Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 6532611 | Erythroblastic islands in the bone marrow of rheumatoid arthritis with anaemia. | 1984 Jan | An increase of erythroblastic islands with recognizable central macrophages was observed in bone marrow of six rheumatoid arthritis (RA) patients suffering from anaemia. Since erythroblastic islands are more prominent in anaemic conditions associated with ineffective erythropoiesis, it is possible that this morphological finding might be an expression of the increased ineffective erythropoiesis observed in RA patients with anaemia. | |
| 6836240 | The value of the diagnostic criteria in rheumatoid arthritis. | 1983 | The ARA and the New York diagnostic criteria for rheumatoid arthritis were studied in 411 patients with a recent inflammatory joint disease (100 with RA, 311 with other disease) in order to evaluate their value in distinguishing progressive rheumatoid arthritis from other joint diseases. Rheumatoid factor, symmetrical polyarthritis, morning stiffness, and X-ray changes were of the greatest value in diagnosing RA in the early stage of the disease. Other diagnostic criteria had either a poor specificity or sensitivity, and were thus of less importance as discriminators. | |
| 3872451 | Alpha-1-antitrypsin associated liver disease in rheumatoid arthritis. | 1985 Feb | Two cases of alpha-1-antitrypsin associated liver disease occurring in patients with rheumatoid arthritis are described. Both presented with abnormal liver function tests and the true diagnosis was only apparent after liver biopsy and detailed serological studies. The concurrence of these two conditions is noteworthy because of the postulated role of proteolytic enzymes in producing the characteristic cartilaginous erosions of rheumatoid arthritis. | |
| 4081592 | [Remission of rheumatoid arthritis. Apropos of 32 case reports]. | 1985 Jul | The remission of rheumatoid arthritis is a generally accepted concept, although few studies have been performed in this area. The authors report 32 cases of rheumatoid arthritis in remission in a population of 300 patients (10.7%). These cases of rheumatoid arthritis did not present any distinctive signs in comparison with the other patients. The remission was obtained an average of 6.5 years after the onset of the disease and has lasted, to date, for an average of 2.55 years. 30 of the 32 patients were still in remission at the last consultation. The criteria of remission proposed by the ARA are confirmed by these cases. The authors raise the question of the influence of basic treatment on the incidence of remission. | |
| 6616358 | General surgical principles in rheumatoid arthritis: priorities. | 1983 Sep | The treatment of rheumatoid arthritis depends on a team effort, and the medical team should be led by a rheumatologist. The condition is systemic and the treatment is conservative. Surgery is but an episode in the overall treatment. There should be a therapeutic plan with priorities determined by progression from general to specific considerations. To illustrate general principles the author likens rheumatoid arthritis to a house on fire. Specific problems in treating rheumatoid arthritis are the uncertain prognosis in individual cases and the time taken to establish the progressive nature of the changes or the degree of subjective difficulty that may force surgical measures. Patient motivation is important. This is determined by internal and external forces--personality, social, family and financial factors. The patient's goals and desires must be considered in the light of the possibilities and complications of operation as well as the prognosis when operation is not performed. | |
| 366136 | International symposium on levamisole in rheumatoid arthritis. A review of short and longt | 1978 | Reports of 28 authors with a total of nearly 1,000 enrolled patients have been reviewed regarding changes in clinical manifestations of disease in rheumatoid arthritis during short term and long term administration of levamisole. Global clinical improvement was observed in 60% of patients after three months and in 75% of patients after six months of drug treatment. There was no significant difference in response whether the drug was given in a continuous daily or intermittent weekly fashion. The longest observation times extend to 3 1/2 years. An optimal effect is usually reached between six and 12 months of treatment, after which time no further improvement is observed. After cessation of drug administration, the rate of deterioration varies with the length of previous exposure. | |
| 6678681 | Spontaneous nasal septal perforation in patients with rheumatoid arthritis. | 1983 Mar | Nasal septal perforation is known to be associated with various traumatic and disease states, yet spontaneous nasal septal perforation (SNSP) is relatively rare. SNSP has been reported in three patients with seropositive rheumatoid arthritis (RA) and we report an additional seven patients with SNSP and RA, four of whom were seronegative and none of whom had Raynaud's, in contrast to those reported previously. Manifestations of overt infectious, neoplastic or granulomatous disease have not been found in our seven patients over several years of close follow-up. We have identified no obvious pathogenesis or specific etiology for SNSP. We suggest that SNSP may represent an unusual manifestation of RA previously not well recognized. | |
| 7282107 | Leukocyte locomotion and regulative serum effects in rheumatoid arthritis. | 1981 Mar | Leukocyte locomotion (LL) of 40 patients with rheumatoid arthritis (RA) was found to be unimpaired as compared to LL of 23 control individuals (p Greater Than 0.2). Casein and zymosan activated human sera were used as cytotaxins, and the sera of RA patients proved to be activatable in the same way as control sera in that they produced a similar chemotactic activity (p Greater Than 0.2). However, RA sera inhibited LL significantly (p Less Than 0.01) in comparison to control sera. This phenomenon was unchanged after elimination of immune complexes be ultracentrifugation, but could be reversed, after incubation of cells with RA sera, by reincubation with control sera. | |
| 1153975 | Need, demand, and supply of medical care in a population sample of rheumatoid arthritis. | 1975 | Estimates of medical need in persons with rheumatoid arthritis (RA) are rarely based on data from population surveys. In a population survey of RA in Stockholm City, 293 RA sufferers were identified in four random samples of four age-groups in the adult population, age-range 31-74 years. The influence of age, sex, and severity of disease on the number of pervious hospital admissions was slight, indicating that diagnosis, rather than rehabilitation, is the impetus to hospital admission. Hospital patient inventories might give quite misleading information as to need. Need for hospital admission, out-atient care, reconstructive surgery, ADL-devices, physical therapy, and rehousing were all considered. 17% of the RA group accounted for 48% of the need. Steinbrocker functional classes I and II contributed to 61% of individuals in need of hospital care greatly exceeded those previously having enjoyed such care and possible availabel resources. Estimates of need for outpatient care for joint disease exceeded provided treatment by only 1.7 times. It is concluded that the psychological distance between doctor's decision to choose inpatient or outpatient treatment in the case of RA is generally fairly short. Figures are given for estimates of need based on a population of 100 000 with known age and sex distribution and prevalence of disease. | |
| 978663 | Classical rheumatoid arthritis in a patient with Reiter's syndrome. | 1976 Sep | A 44 year old white male presented with sterile urethritis, anterior uveitis, painless oral ulcers, low back pain, and synovitis of the knees and left ankle. Unilateral sacroiliitis and limited spondylitis further supported a diagnosis of Reiter's syndrome. Serum rheumatoid factor was present. The patient subsequently developed morning stiffness, symmetrical polyarthritis of the hands and wrists, and an olecranon subcutaneous nodule. Histology of the nodule and synovium was consistent with rheumatoid arthritis. Histocompatibility antigen typing established the presence of HLA B27. The occurrence of rheumatoid arthritis and Reiter's syndrome in the same patient is quite rare, and the infrequent co-existence of these two inflammatory rheumatic diseases is discussed. | |
| 7346603 | Clinical and radiological investigations on cervical spine involvement in rheumatoid arthr | 1981 Jul | The radiological and clinical features of cervical spine involvement observed in 49 patients with rheumatoid arthritis are described. The forward atlas-odontoid subluxation, after an x-ray with full flexion of the cervical spine, occurred in 36.9% of the cases. The upward subluxation was found in 8 (17.4%) cases, but only in one (2.2%) case it was of high degree. In one case lateral subluxation could be suspected by the asymmetrical involvement of the atlanto-axial joints. Erosions of the odontoid peg, subluxation at various levels, discitis and osteoporosis with various frequency were observed. A statistically significant relation has been observed between duration of the disease and radiological signs at the level C1-C2; between radiological features and severity of general clinic picture; between cervical lesions at the level C1-C2 and presence of osteolysis affecting hands, wrists, feet. Clinically, signs concerned with cervical spine involvement were found in 83.6%. Besides cervical pain and functional limitation, the headache was the most frequent clinical sign. It was confined to the occipital region in 69.4% of the cases, and was present at awakening or occurred in connection with movements of the cervical spine and head (53.1%). This study confirms the frequent involvement of the cervical spine in rheumatoid arthritis and shows that performing a complete examination of C1-C2 area is useful, in the most serious forms of RA, since the third year of course. | |
| 7209442 | Multiple operations in the rehabilitation of patients with rheumatoid arthritis. | 1980 | There is often a need for multiple orthopaedic operations and other interventions in rheumatoid arthritis. A material of 78 patients with rheumatoid arthritis, all of whom have had one or two total hip replacements (THR) is presented. At the last follow-up examination it was found that these patients had undergone 5.6 orthopaedic operations on the average because of their rheumatoid arthritis. About 60% of the patients wore specially fitted shoes, and about 50% of the patients had received financial help to improve their homes or to find other accommodation more suited to their disability. | |
| 6977762 | [Rheumatoid arthritis with antinuclear factor. A prospective study of 50 cases (author's t | 1982 Feb 13 | The clinical and laboratory features of rheumatoid arthritis (RA) with antinuclear factor (ANF) were prospectively analyzed in 50 patients and compared with those of another series of 50 patients of similar age, sex and duration of disease, but without ANF. The severity of articular lesions was about the same in both series, but systemic symptoms and Gougerot-Sjögren syndrome occurred more frequently in patients with ANF. Gold compounds and D-penicillamine appeared to be well tolerated by all patients. RA patients with ANF had more strongly positive responses to latex and Waaler-Rose tests. Farr's radioimmunoassay was sometimes positive (11/49), but as a rule, the degree of positivity was inferior to 50%. | |
| 6278369 | [Latent neuropathy in rheumatoid arthritis. Electrophysiological study of 45 cases]. | 1982 Mar 3 | Thirty (88.2%) of thirty four patients with rheumatoid arthritis showed evidence of latent neuropathy, as judged by the following tests: measurements of motor and sensory conduction velocity; analysis of single motor units at various sites and under different conditions. All patients demonstrating electrophysiological signs of involvement of nervous functions showed no clinical signs of peripheral neuropathy. On the basis of the present results it is proposed that neurophysiological alterations could depend on a widespread (immunologically mediated?) injury of the axonic membrane. | |
| 4059908 | Spontaneous fractured neck of femur in rheumatoid arthritis: absence of radiographic chang | 1985 Jul | Spontaneous fractures have been documented in patients with osteoporosis and have been described in patients with rheumatoid arthritis. Two patients with rheumatoid arthritis who sustained femoral neck fractures in the absence of trauma are documented. Despite severe pain initial radiograph failed to demonstrate evidence of fracture, but subsequent radiographs later showed fractures in both cases. It is important in rheumatoid patients with continuing severe hip pain of sudden onset to suspect a stress fracture even if initial radiographs are normal. | |
| 7354471 | Serum histidine in rheumatoid arthritis: changes induced by antirheumatic drug therapy. | 1980 Jan | Serum free histidine levels were studied in 15 patients with rheumatoid arthritis treated with D-penicillamine and 15 patients treated with hydroxychloroquine for 6 months. Both drugs produced improvement in the majority of patients, measured in terms of changes in 5 clinical parameters and plasma viscosity. A significant increase in serum histidine was observed only with D-penicillamine. This action, not seen with other specific antirheumatoid drugs may reflect a specific action of the drug. | |
| 216089 | [Is rheumatoid arthritis connected with a digestive tract parasitosis? (author's transl)]. | 1978 Oct 8 | The comparison of blood eosinophil counts and stool parasites in two groups of patients--twenty one suffering from rheumatoid arthritis and twenty one from other various diseases--did not show any significant difference in favour of a parasitological etiology in rheumatoid arthritis, an hypothesis which had to be considered because of the efficacy of levamisole in the treatment of this disease. | |
| 6407307 | Therapeutic trial of cryofiltration in patients with rheumatoid arthritis. | 1983 Jun | Cryofiltration, a new technique for on-line plasma separation and its treatment by cold filtration, enables the selective removal of immune complexes and eliminates the need for replacement proteins. Fifteen patients with rheumatoid arthritis were treated for nine to 10 consecutive sessions over a three- to five-week period. Circulating immune complexes decreased by an average of 78 percent and rheumatoid factor by 32 percent. This was accompanied by significant clinical improvement in morning stiffness, articular index, 50-foot walking time, grip strength, and target joint circumference. Cryofiltration might thus be beneficial for a subgroup of rheumatoid arthritis patients in whom conventional therapy has failed. | |
| 7201815 | The use of thermography in the evaluation of the anti-inflammatory activity of feprazone o | 1982 | By means of the exploration of patients suffering from an active, unequivocal rheumatoid arthritis it was possible to show the unequivocal, and antiinflammatory effect of 4-phenyl-1,2-diphenyl-3,5-pyrazolidinedione (feprazone, Zepelin). Moreover, it was documented that thermography is a very suitable medium to furnish proof of this effect and can be used to the advantage of the patients in clinical routine. The physiological processes of the production and distribution of heat must be taken into account to avoid false interpretation of thermograms. | |
| 441303 | [Soft tissue changes of fingers in rheumatoid arthritis. Results of low k.v. radiographs i | 1979 Apr | Based upon a large series of low k.v. radiographs of fingers in three views, the X-ray anatomy of the soft tissue of fingers is presented and soft tissue changes in joints, tendons and tendon sheaths due to rheumatoid arthritis as well as perifocal effects of the inflammatory process upon the subcutaneous tissue and the skin are described. Because of the resolution of even minute soft tissue changes it is possible to recognize the incipient stage of rheumatoid arthritis and of relapses devoid of clinical symptoms. |