Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 1222225 | Study of cellular immunity in rheumatoid arthritis: inhibition of leucocyte migration by a | 1975 Apr 10 | The antigenicity of aqueous extracts of osteoarthritic and rheumatoid synoviale was studied in patients with rheumatoid arthritis, other diseases and in normal controls by the mean of leucocyte migration test, lymphoblastic transformation test and cutaneous reactions. In 59% cases of rheumatoid arthritis an inhibition of the migration of leucocytes was found but there was no relation between this test and the clinical state, the evolution, rheumatoid serology and other laboratory parameters. In some cases of rheumatoid arthritis an inhibition of the migration of leucocytes was observed also with a pericardial and hepatic extract. In normal controls the leucocyte migration test is always negative, but it is positive in 37% of cases of various inflammatory and neoplastic diseases and the difference is not significant considering the percentage of positivity of the test in rheumatoid arthritis. The lymphoblastic transformation test and the cutaneous reactions were always negative in rheumatoid arthritis and in controls. Thus, the leucocyte migration test using a synovial extract as an antigen does not bring evidence in favour of an auto-immune conflict in rheumatoid arthritis. | |
| 139097 | [The clinical and prognostic importance of IgM rheumatoid factors]. | 1976 | On a total of 1000 subjects diagnosed as having rheumatoid arthritis it was possible to positively correlate the proportion of seropositivity of IgM rheumatoid factors and/or higher titer values to the following clinical characteristics: Male sex; existence, severity, and symmetry of articular alterations determined by morphological x-ray examinations; unfavorable functional values; high inflammatory activity; involvement of various organs; and high rate of progress. So far as this particular clinical picture is concerned, the detection of rheumatoid factors must, therefore, be considered unfavorable to a prediction or conclusion regarding the course of disease, whereas seronegative forms may be regarded as relatively benign. | |
| 6353582 | Effects of nonsteroidal antiinflammatory drugs on the immune network. | 1983 Aug | The immune system is extremely complex. It comprises many different types of cells and their products. In patients with rheumatic diseases the immune system is activated and has disturbed regulation. It is also believed that immune reactions are involved in the pathogenesis of these disorders. Nonsteroidal antiinflammatory drugs (NSAID) have therapeutic effects on rheumatic diseases. These effects can all be explained by inhibition of prostaglandin production locally in the diseased joints, leading to reduced inflammation. Little or no effects on the number of circulating lymphocyte subpopulations or on peripheral blood mononuclear cell immune reactions can be seen after treatment of patients with rheumatoid arthritis (RA) with NSAID. The possibility, however, exists that immune reactions locally in the diseased joints are modulated by NSAID secondary to reduced prostaglandin production. | |
| 6205556 | Clinical and histological evaluation of synovial needle-biopsies in patients suffering fro | 1984 | In 50 patients suffering for 1-15 years from rheumatoid arthritis, needle-biopsy of the synovial membrane was carried out. The finding correlated with the general clinical activity of the disease. Each type of histological change was evaluated with regard to its diagnostic value in assessing clinical activity. Among the histological changes, oedema, synovial cell proliferation, lymphocyte-plasma cell proliferation and necrotic vasculitis showed a negative correlation with clinical activity, while a positive correlation was observed between clinical activity and the presence of fibrin (fresh and old), fibrinoid, fibrinoid basophilia, fibroblast proliferation, synovial cell desquamation, concentric perivascular sclerosis, fibrosis and hyalinosis. Vascular changes of the synovial membrane such as oedema, fresh fibrin exudate, necrotic vasculitis showed a negative correlation with clinical activity while hyalinization and concentric sclerosis and clinical activity were found to be in positive correlation. It is concluded that in the course of rheumatoid arthritis the histological changes do not necessarily run parallel with the clinical activity of the disease. | |
| 1084574 | Extracorporeal irradiation of thoracic duct lymph as immunosuppressive treatment in rheuma | 1976 | Thoracic duct drainage and re-infusion of the irradiated lymph was carried out as immunosuppressive treatment in 2 patients with progressive, therapy-resistant rheumatoid arthritis. In both patients, a marked clinical improvement was achieved even during the first days of treatment. A reduced number of T cells in the blood was seen 3 days after onset of drainage, whereas no significant change in the number of B cells was observed. No recirculation of the infused cells could be detected, nor was the radiation removal of T cells accompanied by rapid proliferation of "new" T cells. As clinical improvement and reduction in T cells occurred simultaneously, there is probably a connection between these two events. The beneficial clinical response and the achievement of T cell suppression by thoracic duct drainage--the result of irradiation and re-infusion of irradiated lymph--encourage further clinical trials with this type of treatment in severe therapy-resistant rheumatoid arthritis. | |
| 4573763 | Cellular-versus-humoral autoimmune responses to salivary gland in Sjögren's syndrome. | 1973 Mar | In Sjögren's syndrome (SS), the earliest glandular infiltration by lymphoid cells surrounds the salivary ducts, which are also the target of the organ-specific antisalivary duct (ASD) autoantibody found in some patients with this disorder. A sensitizing antigen localized in ductal epithelial cells may elicit both humoral and cellular immune responses. In a study using coded specimens from twenty-five patients with SS and eight with rheumatoid arthritis, sera were tested for ASD, and lip biopsies were graded for the degree of lymphoid infiltration and destruction of labial salivary glands. Significantly less cellular infiltration was found in SS patients who had ASD compared to those who lacked this antibody. In SS, the group of ASD-negative patients had greater gland destruction and more severe xerostomia. The possible role of ASD as a blocking antibody is suggested. | |
| 6673983 | Steroid-sparing action of flurbiprofen and indomethacin in rheumatoid arthritis: a nine-we | 1983 | Thirty out-patients with rheumatoid arthritis aged from 3 yrs. (+/- 0.5 SEM) were included in a between-patient controlled trial comparing effectiveness and safety of flurbiprofen 300 mg daily and indomethacin 150 mg daily. The duration of the treatment was nine weeks. Both drugs allowed to reduce the initial dose of corticosteroids administered (-21% on flurbiprofen and -12% on indomethacin) and were effective in improving clinical signs of the disease such as number of swollen joints, grip strength, articular index and morning stiffness. Flurbiprofen was better tolerated (p less than 0.01). | |
| 6802081 | Side-effects of azathioprine treatment in rheumatoid arthritis: analysis of 10 years of ex | 1982 | Our experience with azathioprine in the treatment of rheumatoid arthritis covers ten years, during which 91 rheumatoid patients (66 female and 25 male) received this drug, with a median treatment period of 36 months. Total follow-up experience, during and after treatment, was 399 person years. Twelve patients died. The principal causes of death were malignant neoplasm (six patients) and cardiovascular diseases (three patients). The mortality in our patients was compared to that of the general Dutch population by the Standardised Mortality Ratio (SMR). In the male patient group a significant excess of both total mortality and mortality from malignancy was observed. The female patients showed no differences from the general population. In this follow-up study, no lymphoreticular tumours occurred during or after azathioprine therapy. | |
| 368086 | Comparative efficacy of pirprofen and aspirin in rheumatoid arthritis. | 1979 Jan | A six-month double-blind, randomized, parallel-design trial comparing pirprofen, a new nonsteroidal antiinflammatory drug, with aspirin in patients with rheumatoid arthritis is described. The dose of pirprofen, a phenylpropionic acid derivative, was 600 mg per day; the dose of aspirin was 3600 mg per day. Pirprofen was found to be as effective as aspirin in improving the modified articular index, swelling joint index, grip strength, walking time, and duration of morning stiffness. Fewer patients receiving pirprofen reported drug-related side effects than those receiving aspirin, however, the difference was not statistically significant (P less than 0.1). There was no significant difference between groups in the incidence of positive stool guaiac tests (three of 17, pirprofen; five of 18, aspirin). Pirprofen was found to be as safe and effective as aspirin in the management of patients with rheumatoid arthritis. | |
| 49178 | Significance of plasma copper and caeruloplasmin concentrations in rheumatoid arthritis. | 1975 Apr | To understand the role of copper in initiating protein alterations in rheumatoid arthritis (RA) as reported previously, concentrations of copper anc caeruloplasmin were determined in RA patients. The mean copper concentration of the RA population examined was 24.8 mumol/l (157.5 mug/100 ml), and the mean caeruloplasmin concentration in this RA population was 45.52 mg/100 ml. These values are not different from those reported by previous workers. However, when the RA population was divided into three groups according to sex and oestrogen therapy it was found that caeruloplasmin and copper concentrations in the group of female RA patients on oestrogens was significantly different from other groups (P less than 0.001). A highly significant (P less than 0.01) positive correlation was obtained between copper and caeruloplasmin concentrations (r = 0.91). Concentrations of copper and caeruloplasmin failed to explain the low sulphydryl content of plasma which was observed to be independent of these two parameters. Increased alpha2-globulin concentration, which was refractory to chrysotherapy but 'finger-printed' with a pure preparation of caeruloplasmin in electrophoresis, along with the absence of Kayser-Fleischer rings, supports the contention that copper is not present in a free ionic state in RA patients. This study shows that only a concurrent oestrogen therapy raises copper and caeruloplasmin concentration significantly in a female RA population. Past investigators appear to have overlooked this fact, and it could be that a disproportionate sex distribution (more female rheumatoid arthritics) could cause misleading results in RA studies. The role of oestrogens, copper, and caeruloplasmin in causing exacerbation of RA symptoms is discussed. | |
| 72464 | [Kidney complications in chronic polyarthritis]. | 1977 Jul | 50 patients with definite rheumatoid arthritis treated with D-penicillamine were studied every 4 weeks by disk electrophoresis of the urine to make an early record of the glomerular proteinuria of the immune complex nephritis, which has been described as a side effect of this treatment. In 30 of these patients we found, however, a tubular proteinuria which correlated well with the disease activity and which disappeared after successful basic treatment. This finding indicates interstitual renal involvement due to the basic disease. | |
| 307810 | The effect of transcutaneous electrical nerve stimulation (TNS) on joint pain in patients | 1978 | The effect of transcutaneous nerve stimulation (TNS) on joint pain was studied in patients with rheumatoid arthritis. Three different forms of TNS were used in an attempt to evaluate the influence of placebo effects. The results were evaluated by means of loading tests and from the patients' own assessments of pain relief. High intensity TNS near the painful joint gave pain relief of varying degree in 95% of the patients, while TNS of low intensity and TNS applied at a remote site gave an improvement in 75% and 5% respectively. It seems quite clear that TNS is effective in reducing joint pain. There are a number of factors which intimate that this improvement is not merely a placebo effect. | |
| 849359 | Correlation between levels of breakdown products of C3, C4, and properdin factor B in syno | 1977 Mar | Synovial fluids from 31 patients with seropositive rheumatoid arthritis (RA) and 23 patients with seronegative RA had significantly increased levels of breakdown products to C3, C4, and properdin factor B when compared to patients with osteoarthritis (OA) (P less than 0.01). The same patients exhibited a considerable overlap of native C3, C4, and properdin factor B levels when their results were compared with those of OA patients. The parallel increase of C3d, C4d, and Ba levels in patients with RA suggests an activation of the complement system rather than a nonspecific enzymatic breakdown in synovial fluids. | |
| 869955 | Brown's syndrome. An unusual manifestation of rheumatoid arthritis. | 1977 Jun | Two patients presented with an ocular complication of rheumatoid arthritis that was extraocular in location. Clinical manifestations include vertical diplopia, an intermittent nature, a clicking sensation, and apparent inferior oblique palsy. A stenosing tenovaginitis of the superior oblique tendon and its sheath is the probable underlying pathologic mechanism. | |
| 1239211 | Rheumatoid arthritis of the cricoarytenoid joints: an airway hazard. | 1975 Nov | The anesthesiologist must maintain a high index of suspicion for the presence of cricoarytenoid arthritis and vocal-cord fixation in the rheumatoid arthritic. He must be prepared to intubate the trachea blindly, attempting to minimize trauma by using a smaller endotracheal tube. Indirect laryngoscopy, or direct laryngoscopy using a fiberoptic laryngoscope, may be indicated as part of the preanesthetic evaluation. In some instances, preanesthetic tracheostomy or an alternative regional anesthetic technic may be appropriate. Unusually close vigilance in the postoperative period may be required to detect signs of postextubation airway obstruction. | |
| 1229740 | [Enzyme studies on the pathogenesis of experimental mycoplasma arthritis]. | 1975 May | Biochemical studies of rats with mycoplasma arthritis revealed new findings in pathogenesis and pathophysiology. Preliminary examinations showed that mycoplasmas release specific endonucleases and exonucleases. In evaluating the isoenzymes of the lactate dehydrogenases, malate dehydrogenases as well as of the esterases, which provide certain parallels with human rheumatoid arthritis we made several new observations. Thus a mycoplasma infection which resembles rheumatoid arthritis, leads to an inhibition of the DNA repair. We were able to proof this enzymekinetically and autoradiographically. We also observed for the first time the occurrence of DNA antibodies in this type of arthritis. It is possible that there is a relation between inhibition of DNA repair and the occurrence of DNA antibodies. Thus mycoplasma infection seems to influence DNA metabolism. There are interesting parallels concerning DNA antibodies and DNA-repair between experimental micoplasma arthritis and human systemic lupus erythematosus and rheumatoid arthritis. | |
| 157793 | Inhibition of reticuloendothelial function by gold and its relation to postinjection react | 1979 Jul 28 | A patient with rheumatoid arthritis developed severe exacerbation of symptoms 18 hours after an injection of gold thiomalate (sodium aurothiomalate). Immune complexes were present in his serum and synovial fluid; in the synovial fluid they were associated with intense complement activation. The effect of gold salts on splenic reticuloendothelial function was determined by measuring the clearance of heat-damaged erythrocytes from the circulation. Gold thiomalate (50 mg) substantially delayed clearance in the patient but had no effect in four other patients with rheumatoid arthritis who had not had a postinjection reaction. Severely impaired clearance also occurred in three out of four healthy people given 100 mg gold but they remained asymptomatic. The postinjection reaction may be an immune-complex disease that is triggered in certain patients because gold transiently inhibits reticuloendothelial function. | |
| 472665 | Demonstration of anti-rubella antibody-secreting cells in rheumatoid arthritis patients. | 1979 | In the present study we describe a plaque-forming cell assay using erythrocytes coated with viral antigen, which detected anti-viral antibody-secreting cells against various viral antigens. These anti-viral antibody-secreting cell were studied in normal individuals with known viral infections and in rheumatoid arthritis patients. Rubella anti-viral antibody-secreting cells were present after induction in the peripheral blood of eight out of ten patients. No plaques were seen before induction. Synovial tissue of seven patients out of ten showed rubella-antigen-specific plaques before induction. In all three patients tested, the numbers of plaques increased after induction. The peripheral blood of only one patient showed plaque-forming cells against mumps virus and cytomegalovirus (CMV) antigen. No other patients showed any plaque against CMV, respiratory syncytial virus, mumps virus, measles virus, adenovirus, and varicella zoster virus antigens. The method appears to be promising in studying viral antibody-secreting cells in human immunopathology. | |
| 725461 | [Evolution of patients with rheumatoid arthritis treated with immunosuppressive agents bet | 1978 Jul | The authors report the results of a study of 139 of their patients with severe rheumatoid arthritis, treated with chlorambucil of cyclophosphamide between 1965 and December 1973, with an observation period of 4 to 12 years. 8 patients were lost to follow-up, 38 died and 93 were reexamined. In this series 7 deaths were attributed to hemolymphoreticulopathy of various cytological types; 6 deaths were due to visceral cancer and 2 others to cancer of the tonsils. They confirm that such treatments increase the risk of hemopathy but apparently not the risk of visceral cancer. The risk was not a function of the total dose of the drug administered since no neoplasia was observed in the 25 subjects who received the highest doses. The addition of chlorambucil to cyclophosphamide seems to increase the risk of hemopathy. It was noticed that the 7 cases of hemolymphoreticulopathy occured after 60 years. | |
| 77275 | Changes in proteoglycan and collagen in cartilage in rheumatoid arthritis. | 1978 Apr | Articular cartilage from thirteen patients with rheumatoid arthritis was studied by both light and electron microscopy using recently developed staining techniques for proteoglycan. Normally proteoglycan is concentrated about active chondrocytes, but in the cartilage from these patients it was found to be diminished about most of the chondrocytes while it was increased around a few. Fragmentation of collagen and phagocytosis of the fragments by chondrocytes were also noted. This dissolution of collagen was associated with loss of proteoglycan in the matrix. These findings are consistent with the variable nature of the rheumatoid destructive process and appear to be morphological reflections of biochemical changes which formerly were thought to occur in this disease only at the cartilage-pannus junction. |