Search for: rheumatoid arthritis methotrexate autoimmune disease biomarker gene expression GWAS HLA genes non-HLA genes
| ID | PMID | Title | PublicationDate | abstract |
|---|---|---|---|---|
| 6972106 | Thymosin administration in autoimmune disorders. | 1981 Feb | Five patients with autoimmune disorders were given thymosin, fraction 5, parenterally for periods ranging from 2 to 35 mth. Four patients had systemic lupus erythematosus and the 5th had rheumatoid arthritis and Sjögren's syndrome. Treatment with thymosin was based on the hypothesis of a T-suppressor defect in these autoimmune disorders. Circulating T lymphocytes increased and remained above pretreatment levels in all patients. Assays for cytotoxicity, using mouse thymocytes and patients' sera, were positive initially and declined during the course of the treatment. In all patients, serum cytotoxicity levels were reduced to zero. There has been clinical improvement in 3 patients, and in 1, the disease has become stable. The evaluation of the 5th patient has been inconclusive. No ill effects related to the administration of thymosin were observed. | |
| 6537095 | Lysosomal gold accumulations in pulmonary macrophages. | 1984 | Although soluble gold has been widely used in the treatment of rheumatoid arthritis, little is known about the distribution of gold deposits in extra-articular tissues. In the synovial lining cells and articular cartilage, the morphology of lysosomes containing gold, the aurosomes, is well documented. Because gold may cause pulmonary injury, the morphology and distribution of gold deposits in pulmonary tissue should be recognized. We found morphologically typical aurosomes with electron-dense membranes and granules, giving the spectrum of gold in electron microprobe analysis, in the interstitial and alveolar macrophages in the open lung biopsies of 3 patients who had received gold treatment but not in 12 patients who had not received gold treatment. In contrast to previous studies, aurosomes were not found in the endothelial cells. | |
| 6432403 | Gold-induced thrombocytopenia: detection of anti-platelet antibody. | 1983 Jun | We describe a patient with rheumatoid arthritis who developed a sudden, severe thrombocytopenia during the early stages of treatment with sodium aurothiomalate. There were no haemorrhagic manifestations and the thrombocytopenia was rapidly corrected by corticosteroid treatment. The presence of anti-platelet IgG was demonstrated in serial serum specimens by an enzyme-linked immunosorbent assay (ELISA). Although most of this reactivity proved to be directed against allogeneic antigens on donor platelets, IgG reactive with autologous platelets was detected in the first serum sample obtained. | |
| 1066564 | Compliancy in splint-wearing behaviour of patients with rheumatoid arthritis. | 1976 May 26 | Forty-six patients with rheumatoid arthritis affecting their hands were questioned to establish whether or not they complied with the medical specialist's instructions about wearing splints. Only one-third of the patients appeared to comply. A high extraversion score (measured on the EPI questionnnaire) identified half of the patients who did not comply. All patients scored significantly lower then the population norm on the introversion-extraversion dimension, indicating that this dimension may be involved in the psychosomatic aspect of rheumatoid arthritis. | |
| 6127461 | Defective repair of 0(6)-methylguanine in autoimmune diseases. | 1982 Oct 30 | On the premise that somatic mutations may be involved in the pathogenesis of diseases such as systemic lupus erythematosus and rheumatoid arthritis, the proficiency of repair of 0(6)-methylguanine, a powerful, premutagenic, directly miscoding base lesion, was examined in the DNA of peripheral-blood mononuclear cells (mainly lymphocytes) from patients with such diseases. The capacity of lymphocytes to repair this lesion was impaired in many patients with autoimmune disease. In some healthy controls repair was also defective whereas in other, nonautoimmune diseases, it was not. These findings support the hypothesis that this defect of repair was not simply a result of the disease state. It is therefore postulated that defective repair of 0(6)-methylguanine could be one of the factors determining the susceptibility of autoimmune diseases in genetically predisposed individuals. | |
| 877798 | Jaccoud's arthropathy: report of seven cases. | 1977 May 21 | Seven patients with severe rheumatic heart disease and joint deformities, in whom there were no signs of active arthritis, are described. The fulfill the criteria for the diagnosis of Jaccoud's arthropathy (or 'chronic post-rheumatic arthritis'). We postulate that hypermobility may be a predisposing factor in the development of the deformity. This rare condition should be distinguished from rheumatoid arthritis because of its relatively favourable prognosis. | |
| 6623009 | Circulating immune complexes in rheumatoid arthritis with extra-articular manifestations. | 1983 | Circulating immune complexes (CIC) and complement C4, C3 and CH50 levels in serum were monitored during 6-30 months in 10 patients with rheumatoid arthritis and extra-articular manifestations (EM). A total of 58 observations were made, 17 at times when new EM emerged, 41 at times when the patients were in a steady state. CIC were demonstrated by two methods, viz. a complement consumption test (CCT) and a polyethyleneglycol (PEG) precipitation assay. The precipitates were analysed for their content of IgG, IgM and IgA. The CCT titre decreased significantly at the time of a new EM, whereas PEG precipitates were found most often at this time. Two types of precipitate could be demonstrated. One consisted of IgG only, which was found most often when the patients were in a steady state. The other one was composed of IgG and other immunoglobulins, most often IgA. The latter type was found most often at the time when the patients developed new EM. Subnormal serum complement levels were demonstrated frequently. The level of C4 was significantly lower at the time of a new EM, compared with the level of patients with RA but without EM. The decrease in anticomplementary effect and the signs of complement activation suggest that the qualitative and quantitative changes in CIC observed at the time of new EM were the cause rather than the consequence of the clinical manifestations. | |
| 6377492 | Controlled release indomethacin (Indotard). Clinical trial in patients with rheumatoid art | 1984 | In a double-blind, crossover multicentre trial the effect on morning stiffness and occurrence of side effects of a controlled-release indomethacin preparation, Indotard, was compared with a conventional preparation, Indocid. 30 Patients between 38 and 74 years of age--six from each centre--underwent the investigation: A 4-day escalating period and 2 X 7 days' treatment. In the average figures, no difference in effect or side effects could be seen between Indotard 50 mg given twice and Indocid 25 mg given four times daily. There was, however, a marked preference among the younger (less than 62 years) for the controlled-release formulation and a preference among the older for the conventional preparation. | |
| 880058 | [Complex laboratory-morphologic study of allergic joint inflammation in rabbits]. | 1977 | During the period of sensitization and in the dynamics of the development of the articular allergic inflammation in rabbits there occured regular slowing down of the properdin activity, decrease in the compliment titres and increase in the blood plasma magnesium content. An increased liability of the basophilic leukocytes to damage and an elevated activity of acid phosphotase in lymphocytes of the peripheral blood were also noted. In the acute period of inflammation the synovial sheaths were found to be diffusibly infiltrated by the lymphoid-histocytic and plasma cells. Proliferation of synoviocytes and the appearance therein of the PAS-positive granules were observed. Weakening of the myocardial staining with Schiff's reagent was established. The processes of disorganization of the connective tissue in a joint and in the heart were closely conjugated and manifested themselves in mucoid and fibrinoid swelling, and changes in the PAS-reaction. Dissociation of the natural resistance of the organism was revealed: mobilization of the processes of immunogenesis and inhibition of the nonspecific link of protection. Decrease in the immunological reactivity was associated with formation of hypersensitivity of delayed type. Cosequently, arthritis developed in rabbits on the immune basis. | |
| 213353 | Ulnar neuropathies in rheumatoid arthritis. | 1978 Feb | A loss of functional motor axons in the median and ulnar nerves occurred in half of thirty-three patients with rheumatoid arthritis. Weakness of small hand muscles may predispose to the development of ulnar deviation of the fingers in patients with joint disease at the radio-ulnar and metacarpophalangeal joints. There is no evidence that spasm of small hand muscles is a significant cause of ulnar deviation of the fingers in rheumatoid arthritis. Ulnar deviation of the fingers in rheumatoid arthritis is not due to selective impairment of the ulnar nerve or the deep palmar branch of the ulnar nerve even though ulnar deviation of the fingers can occur in association with such lesions and in the absence of joint disease. | |
| 302025 | [Hydroxyapatite rheumatism (multiple tendon calcification disease). I.- Clinical study]. | 1977 May | A study was made of 45 patients suffering from hydroxyapatite rheumatism (multiple tendon calcifications disease). There were 36 women and 9 men aged between 15 and 61 years with an average age of 14. The following joints were involved (the first figure refers to clinical affection, that between brackets to radiologically demonstrable calcifications): shoulder 34 (36); neck 14 (15); wrist 18 (11); fingers 19 (17); hip 11 (29); knee 14 (18); ankle 10 (14); foot 5 (6); spinal column 16 (24). In 30 patients the disease manifested itself in the form of acute recurrent migratory arthritis resembling gout. In 8 cases, it developed in the form of acute recurrent migratory arthritis resembling gout. In 8 cases, it developed in the form of acute polyarthritis and in 7 as rheumatoid arthritis without radiological lesions. Thirty-two patients could be followed up. Four of them were cured, 9 showed improvement but still suffered attacks of pain. Eighteen patients were not improved, their pains growing more chronic. Four patients had a family history of multiple tendon calcifications disease. | |
| 6663594 | Judging "current disease activity" in rheumatoid arthritis--an international comparison. | 1983 Dec | Judgments of "current disease activity" made on "paper patients" (patient data presented on simple forms) reflect those made when seeing the real patients on whom the "paper patients" are based (R = 0.853) and furthermore are highly reproducible (R = 0.952). Judgments made on the same "paper patients" in a rheumatology department in the UK and one in Canada also correlate highly (R = 0.860) and this may reflect a common experience in the type of patients seen. Such general similarities between centers justify comparisons of more detailed analysis of clinical judgment using "paper patients." | |
| 3920393 | One-year comparative study of gold sodium thiomalate and auranofin in the treatment of rhe | 1985 Feb | The therapeutic benefits and toxicity profile of auranofin (AF) have been compared with that of gold sodium thiomalate (GSTM) over a one-year period in 120 patients with rheumatoid arthritis. A similar number of patients on both drugs remained in the study at one year (approximately 60%), and showed similar statistically significant improvement (p less than 0.01) in all clinical variables measured. At no time during the study was there a statistically significant difference in the clinical benefit obtained with either drug. Withdrawal from the study through lack of therapeutic benefit was twice as frequent with AF as with GSTM (11 compared to 6). Withdrawal due to a toxic reaction was twice as frequent and were potentially more serious with GSTM than with AF (15 compared to 9). We conclude that AF has a therapeutic potential similar to that of GSTM, however side effects were less prevalent and, when they did cause withdrawal of the drug, were potentially less serious. | |
| 350499 | Night medication in rheumatoid arthritis. III. the use of sulindac. | 1978 | A double-blind controlled trial was carried out in 18 in-patients with classical or definite rheumatoid arthritis to assess the effectiveness of night-time medication with 100 mg indomethacin plus 10 mg diazepam, 200 mg sulindac, and 200 mg sulindac plus 10 mg diazepam in improving sleep and reducing night pain and the duration of morning stiffness. Patients received each treatment regimen for 1 night. The results from the 17 patients completing the full trial protocol indicated that indomethacin plus diazepam was the most effective of the three regimens, although the differences did not reach conventional statistical significance. It is suggested that in further such studies with sulindac a larger dose and a longer duration of treatment should be used. | |
| 6208286 | The effects of the antirheumatic agents N-(2-carboxyphenyl)-4-chloroanthranilic acid disod | 1984 | CCA and D-penicillamine enhanced the NK activity of human lymphocytes in vitro incubation. ADCC activity of the lymphocytes was increased slightly by D-penicillamine but not by CCA. CCA enhanced interferon production from lymphocytes but D-penicillamine did not. | |
| 863527 | Rheumatoid-like joint lesions in rabbits injected intravenously with bovine serum. | 1977 | Rheumatoid-like synovial lesions have been produced experimentally in 21% of rabbits receiving intravenous injections of bovine serum by various regimens. They were characterized by lining cell hyperplasia, accumulations, often follicular, of lymphocytes and plasma cells just under the lining layer, sometimes with extensive fibroplasia and pannus formation with cartilage erosion. | |
| 971882 | [Scintigraphic demonstration of the synovial membrane]. | 1976 | A new technique to diagnose and control the progress of pcp in the hand is described using Tc 99 m to visualize inflammatory reactions in various tissues. Objectivity, repeatability and the possibility to see the disease in its earliest stages are advantages of the method. | |
| 3983565 | [Psychological aspects of rheumatoid arthritis. Attempt at a better understanding of the p | 1985 Feb | This study is an attempt to identify the principle causes of stress in patients affected with rheumatoid arthritis. It is based on personal experience with 62 patients treated in a multidisciplinary manner over a time period of two years. The psychological impact of these stress factors on the patients were evaluated in an effort to further the treatment methodologies in this area. Among the factors considered are: the disease as a chronic process and as a result the progressive destruction of bodily function, the limitations produced by a disease of the joints, the presence of pain and the side effects produced by the medications. As a step to lessen the mental distress caused by RA, it is proposed that the physician team should seek to inform the patient in a clear and concise manner about RA to establish a working doctor-patient line of communication, and to encourage activities that promote the maintenance of patient self esteem. | |
| 1211212 | Sudden death in rheumatoid arthritis with atlanto-axial dislocation. | 1975 Dec | A post mortem material of 11 consecutive cases of severe atlanto-axial dislocation (a.a.d.) with cord compression is reported. The total number of deaths from rheumatoid arthritis (RA) during the period of 5 years was 104, and all were autopsied. Neurological symptoms correlated poorly to fatal a.a.d. Hemiplegia was found in three cases, one of which, however, was caused by thrombosis cerebri. Spastic signs were transiently recorded in two patients and dysphagia in a further two. Five patients had a history of recent vomiting. A.a.d. was the sole or main cause of death in 8 cases and contributory in 2. Sudden death occurred in 7 of the cases. Only 2 cases had obtained a correct diagnosis intra vitam. The CNS findings at autopsy consisted of cord compression (11/11 cases), cord malacia (2/11) and cerebral oedema (3/11). One case had polyarteritis and renal amyloidosis and one pulmonary carcinoma with metastatic spread. Signs of active inflammation in the axial joints were present in 4 cases. This study, based on systematic post mortem examinations, revealed an unexpectedly high and not previously reported incidence of fatal medulla compression in RA patients with a.a.d. (10%). | |
| 6259207 | Seroepidemiological study of relationships between Epstein-Barr virus and rheumatoid arthr | 1981 Mar | To elucidate the relationship between Epstein-Barr virus (EBV) and rheumatoid arthritis (RA), we measured antibodies to RA-associated nuclear antigen (anti-RANA) and three other EBV-related antigens in the sera of RA patients and controls. Our study groups consisted of 89 patients with definite or classical RA, mean age 56, male/female ratio 47:42; and 53 normal and osteoarthritis controls, mean age 51, male/female ratio 25:28. In addition to anti-RANA, we measured antibodies to viral capsid antigen (anti-VCA), early antigen (anti-EA) and EBV-associated nuclear antigen (anti-EBNA). Anti-RANA was detected in 71% of RA patients but in only 6% of controls. Elevated anti-VCA titers (greater than 1:160) were more common in RA patients than controls, 31% compared with 15%. The geometric mean titer of anti-VCA was significantly higher iun the RA group, 133 compared with 58. Anti-EA was present in 53% of RA patients but only 19% of controls. Anti-EA in elevated titers (greater than 1:20) was present in 26% of RA patients but only 7% of controls. Characterization of the anti-EA antibodies revealed that the RA patients reacted primarily with the diffuse component, whereas the majority of the controls reacted with the restricted component of the EA complex. In contrast, the frequencies, distributions, and geometric mean titers of anti-EBNA were not significantly different between the two groups. Correlative analysis of these antibodies showed highly significant relationships between anti-VCA and anti-EA, and anti-RANA and anti-EBNA in the RA group. These data are compatible with the interpretation that RA patients have either more active EBV infections than controls or an altered regulation of their immune response to this infectious agent. |