Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 939437 | Extensor indicis proprius transfer to supplement replacement arthroplasty of the rheumatoi | 1976 Jun | A new procedure is described to cope with the rotation deformity so often seen after replacement arthroplasty of the destroyed metacarpophalangeal joints in rheumatoid arthritis. The same procedure, in combination with a similar transfer to the ring and little fingers, but using extensor digiti minimi as the motor, can be used as a suspension procedure to stabilise the early unstable metacarpophalangeal joint. Thirty hands have been treated with the longest follow-up of two-and-a-half years; so far the results have been encouraging. | |
| 3885372 | Antibodies to rheumatoid arthritis nuclear antigen (RANA) in Japanese patients with rheuma | 1985 | We studied antibodies to rheumatoid arthritis nuclear antigen (RANA) by the Ouchterlony method in 0.5% agarose plates, using soluble antigen extracted with 0.25 M sucrose solution from cultured Raji cells. Anti-RANA antibody was found in sera from 24 to 40 (60%) patients with rheumatoid arthritis (RA), from 4 of 20 (20%) patients with systemic lupus erythematosus (SLE), and from 2 of 30 (7%) healthy controls. When sucrose extracts from BJAB, Ramos, and JM cells were used as the cellular antigens, no anti-RANA precipitin lines were detected. Indirect immunofluorescence study, using Raji cells or human B lymphocytes transformed by EB virus as substrate tissues, demonstrated anti-RANA antibody as fine speckled nuclear staining. Although RA patients with positive anti-RANA antibody usually had high titers of anti-Epstein-Barr nuclear antigen (EBNA) and anti-viral capsid antigen (VCA) IgG antibodies, the Wilcoxon ranks sum test showed no close statistical correlation between the presence of anti-RANA antibodies and the titers of anti-EBNA or anti-VCA (IgG) antibodies. These data showed that the incidence of positivity of anti-RANA antibodies in Japanese RA patients is almost the same as that in American and European RA patients. | |
| 169295 | Cryoimmunoglobulinemia in rheumatoid arthritis. Significance in serum of patients with rhe | 1975 Sep | Cryogloculins were examined in a standardized manner in an unselected group of 35 patients with rheumatoid arthritis (RA) and 8 patients with RA complicated by cutaneous vasuclitis and neuropathy. Optimum conditions for detection and characterization of cryoglobulins were established; the proportion of resolubilized to total precipitable protein remained constant in an individual patient under these conditions. All 8 vascultis patients and 9 of 35 other patients with RA exhibited cryoglobulins; total protein and immunoglobin content were significantly higher in the cryoglobulins of patients with vasculitis. Immunoglobulins G and M constituted two-thirds and three-quarters of the total protein in the cryoglobulins from uncomplicated rheumatoid and vasculitis patients, respectively. Serum antiglobulin titers were higher, and serum C3 levels were lower, in vasculitis patients compared to rheumatoid patients without vasclitis. Anti-gamma globulin activity was detected in all cryoglobulins from vasculitis patients. Cryoglobulin IgG and IgM were polyclonal. Density gradient analyses demonstrated the majority of the cryoglobulin activity to reside in the 19S IgM fraction. There was no evidence of a light weight (8S) IgM. A monoclonal rheumatoid factor did not detect 7S-ANTI-7S complexes in the cryoprecipitates, but acid eluates from some cryoglobulins absorbed with insoluble IgG revealed an antiglobulin of the IgG class. Serial studies performed on vasculitis patients treated with cyclophosphamide disclosed a relationship between clinical evidence of vasculitis and the presence of cryoglobulins. The antigen (IgG) and antibody (largely IgM rheumatoid factor) nature of these cryglobulins is presented as evidence that the widespread vascular complications of RA are mediated, at least in part, by circulating immune complexes. | |
| 7232724 | Radiographic projections for the diagnosis of arthritis of the hands and wrists. | 1981 Jun | One hundred consecutive sets of radiographs with the hands halfway supinated (Nørgaard's view) were reviewed retrospectively without knowledge of the clinical diagnosis to determine the value of this view for diagnosis of rheumatoid arthritis. Indistinct cortex at specific sites, reported to be a sensitive indicator of rheumatoid arthritis, was seen in 81% of rheumatoid patients: however, it was not specific for rheumatoid arthritis, being present in both inflammatory and noninflammatory arthritides. These changes are apparently due to variations in cortical morphology and are not true erosions. Definite erosions, which were more specific for inflammatory arthritis, were seen at the same sites; however, erosions could be identified on postero-anterior radiographs in 14 of the 16 cases in which they were seen on the Nørgaard views. | |
| 1214508 | Studies on the immunochemical composition of human thoracic duct lymph of patients with rh | 1975 Dec | Analysis of immunoglobulins, autoantibodies and third component of complement was carried out on the thoracic duct lymph of 6 patients with rheumatoid arthritis and 2 patients with polymyositis. It was found that the distribution of these immunoproteins between lymph and serum reflected the distribution of total protein and did not appear to be dependent on molecular size. There was no significant difference in the distribution of the macromolecule IgM as compared to the other immunoglobulins. IgD was an exception with an unanticipated and unexplained lower concentration in lymph and higher serum to lymph ratio when compared to the other immunoglobulins. | |
| 6949549 | Results of geometric arthroplasty for rheumatoid and osteoarthritis of the knee. | 1981 Dec | The Geometric Total Knee Arthroplasty was one of the earliest unconstrained knee arthroplasties available for the replacement of knees severely affected by destructive arthritis. This paper presents the results of Geometric knee arthroplasty performed by surgeons of the Alfred Hospital, Melbourne, during the years 1973 to 1977, this being the initial five years experience with this procedure. One hundred and fifty arthroplasty operations were performed in 106 patients, 78 for osteoarthritis and 72 for rheumatoid arthritis, with the average time from operation to review being four years. The Geometric arthroplasty was used in 147 of these operations. Assessment was based on a modification of the British Orthopaedic Association Knee Function Assessment Chart (1978) and 137 knees were available for review. Eighty nine percent of patients suffering osteoarthritis, and 79% of patients with rheumatoid arthritis were satisfied or enthusiastic with their prosthesis. Nineteen percent of rheumatoid patients and 4% of osteoarthritic patients considered the result of their operation disappointing. In both groups, the operated knee constituted minimal persisting disability to the patient when reviewed. Seventeen knees (11.3%) were assessed as unsatisfactory, of which 7 (4.6%) were due to infection, and 5 (3.3%) were due to loosening. Revision procedures were performed in 7 knees (5%), for instability or loosening. Improvements in arthroplasty design have resulted in alternative prostheses now being chosen by most surgeons for knee replacement, and the long term results of these newer prostheses must be evaluated with those results obtained using the original geometric prosthesis. | |
| 3936929 | The effects of auranofin and gold sodium aurothiomalate on the chemiluminescent response o | 1985 Oct | Mononuclear cells were obtained from synovial tissue of patients with rheumatoid arthritis. The cells were stimulated with opsonized zymosan and generation of reactive oxygen species (ROS) was assayed by chemiluminescence. The effects of gold sodium thiomalate (GSTM) and auranofin (AF) on the chemiluminescent response were observed. Synovial tissue cells showed a chemiluminescent response suggesting their ability to release ROS; this response was inhibited by AF but not by GSTM. | |
| 6609690 | [T lymphocyte subpopulations in rheumatoid arthritis]. | 1983 Jul | The study of T lymphocyte subpopulations defined by monoclonal antibodies in a group of patients with rheumatoid arthritis and a control group indicated no significant differences in the percentages of total T lymphocytes (OKT3+) or helper-inducer lymphocytes (OKT4+). However there was a significant diminution in suppressor-cytoxic lymphocytes (OKT8+) in patients with active forms of the disease. This diminution led to an increase in the proportion of OKT4+/OKT8+ in patients with active R.A. forms compared to both those in remission and the control group. | |
| 4059903 | Have the newer NSAIDS contributed to the management of rheumatoid arthritis? | 1985 Jul | Approximately 30 non-steroidal anti-inflammatory agents are available for the treatment of rheumatoid arthritis. In this study patient acceptability of five such agents (benoxaprofen, fenbufen, feprazone, flurbiprofen, ketoprofen) is compared in groups of 50 patients with rheumatoid arthritis. Less than 40 per cent of patients continued on the prescribed drug for six months. Significantly more patients stopped fenbufen than stopped feprazone, otherwise dropout rates between the groups were similar. The overall efficacy and toxicity of most currently prescribed NSAIDs appear to be similar, and the availability of a surfeit of such agents dilutes clinical experience with any one drug. Despite subsequent events this method failed to differentiate benoxaprofen from the other agents. It would seem likely that this surfeit of similar drugs hinders detection of unusual complications, and impedes satisfactory management of inflammatory rheumatic disorders. | |
| 1101758 | Naproxen in rheumatoid arthritis. A controlled trial. | 1975 Oct | The efficacy of naproxen in treating rheumatoid arthritis patients was evaluated in a double-blind clinical trial using aspirin as the control drug. The study was conducted at seven centers and involved 80 patients. After an unequivocal increase in disease activity during a drug-free period, patients were randomly assigned to either drug and continued in the trial for 16 weeks. Some patients took low maintenance doses of corticosteroids, or gold salts, or both throughout the trial. Both test drugs significantly decreased disease activity as measured by a number of ways. By objective measurements, naproxen was as effective as aspirin, although patients in the naproxen-treated group entered the trial with more severe disease. By some subjective evaluations, naproxen was considered more effective than aspirin. Although patients taking naproxen had less frequent gastrointestinal side effects and fewer symptoms VIIIth nerve toxicity, the differences were not statistically significant. We conclude that naproxen is a useful addition to the physician's armamentarium for the treatment of rheumatoid arthritis. | |
| 316761 | Hitherto assembled results with the assessment of HLA antigens in rheumatic diseases and t | 1979 | The authors characterize the position which developed in the sphere of rheumatic diseases, in particular inflammatory ones, after in these diseases the association with HLA antigens was revealed; most important is still the association of HLA B 27 with ankylosing spondylitis (Bekhterev's disease) which stimulated a new line of research and helped to detect the projection of antigen into all so-called rheumatic diseases which have in addition to affected peripheral joints inflammatory change of the SI synchrondrosis and segmentary signs of ankylosing spondylitis. The authors examined patients with psoriatic arthropathy and pure dermatological psoriasis but found only association with B 17 and B 13. In ankylosing hyperotosis (Forestier) they prove, based on the findings in 36 patients that in controversial cases the absence of B 27 may be important. They report also on their finding of an enhanced association of A 10 and B 14 in a group of 48 patients with seropositive rheumatoid arthritis. | |
| 322586 | [Immunofluorescent deposits in normal rheumatoid skin]. | 1977 Jan | Predominantly IgM immunofluorescent deposits have been found in 30% of normal, non exposed skin in a group of rheumatoid arthritis patients. Neither clinical nor biological correlation have been found. Because one case with cryoglobulinemia was positive, study of other non lupus, cryoglobulinemic, immune complexe type of diseases has been done. The results were negative. Further investigations are needed to explain this observation. | |
| 1206673 | Irreversible bone marrow failure with chlorambucil. | 1975 Dec | Two cases of irreversible bone marrow failure are described, one with rheumatoid disease and one with systemic lupus erythematosus. Each case was associated with prior chlorambucil administration, effective in controlling the clinical manifestations (total dosage 398 and 1,764 mg respectively). The irreversibility of the bone marrow depression in the two cases presented stands in contrast to published assurances that chlorambucil-associated leukopenia is dose-related and readily reversible. The cases illustrate that chlorambucil therapy should not be continued after initial leukopenia, until peripheral counts or marrow cellularity has returned to normal. Titration of drug dosage and leukocyte count, as frequently employed with cyclophosphamide and other alkylating agents, must be presumed hazardous. Additional studies are needed to determine if irreversible bone marrow depression is dose-related or idiosyncratic. | |
| 7175843 | Manubriosternal joint subluxation in rheumatoid arthritis. | 1982 Sep | Manubriosternal joint involvement in rheumatoid arthritis is not rare and may be evidenced by erosion, reactive sclerosis and ankylosis. Frequent reports of such involvements appear in the radiological literature but only 3 cases where this had been associated with clinically evident subluxation of the joint have been reported previously. It is, nonetheless, our observation that clinical deformity of this joint is common and careful review at our clinic has revealed the 10 cases reported here. Chronic or recurrent chest infections have been incriminated in the production of this deformity. However, the evidence seen in our series suggests rather, that this deformity is closely associated with severe cervicodorsal spinal erosion and deformity and that its presence should alert clinicians to potential problems of cervical cord compression. | |
| 6459096 | Ia+ T cells in synovial fluid and tissues of patients with rheumatoid arthritis. | 1981 Nov | Markedly elevated levels of T cells expressing Ia antigens were found in the synovial membranes and synovial fluids of patients with rheumatoid arthritis. The primary increase in expression of the Ia antigens was on the OKT 8+ (suppressor/cytotoxic) T cell subset. In addition, the total percentage of OKT 8+ T cells in intraarticular sites was usually greater than levels in peripheral blood. Small numbers of OKT 4+ (helper/inducer) cells bearing Ia antigens were also identified. The characteristic increase in the Ia+ T cells in peripheral blood was not encountered in most patients treated with D-penicillamine. | |
| 810648 | [Long term treatment of rheumatoid arthritis. Experiences with D-penicillamine in comparis | 1975 Sep 19 | In a controlled trial including 80 patients suffering from different stages of rheumatoid arthritis it was demonstrated that D-penicillamine therapy favourably influences the clinical course of the disease as compared to a control group treated with antirheumatic drugs. Particularly the therapy continued over one year resulted in a significant fall of the joint and activity index as well as of the BSR. Side effects were observed in more than half of the cases. Renal, hematological and severe exanthematic complications forced to discontinue the administration of D-penicillamine in 6 of 41 cases. As compared to other therapeutics our study indicates that D-penicillamine and gold treatment are equivalent drugs in rheumatoid arthritis whereas immunosuppressive drugs are reserved for severe cases of rheumatoid arthritis because of their strong side effects. | |
| 615415 | Cell-to-cell contacts between lymphoreticular cells in rheumatoid synovial membrane. | 1977 | Nodular type and diffuse perivascular lymphoid cell infiltrates in rheumatoid synovial membranes from 72 patients were examined under the electron microscope. Attempts were made to describe the ultrastructural relations of the cells examined and to classify the different types of cell-to-cell contracts between them. Members of a complex series, composed of gradually differentiating forms of cell contacts beginning from simple membrane adherences and interdigitations and gap junctions; minute filamentous intercellular bridges: subsurface confronting cisternae and desmosome-like structures, are described and suggested as function-dependent morphological representatives of sites of cellular interactions. | |
| 3930719 | Class specific rheumatoid factors in rheumatoid arthritis: response to chrysotherapy and r | 1985 Jun | IgG rheumatoid factors (RF) may play an important role in the pathogenesis of rheumatoid arthritis (RA). Our study investigates the relationship between class specific RF levels measured by radioimmunoassay and disease activity in patients with RA undergoing chrysotherapy. Nineteen patients were treated with 20 mg disodium aurothiomalate weekly for 6 months. Rheumatoid disease activity was assessed before and after 6 months' treatment and the level of IgG, IgA and IgM RF measured. There were significant falls in disease activity (p less than 0.005), IgA RF (p less than 0.005) IgG RF (p less than 0.005) and SCAT (p less than 0.025), but not IgM RF, over the 6 month treatment period. No correlation was found between absolute levels of IgA, IgG or IgM RF and disease activity before or after 6 months' therapy but there was a highly significant linear correlation between reduction in IgG RF levels and fall in disease activity (r = 0.642, p less than 0.005) with treatment. | |
| 1145012 | Phenylbutazone and hepatitis. | 1975 May | During a comparative trial between enteric-coated and rectally administered phenylbutazone in patients with rheumatoid disease, one patient developed a mild hepatitis. She had recently concluded a long period of gold therapy. The natural history of phenylbutazone hepatitis is reviewed on the basis of 41 case histories, and the experience with this individual patient interpreted accordingly. | |
| 6978034 | Irregularities at the base of the proximal phalanges: false indicator of early rheumatoid | 1982 Apr | Fifty posteroanterior hand radiographs from normal adults were reviewed retrospectively to assess the incidence of cortical indistinctness at the base of the proximal phalanges in a normal population. This radiographic change, reported to be an early indicator of rheumatoid arthritis, was seen in at least one site in 10% of the films reviewed. Focal areas of cortical erosion or indistinctness at the bases of the proximal phalanges are not considered to be a reliable sign of early rheumatoid arthritis in the absence of juxtaarticular osteoporosis or changes in the metacarpal heads. |