the acetabulum. Mesh is applied over the greater trochanter in instances when the trochanter is excessively porotic and would crush as the wires are tightened. It is used to "recapture" the trochanter or trochanteric fragments if migration has occurred. The wires are then brought through the mesh and tied over the mesh, thus distributing the load widely across the porotic trochanter. The problem of a thin medial acetabular wall is dealt with by medially embedding a hemisphere of metal mesh in the methacrylate creating the effect of reinforced concrete. This increases the physical properties of the methacrylate and helps to distribute the load to the public, ischial and iliac portions of the socket. Potentially this approach will be useful in treating fatigue fractures of the medial acetabular wall after total hip replacement. Thirteen patients treated using chrome cobalt metal mesh in association with total hip replacement are presented. | |
| 7117167 | [Onset of rheumatoid arthritis in the elderly]. | 1982 Oct 8 | The predominant age of manifestation of rheumatoid arthritis (chronic polyarthritis) is between the 35th and 45th year of life. Onset of disease in the higher age groups is, however, not infrequent. Comparison of two groups of patients with rheumatoid arthritis with disease onset before or after the age of 60 showed that a quarter of late-onset cases commence particularly acutely. These was a remarkably early involvement of shoulder joints with a frequency of up to 50%. The symptom triad of shoulder joint involvement, markedly raised ESR and severe generalised disease was characteristic. This combination of symptoms is not infrequently attributed erroneously to the "shoulder-arm syndrome or suspect malignant tumour". Differential diagnosis from rheumatic polymyalgia or true paraneoplastic arthropathy may be difficult. Therapeutic problems arise mainly due to the high number of other medical problems of the elderly. | |
| 1257708 | Chloroquine treatment and bone changes in rheumatoid arthritis. | 1976 | The effect of chloroquine on bone and articular cartilage was studied in 28 rheumatoid arthritis patients. After the administration of chloroquine for a minimum of 6 months, a metatarsal bone specimen was taken at operation. The control material consisted of 24 operated patients treated in the same way, except that they had not received chloroquine. Histological investigation, in which pairs of slides were compared in a blind test, revealed that the changes in the articular cartilage in those given chloroquine were less marked. Moreover, a diminished tendency to pannus formation and a more vigorous bone regeneration were observed in this group. Chloroquine seems thus to have a prophylactic effect on the articular cartilage changes in case of rheumatoid arthritis. | |
| 7217433 | CT appearance of rheumatoid pericarditis. | 1980 Dec | In patients with rheumatoid arthritis who develop symptoms of right heart failure, it is important to consider rheumatoid involvement of the pericardium because untreated rheumatoid pericarditis is often fatal. In addition to echocardiography and right heart catheterization, computed tomography affords a method of detecting pericardial effusion or a markedly thickened pericardium. | |
| 6937065 | Cytologic manifestation of rheumatoid arthritis in pleural effusion: a case report. | 1981 Jan | The cytologic changes of rheumatoid pleural effusions have been reported infrequently. A case is presented illustrating that the recognition of these changes can have clinical significance. The diagnostic cytologic picture comprises multinucleated giant cells and histiocytes in a granular, necrotic background. The probable tissue origin of the cytologic findings is discussed. | |
| 1275579 | Serum immunoreactive gastrin: specificity for rheumatoid arthritis, bimodality of distribu | 1976 Feb | A significant rise in immunoreactive gastrin in a proportion of patients with rheumatoid arthritis is confirmed. Such a rise does not seem to occur in other inflammatory or tissue destructive diseases. The patients with raised immunoreactive gastrin appear to form a separate population but the factors determining this separation remain obscure. Anti-inflammatory drugs, at least during short-term administration have no influence on immunoreactive gastrin concentrations. | |
| 6864686 | Preceding tonsillectomy and appendicectomy in rheumatoid and degenerative arthritis. | 1983 Apr | One hundred and sixty-eight patients with rheumatoid arthritis (RA) and 87 patients with degenerative arthritis (osteoarthritis, OA) were questioned regarding appendicectomy and tonsillectomy surgery. Thirty point four % of patients with RA and 33.3% of those with OA had had a tonsillectomy preceding the onset of their arthritis. Preceding appendicectomy had been performed in 18.5% of RA and 32.2% of OA patients. These results do not support the hypothesis either of inherent or acquired susceptibility to infection in patients with RA. | |
| 6315935 | Superoxide production in neutrophils of patients with rheumatoid arthritis and Felty's syn | 1983 Oct | The production of superoxide by N-formylmethionyl-leucyl-phenylalanine activated neutrophils was measured prospectively with a ferricytochrome C reduction assay in 33 normals, 33 patients with rheumatoid arthritis and 9 patients with Felty's syndrome. Both the rate and quantity of superoxide production were significantly lower in patients with Felty's syndrome when compared to the other 2 groups. This finding suggests a possible additional factor in the increased propensity of these patients to develop infections. | |
| 782079 | [The presence of fluorescein-conjugated antibodies in synovial tissues of rheumatic joints | 1976 May | With a modified Coons technique synovial tissue, anti human IgG, IgA, IgM, anti-coeruloplasmine, anti-transferrin, and anti-fibrin were investigated by means of immunofluorescence and evaluated with reference to place, type, and intensity of fluorescence. It was shown that fibrin deposits in the synovial tissue in rheumatoid synovitis do not only consist of the actual fibrin but often of immune complexes. These were mainly found near vessels and necroses, whereas unspecific fibrin was detected mainly in fibers and limiting areas. Coeruloplasmine and transferrin seem to have a marked affinity to pathogenetically changed fibers, whereas they do not combine with normal fibers. In seropositive RA remarkable immuno fluorescence was observed in vessels. From these facts certain etiological conclusions on rheumatoid diseases can be drawn. | |
| 6332326 | Introduction and classification of rheumatic diseases. | 1984 Jun | Rheumatic diseases affect a large segment of the world's population. The rheumatic diseases may be classified by type or by several clinical schema of signs and symptoms. | |
| 1081361 | Different lymphocyte populations in rheumatoid arthritis and their relationship to anti-Ig | 1975 Jun | The anti-immunoglobulin activities of rheumatoid arthritis appear to be related not only to plasma cells and their precursors, the B-lymphocytes. Evidence for interaction of IgG with T-lymphocytes and with Fc-bearing lymphocyte-like cells has now appeared. Both these cell types can mediate cytotoxicity which may also induce inflammation in addition to that provoked by rheumatoid factors and immune complexes. Rheumatoid factors and immune complexes may act primarily through the complement system. However, active inflammation in rheumatoid patients can occur without abundant immune complexes, e.g. in B-cell-deficient patients (31). In some cases this may be due to activation of the alternate complement pathway. However, the T-cell system with its series of lymphokines may also play an active part-in the inflammatory process. And both T-lymphocytes and Fc-bearing lymphocyte-like cells, the K-cells, can mediate cytotoxicity. Also in such patients further studies are needed to work out the complex interactions between these cell types and to discover the underlying cause or agent in the chronic destructive rheumatoid inflammation. | |
| 6589104 | Plasma levels and urinary excretion of prostaglandins in patients with rheumatoid arthriti | 1983 Dec | No significant differences were found in plasma concentrations and urinary excretion of prostaglandin E2 (PGE2), 6-keto-prostaglandin-F1 alpha (6-keto-PGF1 alpha) and thromboxane B2 (TxB2), between rheumatoid arthritis patients and controls. However, urinary excretion of PGEe and 6-keto-PGF1 alpha tended to be greater and plasma levels of TxB2 lower in rheumatoid arthritis. Plasma concentrations and urinary excretion showed no marked circadian variation, although night or morning values were slightly lower. Plasma and urine prostaglandins do not correlate with clinical symptomatology in rheumatoid arthritis. | |
| 535280 | Polycentric total knee arthroplasty: a prognostic assessment. | 1979 Nov | Polycentric total knee arthroplasty has been performed at the Mayo Clinic on more than 1,600 knees since July 1970. Two groups of 106 and 101 knee arthroplasties performed between July 1970 and July 1971 and June 1971 and January 1972, respectively, were compared at 5 and 7 years. The technique used exposed the joint to methacrylate particles, yet, despite this, wear did not prove to be a problem. Failures occurred because of infection, loosening of the tibial components, settling of the tibial components, subluxation or dislocation, ligamentous laxity, progression of patellofemoral arthritis, and persistence of pain. We did not encounter patellar problems in our patients with osteoarthritis. In the first group with 106 knees, 45 patients with 58 rheumatoid knees survived 7 years; 79% of knees had good results at 5 years and 72% had good results at 7 years. Twenty-one patients with 28 osteoarthritic knees survived 7 years; 75% of knees had good results at 5 years and 61% had good results at 7 years. In group 2 with 101 knees, 43 patients with 64 rheumatoid knees survived 7 years. The results were good in 83% at 5 years and in 64% at 7 years. Among the 20 patients with osteoarthritic knees who survived 7 years, 92% of knees had good results at 5 years and 62.5% had good results at 7 years. This figure is somewhat misleading because 7 patients were lost to follow up in group 2 after 5 years. There is still a need for a well-tolerated resurfacing procedure by means of a nonconstrained prosthesis. | |
| 6104360 | Perforation of the small bowel with rheumatoid arthritis. | 1980 Jul | Mesenteric occlusion is a rare and usually fatal complication of rheumatoid arthritis (RA). We report a patient with RA who had an acute condition of the abdomen, with clinical evidence of perforated bowel confirmed by histologic study. The successful result in this case is attributed to early surgical intervention. Additional experience in dealing with this complication of RA is provided. | |
| 7082982 | Rheumatoid arthritis, ankylosing spondylitis, and Reiter's syndrome occurring simultaneous | 1982 Jun | Features of rheumatoid arthritis, ankylosing spondylitis and Reiter's disease occurred simultaneously in the same patient. This is a rare finding and appears to be the first published report of such a case. | |
| 675175 | Psychological aspects of rheumatoid arthritis vis-Ã -vis osteoarthrosis. | 1978 | Using objective techniques (M.M.P.I; M.H.P.A.; ANAM; S.T.A.I.), a transverse investigation of two groups of arthritic patients (35 rheumatoid arthritis and 30 oesteoarthrosis) was carried out. The Rheumatoid Arthritis (RA) patients evidence greater depression (p less than 0.02), while the osteoarthrosis (OA) patients had higher levels of manifest aggressivity (p less than 0.01) and more somatic preoccupation (p less than 0.02). The RA group had a higher incidence of loss of a family member as a preceding life event (p less than 0.05), and a greater incidence of psychopathological problems in infancy (p less than 0.05). These findings were used to construct an interpretative hypothetical model which represents a starting point and a stimulus for future research. | |
| 685611 | [Lesions of the central and peripheral nervous systems in rheumatoid arthritis]. | 1978 | Using morhological, neurohistological and histochemical methods the author studied different areas and anatomical structures of the central and peripheral somatic and vegetative nervous system in 4 patients who had died during different periods of rheumatoid arthritis at the age of 27, 48, 51, and 60. The studies demonstrated symptoms of disorganization of the connective tissue in the sheaths and walls of vessels (mainly in the microcirculatory bed), lymphoid histocyte infiltrates, rheumatoid nodules and nonspecific changes of neurocytes and conductors. The paper contains a description of the main form of lesions in rheumatoid, arthritis of the nervous system. |