Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 6433938 | Decreased pokeweed mitogen-induced IgM and IgM rheumatoid factor synthesis in rheumatoid a | 1984 Sep | Prospective and retrospective analysis of data obtained on 119 patients with rheumatoid arthritis suggested a relationship between clinical response induced by gold salts or D-penicillamine and decreased in vitro antibody synthesis by peripheral blood mononuclear cells. A subgroup of 21 patients with inactive disease receiving these drugs was found to have decreased pokeweed mitogen-induced in vitro synthesis of IgM and IgM rheumatoid factor. Detailed analysis of the cellular mechanisms responsible for this decreased responsiveness demonstrated markedly decreased B cell function. Patients treated with D-penicillamine also had altered T cell helper function manifested by incomplete reconstitution of the normal IgM response, while patients treated with gold salts had normal T cell function. Monocytes appeared not to have a major role in the decreased in vitro responsiveness. The results suggest that, in patients who respond to gold salts or D-penicillamine, antibody synthesis by circulating B cells is profoundly decreased, probably due to an indirect effect of these disease-modifying agents. | |
| 6150854 | Are leg ulcers in rheumatoid arthritis due to vasculitis? | 1983 | Five patients with severe rheumatoid arthritis are reported in whom leg ulcers were not apparently associated with vasculitis. The conventional explanation for these ulcers deserves review. Patients with rheumatoid arthritis may develop 'gravitational' leg ulceration and pressure sores on their legs. In addition, they may develop ulcers on the lower aspects of the legs and around the ankles which are well demarcated, punched out, painful and slow to heal. These ulcers usually occur in patients with longstanding, severe, seropositive disease. They are presently considered to be due to a necrotising arteritis causing dermal infarction, since they are frequently associated with other clinical features of rheumatoid vasculitis. Wilkinson has commented that 'biopsies are seldom taken from leg ulcers'. In this paper we report five patients with severe rheumatoid arthritis who developed such leg ulcers in the absence of other clinical evidence of vasculitis and in whom biopsies of the ulcers failed to reveal vasculitis. A case is summarised as illustrative of the five patients, whose relevant histories, clinical findings, and laboratory investigations are summarised in Table 1. | |
| 6743967 | The correlation of clinical assessment of synovial fluid with its measured viscosity. | 1984 Aug | The viscosity of 10 specimens of rheumatoid synovial fluid was assessed using side-room tests as well as being measured in a viscometer. All of the tests, and particularly the 'mucin clot', correlated well with measured viscosity. We conclude that the mucin clot test does indeed reflect viscosity and can demonstrate the presence of inflammatory joint disease. | |
| 300499 | Inhibition of spontaneous and antibody-dependent cellular cytotoxicity by sera and isolate | 1977 | Using sera from patients with rheumatoid arthritis and antiglobulin preparations obtained from such sera, inhibition of human lymphocyte cytotoxicity in antibody-dependent (ADCC) and spontaneous cell-mediated cytotoxicity (SCMC) reactions against an allogeneic melanoma cell line (IGR3) has been demonstrated. Fractionation of effector cell preparations indicated that Fc-receptor-bearing lymphocytes were operative in both reactions. Removal of phagocytic and adherent cells from the effector cell population resulted in more pronounced inhibition of SCMC and ADCC reactions by rheumatoid sera. The results indicate that antiglobulin preparations from human sera containing rheumatoid factor activity can effectively block the cytotoxic activity of Fc-receptor-bearing effector lymphocytes (K cells) in vitro. On analogy with the inhibition of ADCC and SCMC reactions by immune complexes and aggregated IgG, antiglobulin complexes present in the antiglobulin preparations are responsible for this effect. | |
| 4085151 | Lymphoid irradiation in intractable rheumatoid arthritis: effects on the production of imm | 1985 Dec | Changes in the production of immunoglobulins and rheumatoid factors (RF's) were studied in 20 patients with intractable rheumatoid arthritis (RA) following total doses of 750 rad or 2,000 rad lymphoid irradiation. Over a 12 month follow up period there was no consistent change in absolute serum or synovial fluid levels, or in synovial membrane production of either total IgG, IgA or IgM, or the corresponding RF fractions. The invitro production of immunoglobulins and IgM RF by peripheral blood mononuclear cells was also unaltered, except for one patient who had a dramatic rise in IgM RF production. Over the same period there was a significant overall reduction in disease activity following both doses of radiotherapy. It is concluded that the clinical response which occurs following lymphoid irradiation is not due to a reduction in RF production. Furthermore, the production of RF's appears to be unaffected by the changes in T cell immunity which occur following lymphoid irradiation. | |
| 6223644 | Social and economic impacts of four musculoskeletal conditions. A study using national com | 1983 Jul | The present study uses data from a national, community-based survey to compare the social impact of and medical care use due to 4 musculoskeletal conditions: rheumatoid arthritis, osteoarthritis, lower back pain, and tendinitis. The study also compares the impacts experienced by persons with these conditions with those experienced by a sample of persons having a broader range of musculoskeletal conditions, and by an age-adjusted sample representing the entire U.S. population. Rheumatoid arthritis leads to the most frequent use of physician services; lower back pain results in the most hospitalizations and surgery. Rheumatoid arthritis also causes the most restriction in activity. We found that as a broad group, persons with musculoskeletal disease experience about the same amount of restriction in activity and use about the same amount of medical care as U.S. citizens as a whole. This study demonstrates that health planning on the basis of specific musculoskeletal conditions is necessary to serve the disparate needs of persons with particular, discrete conditions. | |
| 3876589 | [Regulation of natural killer activity by adherent cells in synovial rheumatoid medium]. | 1985 Jun | The activity of natural killer cells in the synovial fluid, the synovial tissue and the peripheral blood was studied in 23 patients with active rheumatoid arthritis and was found to be significantly lower than that in the blood of 28 controls. This decrease was inversely related to the erythrocyte sedimentation rate. The preincubation of mononuclear cells with indomethacin significantly increased the natural killer activity in the blood of the controls and the patients with rheumatoid arthritis, but did not have any effect in the synovial compartment. The elimination of the adherent cells increased the natural killer activity in the blood of the controls and the patients with rheumatoid arthritis, but decreased this activity in the synovium. The stimulatory effect of synovial macrophages and the suppressor effect of the blood macrophages on the natural killer activity were confirmed when the adherent and non-adherent populations were mixed and these effects were reproduced by using supernatants of total mononuclear cells. The stimulation of the natural killer activity by interleukin 2 and poly-I:C, an interferon inducer, is independent of the macrophages in rheumatoid arthritis. These results suggest a deficient natural killer activity in active rheumatoid arthritis and a difference in the modulation of these natural killer cells by macrophages in rheumatoid synovium and normal or rheumatoid arthritis blood. | |
| 300600 | [Antinuclear antibodies and PHA response in rheumatoid arthritis]. | 1977 Jan | We have studied the in vitro PHA response of two groups of rheumatoid arthritis patients differing only in the presence or absence of antinuclear antibodies. The response was depressed in positive patients and normal in negative patients. Differences in peripheral blood mononuclear cell sub-populations or lymphocytotoxic antibodies do not seem to explain this observation. Simple antinuclear antibody screening could serve as a simple method to identify a sub-group of immunodepressed rheumatoid patients as potential candidates for immunostimulating therapy. | |
| 131876 | Use of Freund's adjuvant arthritis test in anti-flammatory drug screening in the rat: valu | 1976 Apr | The Freund's adjuvant technic, using killed Mycobacterium butyricum suspended in mineral oil, is a refined tool for anti-inflammatory drug evaluation. Its use has long been reserved for testing and not for screening due to technical problems in the preparation of valid animal models. After reviewing the methodology, the authors demonstrated that the availability of arthritic rats from a modern breeding center (Charles River France, SA, Elbeuf, France) make the procedure applicable to drug screening. This has both practical and economic advantages. The animals can be used as test organisms for drug evaluation 14 da after treatment. Three criteria for measuring the effectiveness of anti-arthritic drugs have been established: an arithritic index determined by examination of the 4 paws; changes in the erythrocyte sedimentation rate; and changes in levels of plasma fibrinogen. The curative activity of test substances can be evaluated by a single series of measurements of these 3 criteria after 14 da of treatment. This test was compared with 2 others; edema of the paw induced by the subcutaneous injection of kaolin or carrageenan, and was found to be superior. | |
| 6088823 | Cefotaxime-associated diarrhea and Clostridium difficile. | 1984 Apr | A patient with rheumatoid arthritis-associated interstitial pneumonitis, treated with prednisolone, developed mild colitis due to Clostridium difficile in association with the use of cefotaxime (CTX). Diarrhea was successfully treated with the discontinuation of CTX and initiation of oral vancomycin. | |
| 6636111 | Genetics of HLA-associated disease; rheumatoid arthritis. | 1983 Sep | An association between rheumatoid arthritis (RA) and the HLA antigen DR4 supports the view that genes in the HLA region are important in susceptibility to this disease. To further define the basis for genetic susceptibility to RA, we analyzed HLA haplotype sharing among affected and unaffected individuals in 29 multiple-case families with definite or classic RA. We have observed a non-random distribution of HLA haplotypes to unaffected as compared with affected offspring in sibships containing two or more affected individuals having 3 of 4 parental haplotypes. These data support the view that susceptibility to RA is determined, at least in part, by genes in the HLA region of chromosome 6. | |
| 7149802 | Septic arthritis due to Bacteroides fragilis in a wrist affected by rheumatoid arthritis. | 1982 Dec | The first case of septic arthritis due to Bacteroides fragilis in a wrist joint is described together with its successful treatment. | |
| 1136736 | The normal and pathological mobility of the metacarpo-phalangeal joint. | 1975 Apr | The pathological mobility of the metacarpo-phalangeal joints of 100 patients affected by rheumatoid arthritis was studied, and the results were analysed and compared with the results obtained in a control non-rheumatoid group. This report seems to suggest that rheumatoid metacarpo-phalangeal joints become more lax the longer the rheumatoid disease has been present. However, when there is marked local involvement of the joint this hyperlaxity cannot be proven because of pain and/or mechanical blockage. | |
| 7310773 | Annual fluctuations in rheumatoid arthritis. | 1981 Sep | A literature survey revealed many reports implicating the microclimate and seasonal changes in arthritic diseases. Therefore, a retrospective study of the erythrocyte sedimentation rate (ESR) and the C-reactive protein (CRP) concentration of 2,802 rheumatoid arthritis (RA) was performed. No statistically significant fluctuation was found when analyzed according to the month of the year in which blood was taken. The significance of this is discussed in relation to other RA symptoms, meteorologic phenomena, microclimate, and the joint circulatory responses in RA. The observations reported are consistent with the concept that seasons and microclimate may affect some of the symptoms of RA, but not the inflammatory processes represented by the ESR and CRP. | |
| 6750282 | Effectiveness of tolmetin in rheumatoid arthritis: evaluation by means of a new method. | 1982 | Twelve patients with rheumatoid arthritis were treated in a random double-blind crossover study with Tolmetin (1,200 mg/day) and Paracetamol (2,000 mg/day). Each drug was administered for 4 days. A three-days wash-out period was fixed between the administrations of the first drug and that of the second one. The efficacy of the treatments was investigated by self-evaluation of the grip strength expressed as mmHg.h during the day. Tolmetin proved significantly more effective than Paracetamol and induced a significant increase of grip strength, as compared to the baseline values, from the first day of administration. The self-evaluation of the grip strength proved a simple and useful method to evaluate, within an extremely short time and on few groups of patients, the effectiveness of non-steroidal anti-inflammatory drugs in rheumatoid arthritis. | |
| 109906 | Is there a place for chemical and radiation synovectomy in rheumatic diseases? | 1979 May | Synoviorthesis has the same indications as surgical synovectomy. But it is easy to perform, can be repeated and does not leave any scars. It should be tied first. The choice of the product to be injected depends on the joint, the number of injections and the age of the patient. In all cases a long-acting local steroid should be tried first. In combination, osmic acid seems to potentiate the effect of the steroid. If osmium tetroxide damages the cartilage, it has been demonstrated that the damage is limited and superficial and as far as we know without clinical consequence. The fear of side-effects has limited the use of synoviortheses in the United States. Sledge et al. (1977), in animals, have used a new rare earth isotope, dysprosium-165, a beta-emitter with a maximum tissue penetrance of 5.7 mm and the advantage of a very short half-life of 140 minutes. In so far as systemic therapy is only partly successful there is still a place for chemical and radiation synovectomy in rheumatic diseases. | |
| 1266422 | [Ceruloplasmin and immunoglobulins under controlled D-penicillamine therapy in rheumatoid | 1976 Mar | In a controlled therapeutic trial 17 patients with active rheumatoid arthritis (stage II and III) were divided in two randomized groups. One group of 9 patients was treated with 900 mg of D(-)penicillamine (Trolovol) plus 1500 mg of salicylate per day, the other group of 8 patients with 10 mg of prednisolone plus 1500 mg of salicylate daily. Before and after 1, 2, 3, 4 and 6 months of treatment IgA, IgG, IgM and caeruloplasmin were estimated with immunodiffusion technique. In both groups the IgA and IgG levels remained unchanged; unter D-penicillamine, on the contrary, a statistically significant and continuous fall of IgM and caeruloplasmin was observed; prednisolone treatment induced only a temporary fall of caeruloplasmin. In the DPA treated patients, a significant correlation of IgM with caeruloplasmin and of caeruloplasmin with ESR was found. In both groups there was no correlation between joint count and caeruloplasmin, joint count and IgM, caeruloplasmin and copper, copper and ESR; in the prednisolone group no correlation between caeruloplasmin, ESR and IgM was observed. The correlations suggest that the remarkable fall of IgM and caeruloplasmin under D(-)penicillamine treatment is caused at least partially by direct interference of DPA with these plasma proteins. | |
| 7020613 | Synovial histopathology of behçet's syndrome. | 1981 Aug | Synovial tissue obtained from 7 patients with Behçet's syndrome and 7 patients with early rheumatoid arthritis could not be distinguished under ordinary light microscopy when examined blind. A wide spectrum of features was seen in both diseases, and it is suggested that these may reflect severity and duration as much as the nature of the arthritis. Electron microscopy also failed to illustrate any distinct features of Behçet's syndrome, but immunofluorescent studies indicated consistent deposition of IgG. | |
| 6270332 | Coexistence of rheumatoid arthritis in married couples: a search for etiological factors. | 1981 May | Epstein-Barr virus (EBV) and the genetic marker HLA-DR4 both appear to play a role in the etiology of rheumatoid arthritis (RA). Antibodies to viral capsid antigen and the early antigen complex of the EB virus as well as the HLA phenotype were studied in 6 families. Both spouses had classical or definite RA but none of their offspring, all adult, had any evidence of RA. At least 1 spouse of each couple had DR4 and this phenotype was found in 4 of the 8 offspring. All parents and their offspring had been infected with EBV. This study supports the association of DR4 and RA. The presence of DR4 in 4 normal adult offspring was not associated with the absence of primary infection or enhanced levels of EBV-specific antibodies. | |
| 3830522 | Palmar erythema in rheumatoid arthritis. | 1985 Dec | Palmar erythema ("liver palms") was seen in 32/100 consecutive patients with classical rheumatoid arthritis and in 10/100 patients with various other internal diseases (p less than 0.001). Age of the patients, sex, duration of disease, titer of rheumatoid factor, stage of disease, erythrocyte sedimentation rate and frequency of volar tenosynovitis of the hands did not differ between patients with and those without palmar erythema. Ulnar deviation of the fingers was less common and the hemoglobin content of the blood was higher in patients with palmar erythema. |